iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089880

Ensembl Protein ID

ENSOARP00000015417.1

UniProt Accession

W5PY83; W5PY83_SHEEP

Genbank Protein ID

ENSOARP00000015417

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01022207

Gene Name

RFWD2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000014362.1	ENSOART00000015643.1	ENSOARP00000015417.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.00e-06	28.4	57	95
E3 adaptor/Cullin RING/DCX/DWD	1.60e-22	78.9	391	420

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC++++++  + + CgH f+ +C+++          + rCP C+
   Q: 57   CPICFDMIEE-AYMTKCGHSFCYKCIHQS------LEDNNRCPKCN 95
           ********99.888***********9555......999999****6 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 3    tdsvtclaf..sd.tllvsGsdDgtikvWD 29
           +++++c+++     +ll+s+ + gt+ +WD
   Q: 391  NSKISCISWssYHkNLLASSDYEGTVILWD 420
           689******9622599************** PP

Organism

Ovis aries

Protein Sequence
(Fasta)

GAVPAGLSRL SCAARPSAGV GGSSSSLSSG SRKRPLLAPL CNGLINSYED KSNDFVCPIC 60
FDMIEEAYMT KCGHSFCYKC IHQSLEDNNR CPKCNYVVDN IDHLYPNFLV NELILKQKQR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGGCGGTGC CCGCGGGCCT GTCCCGGCTC AGCTGCGCGG CCAGGCCCAG CGCCGGCGTA 60
GGAGGGAGCA GCTCCAGCCT AAGCAGCGGC AGCAGGAAGC GACCTCTGCT CGCCCCCCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0853--WD repeat

Interpro

IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00400--WD40

SMART

SM00184--RING
SM00320--WD40

Gene Ontology

GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0010212--P:response to ionizing radiation

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000885	Aegilops tauschii	39.65	3.00e-121	429.00
IUUC-Aml-001265	Ailuropoda melanoleuca	99.83	0.00e+00	1222.00
IUUC-Atr-002460	Amborella trichopoda	38.18	7.00e-120	424.00
IUUC-Apl-003796	Anas platyrhynchos	98.45	0.00e+00	1158.00
IUUC-Aca-005078	Anolis carolinensis	97.51	0.00e+00	1177.00
IUUC-Aly-006014	Arabidopsis lyrata	39.65	3.00e-125	442.00
IUUC-Ath-007636	Arabidopsis thaliana	39.55	7.00e-125	441.00
IUUC-Ame-011176	Astyanax mexicanus	74.21	8.00e-70	258.00
IUUC-Bta-012595	Bos taurus	99.68	0.00e+00	1228.00
IUUC-Bdi-014152	Brachypodium distachyon	38.60	5.00e-124	438.00
IUUC-Bol-016380	Brassica oleracea	40.00	2.00e-126	446.00
IUUC-Bra-017690	Brassica rapa	38.84	8.00e-121	427.00
IUUC-Cja-018926	Callithrix jacchus	99.20	0.00e+00	1222.00
IUUC-Cfa-021088	Canis familiaris	99.04	0.00e+00	1228.00
IUUC-Cpo-022442	Cavia porcellus	96.90	0.00e+00	1230.00
IUUC-Cre-022579	Chlamydomonas reinhardtii	33.45	3.00e-33	135.00
IUUC-Csa-024119	Chlorocebus sabaeus	97.94	0.00e+00	1222.00
IUUC-Cho-024883	Choloepus hoffmanni	86.07	8.00e-105	374.00
IUUC-Cin-025375	Ciona intestinalis	54.85	0.00e+00	659.00
IUUC-Cme-027350	Cyanidioschyzon merolae	45.45	1.00e-74	274.00
IUUC-Dre-028453	Danio rerio	87.36	0.00e+00	1050.00
IUUC-Dno-029887	Dasypus novemcinctus	98.72	0.00e+00	1215.00
IUUC-Dor-031110	Dipodomys ordii	79.53	0.00e+00	889.00
IUUC-Ete-033016	Echinops telfairi	84.05	0.00e+00	1008.00
IUUC-Eca-034403	Equus caballus	99.48	0.00e+00	1162.00
IUUC-Eeu-034690	Erinaceus europaeus	84.35	0.00e+00	959.00
IUUC-Fca-036475	Felis catus	99.48	0.00e+00	1159.00
IUUC-Fal-037189	Ficedula albicollis	98.62	0.00e+00	1157.00
IUUC-Gmo-039245	Gadus morhua	86.50	0.00e+00	1031.00
IUUC-Gga-040806	Gallus gallus	98.34	0.00e+00	1204.00
IUUC-Gac-042177	Gasterosteus aculeatus	87.81	0.00e+00	1068.00
IUUC-Gma-044187	Glycine max	40.38	1.00e-122	433.00
IUUC-Ggo-044430	Gorilla gorilla	98.73	0.00e+00	931.00
IUUC-Hsa-045853	Homo sapiens	99.20	0.00e+00	1223.00
IUUC-Hvu-047750	Hordeum vulgare	37.88	3.00e-87	317.00
IUUC-Itr-048238	Ictidomys tridecemlineatus	100.00	1.00e-143	501.00
IUUC-Lch-050420	Latimeria chalumnae	91.97	0.00e+00	1118.00
IUUC-Lpe-051219	Leersia perrieri	38.85	4.00e-122	432.00
IUUC-Loc-052728	Lepisosteus oculatus	91.20	0.00e+00	1073.00
IUUC-Laf-053775	Loxodonta africana	98.25	0.00e+00	1228.00
IUUC-Meu-056595	Macropus eugenii	77.93	2.00e-177	615.00
IUUC-Mtr-058555	Medicago truncatula	40.19	2.00e-129	456.00
IUUC-Mga-059646	Meleagris gallopavo	97.94	0.00e+00	1157.00
IUUC-Mmr-060990	Microcebus murinus	99.20	0.00e+00	1229.00
IUUC-Mdo-062287	Monodelphis domestica	99.00	0.00e+00	1213.00
IUUC-Mmu-064097	Mus musculus	98.88	0.00e+00	1227.00
IUUC-Mac-065240	Musa acuminata	40.82	3.00e-130	459.00
IUUC-Mpu-066612	Mustela putorius furo	99.65	0.00e+00	1164.00
IUUC-Mlu-067967	Myotis lucifugus	97.15	0.00e+00	1160.00
IUUC-Nle-069543	Nomascus leucogenys	99.36	0.00e+00	1227.00
IUUC-Opr-070366	Ochotona princeps	83.88	0.00e+00	716.00
IUUC-Ont-071522	Oreochromis niloticus	84.64	0.00e+00	1060.00
IUUC-Oan-073409	Ornithorhynchus anatinus	99.48	0.00e+00	1157.00
IUUC-Ocu-073756	Oryctolagus cuniculus	99.20	0.00e+00	1234.00
IUUC-Oba-075149	Oryza barthii	38.47	5.00e-122	432.00
IUUC-Obr-076563	Oryza brachyantha	39.17	5.00e-122	431.00
IUUC-Ogl-077701	Oryza glaberrima	38.47	3.00e-122	432.00
IUUC-Ogu-078383	Oryza glumaepatula	38.47	3.00e-122	432.00
IUUC-Oin-079965	Oryza indica	36.58	1.00e-108	387.00
IUUC-Olo-080639	Oryza longistaminata	38.32	5.00e-120	424.00
IUUC-Ome-081821	Oryza meridionalis	38.24	4.00e-110	392.00
IUUC-Oni-082622	Oryza nivara	38.47	3.00e-122	432.00
IUUC-Opu-083295	Oryza punctata	38.47	5.00e-122	431.00
IUUC-Oru-084661	Oryza rufipogon	38.47	3.00e-122	432.00
IUUC-Osa-085766	Oryza sativa	38.47	3.00e-122	432.00
IUUC-Ola-086727	Oryzias latipes	87.46	0.00e+00	1075.00
IUUC-Olu-087702	Ostreococcus lucimarinus	43.10	2.00e-65	242.00
IUUC-Oga-088215	Otolemur garnettii	97.97	0.00e+00	1234.00
IUUC-Ptr-090597	Pan troglodytes	99.20	0.00e+00	1223.00
IUUC-Pan-091987	Papio anubis	99.36	0.00e+00	1227.00
IUUC-Psi-094033	Pelodiscus sinensis	98.08	0.00e+00	1134.00
IUUC-Pma-094587	Petromyzon marinus	70.56	0.00e+00	802.00
IUUC-Ppa-095256	Physcomitrella patens	39.18	5.00e-127	448.00
IUUC-Pfo-097388	Poecilia formosa	86.45	0.00e+00	1036.00
IUUC-Pab-098029	Pongo abelii	99.20	0.00e+00	1224.00
IUUC-Pop-099319	Populus trichocarpa	38.44	1.00e-125	444.00
IUUC-Pca-100846	Procavia capensis	90.53	0.00e+00	1109.00
IUUC-Ppe-101250	Prunus persica	38.52	3.00e-116	412.00
IUUC-Pva-102407	Pteropus vampyrus	98.88	0.00e+00	1216.00
IUUC-Rno-105312	Rattus norvegicus	98.88	0.00e+00	1225.00
IUUC-Sha-106514	Sarcophilus harrisii	99.19	0.00e+00	773.00
IUUC-Smo-109418	Selaginella moellendorffii	39.33	1.00e-124	440.00
IUUC-Sit-110248	Setaria italica	38.44	3.00e-123	435.00
IUUC-Sly-110964	Solanum lycopersicum	40.51	1.00e-127	450.00
IUUC-Stu-112882	Solanum tuberosum	40.61	3.00e-128	452.00
IUUC-Sar-113230	Sorex araneus	71.58	0.00e+00	777.00
IUUC-Sbi-113962	Sorghum bicolor	36.52	5.00e-118	418.00
IUUC-Ssc-115987	Sus scrofa	99.41	0.00e+00	628.00
IUUC-Tgu-116471	Taeniopygia guttata	98.34	0.00e+00	1206.00
IUUC-Tru-118231	Takifugu rubripes	87.15	0.00e+00	1019.00
IUUC-Tsy-119415	Tarsius syrichta	98.79	0.00e+00	1137.00
IUUC-Tni-120893	Tetraodon nigroviridis	87.31	0.00e+00	1028.00
IUUC-Tca-121703	Theobroma cacao	41.03	4.00e-125	441.00
IUUC-Tae-125440	Triticum aestivum	40.73	3.00e-129	455.00
IUUC-Tur-126557	Triticum urartu	40.36	2.00e-124	439.00
IUUC-Tbe-127253	Tupaia belangeri	70.33	0.00e+00	815.00
IUUC-Ttr-129100	Tursiops truncatus	98.42	0.00e+00	1108.00
IUUC-Vpa-130613	Vicugna pacos	92.55	0.00e+00	1063.00
IUUC-Vvi-130880	Vitis vinifera	40.70	2.00e-118	419.00
IUUC-Xtr-132033	Xenopus tropicalis	95.52	0.00e+00	1202.00
IUUC-Xma-133421	Xiphophorus maculatus	86.28	0.00e+00	1034.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence