iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-098676

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABGA01094331

Gene Name

USP30

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000004927.2	ENSPPYT00000005836.2	ENSPPYP00000005620.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.40e-67	228.3	69	498

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw...kskkkavsprellkalkkeaeefsgy 87
           Gl NlgNtC+mNS+LQ Ls++p + + l e +++  ++++++ +++ l+ +l +l+++l     +++++ + + ll++l+++  ++s  
   Q: 69   GLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALScqeVTDDEVLDASCLLDVLRMYRWQIS-- 155
           9*****************************66666666666788899************888899999****************966.. PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde..........aeekkkkknkslisdlFqgqlksqikclecdnvs.sr 165
              Da+E+++++ ++le+e    ++ +++++++ ++ e+++e          + + ++++n+   ++ F+g+l+s+++c++c+++s +r
   Q: 156  -SFDAHELFHVITSSLEDER--DRQPRVTHLFDVHSLEQQSEitpkqitcrtRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSpVR 241
           .66****************9..668888889998888888888999999999999********************************** PP
   S: 166  eepfldlslpvpgkeetkkeslqdcLesftkeeelegenkyycekck...............kkqeaekklklkklPevLilhLkRfsf 239
           +++f +lsl++p  +  ++++l++cL++f++ e++++   + c++c+               ++++ +k+lkl klP++L++hL+R s+
   Q: 242  FDTFDSLSLSIPAATWGHPLTLDHCLHHFVSSESVRD---VVCDNCTkieakgtlngekvehQRTTFVKQLKLGKLPQCLCIHLQRLSW 327
           ***********************************97...9******8888888888888777777*********************** PP
   S: 240  seeqksrekinkkvefpleLdlspfcts..........peekqke............................................ 274
           s++ + + k +++v+f++ L ++ +  +          p     +                                            
   Q: 328  SSH-GTPLKRHEHVQFNEFLMMDIYKYHllghkpsqhnP-----Klnknpgptlelqdgpgaptpvlnqpgtpktqifmngtcspsllp 410
           998.8888*********8877775544444566555551.....144455555556666666666666666666666666777777777 PP
   S: 275  ...................kkkYeLiavvvHsGslssGHYvayvkn.........ekgkWllfdDskVtevkeeevleetgstaYvlfY 335
                              ++ ++L+avvvH+G ++sGH+v+y ++         ++++Wl ++D++V++ + +evl+   s+aY+lfY
   Q: 411  tlsapmpfplpvvpdysssTYLFRLMAVVVHHGDMHSGHFVTYRRSppsarnplsTSNQWLWVSDDTVRKASLQEVLS---SSAYLLFY 496
           77777777777777777669999***********************9999988888999*******************...******** PP
   S: 336  kr 337
           +r
   Q: 497  ER 498
           98 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

MLSSRAEAAM TAADRAIQRF LRTGAAVRYK VMKNWGVIGG IAAALAAGIY VIWGPITERK 60
KRRKGLVPGL VNLGNTCFMN SLLQGLSACP AFIRWLEEFT SQYSRDQKEP PSHQYLSLTL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCGGTCTAC GTTCCCCCGA GGTGCTGGGA CTTCGTAGCC TGCGGTCCGG CGGCGGCGGC 60
GGCGGCGGCA GTAGCGGAGG AGGTGGTTTC AGGCCTCCGG TGCGGCTGCA ATGCTGAGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0005741--C:mitochondrial outer membrane
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008053--P:mitochondrial fusion
GO:0000422--P:mitophagy
GO:0035871--P:protein K11-linked deubiquitination
GO:0044313--P:protein K6-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000204	Aegilops tauschii	28.52	7.00e-17	82.00
IUUC-Aml-001733	Ailuropoda melanoleuca	91.92	0.00e+00	853.00
IUUC-Atr-002510	Amborella trichopoda	23.66	5.00e-20	92.40
IUUC-Apl-003645	Anas platyrhynchos	70.14	2.00e-104	371.00
IUUC-Aca-004583	Anolis carolinensis	68.42	1.00e-24	103.00
IUUC-Aly-005754	Arabidopsis lyrata	26.55	3.00e-21	96.70
IUUC-Ath-007622	Arabidopsis thaliana	26.49	6.00e-23	102.00
IUUC-Ame-010896	Astyanax mexicanus	61.25	7.00e-152	530.00
IUUC-Bta-012321	Bos taurus	90.33	0.00e+00	840.00
IUUC-Bdi-014795	Brachypodium distachyon	27.92	2.00e-18	87.00
IUUC-Bol-015637	Brassica oleracea	26.70	1.00e-22	101.00
IUUC-Bra-016801	Brassica rapa	24.84	4.00e-22	99.40
IUUC-Cel-018308	Caenorhabditis elegans	27.67	2.00e-35	143.00
IUUC-Cja-018826	Callithrix jacchus	97.10	0.00e+00	948.00
IUUC-Cfa-021206	Canis familiaris	89.81	0.00e+00	858.00
IUUC-Cpo-021343	Cavia porcellus	92.02	0.00e+00	845.00
IUUC-Csa-023419	Chlorocebus sabaeus	98.26	0.00e+00	956.00
IUUC-Cho-024475	Choloepus hoffmanni	89.09	1.00e-138	486.00
IUUC-Cgl-026621	Colletotrichum gloeosporioides	20.88	6.00e-10	59.30
IUUC-Cne-027061	Cryptococcus neoformans	23.65	6.00e-07	49.30
IUUC-Dre-027563	Danio rerio	59.72	6.00e-157	547.00
IUUC-Dno-029929	Dasypus novemcinctus	92.07	0.00e+00	890.00
IUUC-Dor-030166	Dipodomys ordii	82.79	0.00e+00	742.00
IUUC-Dme-031627	Drosophila melanogaster	34.95	2.00e-36	147.00
IUUC-Ete-032634	Echinops telfairi	79.50	0.00e+00	679.00
IUUC-Eca-033968	Equus caballus	92.86	0.00e+00	830.00
IUUC-Eeu-035279	Erinaceus europaeus	80.49	2.00e-55	209.00
IUUC-Fca-036525	Felis catus	92.65	0.00e+00	883.00
IUUC-Fal-036606	Ficedula albicollis	73.30	3.00e-156	544.00
IUUC-Gmo-038726	Gadus morhua	55.78	4.00e-139	488.00
IUUC-Gga-040718	Gallus gallus	73.68	3.00e-158	550.00
IUUC-Gac-042645	Gasterosteus aculeatus	57.34	2.00e-148	518.00
IUUC-Gma-042890	Glycine max	25.28	1.00e-23	104.00
IUUC-Ggo-045021	Gorilla gorilla	98.65	0.00e+00	961.00
IUUC-Hsa-045832	Homo sapiens	98.65	0.00e+00	961.00
IUUC-Itr-048392	Ictidomys tridecemlineatus	93.67	0.00e+00	848.00
IUUC-Lch-050662	Latimeria chalumnae	69.92	4.00e-178	617.00
IUUC-Lpe-051078	Leersia perrieri	26.61	9.00e-31	127.00
IUUC-Loc-052611	Lepisosteus oculatus	64.37	2.00e-175	608.00
IUUC-Lma-053048	Leptosphaeria maculans	20.67	2.00e-15	77.80
IUUC-Laf-053752	Loxodonta africana	91.22	0.00e+00	820.00
IUUC-Mcc-054892	Macaca mulatta	98.26	0.00e+00	957.00
IUUC-Meu-056673	Macropus eugenii	73.70	1.00e-159	555.00
IUUC-Mor-057143	Magnaporthe oryzae	20.21	3.00e-07	50.80
IUUC-Mtr-057976	Medicago truncatula	26.51	6.00e-31	128.00
IUUC-Mla-058970	Melampsora laricipopulina	23.38	4.00e-18	86.30
IUUC-Mga-059543	Meleagris gallopavo	75.33	0.00e+00	651.00
IUUC-Mmr-061534	Microcebus murinus	93.81	0.00e+00	887.00
IUUC-Mdo-062140	Monodelphis domestica	68.35	1.00e-162	566.00
IUUC-Mmu-063673	Mus musculus	88.39	0.00e+00	829.00
IUUC-Mpu-066328	Mustela putorius furo	91.30	0.00e+00	843.00
IUUC-Mlu-067938	Myotis lucifugus	92.44	0.00e+00	904.00
IUUC-Nle-069426	Nomascus leucogenys	97.74	0.00e+00	861.00
IUUC-Opr-070796	Ochotona princeps	84.82	3.00e-122	432.00
IUUC-Ont-072248	Oreochromis niloticus	58.15	5.00e-153	534.00
IUUC-Oan-072916	Ornithorhynchus anatinus	79.14	0.00e+00	753.00
IUUC-Ocu-074459	Oryctolagus cuniculus	86.15	0.00e+00	650.00
IUUC-Oba-075765	Oryza barthii	25.97	8.00e-30	125.00
IUUC-Obr-076005	Oryza brachyantha	27.14	2.00e-29	123.00
IUUC-Ogl-077916	Oryza glaberrima	27.36	2.00e-31	130.00
IUUC-Ogu-078263	Oryza glumaepatula	26.21	1.00e-30	127.00
IUUC-Oin-080096	Oryza indica	27.29	5.00e-24	105.00
IUUC-Ome-081928	Oryza meridionalis	27.22	9.00e-33	134.00
IUUC-Oni-082424	Oryza nivara	26.36	1.00e-30	127.00
IUUC-Oru-085117	Oryza rufipogon	26.36	1.00e-30	127.00
IUUC-Ola-087429	Oryzias latipes	56.86	2.00e-145	509.00
IUUC-Oga-087981	Otolemur garnettii	93.99	0.00e+00	889.00
IUUC-Oar-089927	Ovis aries	89.75	0.00e+00	833.00
IUUC-Ptr-090878	Pan troglodytes	98.65	0.00e+00	961.00
IUUC-Pan-092698	Papio anubis	98.26	0.00e+00	957.00
IUUC-Psi-093451	Pelodiscus sinensis	76.27	0.00e+00	704.00
IUUC-Pfo-096096	Poecilia formosa	57.54	7.00e-151	526.00
IUUC-Pca-100418	Procavia capensis	95.02	2.00e-127	449.00
IUUC-Ppe-101898	Prunus persica	24.14	4.00e-23	102.00
IUUC-Pva-103018	Pteropus vampyrus	90.91	0.00e+00	864.00
IUUC-Pgr-103423	Puccinia graminis	25.26	8.00e-10	59.30
IUUC-Ptt-103779	Puccinia triticina	20.28	3.00e-11	63.90
IUUC-Pte-104330	Pyrenophora teres	21.54	4.00e-12	66.60
IUUC-Pyt-104518	Pyrenophora triticirepentis	21.25	1.00e-13	72.00
IUUC-Rno-105708	Rattus norvegicus	87.43	0.00e+00	819.00
IUUC-Sha-106971	Sarcophilus harrisii	78.59	0.00e+00	768.00
IUUC-Sit-110442	Setaria italica	26.78	3.00e-28	119.00
IUUC-Sly-110928	Solanum lycopersicum	24.08	6.00e-16	79.00
IUUC-Stu-112223	Solanum tuberosum	24.93	4.00e-17	82.40
IUUC-Ssc-116397	Sus scrofa	89.94	0.00e+00	837.00
IUUC-Tgu-117446	Taeniopygia guttata	69.73	0.00e+00	632.00
IUUC-Tru-118268	Takifugu rubripes	58.48	4.00e-140	491.00
IUUC-Tsy-119484	Tarsius syrichta	89.76	1.00e-49	191.00
IUUC-Tni-119735	Tetraodon nigroviridis	52.72	4.00e-119	421.00
IUUC-Tca-121660	Theobroma cacao	24.67	2.00e-26	113.00
IUUC-Tae-125383	Triticum aestivum	27.98	1.00e-27	117.00
IUUC-Tur-126458	Triticum urartu	27.82	1.00e-25	110.00
IUUC-Tbe-127740	Tupaia belangeri	87.81	0.00e+00	794.00
IUUC-Ttr-129273	Tursiops truncatus	89.17	0.00e+00	830.00
IUUC-Vda-129789	Verticillium dahliae	23.43	1.00e-07	51.60
IUUC-Vvi-131177	Vitis vinifera	26.01	7.00e-26	111.00
IUUC-Xtr-132374	Xenopus tropicalis	65.60	6.00e-171	593.00
IUUC-Xma-133267	Xiphophorus maculatus	60.12	3.00e-154	538.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence