iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000090115.7	ENSMUST00000024779.14	ENSMUSP00000024779.8
ENSMUSG00000090115.7	ENSMUST00000152724.1	ENSMUSP00000120034.1
ENSMUSG00000090115.7	ENSMUST00000131550.1	ENSMUSP00000118100.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
microRNA	TRANSFAC	RepTar	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	4.00e-98	329.9	250	654

Active Site

Position(s)	Description	Evidence
259	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
612	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle........kkkeklneenp....................................... 42
           tGl+NlgNtCYmNS+LQ+Ls+++++re++l+         +++++n +++                                       
   Q: 250  TGLRNLGNTCYMNSILQVLSHLQKFRECFLNldpstsehLFPQATNGKAQlsgrpasssaaelsvrsvraqgcepqglcwssgasisrs 338
           7******************************6665555555555555555999999******************************999 PP
   S: 43   .........kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeed 122
                    ++++ +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ ll+++++el         e+e+++
   Q: 339  leliqnkepSSKHISLCHELHTLFRVMWSGKWALVSPFAMLHSVWSLIPAFRGYDQQDAQEFLCELLHKVQQEL---------ESEGST 418
           99999999999999************************************************************.........678899 PP
   S: 123  kselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..........slqdcLesftkeeele 201
           ++ l   +++k +k+  ++++++F+gql sq++c +c+ +s++ epf+dlsl++p++ ++ ++           l+++L++ft++e le
   Q: 419  RRILIPFSQRKLTKQVLKVVNTIFHGQLLSQVTCISCNYKSNTIEPFWDLSLEFPERYHCIEKgfvplnqtecLLTEMLAKFTETEALE 507
           9999999***************************************************998879************************* PP
   S: 202  genkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..kkk 277
           g+  y c++c++k++           a+k+l++ +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c+++  ++ +  +  
   Q: 508  GRI-YACDQCNSKRRksnpkplvlseARKQLMIYRLPQVLRLHLKRFRWSGR-NHREKIGVHVIFDQVLTMEPYCCRDMLSSLDkeTFA 594
           965.*******9999999*******************************997.8889********************876654433999 PP
   S: 278  YeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkrr 338
           Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk  +++ eev++   ++aY+lfY+rr
   Q: 595  YDLSAVVMHHGkGFGSGHYTAYCYNTEGGfWVHCNDSKLDVCSVEEVCK---TQAYILFYTRR 654
           *************************9999********************...********985 PP

Organism

Mus musculus

Functional Description
(View)

Specifically deubiquitinates histone H2B at 'Lys-120' (H2BK120Ub). H2BK120Ub is a specific tag for epigenetic transcriptional activation and acts as a regulator of mRNA splicing. Deubiquitination is required for efficient cotranscriptional splicing of a large set of exons (By similarity).

Protein Sequence
(Fasta)

MDRCKHVGRL RLAQDHSILN PQKWCCLQCA TTESAWACLK CSHVACGRYI EDHALKHFEE 60
TGHPLAMEVR DLYVFCYLCK DYVLNDNPEG DLKLLRSSLL AVRGQKQDLL ARRGRTLRST 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGGCCCTGG GAATTAAAGG ATGGAATGGG GAGTGGGGAA AGAGAAAGGA GATTAAGGCA 60
AGCTAGGGAA GTCCTGGTGG GTATAGAACT GGGGTGGGCT GCACAGGAGT GGGAAACGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0507--mRNA processing
KW-0508--mRNA splicing
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0042393--F:histone binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0035616--P:histone H2B conserved C-terminal lysine deubiquitination
GO:0000398--P:mRNA splicing, via spliceosome
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

mmu:224836

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002395	Ailuropoda melanoleuca	91.10	0.00e+00	816.00
IUUC-Apl-003658	Anas platyrhynchos	78.11	0.00e+00	1048.00
IUUC-Aca-005278	Anolis carolinensis	78.11	0.00e+00	1067.00
IUUC-Bta-012911	Bos taurus	87.90	0.00e+00	1109.00
IUUC-Cja-019171	Callithrix jacchus	91.56	0.00e+00	1216.00
IUUC-Cfa-020408	Canis familiaris	89.56	0.00e+00	1149.00
IUUC-Cpo-022233	Cavia porcellus	82.78	0.00e+00	1061.00
IUUC-Csa-024272	Chlorocebus sabaeus	92.03	0.00e+00	1009.00
IUUC-Cho-025051	Choloepus hoffmanni	89.14	0.00e+00	651.00
IUUC-Cin-025587	Ciona intestinalis	47.43	5.00e-108	385.00
IUUC-Csv-025814	Ciona savignyi	43.40	3.00e-148	519.00
IUUC-Dno-029856	Dasypus novemcinctus	87.79	0.00e+00	1162.00
IUUC-Ete-032761	Echinops telfairi	75.68	0.00e+00	857.00
IUUC-Eca-033851	Equus caballus	82.57	0.00e+00	1007.00
IUUC-Fal-037290	Ficedula albicollis	76.20	0.00e+00	941.00
IUUC-Gmo-039249	Gadus morhua	77.36	1.00e-145	510.00
IUUC-Gac-042595	Gasterosteus aculeatus	60.23	0.00e+00	762.00
IUUC-Ggo-044979	Gorilla gorilla	90.68	0.00e+00	1209.00
IUUC-Hsa-046743	Homo sapiens	90.54	0.00e+00	1205.00
IUUC-Itr-048251	Ictidomys tridecemlineatus	91.68	0.00e+00	1216.00
IUUC-Lch-050294	Latimeria chalumnae	74.71	0.00e+00	944.00
IUUC-Loc-051961	Lepisosteus oculatus	68.39	0.00e+00	810.00
IUUC-Laf-053819	Loxodonta africana	90.19	0.00e+00	816.00
IUUC-Mcc-055048	Macaca mulatta	91.56	0.00e+00	1220.00
IUUC-Meu-055971	Macropus eugenii	65.93	4.00e-148	518.00
IUUC-Mmr-061253	Microcebus murinus	83.17	3.00e-150	525.00
IUUC-Mdo-062073	Monodelphis domestica	80.26	0.00e+00	1092.00
IUUC-Mpu-066318	Mustela putorius furo	91.12	0.00e+00	838.00
IUUC-Mlu-067090	Myotis lucifugus	87.88	0.00e+00	1138.00
IUUC-Nle-069486	Nomascus leucogenys	91.12	0.00e+00	1213.00
IUUC-Opr-070563	Ochotona princeps	88.97	0.00e+00	1182.00
IUUC-Ont-071637	Oreochromis niloticus	60.49	0.00e+00	790.00
IUUC-Oan-073245	Ornithorhynchus anatinus	88.86	2.00e-180	624.00
IUUC-Ocu-074851	Oryctolagus cuniculus	90.94	0.00e+00	954.00
IUUC-Ola-086413	Oryzias latipes	57.96	0.00e+00	738.00
IUUC-Oga-088862	Otolemur garnettii	90.12	0.00e+00	1179.00
IUUC-Ptr-091525	Pan troglodytes	91.85	0.00e+00	1105.00
IUUC-Pan-092363	Papio anubis	91.94	0.00e+00	1192.00
IUUC-Psi-093353	Pelodiscus sinensis	79.37	0.00e+00	1055.00
IUUC-Pma-094155	Petromyzon marinus	59.39	1.00e-83	302.00
IUUC-Pfo-096413	Poecilia formosa	60.71	0.00e+00	785.00
IUUC-Pab-098592	Pongo abelii	90.99	0.00e+00	997.00
IUUC-Pca-100449	Procavia capensis	87.12	0.00e+00	1155.00
IUUC-Pva-102868	Pteropus vampyrus	88.76	0.00e+00	1149.00
IUUC-Rno-105190	Rattus norvegicus	96.64	0.00e+00	1299.00
IUUC-Sha-107337	Sarcophilus harrisii	80.09	0.00e+00	1078.00
IUUC-Sar-113561	Sorex araneus	89.82	2.00e-89	322.00
IUUC-Ssc-115735	Sus scrofa	88.61	0.00e+00	1131.00
IUUC-Tgu-117025	Taeniopygia guttata	71.49	0.00e+00	869.00
IUUC-Tru-117585	Takifugu rubripes	61.53	0.00e+00	767.00
IUUC-Tsy-118814	Tarsius syrichta	91.57	0.00e+00	1196.00
IUUC-Tni-120600	Tetraodon nigroviridis	61.95	0.00e+00	744.00
IUUC-Xtr-132090	Xenopus tropicalis	70.25	0.00e+00	930.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence