iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-002084

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

ACTA01082156

Gene Name

USP27X

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000012113.1	ENSAMET00000013285.1	ENSAMEP00000012745.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.90e-91	304.5	181	523

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L+++p lr+++l+ ++++++    ++p+ +l++++ +lf+el++++ +   p +ll+ ++  a+++ gy+qq
   Q: 181  GLINLGNTCFMNCIVQALTHTPILRDFFLS-DRHRCEM---PSPELCLVCEMSSLFRELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQ 265
           9*****************************.9999987...589********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl   ld l++++k                  +  +  +++++ +++i+++F g l+s+++c++c+ vs++ +p +d+sl++pg+
   Q: 266  DAHEFLIAALDVLHRHCKG----------------DDAGKAANNPNHCNCIIDQIFTGGLQSDVTCQACHGVSTTIDPCWDISLDLPGS 338
           *****************22................22335678899999***************************************9 PP
   S: 180  eetkke...................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksreki 249
            ++  +                   +l+dcL+ ft++e+l ++ k++c +c+++qe++k+l+++klP v ++h+kRf  +++ k+r+ki
   Q: 339  CTSFWPmspgressvngeshipgitTLTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLTMNKLPVVACFHFKRF--EHSAKQRRKI 425
           98766699*********************************************************************..55667999** PP
   S: 250  nkkvefpleLdlspfctspeekqke............kkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleet 326
           +++++fpleLd++pf++s++e+  +            ++kY+L+avv+H+G+l+sGHY+++++++k++W+++dD  +t+ + ++vl   
   Q: 426  TTYISFPLELDMTPFMASSKESRMNgqlqlptnsgndENKYSLFAVVNHQGTLESGHYTSFIRHHKDQWFKCDDAVITKASIKDVLD-- 512
           ******************5544444566666666666**************************************************.. PP
   S: 327  gstaYvlfYkrr 338
            s++Y+lfY+++
   Q: 513  -SEGYLLFYHKQ 523
           .********985 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

PRRGPGGGCL DVDFAVGPPG CSHVNSFKVG ENWRQELRVI YQCFVWCGTP ETRKSKAKSC 60
ICHVCGTHLN RLHSCLSCVF FGCFTEKHIH EHAETKQHNL AVDLYYGGIY CFMCKDYVYD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCCGGCGCG GCCCTGGGGG CGGATGCCTG GATGTGGATT TCGCTGTGGG TCCACCAGGC 60
TGTTCCCACG TGAACAGCTT TAAGGTGGGA GAGAACTGGA GGCAGGAACT GCGGGTGATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0043065--P:positive regulation of apoptotic process
GO:0050821--P:protein stabilization
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aly-006565	Arabidopsis lyrata	37.00	3.00e-73	269.00
IUUC-Ath-007536	Arabidopsis thaliana	34.56	2.00e-74	273.00
IUUC-Cja-019954	Callithrix jacchus	89.25	0.00e+00	957.00
IUUC-Cfa-020956	Canis familiaris	97.42	0.00e+00	1020.00
IUUC-Cpo-022014	Cavia porcellus	99.43	0.00e+00	1095.00
IUUC-Dno-029905	Dasypus novemcinctus	96.01	0.00e+00	852.00
IUUC-Dor-030832	Dipodomys ordii	97.41	8.00e-112	397.00
IUUC-Eca-033957	Equus caballus	98.10	0.00e+00	1080.00
IUUC-Fca-035768	Felis catus	99.62	0.00e+00	1104.00
IUUC-Ggr-040044	Gaeumannomyces graminis	32.34	7.00e-57	214.00
IUUC-Ggo-044925	Gorilla gorilla	99.43	0.00e+00	1099.00
IUUC-Laf-053947	Loxodonta africana	97.90	0.00e+00	1081.00
IUUC-Mpu-066433	Mustela putorius furo	99.62	0.00e+00	1090.00
IUUC-Mlu-067330	Myotis lucifugus	98.48	0.00e+00	1091.00
IUUC-Nle-069084	Nomascus leucogenys	96.95	0.00e+00	860.00
IUUC-Ocu-074951	Oryctolagus cuniculus	96.92	0.00e+00	1062.00
IUUC-Oba-075688	Oryza barthii	35.52	2.00e-75	276.00
IUUC-Oga-088771	Otolemur garnettii	97.13	0.00e+00	1061.00
IUUC-Oar-089610	Ovis aries	97.02	0.00e+00	1017.00
IUUC-Pan-092253	Papio anubis	97.42	0.00e+00	1021.00
IUUC-Ppa-095413	Physcomitrella patens	33.84	1.00e-82	301.00
IUUC-Pab-098324	Pongo abelii	99.43	0.00e+00	1102.00
IUUC-Pop-099558	Populus trichocarpa	35.58	2.00e-87	316.00
IUUC-Pca-100329	Procavia capensis	97.91	0.00e+00	1080.00
IUUC-Ppe-102020	Prunus persica	36.66	9.00e-93	334.00
IUUC-Pva-102721	Pteropus vampyrus	94.23	0.00e+00	1008.00
IUUC-Pgr-103657	Puccinia graminis	29.48	9.00e-39	154.00
IUUC-Spo-108226	Schizosaccharomyces pombe	33.12	3.00e-60	225.00
IUUC-Smo-109310	Selaginella moellendorffii	36.27	7.00e-87	314.00
IUUC-Sit-109716	Setaria italica	35.77	3.00e-78	286.00
IUUC-Sly-111077	Solanum lycopersicum	37.31	1.00e-81	297.00
IUUC-Stu-112203	Solanum tuberosum	39.26	2.00e-76	279.00
IUUC-Sar-113174	Sorex araneus	92.28	0.00e+00	951.00
IUUC-Sbi-114205	Sorghum bicolor	35.41	8.00e-79	287.00
IUUC-Sre-115195	Sporisorium reilianum	27.40	8.00e-53	201.00
IUUC-Ssc-115315	Sus scrofa	97.90	0.00e+00	1066.00
IUUC-Ttr-129006	Tursiops truncatus	99.42	0.00e+00	1080.00
IUUC-Zma-134945	Zea mays	35.63	4.00e-76	278.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence