iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-028536

UUCD1 version

UUC-DaR-00728

Ensembl Protein ID

ENSDARP00000096314.3

UniProt Accession

Q6NYJ2; Q6NYJ2_DANRE

Genbank Protein ID

AAH66573.1; ABC75031.1; CBY83937.1

Protein Name

Suppressor of cytokine signaling 3b; Suppressor of cytokine-signaling 3b

Genbank Nucleotide ID

CU855552; DQ345761; FR750001

Gene Name

socs3b

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000026611.7	ENSDART00000037904.6	ENSDARP00000096314.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	59.57	2.00e-72	269.00	IUUC-Hsa-046909

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Danio rerio

Protein Sequence
(Fasta)

MVTHSRLDSA MSSSPFEGGV RLPPHRYKTF SSREQYQMVL AAVRKLQESG FYWSTVSGKE 60
ASTLLSSEPP GTFLVRDSSD HHHFFTLSVK TATGTKNLRI QCDSSSFFLQ TDPRSEQVVP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACCAGCAAA GTCACTTTAT TAATATTCTT TGGTCTTTGA CACCAGTCAC GATGGTCACG 60
ATACCGAAGA TTGTAGAGAA CGAAAATGCT AACTTGCGGA GTTGAAAAGG TATTGTTGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028414--SOCS3
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0007259--P:JAK-STAT cascade
GO:0043066--P:negative regulation of apoptotic process
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0016567--P:protein ubiquitination

KEGG

dre:406596

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001529	Ailuropoda melanoleuca	58.70	2.00e-70	258.00
IUUC-Apl-003607	Anas platyrhynchos	63.81	7.00e-68	249.00
IUUC-Aca-005063	Anolis carolinensis	61.57	9.00e-71	259.00
IUUC-Ame-010859	Astyanax mexicanus	78.57	6.00e-100	356.00
IUUC-Bta-012817	Bos taurus	58.55	1.00e-73	269.00
IUUC-Cja-019605	Callithrix jacchus	59.57	4.00e-71	260.00
IUUC-Cfa-021231	Canis familiaris	58.26	6.00e-71	260.00
IUUC-Cpo-022003	Cavia porcellus	57.94	1.00e-70	259.00
IUUC-Csa-023511	Chlorocebus sabaeus	59.13	7.00e-71	259.00
IUUC-Dno-029003	Dasypus novemcinctus	57.64	2.00e-71	261.00
IUUC-Eca-034205	Equus caballus	52.51	9.00e-46	176.00
IUUC-Fca-036317	Felis catus	56.58	6.00e-68	249.00
IUUC-Gmo-038777	Gadus morhua	66.67	6.00e-44	169.00
IUUC-Gga-041258	Gallus gallus	62.62	5.00e-68	250.00
IUUC-Gac-041837	Gasterosteus aculeatus	68.98	1.00e-78	285.00
IUUC-Ggo-045620	Gorilla gorilla	59.13	7.00e-71	259.00
IUUC-Hsa-046909	Homo sapiens	59.13	7.00e-71	259.00
IUUC-Itr-048023	Ictidomys tridecemlineatus	55.65	6.00e-70	256.00
IUUC-Lch-049510	Latimeria chalumnae	64.76	7.00e-78	283.00
IUUC-Loc-052863	Lepisosteus oculatus	80.09	2.00e-100	357.00
IUUC-Laf-054136	Loxodonta africana	56.22	7.00e-71	259.00
IUUC-Mcc-055383	Macaca mulatta	59.13	7.00e-71	259.00
IUUC-Meu-056153	Macropus eugenii	58.01	1.00e-70	259.00
IUUC-Mmr-061185	Microcebus murinus	58.01	4.00e-71	260.00
IUUC-Mdo-061819	Monodelphis domestica	58.26	4.00e-71	261.00
IUUC-Mmu-064231	Mus musculus	59.13	8.00e-72	263.00
IUUC-Mpu-066691	Mustela putorius furo	58.26	6.00e-71	260.00
IUUC-Mlu-067673	Myotis lucifugus	57.08	2.00e-71	261.00
IUUC-Ont-072406	Oreochromis niloticus	66.19	2.00e-83	301.00
IUUC-Oan-073249	Ornithorhynchus anatinus	58.57	1.00e-66	245.00
IUUC-Ola-087373	Oryzias latipes	58.33	2.00e-63	234.00
IUUC-Oga-088041	Otolemur garnettii	58.08	6.00e-71	259.00
IUUC-Oar-089646	Ovis aries	57.26	1.00e-68	252.00
IUUC-Ptr-091502	Pan troglodytes	59.13	7.00e-71	259.00
IUUC-Pan-091934	Papio anubis	59.13	7.00e-71	259.00
IUUC-Pfo-096412	Poecilia formosa	48.06	9.00e-53	199.00
IUUC-Pab-098554	Pongo abelii	59.13	7.00e-71	259.00
IUUC-Rno-105874	Rattus norvegicus	58.70	1.00e-71	262.00
IUUC-Sha-107151	Sarcophilus harrisii	57.08	8.00e-70	256.00
IUUC-Ssc-115722	Sus scrofa	53.53	4.00e-45	173.00
IUUC-Tgu-117151	Taeniopygia guttata	63.08	6.00e-67	246.00
IUUC-Tru-118428	Takifugu rubripes	63.33	6.00e-81	293.00
IUUC-Tni-120590	Tetraodon nigroviridis	65.71	1.00e-80	292.00
IUUC-Ttr-129065	Tursiops truncatus	58.55	2.00e-70	258.00
IUUC-Xtr-132167	Xenopus tropicalis	61.90	1.00e-71	262.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence