iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-027672

Ensembl Protein ID

ENSDARP00000137761.1

UniProt Accession

Q90W33; HIC2_DANRE

Genbank Protein ID

CAC70661.1

Protein Name

Hypermethylated in cancer 2 protein

Genbank Nucleotide ID

AJ307688

Gene Name

hic2; hrg22

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000100497.1	ENSDART00000160046.1	ENSDARP00000137761.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	5.30e-14	53.3	24	83

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveik.d.vqpevfrallkFlYtgkl 65
           +Dvi+vv++  f+ahk +LaasS +F++l+l+        + ++++ d v p+vfr++l+F+Ytgkl
   Q: 24   CDVIIVVENALFRAHKNILAASSIYFKSLILH-------DNLINLDtDmVNPSVFRQVLDFIYTGKL 83
           9*****************************99.......5789999889*****************8 PP

Organism

Danio rerio

Functional Description
(View)

Transcriptional repressor.

Protein Sequence
(Fasta)

MELPNHAKQL LLQLNQQRAK GYLCDVIIVV ENALFRAHKN ILAASSIYFK SLILHDNLIN 60
LDTDMVNPSV FRQVLDFIYT GKLLSSDQFS DHNFNALLTA ASYLQLHDLA ALCRKKLKRN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTCTCACGT CACACAAGCT TGCAGGCAAG ATGGCGCTCG GAAAGCTGTG AGATGTGAAA 60
ACAGAATGAC TGTTTGAAGA GCTTCTGTCG ATGCATTAAG GTACGGATAC TTCATTATTA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR023413--GFP-like
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-004217	Anas platyrhynchos	62.54	6.00e-171	593.00
IUUC-Ame-010754	Astyanax mexicanus	87.17	0.00e+00	806.00
IUUC-Bta-013162	Bos taurus	50.99	1.00e-139	490.00
IUUC-Cfa-020537	Canis familiaris	61.74	6.00e-92	331.00
IUUC-Cpo-021843	Cavia porcellus	55.59	3.00e-152	531.00
IUUC-Csa-023171	Chlorocebus sabaeus	79.58	1.00e-89	324.00
IUUC-Dno-029125	Dasypus novemcinctus	79.79	2.00e-91	329.00
IUUC-Dor-030484	Dipodomys ordii	60.42	2.00e-51	196.00
IUUC-Ete-033019	Echinops telfairi	58.33	3.00e-46	180.00
IUUC-Eca-033737	Equus caballus	79.27	4.00e-90	325.00
IUUC-Eeu-035190	Erinaceus europaeus	44.89	2.00e-62	233.00
IUUC-Fca-036031	Felis catus	71.49	5.00e-90	325.00
IUUC-Fal-037342	Ficedula albicollis	62.78	1.00e-176	613.00
IUUC-Gmo-039209	Gadus morhua	62.71	1.00e-179	623.00
IUUC-Gga-040433	Gallus gallus	61.79	9.00e-175	606.00
IUUC-Gac-041588	Gasterosteus aculeatus	65.19	0.00e+00	642.00
IUUC-Ggo-045081	Gorilla gorilla	79.58	2.00e-89	323.00
IUUC-Hsa-046397	Homo sapiens	79.58	2.00e-89	323.00
IUUC-Itr-048738	Ictidomys tridecemlineatus	54.56	2.00e-145	509.00
IUUC-Lch-049980	Latimeria chalumnae	62.40	6.00e-139	487.00
IUUC-Loc-052129	Lepisosteus oculatus	72.77	0.00e+00	758.00
IUUC-Mcc-055370	Macaca mulatta	62.63	2.00e-90	326.00
IUUC-Mga-059911	Meleagris gallopavo	61.86	2.00e-169	588.00
IUUC-Mmr-060683	Microcebus murinus	73.78	2.00e-92	333.00
IUUC-Mdo-062271	Monodelphis domestica	58.40	1.00e-94	340.00
IUUC-Mmu-063688	Mus musculus	56.00	6.00e-92	331.00
IUUC-Mpu-066134	Mustela putorius furo	79.17	1.00e-89	324.00
IUUC-Mlu-067531	Myotis lucifugus	63.00	2.00e-92	333.00
IUUC-Nle-069726	Nomascus leucogenys	83.73	3.00e-79	289.00
IUUC-Opr-071056	Ochotona princeps	41.34	2.00e-67	250.00
IUUC-Ont-071390	Oreochromis niloticus	65.53	0.00e+00	650.00
IUUC-Ocu-073887	Oryctolagus cuniculus	78.24	1.00e-88	321.00
IUUC-Ola-087091	Oryzias latipes	62.40	9.00e-140	490.00
IUUC-Oga-088655	Otolemur garnettii	63.23	3.00e-90	326.00
IUUC-Ptr-090786	Pan troglodytes	60.06	1.00e-89	323.00
IUUC-Pan-092901	Papio anubis	79.58	2.00e-89	323.00
IUUC-Psi-093684	Pelodiscus sinensis	63.86	0.00e+00	643.00
IUUC-Pfo-096241	Poecilia formosa	63.79	7.00e-169	587.00
IUUC-Pab-098162	Pongo abelii	79.58	3.00e-89	322.00
IUUC-Pca-101051	Procavia capensis	53.91	1.00e-136	479.00
IUUC-Rno-105690	Rattus norvegicus	54.29	5.00e-151	528.00
IUUC-Ssc-116215	Sus scrofa	61.74	1.00e-84	307.00
IUUC-Tgu-116768	Taeniopygia guttata	62.20	1.00e-175	609.00
IUUC-Tru-117833	Takifugu rubripes	63.68	7.00e-176	610.00
IUUC-Tni-119907	Tetraodon nigroviridis	56.08	2.00e-142	499.00
IUUC-Xtr-132400	Xenopus tropicalis	63.30	2.00e-175	608.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence