iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Sce-106282

UUCD1 version

UUC-SaC-00024

Ensembl Protein ID

YHR115C

UniProt Accession

P38823; D3DL65; Q66GT1; DMA1_YEAST

Genbank Protein ID

DAA05593.1; AAB68865.1; DAA06809.1

Protein Name

E3 ubiquitin-protein ligase DMA1; Checkpoint forkhead associated with RING domains-containing protein 1; Defective in mitotic arrest protein 1; RING-type E3 ubiquitin transferase DMA1

Genbank Nucleotide ID

BK005578; U00059; BK006934

Gene Name

DMA1; CHF1; YHR115C

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
YHR115C	YHR115C	YHR115C

Annotation

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	dbPTM	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18597043

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	1.70e-05	23.7	327	371

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCl+ +  ++  ++ pC H +h++C+ ++     + +++f+CP Cr
   Q: 327  CSICLNKIkpCQAIFISPCAHSWHFHCVRRL---VIMNYPQFMCPNCR 371
           ******9955333899************888...6779*********8 PP

Organism

Saccharomyces cerevisiae

Functional Description
(View)

E3 ubiquitin-protein ligase which functions in cell cycle retarding in conjonction with the UBC4 and UBC13/MMS2 complex, 2 E2 ubiquitin conjugationg enzymes (PubMed:18202552). Involved in nutritional control of the cell cycle (PubMed:15319434). Targets the G1 cyclin PCL1 for destruction (PubMed:23264631). Required for proper spindle positioning, likely regulating septin ring deposition at the bud neck (PubMed:15146058).

Protein Sequence
(Fasta)

MSTNTVPSSP PNQTPPAASG IATSHDHTKF NNPIRLPISI SLTINDTPNN NSNNNSVSNG 60
LGILPSRTAT SLVVANNGSA NGNVGATAAA AATVETNTAP AVNTTKSIRH FIYPPNQVNQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCTACTA ATACTGTTCC CTCATCTCCC CCAAACCAGA CGCCACCTGC TGCTTCTGGC 60
ATCGCTACCT CTCACGATCA CACCAAGTTC AACAATCCCA TCAGACTACC GATATCCATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0498--Mitosis
KW-1185--Reference proteome
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000253--FHA_dom
IPR008984--SMAD_FHA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50006--FHA_DOMAIN
PS50089--ZF_RING_2

Pfam

PF00498--FHA
PF17123--zf-RING_11

SMART

SM00240--FHA

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0032186--P:cellular bud neck septin ring organization
GO:0000132--P:establishment of mitotic spindle orientation
GO:0007067--P:mitotic nuclear division
GO:0031578--P:mitotic spindle orientation checkpoint
GO:0051865--P:protein autoubiquitination
GO:0097271--P:protein localization to bud neck
GO:0016567--P:protein ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090337--P:regulation of formin-nucleated actin cable assembly
GO:0000921--P:septin ring assembly

KEGG

sce:YHR115C

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000514	Aegilops tauschii	40.38	9.00e-07	47.00
IUUC-Aml-002124	Ailuropoda melanoleuca	37.08	2.00e-07	48.90
IUUC-Atr-002911	Amborella trichopoda	33.90	2.00e-07	45.40
IUUC-Aly-005469	Arabidopsis lyrata	42.31	3.00e-06	45.10
IUUC-Ath-007351	Arabidopsis thaliana	43.48	9.00e-06	43.50
IUUC-Ani-009177	Aspergillus nidulans	40.53	1.00e-37	149.00
IUUC-Ang-009606	Aspergillus niger	46.12	4.00e-52	197.00
IUUC-Bta-013297	Bos taurus	35.96	7.00e-08	50.10
IUUC-Bci-013695	Botrytis cinerea	45.56	8.00e-58	216.00
IUUC-Bdi-014237	Brachypodium distachyon	35.29	2.00e-07	49.30
IUUC-Bol-015398	Brassica oleracea	40.38	9.00e-07	46.60
IUUC-Bra-017571	Brassica rapa	41.18	8.00e-07	47.00
IUUC-Cja-019201	Callithrix jacchus	33.71	3.00e-07	48.10
IUUC-Cfa-021041	Canis familiaris	35.96	5.00e-07	47.00
IUUC-Csa-024133	Chlorocebus sabaeus	33.71	9.00e-07	46.20
IUUC-Cme-027312	Cyanidioschyzon merolae	32.26	2.00e-05	40.80
IUUC-Dor-030190	Dipodomys ordii	33.71	2.00e-07	48.50
IUUC-Eeu-035117	Erinaceus europaeus	48.94	3.00e-06	45.40
IUUC-Fca-036075	Felis catus	35.96	2.00e-07	48.10
IUUC-Gmo-039603	Gadus morhua	33.33	4.00e-06	43.50
IUUC-Gma-043422	Glycine max	31.58	3.00e-05	42.00
IUUC-Ggo-045269	Gorilla gorilla	33.71	9.00e-07	46.20
IUUC-Hsa-046249	Homo sapiens	33.71	1.00e-06	46.20
IUUC-Hvu-047585	Hordeum vulgare	40.38	7.00e-07	47.40
IUUC-Itr-048314	Ictidomys tridecemlineatus	35.96	2.00e-07	48.50
IUUC-Lpe-051169	Leersia perrieri	41.67	1.00e-07	49.70
IUUC-Loc-052377	Lepisosteus oculatus	33.64	6.00e-08	50.10
IUUC-Mcc-055344	Macaca mulatta	33.71	1.00e-06	46.20
IUUC-Meu-056408	Macropus eugenii	35.53	2.00e-06	44.30
IUUC-Mtr-058270	Medicago truncatula	45.83	1.00e-07	49.70
IUUC-Mvi-060480	Microbotryum violaceum	42.28	2.00e-53	202.00
IUUC-Mmr-061431	Microcebus murinus	34.83	4.00e-07	47.40
IUUC-Mmu-063235	Mus musculus	34.44	7.00e-08	49.70
IUUC-Mac-065116	Musa acuminata	39.22	8.00e-08	50.10
IUUC-Mpu-066449	Mustela putorius furo	35.96	4.00e-07	47.40
IUUC-Nle-069192	Nomascus leucogenys	33.71	9.00e-07	46.20
IUUC-Ont-071333	Oreochromis niloticus	32.88	7.00e-07	45.80
IUUC-Ocu-074603	Oryctolagus cuniculus	33.71	2.00e-06	45.10
IUUC-Oba-075235	Oryza barthii	41.18	6.00e-08	50.80
IUUC-Obr-076924	Oryza brachyantha	40.38	4.00e-07	48.10
IUUC-Ogl-077320	Oryza glaberrima	41.67	2.00e-07	49.30
IUUC-Ogu-078949	Oryza glumaepatula	41.67	2.00e-07	49.30
IUUC-Oin-080195	Oryza indica	41.67	2.00e-07	48.90
IUUC-Olo-080745	Oryza longistaminata	41.18	7.00e-08	50.40
IUUC-Oni-083034	Oryza nivara	41.67	2.00e-07	49.30
IUUC-Opu-083998	Oryza punctata	41.67	2.00e-07	48.90
IUUC-Oru-084796	Oryza rufipogon	41.67	1.00e-07	49.30
IUUC-Oga-088183	Otolemur garnettii	34.83	7.00e-07	46.60
IUUC-Oar-090255	Ovis aries	42.11	1.00e-06	45.80
IUUC-Pan-092241	Papio anubis	33.71	9.00e-07	46.20
IUUC-Pab-098530	Pongo abelii	33.71	8.00e-07	46.20
IUUC-Rno-105338	Rattus norvegicus	35.56	1.00e-07	49.30
IUUC-Ssl-108562	Sclerotinia sclerotiorum	43.59	7.00e-50	189.00
IUUC-Sit-109961	Setaria italica	39.58	7.00e-06	43.50
IUUC-Sly-111683	Solanum lycopersicum	44.68	2.00e-07	49.30
IUUC-Stu-112230	Solanum tuberosum	44.68	3.00e-07	48.50
IUUC-Sbi-114156	Sorghum bicolor	40.00	1.00e-06	46.60
IUUC-Ssc-116290	Sus scrofa	29.58	1.00e-07	48.90
IUUC-Tca-121823	Theobroma cacao	44.23	9.00e-08	50.40
IUUC-Tae-123974	Triticum aestivum	38.78	4.00e-07	48.10
IUUC-Tur-126698	Triticum urartu	38.78	3.00e-07	48.10
IUUC-Ttr-128997	Tursiops truncatus	42.11	7.00e-07	46.60
IUUC-Vvi-130879	Vitis vinifera	40.98	7.00e-08	50.80
IUUC-Zma-134729	Zea mays	39.58	1.00e-06	46.20

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence