iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045878

UUCD1 version

UUC-HoS-00380

Ensembl Protein ID

ENSP00000354621.1

UniProt Accession

Q9HCE7; A4D279; B7ZMB6; B9EGV3; O75853; Q547Q3; Q9UJT8; SMUF1_HUMAN

Genbank Protein ID

BAB13451.1; AAC62434.1; AAM90910.1; EAL23885.1; EAL23886.1; EAW76687.1; EAW76688.1; AAI36805.1; AAI44415.1; AAI52469.1; AAF08298.2

Protein Name

E3 ubiquitin-protein ligase SMURF1; HECT-type E3 ubiquitin transferase SMURF1; SMAD ubiquitination regulatory factor 1; SMAD-specific E3 ubiquitin-protein ligase 1

Genbank Nucleotide ID

AB046845; AC004893; AF464850; AC073468; CH236956; CH471091; CH471091; BC136804; BC144414; BC152468; AF199364

Gene Name

SMURF1; KIAA1625

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000198742.9	ENST00000361368.6	ENSP00000355326.2
ENSG00000198742.9	ENST00000361125.1	ENSP00000354621.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	UniProt	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/HECT	HECT	20512916; 19561075; 16472676; 14657501; 20621832; 18208356; 15820682; 20558834; 19937093; 21454619; 21382345

Classification

Family	E-value	Score	Start	End
E3 activity/HECT	6.10e-127	425.3	421	756

Active Site

Position(s)	Description	Evidence
725	Glycyl thioester intermediate	N/A

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpls 93
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++  ++
   Q: 421  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYINGGFT 511
           689*********************************************************9.89**************************** PP
   S: 94   ksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkeg 185
            +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+n+pVt+eNk+eYv+l+v++r+ +g
   Q: 512  VPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRG 599
           ********************************99...9***8.************************************************* PP
   S: 186  ikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlg 277
           i+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ + +ds+ ++wFw+++e f++e r+++LqFvTgs r+Pl+
   Q: 600  IEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQ 690
           **************************************************99.*************************************** PP
   S: 278  Gfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Gf++l+       prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 691  GFKALQgstgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 756
           *********************99999**************************************76 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Plays a role in dendrite formation by melanocytes (PubMed:23999003).

Protein Sequence
(Fasta)

MSNPGTRRNG SSIKIRLTVL CAKNLAKKDF FRLPDPFAKI VVDGSGQCHS TDTVKNTLDP 60
KWNQHYDLYV GKTDSITISV WNHKKIHKKQ GAGFLGCVRL LSNAISRLKD TGYQRLDLCK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGCAGCGGCG GAAGCGGCGA GGGCGGCGGG CGTCCGGCTC TGAGGTGGTG GAGGCGGCGG 60
AGGCGGCGGC GGAGGCGGCG GCGGCTCGGG ACTGGGCTCG GCTGGAAGCA GCGAGGGTCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0221--Differentiation
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0030424--C:axon
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0043025--C:neuronal cell body
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0048185--F:activin binding
GO:0070411--F:I-SMAD binding
GO:0005543--F:phospholipid binding
GO:0070412--F:R-SMAD binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030509--P:BMP signaling pathway
GO:0030154--P:cell differentiation
GO:0007398--P:ectoderm development
GO:0061736--P:engulfment of target by autophagosome
GO:0030514--P:negative regulation of BMP signaling pathway
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0072661--P:protein targeting to plasma membrane
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0007179--P:transforming growth factor beta receptor signaling pathway
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process
GO:0060071--P:Wnt signaling pathway, planar cell polarity pathway

KEGG

hsa:57154

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001459	Ailuropoda melanoleuca	89.83	0.00e+00	1406.00
IUUC-Apl-004155	Anas platyrhynchos	93.54	0.00e+00	1456.00
IUUC-Aca-005238	Anolis carolinensis	92.50	0.00e+00	1430.00
IUUC-Ame-010901	Astyanax mexicanus	87.99	0.00e+00	1378.00
IUUC-Bta-013221	Bos taurus	88.10	0.00e+00	1345.00
IUUC-Cja-018985	Callithrix jacchus	99.60	0.00e+00	1572.00
IUUC-Cfa-020568	Canis familiaris	96.29	0.00e+00	1494.00
IUUC-Cpo-022531	Cavia porcellus	98.68	0.00e+00	1558.00
IUUC-Csa-024145	Chlorocebus sabaeus	96.04	0.00e+00	1497.00
IUUC-Cho-024963	Choloepus hoffmanni	80.85	0.00e+00	982.00
IUUC-Dre-028341	Danio rerio	88.67	0.00e+00	1392.00
IUUC-Dno-029705	Dasypus novemcinctus	97.47	0.00e+00	1501.00
IUUC-Dme-031740	Drosophila melanogaster	71.11	2.00e-175	609.00
IUUC-Eca-034125	Equus caballus	98.92	0.00e+00	1524.00
IUUC-Fca-035905	Felis catus	94.40	0.00e+00	1446.00
IUUC-Fal-037336	Ficedula albicollis	93.27	0.00e+00	1408.00
IUUC-Gmo-039486	Gadus morhua	76.71	0.00e+00	858.00
IUUC-Gga-040218	Gallus gallus	95.13	0.00e+00	1485.00
IUUC-Gac-041707	Gasterosteus aculeatus	82.22	0.00e+00	1277.00
IUUC-Ggo-045408	Gorilla gorilla	93.78	0.00e+00	1428.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	98.11	0.00e+00	1510.00
IUUC-Loc-052628	Lepisosteus oculatus	83.17	0.00e+00	1365.00
IUUC-Laf-053644	Loxodonta africana	89.99	0.00e+00	1389.00
IUUC-Mcc-055479	Macaca mulatta	88.51	0.00e+00	1348.00
IUUC-Mga-059723	Meleagris gallopavo	89.82	0.00e+00	1391.00
IUUC-Mdo-063005	Monodelphis domestica	94.98	0.00e+00	1486.00
IUUC-Mmu-063634	Mus musculus	95.24	0.00e+00	1469.00
IUUC-Mpu-065898	Mustela putorius furo	94.89	0.00e+00	1447.00
IUUC-Mlu-067584	Myotis lucifugus	97.72	0.00e+00	1519.00
IUUC-Nle-069033	Nomascus leucogenys	100.00	0.00e+00	1540.00
IUUC-Ont-072265	Oreochromis niloticus	84.89	0.00e+00	1330.00
IUUC-Oan-073621	Ornithorhynchus anatinus	88.58	0.00e+00	1426.00
IUUC-Ocu-073960	Oryctolagus cuniculus	97.44	0.00e+00	1494.00
IUUC-Oga-088579	Otolemur garnettii	99.47	0.00e+00	1568.00
IUUC-Oar-090396	Ovis aries	95.56	0.00e+00	1409.00
IUUC-Ptr-091624	Pan troglodytes	100.00	0.00e+00	1578.00
IUUC-Pan-092479	Papio anubis	99.73	0.00e+00	1539.00
IUUC-Pfo-097203	Poecilia formosa	82.25	0.00e+00	1288.00
IUUC-Pab-097540	Pongo abelii	99.86	0.00e+00	1504.00
IUUC-Pca-100379	Procavia capensis	73.81	0.00e+00	651.00
IUUC-Rno-105396	Rattus norvegicus	95.38	0.00e+00	1471.00
IUUC-Sha-107216	Sarcophilus harrisii	94.95	0.00e+00	1478.00
IUUC-Sar-113250	Sorex araneus	96.85	0.00e+00	833.00
IUUC-Ssc-116413	Sus scrofa	92.85	0.00e+00	1416.00
IUUC-Tgu-116723	Taeniopygia guttata	93.80	0.00e+00	1422.00
IUUC-Tru-117843	Takifugu rubripes	80.25	0.00e+00	1271.00
IUUC-Tsy-119455	Tarsius syrichta	98.87	0.00e+00	1434.00
IUUC-Tni-120037	Tetraodon nigroviridis	81.88	0.00e+00	1230.00
IUUC-Tbe-127879	Tupaia belangeri	84.96	0.00e+00	1256.00
IUUC-Ttr-128423	Tursiops truncatus	97.15	0.00e+00	1440.00
IUUC-Xtr-132237	Xenopus tropicalis	88.13	0.00e+00	1392.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence