iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cpo-022233

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAKN02021414

Gene Name

USP49

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000014200.3	ENSCPOT00000014342.2	ENSCPOP00000012793.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.20e-97	325.3	245	639

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenp.................................... 42
           tGl+NlgNtCYmNS+LQ+Ls+++++re++l+           +         +                                    
   Q: 245  TGLRNLGNTCYMNSILQVLSHLRKFRECFLKldpcttehlfaHR--------Karlsatepqassdraeacrrhdlcwtggaslsrsle 325
           7******************************8887665555533........1344445557888888899999999999999999999 PP
   S: 43   .......kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedks 124
                  ++++ +l+++l++lf+ +w++++  vsp ++l++++++ + f+gy+qqDaqEfl+ ll+++++el         e+e+++++
   Q: 326  liqnkepSSRHISLCHELHTLFRVMWSGRWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQEL---------EAEGSTRR 405
           998888888888************************************************************.........78899999 PP
   S: 125  elsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..........slqdcLesftkeeelege 203
            l   +++k +k+  ++++++F+gql sq++c +c+ +s++ epf+dlsl++p++ ++ ++           l+++L++ft++e leg+
   Q: 406  ILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFPERYHCIEKgfvplnqtecLLTEMLAKFTETEALEGR 494
           999*****************************************************998879*************************96 PP
   S: 204  nkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..kkkYe 279
             y c++c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c+++  ++ +  +  Y+
   Q: 495  I-YACDQCNGKRRksnpkplvlseARKQLMIYTLPQVLRLHLKRFRWSGR-NHREKIGVHVAFEQVLTMEPYCCRDMLSSLDkeTFAYD 581
           5.*******99999999******9***********************997.8889********************876654433999** PP
   S: 280  LiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkrr 338
           L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk ++++ eev++   ++aY+lfY++r
   Q: 582  LSAVVMHHGkGFGSGHYTAYCYNTEGGfWVHCNDSKLNVCSVEEVCK---TQAYILFYTQR 639
           ***********************9999********************...********985 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MDRCKHVGRL RLAQDHSILN PQKWRCLECA TTESVWACLK CSHVACGRYI EDHAREHFVE 60
TGHPLAMEVR DLYVFCYLCQ DYVLNDNPEG DLKLLRSSLL AVRGQQQDQP ARRGRTLRST 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATAGAT GCAAGCATGT AGGGCGCTTG CGGCTGGCCC AGGACCACTC CATCCTGAAC 60
CCCCAGAAGT GGCGCTGCCT GGAGTGCGCC ACCACCGAGT CGGTGTGGGC CTGCCTTAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:0000398--P:mRNA splicing, via spliceosome
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002395	Ailuropoda melanoleuca	88.29	0.00e+00	782.00
IUUC-Apl-003658	Anas platyrhynchos	72.83	0.00e+00	981.00
IUUC-Aca-005278	Anolis carolinensis	73.26	0.00e+00	993.00
IUUC-Ame-010986	Astyanax mexicanus	70.85	7.00e-167	580.00
IUUC-Bta-012911	Bos taurus	84.03	0.00e+00	1064.00
IUUC-Cja-019171	Callithrix jacchus	84.27	0.00e+00	1109.00
IUUC-Cfa-020408	Canis familiaris	85.23	0.00e+00	1093.00
IUUC-Csa-024272	Chlorocebus sabaeus	83.19	0.00e+00	888.00
IUUC-Cho-025051	Choloepus hoffmanni	84.00	9.00e-173	600.00
IUUC-Cin-025587	Ciona intestinalis	47.34	3.00e-105	376.00
IUUC-Csv-025814	Ciona savignyi	50.71	3.00e-108	386.00
IUUC-Dre-027878	Danio rerio	69.43	2.00e-164	572.00
IUUC-Dno-029856	Dasypus novemcinctus	81.41	0.00e+00	1088.00
IUUC-Ete-032627	Echinops telfairi	58.35	0.00e+00	778.00
IUUC-Eca-033851	Equus caballus	80.28	0.00e+00	973.00
IUUC-Eeu-035225	Erinaceus europaeus	55.45	0.00e+00	732.00
IUUC-Fca-035919	Felis catus	91.45	0.00e+00	742.00
IUUC-Fal-037290	Ficedula albicollis	73.44	0.00e+00	893.00
IUUC-Gmo-039249	Gadus morhua	77.67	2.00e-145	509.00
IUUC-Gga-040457	Gallus gallus	60.70	0.00e+00	803.00
IUUC-Gac-042595	Gasterosteus aculeatus	58.40	0.00e+00	729.00
IUUC-Ggo-044979	Gorilla gorilla	84.42	0.00e+00	1107.00
IUUC-Hsa-046743	Homo sapiens	84.42	0.00e+00	1107.00
IUUC-Itr-048251	Ictidomys tridecemlineatus	85.82	0.00e+00	1143.00
IUUC-Lch-050294	Latimeria chalumnae	70.67	0.00e+00	905.00
IUUC-Loc-051961	Lepisosteus oculatus	67.91	0.00e+00	791.00
IUUC-Laf-053819	Loxodonta africana	89.02	0.00e+00	792.00
IUUC-Mcc-055048	Macaca mulatta	84.85	0.00e+00	1110.00
IUUC-Meu-055971	Macropus eugenii	62.67	3.00e-130	458.00
IUUC-Mga-059523	Meleagris gallopavo	60.70	0.00e+00	817.00
IUUC-Mmr-061253	Microcebus murinus	84.44	9.00e-154	536.00
IUUC-Mdo-062073	Monodelphis domestica	75.25	0.00e+00	1014.00
IUUC-Mmu-064095	Mus musculus	83.50	0.00e+00	1096.00
IUUC-Mpu-066318	Mustela putorius furo	88.38	0.00e+00	805.00
IUUC-Mlu-067090	Myotis lucifugus	82.27	0.00e+00	1071.00
IUUC-Nle-069486	Nomascus leucogenys	84.70	0.00e+00	1111.00
IUUC-Opr-070563	Ochotona princeps	83.26	0.00e+00	1107.00
IUUC-Ont-072103	Oreochromis niloticus	59.71	0.00e+00	744.00
IUUC-Oan-073245	Ornithorhynchus anatinus	86.57	4.00e-176	610.00
IUUC-Ocu-074851	Oryctolagus cuniculus	84.66	0.00e+00	882.00
IUUC-Ola-086413	Oryzias latipes	59.96	1.00e-172	599.00
IUUC-Oga-088862	Otolemur garnettii	83.14	0.00e+00	1101.00
IUUC-Oar-089462	Ovis aries	87.85	0.00e+00	773.00
IUUC-Ptr-091525	Pan troglodytes	84.02	0.00e+00	989.00
IUUC-Pan-092363	Papio anubis	85.48	0.00e+00	1073.00
IUUC-Psi-093353	Pelodiscus sinensis	74.86	0.00e+00	998.00
IUUC-Pma-094155	Petromyzon marinus	60.21	1.00e-80	292.00
IUUC-Pfo-096413	Poecilia formosa	59.86	0.00e+00	753.00
IUUC-Pab-098592	Pongo abelii	82.68	0.00e+00	884.00
IUUC-Pca-100449	Procavia capensis	82.21	0.00e+00	1089.00
IUUC-Pva-102868	Pteropus vampyrus	83.53	0.00e+00	1081.00
IUUC-Rno-105190	Rattus norvegicus	82.05	0.00e+00	1092.00
IUUC-Sha-107337	Sarcophilus harrisii	75.62	0.00e+00	1006.00
IUUC-Sar-113561	Sorex araneus	92.81	2.00e-92	332.00
IUUC-Ssc-115735	Sus scrofa	85.03	0.00e+00	1073.00
IUUC-Tgu-117025	Taeniopygia guttata	68.12	0.00e+00	816.00
IUUC-Tru-117585	Takifugu rubripes	59.66	0.00e+00	733.00
IUUC-Tsy-118814	Tarsius syrichta	83.86	0.00e+00	1093.00
IUUC-Tni-120600	Tetraodon nigroviridis	59.39	0.00e+00	714.00
IUUC-Tbe-128084	Tupaia belangeri	57.85	0.00e+00	759.00
IUUC-Ttr-128928	Tursiops truncatus	57.14	0.00e+00	791.00
IUUC-Vpa-130706	Vicugna pacos	58.29	0.00e+00	788.00
IUUC-Xtr-132090	Xenopus tropicalis	69.22	0.00e+00	897.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence