iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Laf-053891

Ensembl Protein ID

ENSLAFP00000024924.1

UniProt Accession

G3UAR6; G3UAR6_LOXAF

Protein Name

Uncharacterized protein

Gene Name

ARHGEF7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLAFG00000001580.3	ENSLAFT00000001581.3	ENSLAFP00000001319.3
ENSLAFG00000001580.3	ENSLAFT00000034145.1	ENSLAFP00000024924.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	7.50e-15	55.0	166	220

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +v++ ++++ +n+deL+++kGd+++v     +++gW++g  + +g+ G fP+n+v++++
   Q: 166  VVRAKFNFQQTNEDELSFTKGDIIHVT--RVEEGGWWEG--THNGRTGWFPSNYVREIK 220
           78999*********************7..999*******..8**************996 PP

Organism

Loxodonta africana

Protein Sequence
(Fasta)

MNSAEQTVTW LITLGVLESP KKTISDPEGF LQSSLKDGVV LCRLLDRLLP RDHRRKAPAQ 60
RVSEPVKTTR TALLTCISAY KLPTFDANDL YQGQNFNKVL SSLVTLNKVT ADIGLGSDSV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGAATCTGT TTCCTCCTTC TGAGTCTTAC ATTTTCCTGT GTAAAAGCAT TTTAACCTAC 60
AGTGAGGTTT AAGAACGAAA ACAAGTTAAA AGAAAAAAAA AAAGATTGCC CTTCCGTAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1185--Reference proteome

Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR032409--GEF_CC
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF16523--betaPIX_CC
PF00307--CH
PF00169--PH
PF00621--RhoGEF
PF07653--SH3_2

PRINTS

PR00452--SH3DOMAIN

SMART

SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0030027--C:lamellipodium
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0000322--C:storage vacuole
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0048041--P:focal adhesion assembly
GO:0007030--P:Golgi organization
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0035556--P:intracellular signal transduction
GO:0030032--P:lamellipodium assembly
GO:0043065--P:positive regulation of apoptotic process
GO:0010763--P:positive regulation of fibroblast migration
GO:0060124--P:positive regulation of growth hormone secretion
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:0032092--P:positive regulation of protein binding
GO:1900026--P:positive regulation of substrate adhesion-dependent cell spreading
GO:1904424--P:regulation of GTP binding
GO:0035023--P:regulation of Rho protein signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001259	Ailuropoda melanoleuca	88.38	0.00e+00	1267.00
IUUC-Aca-004591	Anolis carolinensis	89.33	0.00e+00	1353.00
IUUC-Ago-008003	Ashbya gossypii	24.80	3.00e-14	73.90
IUUC-Ame-010759	Astyanax mexicanus	73.62	0.00e+00	1220.00
IUUC-Bta-013328	Bos taurus	91.30	0.00e+00	1484.00
IUUC-Bra-017802	Brassica rapa	29.51	1.60e+00	28.10
IUUC-Cja-018742	Callithrix jacchus	91.62	0.00e+00	1195.00
IUUC-Cfa-020756	Canis familiaris	81.20	0.00e+00	1176.00
IUUC-Cpo-021284	Cavia porcellus	90.17	0.00e+00	1368.00
IUUC-Csa-023162	Chlorocebus sabaeus	92.34	0.00e+00	1476.00
IUUC-Cho-024736	Choloepus hoffmanni	74.82	2.00e-176	612.00
IUUC-Cin-025535	Ciona intestinalis	40.28	6.00e-94	337.00
IUUC-Cgl-026676	Colletotrichum gloeosporioides	42.86	1.00e-11	66.20
IUUC-Cne-026866	Cryptococcus neoformans	50.79	6.00e-13	70.50
IUUC-Dre-028646	Danio rerio	73.00	0.00e+00	1212.00
IUUC-Dno-029461	Dasypus novemcinctus	93.85	0.00e+00	1491.00
IUUC-Dor-030623	Dipodomys ordii	84.43	0.00e+00	1023.00
IUUC-Dse-031165	Dothistroma septosporum	40.26	9.00e-12	66.20
IUUC-Dme-032219	Drosophila melanogaster	45.09	5.00e-102	366.00
IUUC-Ete-032236	Echinops telfairi	82.89	0.00e+00	827.00
IUUC-Eca-034137	Equus caballus	96.27	0.00e+00	1383.00
IUUC-Fca-035742	Felis catus	82.13	0.00e+00	1150.00
IUUC-Fal-037205	Ficedula albicollis	94.33	0.00e+00	1211.00
IUUC-Fso-038433	Fusarium solani	41.43	1.00e-11	66.20
IUUC-Gmo-039475	Gadus morhua	67.52	0.00e+00	1039.00
IUUC-Gga-040539	Gallus gallus	79.86	0.00e+00	1014.00
IUUC-Gac-042615	Gasterosteus aculeatus	63.77	0.00e+00	936.00
IUUC-Ggo-044470	Gorilla gorilla	89.23	0.00e+00	1296.00
IUUC-Hsa-046398	Homo sapiens	89.02	0.00e+00	1281.00
IUUC-Kpa-049278	Komagataella pastoris	26.36	2.00e-16	81.30
IUUC-Loc-052146	Lepisosteus oculatus	83.78	0.00e+00	1343.00
IUUC-Mcc-055483	Macaca mulatta	88.89	0.00e+00	1281.00
IUUC-Mla-059044	Melampsora laricipopulina	24.91	2.00e-19	91.30
IUUC-Mga-059410	Meleagris gallopavo	93.13	0.00e+00	1347.00
IUUC-Mmr-060758	Microcebus murinus	92.48	0.00e+00	1256.00
IUUC-Mdo-061900	Monodelphis domestica	80.16	0.00e+00	1263.00
IUUC-Mmu-063849	Mus musculus	89.88	0.00e+00	1233.00
IUUC-Mpu-065876	Mustela putorius furo	81.11	0.00e+00	1162.00
IUUC-Mlu-067970	Myotis lucifugus	96.53	0.00e+00	1390.00
IUUC-Nle-069685	Nomascus leucogenys	77.73	0.00e+00	1050.00
IUUC-Opr-071132	Ochotona princeps	62.01	0.00e+00	697.00
IUUC-Ont-071815	Oreochromis niloticus	73.12	0.00e+00	1200.00
IUUC-Oan-073057	Ornithorhynchus anatinus	94.47	0.00e+00	1224.00
IUUC-Ola-086663	Oryzias latipes	72.57	0.00e+00	1048.00
IUUC-Oga-088103	Otolemur garnettii	94.01	0.00e+00	1316.00
IUUC-Ptr-091162	Pan troglodytes	93.27	0.00e+00	1199.00
IUUC-Pan-092093	Papio anubis	82.61	0.00e+00	1326.00
IUUC-Pma-094701	Petromyzon marinus	56.12	1.00e-122	432.00
IUUC-Pfo-096736	Poecilia formosa	66.71	0.00e+00	1051.00
IUUC-Pab-097641	Pongo abelii	80.28	0.00e+00	1267.00
IUUC-Pva-102819	Pteropus vampyrus	89.75	0.00e+00	1244.00
IUUC-Pgr-103400	Puccinia graminis	26.58	2.00e-19	92.00
IUUC-Rno-106099	Rattus norvegicus	90.72	0.00e+00	1407.00
IUUC-Sha-106845	Sarcophilus harrisii	80.90	0.00e+00	1156.00
IUUC-Ssc-116036	Sus scrofa	80.31	0.00e+00	1149.00
IUUC-Tgu-117498	Taeniopygia guttata	88.52	0.00e+00	1385.00
IUUC-Tru-118278	Takifugu rubripes	71.97	0.00e+00	1048.00
IUUC-Tsy-118990	Tarsius syrichta	94.09	0.00e+00	973.00
IUUC-Tni-120852	Tetraodon nigroviridis	71.93	0.00e+00	959.00
IUUC-Ttr-128922	Tursiops truncatus	91.12	0.00e+00	1115.00
IUUC-Xtr-132012	Xenopus tropicalis	83.66	0.00e+00	1233.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence