iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003658

Ensembl Protein ID

ENSAPLP00000008671.1

UniProt Accession

U3IN48; U3IN48_ANAPL

Genbank Protein ID

ENSAPLP00000008671

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

ADON01097849

Gene Name

USP49

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000008994.1	ENSAPLT00000009354.1	ENSAPLP00000008671.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.10e-99	332.6	260	665

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle........kkkeklneenp....................................... 42
           tGl+NlgNtCYmNS+LQ+Ls+++++re++l+           +++    +                                       
   Q: 260  TGLRNLGNTCYMNSILQVLSHLQKFRECFLTldlceteeLLAKTV----Ngksrmpgklangaaanesgktdkvgsygtqslpaglngg 344
           7******************************88875555333344....2455589999999999999********************* PP
   S: 43   ...............kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpke 116
                          ++++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld++++el         
   Q: 345  ssisrsleliqpkepSSKHISLCHELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLDKVQQEL--------- 424
           ********999999999999************************************************************......... PP
   S: 117  eeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..........slqdcLesft 195
           e+e+++++ l   +++k +k+  ++++++F+gql sq++c +c+ +s++ epf+dlsl++p++ ++ ++           l+++L++ft
   Q: 425  ESEGTKRRILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCITCNYKSNTVEPFWDLSLEFPERYHSIEKgiipvnqtecMLTEMLAKFT 513
           6788899999999************************************************999876669******************* PP
   S: 196  keeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqk 273
           ++e leg+  y c++c++k++           a+k+l++ +lP+vL lhLkRf++se+ ++reki  +v f + L+++p+c++++ ++ 
   Q: 514  ETEALEGRI-YACDQCNSKRRksspkplvlseAKKQLMIYRLPQVLRLHLKRFRWSER-NHREKIGVHVLFDQVLNMEPYCCRDSLSSL 600
           ******965.*******9999999*******************************997.8889********************887765 PP
   S: 274  e..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           +  +  Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk ++++ eev++   ++aY+lfY++
   Q: 601  DkeTFVYDLSAVVMHHGkGFGSGHYTAYCYNTEGGfWVHCNDSKLNVCSVEEVCK---TQAYILFYTQ 665
           433899*************************9999********************...********98 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

MDRCKHVGRL RLAQDHSILN PQKWHCMDCQ TTESIWACLK CSHVACGRYI EEHALKHFEE 60
TRHPLAMEVN DLYVFCYLCE DYVLNDNPEG DLKLLRSSLS AIKSQKHDPS TRSGRTLRSM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATAGAT GCAAACATGT TGGGCGGCTA CGACTCGCCC AGGACCATTC TATCCTGAAC 60
CCGCAGAAGT GGCACTGCAT GGACTGCCAG ACAACTGAAT CTATCTGGGC TTGTCTGAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:0000398--P:mRNA splicing, via spliceosome
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

apla:101791234

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-005278	Anolis carolinensis	92.11	0.00e+00	1294.00
IUUC-Bta-012911	Bos taurus	78.05	0.00e+00	1018.00
IUUC-Cja-019171	Callithrix jacchus	78.45	0.00e+00	1050.00
IUUC-Cfa-020408	Canis familiaris	77.87	0.00e+00	1035.00
IUUC-Cpo-022233	Cavia porcellus	72.12	0.00e+00	963.00
IUUC-Csa-024272	Chlorocebus sabaeus	77.00	0.00e+00	846.00
IUUC-Cho-025051	Choloepus hoffmanni	80.11	3.00e-167	581.00
IUUC-Cin-025587	Ciona intestinalis	47.15	1.00e-110	394.00
IUUC-Csv-025814	Ciona savignyi	44.03	1.00e-152	532.00
IUUC-Dno-029856	Dasypus novemcinctus	79.20	0.00e+00	1059.00
IUUC-Eca-033851	Equus caballus	74.17	0.00e+00	924.00
IUUC-Fal-037290	Ficedula albicollis	88.36	0.00e+00	1119.00
IUUC-Gmo-039249	Gadus morhua	79.25	7.00e-151	527.00
IUUC-Gga-040383	Gallus gallus	94.63	0.00e+00	984.00
IUUC-Gac-042595	Gasterosteus aculeatus	63.36	0.00e+00	810.00
IUUC-Ggo-044979	Gorilla gorilla	79.31	0.00e+00	1057.00
IUUC-Hsa-046743	Homo sapiens	79.31	0.00e+00	1056.00
IUUC-Itr-048251	Ictidomys tridecemlineatus	78.34	0.00e+00	1060.00
IUUC-Lch-050294	Latimeria chalumnae	83.60	0.00e+00	1089.00
IUUC-Loc-051961	Lepisosteus oculatus	74.29	0.00e+00	696.00
IUUC-Mcc-055048	Macaca mulatta	78.88	0.00e+00	1051.00
IUUC-Meu-055971	Macropus eugenii	72.89	1.00e-173	602.00
IUUC-Mga-059720	Meleagris gallopavo	97.98	0.00e+00	985.00
IUUC-Mdo-062073	Monodelphis domestica	88.81	0.00e+00	1239.00
IUUC-Mmu-064095	Mus musculus	77.25	0.00e+00	1041.00
IUUC-Mlu-067090	Myotis lucifugus	76.33	0.00e+00	1014.00
IUUC-Nle-069486	Nomascus leucogenys	79.31	0.00e+00	1058.00
IUUC-Opr-070563	Ochotona princeps	76.22	0.00e+00	1029.00
IUUC-Ocu-074851	Oryctolagus cuniculus	75.86	0.00e+00	828.00
IUUC-Ola-086413	Oryzias latipes	59.32	0.00e+00	705.00
IUUC-Oga-088862	Otolemur garnettii	78.34	0.00e+00	1048.00
IUUC-Ptr-091525	Pan troglodytes	79.06	0.00e+00	954.00
IUUC-Pan-092363	Papio anubis	79.67	0.00e+00	1021.00
IUUC-Psi-093353	Pelodiscus sinensis	94.27	0.00e+00	1301.00
IUUC-Pma-094155	Petromyzon marinus	59.66	3.00e-84	304.00
IUUC-Pfo-096413	Poecilia formosa	64.39	0.00e+00	833.00
IUUC-Pab-098592	Pongo abelii	76.66	0.00e+00	845.00
IUUC-Pca-100449	Procavia capensis	78.94	0.00e+00	1045.00
IUUC-Pva-102868	Pteropus vampyrus	78.19	0.00e+00	1025.00
IUUC-Rno-105190	Rattus norvegicus	77.19	0.00e+00	1046.00
IUUC-Sha-107337	Sarcophilus harrisii	88.43	0.00e+00	1209.00
IUUC-Sar-113561	Sorex araneus	88.02	1.00e-86	313.00
IUUC-Ssc-115735	Sus scrofa	77.62	0.00e+00	1021.00
IUUC-Tgu-117025	Taeniopygia guttata	82.77	0.00e+00	1030.00
IUUC-Tru-117585	Takifugu rubripes	64.36	0.00e+00	807.00
IUUC-Tsy-118814	Tarsius syrichta	79.20	0.00e+00	1054.00
IUUC-Tni-120600	Tetraodon nigroviridis	63.39	0.00e+00	773.00
IUUC-Xtr-132090	Xenopus tropicalis	74.29	0.00e+00	1012.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence