iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-001871

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACTA01145405

Gene Name

OTUB1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000018084.1	ENSAMET00000019873.1	ENSAMEP00000019111.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	2.70e-51	173.7	111	301

Active Site

Position(s)	Description	Evidence
118	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
121	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
295		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
           +i+kt++DGnC++rA+++s                                                          ll++f+d+s+sd
   Q: 111  YIRKTRPDGNCFYRAFGFShleallddskelqrfkavsakskedlvsqgfteftiedfhntfmdlieqvekqtsvadLLASFNDQSTSD 199
           89*************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
           +lv++Lr+lts ylq+es+ff++fie+++++kefcq++vep++k +++ihi+aLaq+Ls++i+v+++d++e   gg+++p++fpe + +
   Q: 200  YLVVYLRLLTSGYLQRESKFFEHFIEGGRTVKEFCQQEVEPMCKeSDHIHIIALAQALSVSIQVEYMDRGE---GGTTNPHIFPEGS-E 284
           **********************************************************************9...9************.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           ++++LlYr+gHYd+L++
   Q: 285  PKVYLLYRPGHYDILYK 301
           ***************96 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

GGATRRGSLP GGRQLLTRKR SAVRRCLKMA AEEPQQQKQG PLEGLCSEGG VNCLAYDEAI 60
MAQQDRIQQE IAVQNPLVSE RLELSVLYKE YAEDDNIYQQ KIKDLHKKYS YIRKTRPDGN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGGGGCCA CGAGGAGGGG CTCCCTTCCG GGAGGAAGGC AACTGCTAAC CCGGAAGCGG 60
TCAGCGGTGC GGCGCTGTTT AAAGATGGCG GCGGAGGAAC CTCAGCAGCA GAAGCAGGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR030298--OTUB1
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0006974--P:cellular response to DNA damage stimulus
GO:2000780--P:negative regulation of double-strand break repair
GO:1901315--P:negative regulation of histone H2A K63-linked ubiquitination
GO:0071108--P:protein K48-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003233	Anas platyrhynchos	58.46	9.00e-19	84.30
IUUC-Aca-004648	Anolis carolinensis	84.42	5.00e-135	473.00
IUUC-Aly-005710	Arabidopsis lyrata	42.22	8.00e-52	197.00
IUUC-Ath-007112	Arabidopsis thaliana	43.24	9.00e-51	193.00
IUUC-Afl-008439	Aspergillus flavus	34.18	3.00e-08	52.00
IUUC-Ame-010662	Astyanax mexicanus	81.55	6.00e-130	456.00
IUUC-Bta-013533	Bos taurus	98.81	1.00e-148	518.00
IUUC-Bol-016100	Brassica oleracea	42.05	4.00e-50	191.00
IUUC-Bra-017705	Brassica rapa	39.15	4.00e-45	175.00
IUUC-Cel-018295	Caenorhabditis elegans	35.78	5.00e-41	161.00
IUUC-Cja-019190	Callithrix jacchus	97.67	9.00e-165	572.00
IUUC-Cfa-020430	Canis familiaris	100.00	1.00e-149	521.00
IUUC-Cpo-022355	Cavia porcellus	99.60	5.00e-150	523.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	39.56	6.00e-46	177.00
IUUC-Csa-023286	Chlorocebus sabaeus	96.55	2.00e-147	514.00
IUUC-Cin-025507	Ciona intestinalis	43.33	3.00e-44	171.00
IUUC-Csv-026273	Ciona savignyi	49.80	7.00e-69	253.00
IUUC-Dre-027843	Danio rerio	78.39	1.00e-125	441.00
IUUC-Dno-029165	Dasypus novemcinctus	99.00	9.00e-118	415.00
IUUC-Dor-030943	Dipodomys ordii	99.60	5.00e-150	523.00
IUUC-Dme-031922	Drosophila melanogaster	56.40	2.00e-78	285.00
IUUC-Ete-032296	Echinops telfairi	96.23	2.00e-89	322.00
IUUC-Eca-033695	Equus caballus	98.81	4.00e-148	516.00
IUUC-Fca-036441	Felis catus	97.32	6.00e-150	522.00
IUUC-Gmo-038908	Gadus morhua	78.97	8.00e-126	442.00
IUUC-Ggr-040020	Gaeumannomyces graminis	31.41	7.00e-33	135.00
IUUC-Gga-040460	Gallus gallus	79.27	4.00e-129	453.00
IUUC-Gac-042417	Gasterosteus aculeatus	81.20	1.00e-122	431.00
IUUC-Gma-043712	Glycine max	42.01	3.00e-51	194.00
IUUC-Ggo-044552	Gorilla gorilla	100.00	2.00e-92	331.00
IUUC-Hsa-046766	Homo sapiens	100.00	4.00e-150	523.00
IUUC-Itr-048312	Ictidomys tridecemlineatus	99.60	5.00e-150	523.00
IUUC-Lch-050602	Latimeria chalumnae	81.03	5.00e-119	420.00
IUUC-Laf-053705	Loxodonta africana	99.60	5.00e-150	523.00
IUUC-Mcc-055745	Macaca mulatta	93.33	2.00e-146	511.00
IUUC-Meu-056569	Macropus eugenii	83.88	7.00e-130	456.00
IUUC-Mtr-057712	Medicago truncatula	43.12	1.00e-46	179.00
IUUC-Mvi-060358	Microbotryum violaceum	33.94	3.00e-15	75.50
IUUC-Mmr-061123	Microcebus murinus	99.53	6.00e-124	436.00
IUUC-Mdo-062613	Monodelphis domestica	85.04	3.00e-119	421.00
IUUC-Mmu-063658	Mus musculus	99.60	5.00e-150	523.00
IUUC-Mac-065274	Musa acuminata	37.60	4.00e-39	155.00
IUUC-Mpu-066172	Mustela putorius furo	100.00	4.00e-150	523.00
IUUC-Mlu-066966	Myotis lucifugus	96.68	3.00e-164	570.00
IUUC-Nle-069519	Nomascus leucogenys	88.17	3.00e-93	334.00
IUUC-Ont-071901	Oreochromis niloticus	82.47	6.00e-125	439.00
IUUC-Ola-087331	Oryzias latipes	80.90	6.00e-86	309.00
IUUC-Oga-088064	Otolemur garnettii	100.00	4.00e-150	523.00
IUUC-Oar-089251	Ovis aries	98.80	3.00e-147	513.00
IUUC-Ptr-091430	Pan troglodytes	97.67	3.00e-165	573.00
IUUC-Psi-093823	Pelodiscus sinensis	89.41	2.00e-133	468.00
IUUC-Pma-094366	Petromyzon marinus	71.17	6.00e-103	366.00
IUUC-Pfo-096734	Poecilia formosa	80.88	6.00e-114	403.00
IUUC-Pab-097919	Pongo abelii	100.00	4.00e-123	433.00
IUUC-Pop-099401	Populus trichocarpa	41.24	3.00e-48	185.00
IUUC-Ppe-101977	Prunus persica	42.38	1.00e-51	196.00
IUUC-Pva-102499	Pteropus vampyrus	100.00	3.00e-149	520.00
IUUC-Rno-105233	Rattus norvegicus	99.60	5.00e-150	523.00
IUUC-Sha-107081	Sarcophilus harrisii	92.64	6.00e-157	546.00
IUUC-Sly-111640	Solanum lycopersicum	42.01	3.00e-49	188.00
IUUC-Ssc-116202	Sus scrofa	100.00	4.00e-150	523.00
IUUC-Tru-117664	Takifugu rubripes	76.45	1.00e-122	432.00
IUUC-Tca-121467	Theobroma cacao	41.54	2.00e-50	192.00
IUUC-Tbe-128116	Tupaia belangeri	98.76	3.00e-93	334.00
IUUC-Ttr-128622	Tursiops truncatus	99.21	2.00e-147	514.00
IUUC-Vvi-131389	Vitis vinifera	43.75	7.00e-53	200.00
IUUC-Xma-134191	Xiphophorus maculatus	81.27	9.00e-115	405.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence