iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle............kkkeklneenp................................... 42
           tGl+NlgNtCYmNSvLQ+Ls++  +r+++l+                      +                                   
   Q: 271  TGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKldlnqwlavaasD---------Karsykhsavtdaataaahqlnegqekekgfacsrh 350
           7******************************8776555554431.........144555566677888999999999999999999999 PP
   S: 43   .........................kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleee 106
                                    ++p  +l+++l++lf+ +w++++  vsp ++l++++k+ + f+gy+qqDaqEfl+ lld++++e
   Q: 351  pglssglsggaskgrnmeliqprepSSPYSSLCHELHTLFQVMWSGEWALVSPFAMLHSVWKLIPAFRGYAQQDAQEFLCELLDKIQRE 439
           999999999999998888888888888888*********************************************************** PP
   S: 107  lkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.......slq 188
           l         e+++++  +l   ++++  ++  ++++++F+gql sq++cl+c+n+s++ epf+dlsl++p++ +++ +        ++
   Q: 440  L---------ETTGTKLPALIPTSQRRLIEQVLNVVNNIFHGQLLSQVTCLACNNKSNTIEPFWDLSLEFPERYQCSGKdaasqpcLVT 519
           *.........7888999999999************************************************888877668888888*** PP
   S: 189  dcLesftkeeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfct 266
           d+L +ft++e leg+  y c++c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f ++L+++p+c+
   Q: 520  DMLGKFTETEALEGKI-YVCDHCNSKRRkfsskpvvlteAQKQLMICHLPQVLRLHLKRFRWSGR-NNREKIGVHVVFEETLNMEPYCC 606
           *************965.*******999999999999999***********************998.7778******************* PP
   S: 267  speekqke..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           s++ +  +  + +Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk + +++eevl+   ++aY+lfY++
   Q: 607  SETLNALRpeCFIYNLSAVVIHHGkGFGSGHYTAYCYNSEGGfWVHCNDSKLSMCTMEEVLR---AQAYILFYTQ 678
           *9988766669***************************9999********************...********98 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MDRCKHIEQL QLAQGHSILN PQKWFCMVCN TTESIWACLS CSHVACGQYI QEHALKHFEE 60
SSHPVAFEVN DMYVFCYLCN DYVLNDNTAG DLKSLRSTLS AIKGKSYPCV VQSDSVLQPV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTCTTTGCT GACTTTATAT TGCCCATAGA CAATTTGGGG AGTGATGCAG ACCGAGAATC 60
CTCCAAGACC CAGGTAAACA GGGGTGGTTA TAGAAAGGCA GGTGTGCATG TGTGTGTGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:1904667--P:negative regulation of ubiquitin protein ligase activity
GO:0016579--P:protein deubiquitination
GO:0090231--P:regulation of spindle checkpoint
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	80.56	0.00e+00	1139.00
IUUC-Apl-003673	Anas platyrhynchos	69.07	0.00e+00	946.00
IUUC-Aca-004434	Anolis carolinensis	65.69	0.00e+00	933.00
IUUC-Ame-010986	Astyanax mexicanus	60.31	0.00e+00	819.00
IUUC-Bta-012774	Bos taurus	78.88	0.00e+00	1110.00
IUUC-Cja-019619	Callithrix jacchus	80.70	0.00e+00	1112.00
IUUC-Cfa-020957	Canis familiaris	80.42	0.00e+00	1149.00
IUUC-Csa-023177	Chlorocebus sabaeus	79.75	0.00e+00	1100.00
IUUC-Cho-024877	Choloepus hoffmanni	75.05	0.00e+00	687.00
IUUC-Csv-025814	Ciona savignyi	43.18	5.00e-148	518.00
IUUC-Dno-029832	Dasypus novemcinctus	79.83	0.00e+00	1140.00
IUUC-Ete-032627	Echinops telfairi	77.65	0.00e+00	1107.00
IUUC-Eca-033863	Equus caballus	76.92	0.00e+00	1053.00
IUUC-Eeu-035225	Erinaceus europaeus	73.29	0.00e+00	1030.00
IUUC-Fca-036288	Felis catus	80.28	0.00e+00	1137.00
IUUC-Fal-037207	Ficedula albicollis	68.41	0.00e+00	942.00
IUUC-Gga-040457	Gallus gallus	67.13	0.00e+00	929.00
IUUC-Ggo-044926	Gorilla gorilla	80.42	0.00e+00	1104.00
IUUC-Hsa-046079	Homo sapiens	80.56	0.00e+00	1108.00
IUUC-Itr-048737	Ictidomys tridecemlineatus	79.97	0.00e+00	1132.00
IUUC-Lch-050260	Latimeria chalumnae	61.52	0.00e+00	835.00
IUUC-Loc-051981	Lepisosteus oculatus	72.52	0.00e+00	642.00
IUUC-Laf-054491	Loxodonta africana	78.96	0.00e+00	1076.00
IUUC-Mcc-055694	Macaca mulatta	80.03	0.00e+00	1100.00
IUUC-Mga-059523	Meleagris gallopavo	67.41	0.00e+00	948.00
IUUC-Mmr-060885	Microcebus murinus	81.15	0.00e+00	1141.00
IUUC-Mdo-063018	Monodelphis domestica	71.11	0.00e+00	982.00
IUUC-Mmu-064012	Mus musculus	89.66	0.00e+00	1225.00
IUUC-Mpu-066207	Mustela putorius furo	79.44	0.00e+00	1142.00
IUUC-Mlu-066929	Myotis lucifugus	77.06	0.00e+00	1034.00
IUUC-Nle-069313	Nomascus leucogenys	70.30	0.00e+00	920.00
IUUC-Opr-070375	Ochotona princeps	70.45	0.00e+00	956.00
IUUC-Oan-073030	Ornithorhynchus anatinus	69.68	0.00e+00	748.00
IUUC-Ocu-074836	Oryctolagus cuniculus	78.74	0.00e+00	1097.00
IUUC-Oga-088367	Otolemur garnettii	81.01	0.00e+00	1107.00
IUUC-Oar-089953	Ovis aries	79.47	0.00e+00	1140.00
IUUC-Ptr-090980	Pan troglodytes	80.14	0.00e+00	1102.00
IUUC-Pan-092748	Papio anubis	80.17	0.00e+00	1105.00
IUUC-Pab-098514	Pongo abelii	79.89	0.00e+00	1100.00
IUUC-Pva-102984	Pteropus vampyrus	79.88	0.00e+00	1100.00
IUUC-Sha-106965	Sarcophilus harrisii	70.17	0.00e+00	976.00
IUUC-Ssc-115299	Sus scrofa	79.44	0.00e+00	1147.00
IUUC-Tgu-117160	Taeniopygia guttata	67.63	0.00e+00	924.00
IUUC-Tru-118156	Takifugu rubripes	57.81	0.00e+00	766.00
IUUC-Tni-119733	Tetraodon nigroviridis	58.06	0.00e+00	772.00
IUUC-Tbe-128084	Tupaia belangeri	77.23	0.00e+00	1095.00
IUUC-Ttr-128928	Tursiops truncatus	81.54	0.00e+00	1148.00
IUUC-Vpa-130706	Vicugna pacos	79.72	0.00e+00	1133.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence