iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004452

UUCD1 version

UUC-AnC-00311

Ensembl Protein ID

ENSACAP00000015109.2

UniProt Accession

H9GM85; H9GM85_ANOCA

Protein Name

Uncharacterized protein

Gene Name

HERC1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000015385.2	ENSACAT00000015414.2	ENSACAP00000015109.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	9.50e-17	60.4	3502	3533
E3 activity/HECT	5.10e-86	289.0	4583	4915

Active Site

Position(s)	Description	Evidence
4884	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlr 31
           H+++vt + + +  +ll+++++Dgti+vW+++
   Q: 3502 HQNRVTMCVWcNKkGLLATSGNDGTIRVWSVT 3533
           899999999*9778****************97 PP

E3 activity/HECT

   S: 6    kkrle.vefvgEegldlgGvtreflallsk..elqnpdlglflysen...dketlqpnpdsglknpehlklFeflGrllgkalqdgr 86
            +r++ v++vgE + d+gGv+ ++++++++  el++  + l+  s+n   ++  +  np+++l+  ehl  F+flG+l+g+a+++++
   Q: 4583 PSRAWkVKLVGEGADDAGGVFDDTITEMCQtkELETGVVDLLIPSPNasaGTGRFLFNPSAFLE--EHLLQFKFLGVLMGVAVRTKK 4667
           466666**********************9633788888****9999965555556678888874..9******************** PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNke 171
           +ldl+l++ ++k+l+  +l ledleevd  ++++l++i++ ++  i+e++++ ++  ++ + ++++ ++  ++pgG++ip t +N++
   Q: 4668 PLDLHLAPLVWKQLCCIPLALEDLEEVDLLYVQTLNSILHIEDGGITEENFHEMIPLDSFVGQSADGKMvpIIPGGNSIPLTFSNRK 4754
           *******************************************************9999887777766666**************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
           eYv++ +eyrl+e +++qv+a+reG+++++p  llsl+t+++le+++cG++ei+ve lkk  +y++ + e +  +qwFw++leefs+
   Q: 4755 EYVERAIEYRLHE-MDRQVAAVREGMSWIVPVPLLSLLTARQLEQMVCGMPEISVEVLKKVVRYRE-VDEAHALVQWFWRTLEEFSN 4839
           *************.**************************************************88.******************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           eer  f++Fv+g+srlP+ + a+++ ++f+i k d+  d+lP+s+TCf++L+LP+Yss++++ e+L+yAi++++++++
   Q: 4840 EERVLFMRFVSGRSRLPA-NTADIS-QRFQIMKvDRPYDSLPTSQTCFFQLRLPPYSSQSVMAERLRYAINNCRSIDM 4915
           *****************6.899999.679999956666***********************************99987 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MAAMVPPVKL KWLEHLNSSW ITEDSESIAT REGVAVLYAK LVGNKEVVPL PQQVLCLKGP 60
QLPDFERESL SSDEQDHYLD ALLSSQLALA KMVCSDSPFA GALRKRLLVL QRVFYALSNK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCCGCCA TGGTTCCCCC GGTGAAGCTG AAATGGCTGG AGCACCTGAA CAGCTCGTGG 60
ATCACGGAGG ACAGCGAGTC CATTGCCACG CGGGAGGGGG TGGCGGTGCT GTACGCCAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom

PROSITE

PS50188--B302_SPRY
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY
PF00400--WD40

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc
SM00449--SPRY
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0021702--P:cerebellar Purkinje cell differentiation
GO:0010507--P:negative regulation of autophagy
GO:0050885--P:neuromuscular process controlling balance
GO:0031175--P:neuron projection development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001830	Ailuropoda melanoleuca	86.01	0.00e+00	7700.00
IUUC-Apl-003461	Anas platyrhynchos	86.43	0.00e+00	7736.00
IUUC-Aly-006545	Arabidopsis lyrata	37.24	2.00e-49	191.00
IUUC-Ame-011268	Astyanax mexicanus	60.06	0.00e+00	2172.00
IUUC-Bta-013213	Bos taurus	86.13	0.00e+00	7691.00
IUUC-Bol-015203	Brassica oleracea	36.95	8.00e-52	199.00
IUUC-Bra-017584	Brassica rapa	34.10	2.00e-48	187.00
IUUC-Cja-019298	Callithrix jacchus	85.62	0.00e+00	7671.00
IUUC-Cfa-021213	Canis familiaris	85.67	0.00e+00	7750.00
IUUC-Cpo-021674	Cavia porcellus	84.01	0.00e+00	5163.00
IUUC-Cre-023014	Chlamydomonas reinhardtii	38.11	4.00e-50	191.00
IUUC-Csa-023341	Chlorocebus sabaeus	85.27	0.00e+00	7636.00
IUUC-Cho-024567	Choloepus hoffmanni	81.39	0.00e+00	1516.00
IUUC-Dre-028289	Danio rerio	76.93	0.00e+00	6869.00
IUUC-Dno-029988	Dasypus novemcinctus	85.44	0.00e+00	7642.00
IUUC-Dor-030636	Dipodomys ordii	80.06	0.00e+00	1970.00
IUUC-Ete-032598	Echinops telfairi	81.66	0.00e+00	1315.00
IUUC-Eca-033754	Equus caballus	85.58	0.00e+00	7703.00
IUUC-Eeu-034702	Erinaceus europaeus	77.29	0.00e+00	1317.00
IUUC-Fca-035900	Felis catus	86.22	0.00e+00	7727.00
IUUC-Fal-037034	Ficedula albicollis	84.94	0.00e+00	6675.00
IUUC-Gmo-038634	Gadus morhua	89.53	0.00e+00	1191.00
IUUC-Gga-040321	Gallus gallus	86.60	0.00e+00	7804.00
IUUC-Gac-042444	Gasterosteus aculeatus	56.90	0.00e+00	2179.00
IUUC-Gma-043808	Glycine max	33.42	1.00e-45	178.00
IUUC-Ggo-045134	Gorilla gorilla	79.94	0.00e+00	4086.00
IUUC-Hsa-046516	Homo sapiens	85.51	0.00e+00	7639.00
IUUC-Hvu-047529	Hordeum vulgare	34.36	9.00e-50	192.00
IUUC-Itr-048914	Ictidomys tridecemlineatus	85.85	0.00e+00	2277.00
IUUC-Lch-049903	Latimeria chalumnae	82.52	0.00e+00	7424.00
IUUC-Lpe-051165	Leersia perrieri	33.17	3.00e-50	192.00
IUUC-Loc-052149	Lepisosteus oculatus	80.08	0.00e+00	7094.00
IUUC-Laf-053426	Loxodonta africana	85.71	0.00e+00	7768.00
IUUC-Mcc-055826	Macaca mulatta	85.55	0.00e+00	7690.00
IUUC-Meu-056521	Macropus eugenii	74.41	0.00e+00	1968.00
IUUC-Mga-059567	Meleagris gallopavo	94.12	0.00e+00	2065.00
IUUC-Mmr-061512	Microcebus murinus	85.24	0.00e+00	7603.00
IUUC-Mdo-062177	Monodelphis domestica	83.54	0.00e+00	7497.00
IUUC-Mmu-064373	Mus musculus	85.83	0.00e+00	7685.00
IUUC-Mpu-066148	Mustela putorius furo	85.45	0.00e+00	7666.00
IUUC-Mlu-067680	Myotis lucifugus	85.41	0.00e+00	7638.00
IUUC-Nle-069633	Nomascus leucogenys	85.33	0.00e+00	7607.00
IUUC-Opr-070609	Ochotona princeps	83.06	0.00e+00	1187.00
IUUC-Ont-071249	Oreochromis niloticus	78.36	0.00e+00	7165.00
IUUC-Oan-073157	Ornithorhynchus anatinus	85.59	0.00e+00	7603.00
IUUC-Ocu-074841	Oryctolagus cuniculus	85.66	0.00e+00	7749.00
IUUC-Oba-075262	Oryza barthii	34.07	2.00e-50	192.00
IUUC-Obr-076115	Oryza brachyantha	34.54	2.00e-48	186.00
IUUC-Ogl-077586	Oryza glaberrima	34.07	2.00e-50	192.00
IUUC-Ogu-078796	Oryza glumaepatula	33.83	8.00e-50	191.00
IUUC-Oin-079298	Oryza indica	33.83	8.00e-50	191.00
IUUC-Ome-081908	Oryza meridionalis	33.75	3.00e-49	189.00
IUUC-Oni-082049	Oryza nivara	33.83	8.00e-50	191.00
IUUC-Opu-083608	Oryza punctata	34.00	1.00e-50	193.00
IUUC-Oru-084712	Oryza rufipogon	33.83	8.00e-50	191.00
IUUC-Osa-086078	Oryza sativa	33.83	8.00e-50	191.00
IUUC-Ola-086889	Oryzias latipes	77.45	0.00e+00	6994.00
IUUC-Oga-088459	Otolemur garnettii	84.86	0.00e+00	7621.00
IUUC-Oar-089888	Ovis aries	86.19	0.00e+00	7683.00
IUUC-Ptr-091114	Pan troglodytes	85.57	0.00e+00	7666.00
IUUC-Pan-092442	Papio anubis	85.43	0.00e+00	7666.00
IUUC-Psi-093833	Pelodiscus sinensis	85.83	0.00e+00	5056.00
IUUC-Pma-094275	Petromyzon marinus	77.51	0.00e+00	1708.00
IUUC-Ppa-095790	Physcomitrella patens	35.67	3.00e-55	209.00
IUUC-Pfo-097262	Poecilia formosa	76.08	0.00e+00	4838.00
IUUC-Pab-097760	Pongo abelii	83.77	0.00e+00	4242.00
IUUC-Pop-099121	Populus trichocarpa	37.10	3.00e-52	200.00
IUUC-Pca-100465	Procavia capensis	84.41	0.00e+00	3997.00
IUUC-Ppe-101345	Prunus persica	33.76	1.00e-50	195.00
IUUC-Pva-102950	Pteropus vampyrus	85.76	0.00e+00	3704.00
IUUC-Rno-104892	Rattus norvegicus	85.59	0.00e+00	7625.00
IUUC-Sha-106633	Sarcophilus harrisii	84.81	0.00e+00	7497.00
IUUC-Smo-108827	Selaginella moellendorffii	36.25	9.00e-52	198.00
IUUC-Sly-111155	Solanum lycopersicum	37.10	2.00e-53	204.00
IUUC-Stu-112166	Solanum tuberosum	31.71	3.00e-47	183.00
IUUC-Sar-113251	Sorex araneus	77.23	0.00e+00	2236.00
IUUC-Ssc-116391	Sus scrofa	85.94	0.00e+00	7705.00
IUUC-Tgu-116554	Taeniopygia guttata	86.08	0.00e+00	7741.00
IUUC-Tru-118695	Takifugu rubripes	78.63	0.00e+00	7148.00
IUUC-Tsy-119647	Tarsius syrichta	77.26	0.00e+00	4745.00
IUUC-Tni-120707	Tetraodon nigroviridis	78.58	0.00e+00	7125.00
IUUC-Tur-126300	Triticum urartu	34.36	4.00e-50	193.00
IUUC-Tbe-127346	Tupaia belangeri	78.28	0.00e+00	1668.00
IUUC-Ttr-128542	Tursiops truncatus	79.97	0.00e+00	4993.00
IUUC-Vpa-130611	Vicugna pacos	87.45	0.00e+00	3639.00
IUUC-Xtr-131933	Xenopus tropicalis	81.87	0.00e+00	7333.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence