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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063833
UUCD1 version UUC-MuM-00717
Ensembl Protein ID ENSMUSP00000070168.4
UniProt Accession Q8CA72; GAN_MOUSE
Genbank Protein ID BAC30353.1; AAI12433.1
Protein Name Gigaxonin
Genbank Nucleotide ID AC121116; BC112432
Gene Name Gan
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000052557.11 ENSMUST00000162997.2 ENSMUSP00000124904.1
ENSMUSG00000052557.11 ENSMUST00000064488.10 ENSMUSP00000070168.4
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
miRNAMapRAID2
Protein-protein Interaction
IIDMentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB 3.90e-11 44.3 30 99
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box 5.20e-08 32.1 132 162
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmele.esksklmveikdvqpevfrallkFlYtgkldene 69
           +D  lv++gee++++k +Laa+S++ +  ++ + + +  s+ ++e+++++  v+r++l+++ +g++++ne
   Q: 30   CDAHLVLDGEEIPVQKNILAAASPYIRTKLNYNPPkDDGSTYKIELEGISVMVMREILDYIFSGQIRLNE 99
           899***************************888884666666666668*******************997 PP
   

   E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box
   S: 2    eNclgilrfAdlydcpdLkdaaldfilkhFk 32
           eNc+gi++fA +y++++++  a +++++hF+
   Q: 132  ENCIGIRDFALHYCLHHVHYLATEYLETHFR 162
           9*****************************7 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB (By similarity). Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival.
 Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB (By similarity). Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival.
Protein Sequence
(Fasta)
MAEGSAVSDP QHAARLLRAL SSFREEARFC DAHLVLDGEE IPVQKNILAA ASPYIRTKLN 60
YNPPKDDGST YKIELEGISV MVMREILDYI FSGQIRLNED TIQDVVQAAD LLLLTDLKTL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063833|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATGGCCGAGG GCAGCGCTGT GTCCGACCCT CAGCACGCCG CGCGCCTGCT GCGGGCGCTC 60
AGCTCGTTCC GGGAGGAGGC GCGTTTCTGC GACGCGCATC TGGTCCTCGA CGGCGAGGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063833|E3,BTB_3-box|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0880--Kelch repeat
KW-0523--Neurodegeneration
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR030579--KLHL16
IPR011333--SKP1/BTB/POZ
PROSITE

PS50097--BTB
Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1
SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch
Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0007010--P:cytoskeleton organization
GO:0016567--P:protein ubiquitination
KEGG mmu:209239
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002164 Ailuropoda melanoleuca 97.43 0.00e+00 1069.00
IUUC-Apl-004132 Anas platyrhynchos 91.22 0.00e+00 1008.00
IUUC-Aca-005264 Anolis carolinensis 90.42 0.00e+00 1090.00
IUUC-Ame-011222 Astyanax mexicanus 69.52 0.00e+00 704.00
IUUC-Bta-012855 Bos taurus 97.49 0.00e+00 1167.00
IUUC-Cja-019865 Callithrix jacchus 97.99 0.00e+00 1171.00
IUUC-Cfa-020864 Canis familiaris 97.99 0.00e+00 1175.00
IUUC-Cpo-021500 Cavia porcellus 97.65 0.00e+00 1166.00
IUUC-Csa-023114 Chlorocebus sabaeus 98.32 0.00e+00 1177.00
IUUC-Cho-024996 Choloepus hoffmanni 97.60 0.00e+00 1055.00
IUUC-Dre-028758 Danio rerio 68.49 2.00e-180 625.00
IUUC-Dno-029380 Dasypus novemcinctus 97.97 0.00e+00 1160.00
IUUC-Dor-030704 Dipodomys ordii 97.67 0.00e+00 769.00
IUUC-Ete-032632 Echinops telfairi 96.82 0.00e+00 1156.00
IUUC-Eca-034092 Equus caballus 97.43 0.00e+00 1065.00
IUUC-Eeu-034482 Erinaceus europaeus 91.99 0.00e+00 1080.00
IUUC-Fca-035706 Felis catus 97.61 0.00e+00 1066.00
IUUC-Fal-037414 Ficedula albicollis 92.04 0.00e+00 959.00
IUUC-Gmo-039716 Gadus morhua 67.85 0.00e+00 857.00
IUUC-Gga-040801 Gallus gallus 91.46 0.00e+00 1105.00
IUUC-Gac-042023 Gasterosteus aculeatus 67.79 0.00e+00 867.00
IUUC-Ggo-045209 Gorilla gorilla 97.98 0.00e+00 1072.00
IUUC-Hsa-046018 Homo sapiens 98.32 0.00e+00 1177.00
IUUC-Itr-048003 Ictidomys tridecemlineatus 97.54 0.00e+00 894.00
IUUC-Lch-050253 Latimeria chalumnae 82.04 0.00e+00 988.00
IUUC-Loc-052224 Lepisosteus oculatus 80.17 0.00e+00 966.00
IUUC-Laf-054497 Loxodonta africana 96.64 0.00e+00 1152.00
IUUC-Mcc-055363 Macaca mulatta 98.32 0.00e+00 1177.00
IUUC-Meu-056415 Macropus eugenii 87.60 0.00e+00 1030.00
IUUC-Mga-059506 Meleagris gallopavo 91.53 0.00e+00 1008.00
IUUC-Mmr-060695 Microcebus murinus 97.82 0.00e+00 1172.00
IUUC-Mdo-062539 Monodelphis domestica 95.14 0.00e+00 1144.00
IUUC-Mpu-066163 Mustela putorius furo 97.66 0.00e+00 1170.00
IUUC-Mlu-067351 Myotis lucifugus 98.49 0.00e+00 1178.00
IUUC-Nle-069432 Nomascus leucogenys 98.16 0.00e+00 1175.00
IUUC-Opr-070941 Ochotona princeps 87.62 0.00e+00 921.00
IUUC-Ont-072620 Oreochromis niloticus 69.53 0.00e+00 889.00
IUUC-Oan-073408 Ornithorhynchus anatinus 93.84 7.00e-148 516.00
IUUC-Ocu-074067 Oryctolagus cuniculus 96.98 0.00e+00 1163.00
IUUC-Ola-087263 Oryzias latipes 67.85 0.00e+00 858.00
IUUC-Oga-088387 Otolemur garnettii 97.17 0.00e+00 1167.00
IUUC-Oar-089890 Ovis aries 96.89 0.00e+00 1053.00
IUUC-Ptr-090867 Pan troglodytes 98.34 0.00e+00 1065.00
IUUC-Pan-092790 Papio anubis 97.98 0.00e+00 1072.00
IUUC-Psi-093381 Pelodiscus sinensis 92.04 0.00e+00 920.00
IUUC-Pma-094681 Petromyzon marinus 67.26 2.00e-157 549.00
IUUC-Ppa-095543 Physcomitrella patens 27.81 2.00e-15 76.60
IUUC-Pfo-096446 Poecilia formosa 67.85 0.00e+00 876.00
IUUC-Pab-097839 Pongo abelii 98.32 0.00e+00 1179.00
IUUC-Pca-101042 Procavia capensis 80.70 1.00e-120 426.00
IUUC-Pva-102911 Pteropus vampyrus 97.99 0.00e+00 1172.00
IUUC-Rno-105073 Rattus norvegicus 98.18 0.00e+00 1177.00
IUUC-Sha-107321 Sarcophilus harrisii 93.63 0.00e+00 1156.00
IUUC-Sar-113417 Sorex araneus 87.62 0.00e+00 919.00
IUUC-Ssc-115450 Sus scrofa 97.65 0.00e+00 1171.00
IUUC-Tgu-117089 Taeniopygia guttata 91.41 0.00e+00 1089.00
IUUC-Tru-118452 Takifugu rubripes 64.97 0.00e+00 822.00
IUUC-Tsy-119125 Tarsius syrichta 92.54 0.00e+00 883.00
IUUC-Tni-120845 Tetraodon nigroviridis 64.38 0.00e+00 815.00
IUUC-Tbe-127688 Tupaia belangeri 68.24 1.00e-112 399.00
IUUC-Ttr-128621 Tursiops truncatus 97.17 0.00e+00 912.00
IUUC-Vpa-130159 Vicugna pacos 98.38 2.00e-179 622.00
IUUC-Xtr-132635 Xenopus tropicalis 84.23 0.00e+00 1003.00
Created Date 25-Jun-2017

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