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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046032
Ensembl Protein ID ENSP00000349503.4
UniProt Accession O43829; O00403; Q2TB80; ZBT14_HUMAN
Genbank Protein ID CAA73258.1; BAA20131.1; AAI10520.1
Protein Name Zinc finger and BTB domain-containing protein 14; Zinc finger protein 161 homolog; Zinc finger protein 478; Zinc finger protein 5 homolog
Genbank Nucleotide ID Y12726; D89859; BC110519
Gene Name ZBTB14; ZFP161; ZNF478
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000198081.10 ENST00000357006.8 ENSP00000349503.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitemiRTarBasemicroRNA
TRANSFACTargetScanRepTarmiRNAMap
SomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Variation
OMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 9.70e-15 56.4 36 101
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmele.esksklmveikdvqpevfrallkFlYtgklden 68
           +D+ +vv++++f+ah++vLaa+S +F++lf ++le +s  ++ +ei+ +  + f+++l+++Yt k++ +
   Q: 36   CDIAIVVEDVKFRAHRCVLAACSTYFKKLF-KKLEvDS--SSVIEIDFLRSDIFEEVLNYMYTAKISVK 101
           8*****************************.4566466..89*****9****************99865 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters.
 Transcriptional activator of the dopamine transporter (DAT), binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. Binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters.
Protein Sequence
(Fasta)
MEFFISMSET IKYNDDDHKT LFLKTLNEQR LEGEFCDIAI VVEDVKFRAH RCVLAACSTY 60
FKKLFKKLEV DSSSVIEIDF LRSDIFEEVL NYMYTAKISV KKEDVNLMMS SGQILGIRFL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046032|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TCTAAGGCGG CGCGGCATTG CTGTCCGGCC TCCTGCATCT CGGTGAGCAG AAAACGCGGG 60
AGCGGGAGGG ACTTCCCAGC TCCCGACGCC AGACACAGGC ACAGCCGCCG CGTCAGAGGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046032|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0010--Activator
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
SMART

SM00225--BTB
SM00355--ZnF_C2H2
Gene Ontology

GO:0016235--C:aggresome
GO:0005829--C:cytosol
GO:0005730--C:nucleolus
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0046872--F:metal ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0003700--F:transcription factor activity, sequence-specific DNA binding
GO:0044212--F:transcription regulatory region DNA binding
GO:0003279--P:cardiac septum development
GO:0060976--P:coronary vasculature development
GO:0003170--P:heart valve development
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated
KEGG hsa:7541
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001753 Ailuropoda melanoleuca 100.00 0.00e+00 860.00
IUUC-Apl-003283 Anas platyrhynchos 94.43 0.00e+00 830.00
IUUC-Aca-004393 Anolis carolinensis 93.10 0.00e+00 822.00
IUUC-Ame-011467 Astyanax mexicanus 75.56 0.00e+00 645.00
IUUC-Bta-012973 Bos taurus 99.33 0.00e+00 855.00
IUUC-Cja-019628 Callithrix jacchus 100.00 0.00e+00 863.00
IUUC-Cfa-020023 Canis familiaris 99.78 0.00e+00 852.00
IUUC-Csa-023821 Chlorocebus sabaeus 100.00 0.00e+00 863.00
IUUC-Cho-024977 Choloepus hoffmanni 99.78 0.00e+00 859.00
IUUC-Cin-025199 Ciona intestinalis 26.01 9.00e-28 118.00
IUUC-Dre-027417 Danio rerio 76.73 0.00e+00 627.00
IUUC-Dor-030435 Dipodomys ordii 99.78 0.00e+00 862.00
IUUC-Ete-032628 Echinops telfairi 97.10 0.00e+00 835.00
IUUC-Eca-033287 Equus caballus 99.78 0.00e+00 860.00
IUUC-Fca-036098 Felis catus 99.78 0.00e+00 861.00
IUUC-Fal-037053 Ficedula albicollis 94.44 0.00e+00 805.00
IUUC-Gmo-039037 Gadus morhua 63.66 1.00e-105 376.00
IUUC-Gga-040669 Gallus gallus 95.33 0.00e+00 838.00
IUUC-Gac-041324 Gasterosteus aculeatus 65.88 2.00e-153 535.00
IUUC-Ggo-045482 Gorilla gorilla 100.00 0.00e+00 863.00
IUUC-Itr-048659 Ictidomys tridecemlineatus 99.11 0.00e+00 851.00
IUUC-Lch-050626 Latimeria chalumnae 87.14 0.00e+00 771.00
IUUC-Loc-052339 Lepisosteus oculatus 81.43 0.00e+00 714.00
IUUC-Laf-054425 Loxodonta africana 88.17 0.00e+00 722.00
IUUC-Mcc-054963 Macaca mulatta 100.00 0.00e+00 863.00
IUUC-Meu-056097 Macropus eugenii 95.77 0.00e+00 853.00
IUUC-Mga-060044 Meleagris gallopavo 94.61 0.00e+00 829.00
IUUC-Mmr-060645 Microcebus murinus 99.78 0.00e+00 861.00
IUUC-Mdo-062972 Monodelphis domestica 95.77 0.00e+00 852.00
IUUC-Mmu-064130 Mus musculus 99.33 0.00e+00 848.00
IUUC-Mpu-066481 Mustela putorius furo 100.00 0.00e+00 863.00
IUUC-Mlu-067950 Myotis lucifugus 85.49 0.00e+00 711.00
IUUC-Nle-069887 Nomascus leucogenys 99.78 0.00e+00 861.00
IUUC-Ont-071683 Oreochromis niloticus 70.67 3.00e-178 617.00
IUUC-Oan-073523 Ornithorhynchus anatinus 89.98 0.00e+00 791.00
IUUC-Ocu-074079 Oryctolagus cuniculus 99.55 0.00e+00 858.00
IUUC-Ola-087045 Oryzias latipes 52.12 3.00e-121 428.00
IUUC-Oga-088178 Otolemur garnettii 100.00 0.00e+00 860.00
IUUC-Ptr-091539 Pan troglodytes 99.55 0.00e+00 859.00
IUUC-Pan-092044 Papio anubis 100.00 0.00e+00 863.00
IUUC-Psi-093698 Pelodiscus sinensis 94.13 0.00e+00 827.00
IUUC-Pma-094150 Petromyzon marinus 40.87 2.00e-89 323.00
IUUC-Pfo-096504 Poecilia formosa 71.97 0.00e+00 627.00
IUUC-Pab-098387 Pongo abelii 100.00 0.00e+00 863.00
IUUC-Pop-098852 Populus trichocarpa 39.24 7.00e-08 52.40
IUUC-Pca-100494 Procavia capensis 99.78 0.00e+00 861.00
IUUC-Pva-102568 Pteropus vampyrus 100.00 0.00e+00 863.00
IUUC-Rno-105873 Rattus norvegicus 99.33 0.00e+00 848.00
IUUC-Sha-107503 Sarcophilus harrisii 95.09 0.00e+00 643.00
IUUC-Tru-118010 Takifugu rubripes 70.96 7.00e-172 596.00
IUUC-Tni-120503 Tetraodon nigroviridis 70.89 9.00e-178 616.00
IUUC-Tca-121013 Theobroma cacao 34.67 1.00e-05 45.10
IUUC-Tbe-127288 Tupaia belangeri 99.55 0.00e+00 860.00
IUUC-Xtr-132271 Xenopus tropicalis 89.18 0.00e+00 789.00
Created Date 25-Jun-2017

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