iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000003813.15	ENSMUST00000144675.7	ENSMUSP00000114431.1
ENSMUSG00000003813.15	ENSMUST00000003911.12	ENSMUSP00000003911.6
ENSMUSG00000003813.15	ENSMUST00000109761.8	ENSMUSP00000105383.2
ENSMUSG00000003813.15	ENSMUST00000128035.1	ENSMUSP00000115664.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
miRTarBase	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
Phospho.ELM	UniProt	PHOSIDA	mUbiSiDa
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	15336624
ULD/UDP/UBQ/UBQ_PIM	UBQ_PIM	15336624

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	1.40e-20	73.8	162	201
ULD/UDP/UBQ/UBQ_PIM	3.20e-26	92.2	3	80

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 2    ededkleqlveMGFdreealqaLraannnleaAveyLldg 41
           e+e +l ++++MG++re+++ aLra++nn+ +AveyLl+g
   Q: 162  EYETMLTEIMSMGYERERVVAALRASYNNPHRAVEYLLTG 201
           7899**********************************97 PP

ULD/UDP/UBQ/UBQ_PIM

   S: 1    mkltvktlkgkefelevseddtveelKekiakesg...vppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkksk 75
           +++t+ktl++++f++++++d+tv+ lKeki++e+g   +p++ qkLIyaGkiL+Dd +++e++i+++++v+++v+k+k
   Q: 3    VTITLKTLQQQTFKIRMEPDETVKVLKEKIEAEKGrdaFPVAGQKLIYAGKILSDDVPIKEYHIDEKNFVVVMVTKAK 80
           68*************************************************************************987 PP

Organism

Mus musculus

Functional Description
(View)

Involved in nucleotide excision repair and is thought to be functional equivalent for Rad23b in global genome nucleotide excision repair (GG-NER) by association with Xpc. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize Xpc. Reported differences to Rad23b in regard to NER activity and Xpc stabilization are probably due to differences in expression levels with Rad23a being much less expressed than Rad23b.

Protein Sequence
(Fasta)

MAVTITLKTL QQQTFKIRME PDETVKVLKE KIEAEKGRDA FPVAGQKLIY AGKILSDDVP 60
IKEYHIDEKN FVVVMVTKAK AGQGIPAPPE ASPTAVPEPS TPFPPVLASG MSHPPPTSRE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAAGTGCTT GGCGCGGCGC GGCTGGGCGC TAAGATGGCG GCGGCGTGAG TTGCATGTAG 60
TACGAGGATC CCGGGGCTGC CGCATTGCTC CGGCCCCGCC ATGGCCGTCA CCATCACCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-1017--Isopeptide bond
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0832--Ubl conjugation

Interpro

IPR004806--Rad23
IPR006636--STI1_HS-bd
IPR015940--UBA
IPR009060--UBA-like
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom
IPR015360--XPC-bd

PROSITE

PS50030--UBA
PS50053--UBIQUITIN_2

Pfam

PF00627--UBA
PF00240--ubiquitin
PF09280--XPC-binding

PRINTS

PR01839--RAD23PROTEIN

SMART

SM00727--STI1
SM00165--UBA
SM00213--UBQ

Gene Ontology

GO:0005829--C:cytosol
GO:0005815--C:microtubule organizing center
GO:0005654--C:nucleoplasm
GO:0000502--C:proteasome complex
GO:0003684--F:damaged DNA binding
GO:0031593--F:polyubiquitin binding
GO:1990381--F:ubiquitin-specific protease binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0006289--P:nucleotide-excision repair
GO:0045070--P:positive regulation of viral genome replication
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0032434--P:regulation of proteasomal ubiquitin-dependent protein catabolic process

KEGG

mmu:19358

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000770	Aegilops tauschii	38.52	8.00e-33	134.00
IUUC-Aml-001515	Ailuropoda melanoleuca	89.69	1.00e-140	493.00
IUUC-Atr-003116	Amborella trichopoda	41.15	8.00e-31	127.00
IUUC-Aca-004704	Anolis carolinensis	80.40	3.00e-114	404.00
IUUC-Aly-006159	Arabidopsis lyrata	35.44	1.00e-49	189.00
IUUC-Ago-007830	Ashbya gossypii	29.06	2.00e-15	76.60
IUUC-Ani-009460	Aspergillus nidulans	39.20	3.00e-29	122.00
IUUC-Bta-012377	Bos taurus	92.84	1.00e-145	508.00
IUUC-Bci-013933	Botrytis cinerea	35.43	5.00e-22	98.60
IUUC-Bra-016970	Brassica rapa	35.14	5.00e-45	174.00
IUUC-Cja-018946	Callithrix jacchus	93.39	4.00e-142	497.00
IUUC-Cfa-020577	Canis familiaris	93.94	5.00e-151	527.00
IUUC-Cpo-021850	Cavia porcellus	91.46	1.00e-165	575.00
IUUC-Csa-023183	Chlorocebus sabaeus	94.49	1.00e-151	528.00
IUUC-Dre-027581	Danio rerio	51.58	4.00e-72	265.00
IUUC-Dno-030017	Dasypus novemcinctus	90.40	2.00e-128	451.00
IUUC-Dor-030358	Dipodomys ordii	84.89	3.00e-127	448.00
IUUC-Eca-033599	Equus caballus	90.56	1.00e-133	469.00
IUUC-Fca-036051	Felis catus	93.11	4.00e-149	520.00
IUUC-Gmo-038528	Gadus morhua	58.29	1.00e-90	326.00
IUUC-Gga-040133	Gallus gallus	87.91	3.00e-76	278.00
IUUC-Ggo-045084	Gorilla gorilla	94.77	7.00e-152	530.00
IUUC-Hsa-046614	Homo sapiens	94.77	2.00e-152	531.00
IUUC-Itr-047875	Ictidomys tridecemlineatus	95.32	5.00e-170	590.00
IUUC-Lch-050563	Latimeria chalumnae	62.91	3.00e-103	368.00
IUUC-Laf-054589	Loxodonta africana	93.66	4.00e-144	503.00
IUUC-Mcc-055860	Macaca mulatta	94.49	1.00e-151	528.00
IUUC-Meu-056459	Macropus eugenii	94.88	2.00e-106	378.00
IUUC-Mmr-060819	Microcebus murinus	94.21	8.00e-162	562.00
IUUC-Mdo-062742	Monodelphis domestica	84.42	1.00e-143	502.00
IUUC-Mac-065180	Musa acuminata	34.27	8.00e-43	167.00
IUUC-Mpu-066684	Mustela putorius furo	93.94	7.00e-154	536.00
IUUC-Mlu-067787	Myotis lucifugus	92.01	5.00e-148	517.00
IUUC-Nle-069846	Nomascus leucogenys	83.11	5.00e-131	460.00
IUUC-Oan-073572	Ornithorhynchus anatinus	79.06	4.00e-130	457.00
IUUC-Ocu-074968	Oryctolagus cuniculus	91.24	1.00e-102	367.00
IUUC-Oba-074972	Oryza barthii	34.41	1.00e-45	176.00
IUUC-Olo-080559	Oryza longistaminata	33.42	4.00e-45	175.00
IUUC-Oni-082812	Oryza nivara	34.41	2.00e-45	176.00
IUUC-Oga-089075	Otolemur garnettii	93.66	9.00e-145	506.00
IUUC-Oar-090387	Ovis aries	92.56	6.00e-143	500.00
IUUC-Ptr-090912	Pan troglodytes	91.18	1.00e-141	495.00
IUUC-Pan-092140	Papio anubis	94.49	3.00e-151	527.00
IUUC-Psi-093347	Pelodiscus sinensis	87.50	3.00e-62	231.00
IUUC-Pfo-096607	Poecilia formosa	63.97	2.00e-96	345.00
IUUC-Pab-097738	Pongo abelii	90.91	1.00e-143	502.00
IUUC-Pca-100348	Procavia capensis	90.93	8.00e-142	496.00
IUUC-Pva-102412	Pteropus vampyrus	93.66	3.00e-152	531.00
IUUC-Pgr-103618	Puccinia graminis	37.45	5.00e-25	108.00
IUUC-Ptt-103717	Puccinia triticina	50.76	2.00e-24	107.00
IUUC-Rno-105569	Rattus norvegicus	96.97	1.00e-153	535.00
IUUC-Sha-106918	Sarcophilus harrisii	85.42	5.00e-131	461.00
IUUC-Sja-107851	Schizosaccharomyces japonicus	38.87	8.00e-33	134.00
IUUC-Spo-108298	Schizosaccharomyces pombe	35.00	1.00e-46	180.00
IUUC-Smo-109518	Selaginella moellendorffii	38.00	1.00e-31	130.00
IUUC-Sit-109813	Setaria italica	35.68	1.00e-46	180.00
IUUC-Sly-111480	Solanum lycopersicum	35.86	5.00e-53	201.00
IUUC-Ssc-115460	Sus scrofa	93.11	7.00e-150	523.00
IUUC-Tsy-119385	Tarsius syrichta	76.47	6.00e-69	253.00
IUUC-Tni-120493	Tetraodon nigroviridis	71.16	1.00e-73	270.00
IUUC-Tca-121594	Theobroma cacao	35.01	3.00e-50	192.00
IUUC-Tae-125354	Triticum aestivum	38.11	3.00e-33	135.00
IUUC-Tur-126610	Triticum urartu	38.52	3.00e-33	136.00
IUUC-Tbe-127603	Tupaia belangeri	84.67	6.00e-55	207.00
IUUC-Ttr-129232	Tursiops truncatus	99.53	6.00e-105	374.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence