iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID	PINA	HINT
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UBL/ATG12	91.96	7.00e-58	219.00	IUUC-Hsa-046903

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Rattus norvegicus

Functional Description
(View)

Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus (By similarity).

Protein Sequence
(Fasta)

MAEDPEAVLQ LPAAPAAAAG ESLLELSPET AIPEPPSSVA VSPGTEEPPG DTKKKIDILL 60
KAVGDTPIMK TKKWAVERTR TVQALIDFIR KFLRLLASEQ LFIYVNQSFA PSPDQEVGTL 120

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Nucleotide Sequence
(Fasta)

CGCTCAGCAA GCAAGATGGC AGAAGACCCA GAGGCTGTGC TGCAGCTCCC CGCGGCTCCG 60
GCTGCTGCGG CGGGCGAGAG CCTTTTGGAG CTCTCCCCAG AAACAGCCAT CCCAGAGCCC 120

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Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0391--Immunity
KW-0399--Innate immunity
KW-1017--Isopeptide bond
KW-0472--Membrane
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR007242--Atg12
IPR029071--Ubiquitin-rel_dom

Pfam

PF04110--APG12

Gene Ontology

GO:0034274--C:Atg12-Atg5-Atg16 complex
GO:0016020--C:membrane
GO:0034045--C:pre-autophagosomal structure membrane
GO:0043234--C:protein complex
GO:0019776--F:Atg8 ligase activity
GO:0000045--P:autophagosome assembly
GO:0006914--P:autophagy
GO:0006501--P:C-terminal protein lipidation
GO:0045087--P:innate immune response
GO:0000422--P:mitophagy
GO:0044804--P:nucleophagy

KEGG

rno:361321

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001177	Aegilops tauschii	38.46	4.00e-16	75.90
IUUC-Aml-002116	Ailuropoda melanoleuca	85.11	9.00e-54	202.00
IUUC-Atr-002615	Amborella trichopoda	46.67	1.00e-19	87.00
IUUC-Apl-003753	Anas platyrhynchos	97.50	2.00e-21	93.60
IUUC-Aca-005231	Anolis carolinensis	90.72	3.00e-43	167.00
IUUC-Aly-006172	Arabidopsis lyrata	45.16	3.00e-19	86.30
IUUC-Ath-006953	Arabidopsis thaliana	45.36	1.00e-19	87.40
IUUC-Ago-007970	Ashbya gossypii	46.34	3.00e-06	45.10
IUUC-Acl-008072	Aspergillus clavatus	29.89	3.00e-11	60.10
IUUC-Afl-008725	Aspergillus flavus	31.46	2.00e-12	64.70
IUUC-Afu-008967	Aspergillus fumigatus	29.89	5.00e-12	63.90
IUUC-Ani-009248	Aspergillus nidulans	28.74	1.00e-11	62.80
IUUC-Ang-009684	Aspergillus niger	29.03	1.00e-11	62.40
IUUC-Aor-009947	Aspergillus oryzae	31.46	2.00e-12	64.70
IUUC-Ame-011656	Astyanax mexicanus	81.52	3.00e-42	163.00
IUUC-Bgr-012174	Blumeria graminis	32.22	1.00e-13	68.20
IUUC-Bta-012483	Bos taurus	93.88	1.00e-52	197.00
IUUC-Bci-013755	Botrytis cinerea	28.42	3.00e-09	53.90
IUUC-Bdi-014156	Brachypodium distachyon	37.50	1.00e-15	73.90
IUUC-Bol-015683	Brassica oleracea	44.33	7.00e-20	88.20
IUUC-Bra-016802	Brassica rapa	45.45	2.00e-18	82.80
IUUC-Cel-018242	Caenorhabditis elegans	36.26	2.00e-13	67.80
IUUC-Cja-019514	Callithrix jacchus	85.11	5.00e-58	216.00
IUUC-Cfa-020748	Canis familiaris	84.40	9.00e-53	198.00
IUUC-Cpo-021965	Cavia porcellus	84.40	4.00e-53	200.00
IUUC-Cre-023009	Chlamydomonas reinhardtii	32.58	2.00e-11	60.10
IUUC-Csa-023494	Chlorocebus sabaeus	85.11	1.00e-54	204.00
IUUC-Cho-024631	Choloepus hoffmanni	85.82	2.00e-53	201.00
IUUC-Cin-025609	Ciona intestinalis	58.24	5.00e-31	125.00
IUUC-Cgl-026722	Colletotrichum gloeosporioides	39.33	2.00e-14	71.60
IUUC-Dre-027479	Danio rerio	70.54	6.00e-44	168.00
IUUC-Dno-029693	Dasypus novemcinctus	74.47	5.00e-37	146.00
IUUC-Dse-031440	Dothistroma septosporum	31.46	4.00e-12	63.50
IUUC-Dme-031892	Drosophila melanogaster	53.27	5.00e-31	125.00
IUUC-Ete-032550	Echinops telfairi	94.12	2.00e-45	173.00
IUUC-Eca-033553	Equus caballus	85.11	1.00e-54	204.00
IUUC-Fca-036524	Felis catus	83.69	4.00e-52	196.00
IUUC-Fal-036942	Ficedula albicollis	88.37	1.00e-45	173.00
IUUC-Fox-037753	Fusarium oxysporum	35.23	5.00e-13	66.60
IUUC-Gmo-039498	Gadus morhua	75.00	6.00e-43	165.00
IUUC-Ggr-039852	Gaeumannomyces graminis	29.21	1.00e-09	56.60
IUUC-Gga-041263	Gallus gallus	78.57	2.00e-55	207.00
IUUC-Gac-042346	Gasterosteus aculeatus	80.95	6.00e-39	152.00
IUUC-Gma-042896	Glycine max	45.45	8.00e-19	84.70
IUUC-Ggo-045601	Gorilla gorilla	84.40	4.00e-54	203.00
IUUC-Hsa-046903	Homo sapiens	85.11	1.00e-55	208.00
IUUC-Hvu-047239	Hordeum vulgare	39.56	3.00e-16	75.90
IUUC-Itr-048445	Ictidomys tridecemlineatus	86.52	1.00e-55	208.00
IUUC-Kpa-049355	Komagataella pastoris	31.25	1.00e-09	55.10
IUUC-Lch-050619	Latimeria chalumnae	84.27	1.00e-43	168.00
IUUC-Loc-052102	Lepisosteus oculatus	74.58	7.00e-21	91.30
IUUC-Lma-053299	Leptosphaeria maculans	30.88	2.00e-06	43.90
IUUC-Laf-054205	Loxodonta africana	84.40	4.00e-64	236.00
IUUC-Meu-056804	Macropus eugenii	88.89	3.00e-55	206.00
IUUC-Mor-057052	Magnaporthe oryzae	28.95	4.00e-11	60.80
IUUC-Mtr-057961	Medicago truncatula	46.59	2.00e-19	86.70
IUUC-Mla-059045	Melampsora laricipopulina	40.23	2.00e-18	84.00
IUUC-Mvi-060360	Microbotryum violaceum	41.38	2.00e-19	87.40
IUUC-Mmr-061654	Microcebus murinus	77.37	8.00e-54	201.00
IUUC-Mdo-062649	Monodelphis domestica	84.43	7.00e-59	218.00
IUUC-Mmu-064105	Mus musculus	89.36	2.00e-58	217.00
IUUC-Mac-065532	Musa acuminata	41.57	2.00e-18	83.20
IUUC-Mpu-066269	Mustela putorius furo	83.69	3.00e-64	236.00
IUUC-Mlu-067631	Myotis lucifugus	88.52	3.00e-61	226.00
IUUC-Nfi-068468	Neosartorya fischeri	29.89	1.00e-11	61.20
IUUC-Ncr-068750	Neurospora crassa	31.11	1.00e-11	62.00
IUUC-Nle-069483	Nomascus leucogenys	85.82	5.00e-55	206.00
IUUC-Opr-070936	Ochotona princeps	93.88	2.00e-52	198.00
IUUC-Obr-076322	Oryza brachyantha	35.96	1.00e-15	73.90
IUUC-Ogl-077226	Oryza glaberrima	36.59	2.00e-14	69.70
IUUC-Oin-079220	Oryza indica	45.61	3.00e-11	60.10
IUUC-Olo-080688	Oryza longistaminata	36.59	2.00e-14	69.70
IUUC-Ome-081265	Oryza meridionalis	36.59	2.00e-14	69.70
IUUC-Oru-084342	Oryza rufipogon	35.96	4.00e-15	74.70
IUUC-Osa-086212	Oryza sativa	36.59	2.00e-14	69.70
IUUC-Ola-087277	Oryzias latipes	76.47	5.00e-43	165.00
IUUC-Olu-087780	Ostreococcus lucimarinus	32.65	3.00e-11	59.30
IUUC-Oga-088175	Otolemur garnettii	83.69	1.00e-55	208.00
IUUC-Oar-089477	Ovis aries	93.88	3.00e-52	197.00
IUUC-Ptr-091129	Pan troglodytes	85.11	7.00e-55	206.00
IUUC-Psi-093351	Pelodiscus sinensis	89.80	3.00e-49	186.00
IUUC-Pno-094948	Phaeosphaeria nodorum	26.80	7.00e-06	42.70
IUUC-Ppa-095788	Physcomitrella patens	41.58	2.00e-20	90.50
IUUC-Pfo-096993	Poecilia formosa	75.00	7.00e-43	165.00
IUUC-Pab-098502	Pongo abelii	85.11	1.00e-54	205.00
IUUC-Pop-098819	Populus trichocarpa	42.86	6.00e-18	81.60
IUUC-Pca-100144	Procavia capensis	70.21	2.00e-41	161.00
IUUC-Ppe-101560	Prunus persica	45.24	5.00e-17	78.60
IUUC-Pva-102810	Pteropus vampyrus	82.79	4.00e-51	193.00
IUUC-Pgr-103531	Puccinia graminis	40.23	3.00e-19	87.00
IUUC-Ptt-103753	Puccinia triticina	40.23	3.00e-19	86.70
IUUC-Pyt-104733	Pyrenophora triticirepentis	32.56	6.00e-11	59.70
IUUC-Sce-106275	Saccharomyces cerevisiae	29.55	8.00e-10	56.60
IUUC-Sha-107554	Sarcophilus harrisii	89.81	8.00e-56	208.00
IUUC-Sja-107682	Schizosaccharomyces japonicus	28.09	3.00e-13	67.00
IUUC-Spo-108275	Schizosaccharomyces pombe	34.83	4.00e-16	76.60
IUUC-Smo-109151	Selaginella moellendorffii	30.23	1.00e-11	60.80
IUUC-Sit-110270	Setaria italica	38.04	1.00e-16	77.00
IUUC-Sly-111862	Solanum lycopersicum	46.59	6.00e-19	84.70
IUUC-Stu-112663	Solanum tuberosum	53.49	8.00e-10	55.10
IUUC-Sbi-114148	Sorghum bicolor	38.04	1.00e-16	77.00
IUUC-Sre-115216	Sporisorium reilianum	40.23	7.00e-20	89.40
IUUC-Ssc-116051	Sus scrofa	85.11	5.00e-54	202.00
IUUC-Tgu-117008	Taeniopygia guttata	78.43	2.00e-20	90.10
IUUC-Tru-118466	Takifugu rubripes	81.40	7.00e-40	154.00
IUUC-Tsy-119334	Tarsius syrichta	79.43	8.00e-59	219.00
IUUC-Tni-119792	Tetraodon nigroviridis	82.56	2.00e-40	156.00
IUUC-Tca-121861	Theobroma cacao	39.66	2.00e-18	84.30
IUUC-Tvi-122499	Trichoderma virens	29.60	1.00e-12	65.10
IUUC-Tae-123431	Triticum aestivum	38.46	4.00e-16	75.90
IUUC-Tme-126934	Tuber melanosporum	33.33	2.00e-13	67.80
IUUC-Ttr-129001	Tursiops truncatus	82.98	4.00e-48	183.00
IUUC-Uma-129324	Ustilago maydis	42.53	1.00e-20	91.70
IUUC-Vda-129846	Verticillium dahliae	29.55	5.00e-10	56.60
IUUC-Vpa-130202	Vicugna pacos	50.35	4.00e-25	107.00
IUUC-Vvi-131474	Vitis vinifera	38.36	1.00e-10	58.50
IUUC-Xtr-132782	Xenopus tropicalis	73.77	5.00e-50	189.00
IUUC-Xma-134140	Xiphophorus maculatus	76.00	2.00e-43	167.00
IUUC-Yli-134517	Yarrowia lipolytica	36.25	1.00e-10	59.70
IUUC-Zma-134764	Zea mays	38.04	1.00e-16	77.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence