iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066478

Ensembl Protein ID

ENSMPUP00000017270.1

UniProt Accession

M3Z108; M3Z108_MUSPF

Genbank Protein ID

ENSMPUP00000017270

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AEYP01046788

Gene Name

HERC2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000017380.1	ENSMPUT00000017526.1	ENSMPUP00000017270.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.60e-86	289.6	4470	4799

Active Site

Position(s)	Description	Evidence
4768	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 7    krlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgrll 88
           ++++v+fvgE++ d+gG  +e +a++++elqn  ++l+  ++n++ +   n+d +l +p      h+++F+flG+llg+a+++g +l
   Q: 4470 RVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPLLIVTPNGRDESGANRDCYLFSPaarapVHTNMFRFLGVLLGIAIRTGSPL 4556
           4566****************************************************99999999*********************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
            l+l+++++k+l g +l++ dl+evd++++  l++i++n+ ++ e +++ l f+     +++++ +++  +++ +++t +N+ eYv+
   Q: 4557 SLNLAEPVWKQLAGMSLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMSLPFT-----VPSASGQDIQLSSKYTHITLDNRAEYVR 4638
           ***************************************9999999999***99.....788999999******************* PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           l ++yrl+e ++eqv+a+reG+ +v+p  llslFt  ele+++cG+++i ++ lk+ ++ykg ++++ + iqwFwev+e+fs++er+
   Q: 4639 LAINYRLHE-FDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDIPLHLLKSVATYKG-IEPSASLIQWFWEVMESFSNTERS 4723
           *********.**************************************************77.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirk....dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
            fL+Fv+g+ rlP + +a+++ r fvi+     +  d+ lP+s TCf++LkLP+Ys k++l+ekL yAi+ +k++++
   Q: 4724 LFLRFVWGRTRLP-RTIADFRGRDFVIQVldkyNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDT 4799
           *************.8*************999988888***********************************99875 PP

Organism

Mustela putorius furo

Protein Sequence
(Fasta)

MPSDSFCLAA QTRLDSKWLK TDIQLAFTRD GLCGLWNEMV KDGEIVYTGT ELNQNGELPP 60
RKDDGVDTQS GTKKEDLNDK EKKDEEETPA PACRAKLILE SWVWGKQPDV NELKECLSVL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CCCGGCGCCT GCGGTTGGCC ATGACCGCAA GGAATGAACC CCAAGGAGGA AGATGAGCGG 60
GATTGAAGGA AACAGGGGAG TAGGGAGGAA GGGCGAGAGG GCTCCTCTTT CTCATTGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR004939--APC_su10/DOC_dom
IPR006624--Beta-propeller_rpt_TECPR
IPR021097--CPH_domain
IPR001199--Cyt_B5-like_heme/steroid-bd
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR014722--Rib_L2_dom2
IPR000433--Znf_ZZ

PROSITE

PS50255--CYTOCHROME_B5_2
PS51284--DOC
PS50237--HECT
PS51416--MIB_HERC2
PS00626--RCC1_2
PS50012--RCC1_3
PS01357--ZF_ZZ_1
PS50135--ZF_ZZ_2

Pfam

PF03256--ANAPC10
PF11515--Cul7
PF00173--Cyt-b5
PF00632--HECT
PF06701--MIB_HERC2
PF00415--RCC1
PF00569--ZZ

PRINTS

PR00633--RCCNDNSATION

SMART

SM01337--APC10
SM01117--Cyt-b5
SM00119--HECTc
SM00706--TECPR
SM00291--ZnF_ZZ

Gene Ontology

GO:0005743--C:mitochondrial inner membrane
GO:0005634--C:nucleus
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007283--P:spermatogenesis

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002112	Ailuropoda melanoleuca	98.73	0.00e+00	7279.00
IUUC-Apl-003983	Anas platyrhynchos	90.93	0.00e+00	8367.00
IUUC-Aca-004300	Anolis carolinensis	89.88	0.00e+00	8227.00
IUUC-Ame-010621	Astyanax mexicanus	84.39	0.00e+00	6893.00
IUUC-Bta-013067	Bos taurus	96.72	0.00e+00	8721.00
IUUC-Bdi-014093	Brachypodium distachyon	35.10	3.00e-44	173.00
IUUC-Cja-019687	Callithrix jacchus	94.44	0.00e+00	8440.00
IUUC-Cfa-020672	Canis familiaris	98.47	0.00e+00	8905.00
IUUC-Cpo-021819	Cavia porcellus	93.54	0.00e+00	8430.00
IUUC-Csa-023817	Chlorocebus sabaeus	96.20	0.00e+00	8682.00
IUUC-Cho-024387	Choloepus hoffmanni	92.73	0.00e+00	1834.00
IUUC-Cin-025709	Ciona intestinalis	57.78	0.00e+00	1437.00
IUUC-Csv-026336	Ciona savignyi	36.24	0.00e+00	1519.00
IUUC-Dre-027717	Danio rerio	82.00	0.00e+00	7243.00
IUUC-Dno-029296	Dasypus novemcinctus	95.27	0.00e+00	8600.00
IUUC-Dor-030979	Dipodomys ordii	89.55	0.00e+00	2846.00
IUUC-Dme-032171	Drosophila melanogaster	59.94	0.00e+00	1530.00
IUUC-Ete-032687	Echinops telfairi	85.92	0.00e+00	2909.00
IUUC-Eca-034046	Equus caballus	97.34	0.00e+00	8784.00
IUUC-Eeu-034859	Erinaceus europaeus	85.57	0.00e+00	1978.00
IUUC-Fca-036262	Felis catus	98.53	0.00e+00	8925.00
IUUC-Fal-037562	Ficedula albicollis	90.88	0.00e+00	8287.00
IUUC-Gmo-039054	Gadus morhua	83.26	0.00e+00	1031.00
IUUC-Gga-040359	Gallus gallus	90.83	0.00e+00	8317.00
IUUC-Gac-041879	Gasterosteus aculeatus	90.75	0.00e+00	1043.00
IUUC-Ggo-044692	Gorilla gorilla	96.26	0.00e+00	4268.00
IUUC-Hsa-045995	Homo sapiens	96.24	0.00e+00	8718.00
IUUC-Itr-048553	Ictidomys tridecemlineatus	95.64	0.00e+00	2438.00
IUUC-Lch-049808	Latimeria chalumnae	86.30	0.00e+00	3307.00
IUUC-Loc-052685	Lepisosteus oculatus	84.35	0.00e+00	7546.00
IUUC-Laf-053372	Loxodonta africana	94.84	0.00e+00	8571.00
IUUC-Mcc-054693	Macaca mulatta	96.22	0.00e+00	8712.00
IUUC-Meu-056660	Macropus eugenii	96.30	0.00e+00	1930.00
IUUC-Mga-059371	Meleagris gallopavo	90.90	0.00e+00	7169.00
IUUC-Mmr-060787	Microcebus murinus	96.65	0.00e+00	8783.00
IUUC-Mdo-062518	Monodelphis domestica	89.38	0.00e+00	8032.00
IUUC-Mmu-063690	Mus musculus	95.00	0.00e+00	8567.00
IUUC-Mlu-067596	Myotis lucifugus	90.55	0.00e+00	4355.00
IUUC-Nle-069445	Nomascus leucogenys	97.00	0.00e+00	2193.00
IUUC-Opr-070990	Ochotona princeps	87.41	0.00e+00	2933.00
IUUC-Ont-072285	Oreochromis niloticus	82.81	0.00e+00	7326.00
IUUC-Oan-072721	Ornithorhynchus anatinus	85.97	0.00e+00	3411.00
IUUC-Ocu-074273	Oryctolagus cuniculus	96.04	0.00e+00	8671.00
IUUC-Ola-087346	Oryzias latipes	92.45	0.00e+00	1205.00
IUUC-Oga-088742	Otolemur garnettii	95.56	0.00e+00	8558.00
IUUC-Oar-090093	Ovis aries	96.78	0.00e+00	8734.00
IUUC-Ptr-091034	Pan troglodytes	90.19	0.00e+00	5645.00
IUUC-Pan-092783	Papio anubis	93.83	0.00e+00	8465.00
IUUC-Psi-094027	Pelodiscus sinensis	90.76	0.00e+00	7965.00
IUUC-Pfo-096208	Poecilia formosa	80.33	0.00e+00	5974.00
IUUC-Pab-097681	Pongo abelii	93.70	0.00e+00	2596.00
IUUC-Pca-100705	Procavia capensis	91.99	0.00e+00	1111.00
IUUC-Pva-103147	Pteropus vampyrus	88.48	0.00e+00	2558.00
IUUC-Rno-105458	Rattus norvegicus	94.92	0.00e+00	8550.00
IUUC-Sha-106959	Sarcophilus harrisii	81.51	0.00e+00	6963.00
IUUC-Sar-113532	Sorex araneus	84.33	0.00e+00	1768.00
IUUC-Sbi-114352	Sorghum bicolor	32.89	1.00e-45	178.00
IUUC-Ssc-115337	Sus scrofa	95.48	0.00e+00	3119.00
IUUC-Tgu-116789	Taeniopygia guttata	90.71	0.00e+00	8315.00
IUUC-Tru-118129	Takifugu rubripes	82.17	0.00e+00	7354.00
IUUC-Tsy-119302	Tarsius syrichta	84.05	0.00e+00	1254.00
IUUC-Tni-120374	Tetraodon nigroviridis	80.71	0.00e+00	7200.00
IUUC-Tbe-128137	Tupaia belangeri	88.72	0.00e+00	2363.00
IUUC-Ttr-128273	Tursiops truncatus	92.02	0.00e+00	6408.00
IUUC-Vpa-130471	Vicugna pacos	84.52	0.00e+00	1493.00
IUUC-Xtr-132185	Xenopus tropicalis	85.35	0.00e+00	7695.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence