iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-090431

Ensembl Protein ID

ENSOARP00000022555.1

UniProt Accession

W5QIK3; W5QIK3_SHEEP

Genbank Protein ID

ENSOARP00000022555

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01103599

Gene Name

USP8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000020988.1	ENSOART00000022866.1	ENSOARP00000022555.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.10e-109	366.9	748	1078

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl+NlgNtCYmNS+LQcL n+p l++++++  ++ ++n++n  ++kge+++++  ++++lw+++ +++sp++++ +++k++ +f g
   Q: 748  TGLRNLGNTCYMNSILQCLCNTPHLADYFNRnCYQDDINRSNLLGHKGEVAEEFGIIMKALWTGQYRYISPKDFKITIGKINDQFAG 834
           7*****************************9899***************************************************** PP
   S: 87   yeqqDaqEflaflldqleeelkkeknkpkeeeeee...dkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfl 170
           y+qqD+qE+l fl+d+l+e+l+k +n ++++ee++   d+ ++ ++a++k+k+ n+s+i+ lFqgq+ks+++cl+c+++s ++e f+
   Q: 835  YSQQDSQELLLFLMDGLHEDLNKADNRKRHKEENNdhlDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFM 921
           *********************9855555555444411145566667***************************************** PP
   S: 171  dlslpvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpl 257
           +lslp+ + +++   +lqdcL+ f+kee+l+++n++yc++c++++++ kk++++klP+vL +hLkRfs++ + ++ +k++++v+fpl
   Q: 922  YLSLPLASTSKC---TLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGR-WK-QKLQTSVDFPL 1003
           ***********9...******************************************************996.55.6********** PP
   S: 258  e.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYk 336
           e Ldls++++ p+++    kkY+L++v +H+G+l++GHY+ay+kn  ++ W++fdD++V+ ++ ++v++   s aY+lfY+
   Q: 1004 EnLDLSQYVIGPKNN---LKKYNLFSVSNHYGGLDGGHYTAYCKNAARQrWFKFDDHEVSDISISSVKS---SAAYILFYT 1078
           ***********9988...69*************************88888*******************...********8 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MPAVASVPKE LYLSSSLKDL NKKTEVKPEK ISTKNYVQSA LKIFKTAEES RLDRDEERAY 60
VLYMKYVTVY NLIKKRPDFK QQQDYFHSIL GPANIKKAIE EAERLSESLK LRYEEAEVRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAAAGAACTC CTTTTAATGA AGTACACCAT TCATTGCAGA AGTGGAAGAG TAAAGATTAT 60
TCATCATGCC TGCCGTGGCT TCAGTTCCTA AAGAACTCTA CCTCAGTTCT TCACTAAAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR001763--Rhodanese-like_dom
IPR015063--USP8_dimer
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50206--RHODANESE_3
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00581--Rhodanese
PF00443--UCH
PF08969--USP8_dimer

SMART

SM00450--RHOD

Gene Ontology

GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0019897--C:extrinsic component of plasma membrane
GO:0030496--C:midbody
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0007032--P:endosome organization
GO:0000281--P:mitotic cytokinesis
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001661	Ailuropoda melanoleuca	90.45	0.00e+00	1868.00
IUUC-Apl-003226	Anas platyrhynchos	69.51	0.00e+00	1424.00
IUUC-Aca-004936	Anolis carolinensis	67.82	0.00e+00	1298.00
IUUC-Ago-007959	Ashbya gossypii	36.16	3.00e-56	213.00
IUUC-Acl-008102	Aspergillus clavatus	31.87	3.00e-53	204.00
IUUC-Afl-008604	Aspergillus flavus	31.59	6.00e-52	199.00
IUUC-Afu-009001	Aspergillus fumigatus	31.87	1.00e-52	201.00
IUUC-Ani-009291	Aspergillus nidulans	30.77	9.00e-52	199.00
IUUC-Ang-009844	Aspergillus niger	32.50	3.00e-52	199.00
IUUC-Aor-010098	Aspergillus oryzae	31.59	3.00e-51	197.00
IUUC-Ate-010585	Aspergillus terreus	31.49	1.00e-51	198.00
IUUC-Ame-011029	Astyanax mexicanus	60.28	4.00e-71	261.00
IUUC-Bta-013008	Bos taurus	98.35	0.00e+00	1951.00
IUUC-Bol-015281	Brassica oleracea	38.51	5.00e-51	195.00
IUUC-Bra-017228	Brassica rapa	39.40	2.00e-52	200.00
IUUC-Cel-018482	Caenorhabditis elegans	34.11	4.00e-54	206.00
IUUC-Cja-019173	Callithrix jacchus	87.15	0.00e+00	1810.00
IUUC-Cfa-021243	Canis familiaris	90.09	0.00e+00	1861.00
IUUC-Cpo-021522	Cavia porcellus	86.51	0.00e+00	1758.00
IUUC-Cre-022582	Chlamydomonas reinhardtii	44.06	8.00e-85	306.00
IUUC-Csa-023616	Chlorocebus sabaeus	87.58	0.00e+00	1539.00
IUUC-Cho-024381	Choloepus hoffmanni	77.25	0.00e+00	1544.00
IUUC-Cin-025287	Ciona intestinalis	50.13	3.00e-100	359.00
IUUC-Csv-026253	Ciona savignyi	47.92	2.00e-89	323.00
IUUC-Cne-026821	Cryptococcus neoformans	40.17	3.00e-76	280.00
IUUC-Dre-028440	Danio rerio	64.92	0.00e+00	761.00
IUUC-Dno-029039	Dasypus novemcinctus	85.99	0.00e+00	1827.00
IUUC-Dor-031043	Dipodomys ordii	95.69	3.00e-139	489.00
IUUC-Dse-031463	Dothistroma septosporum	28.34	1.00e-44	175.00
IUUC-Dme-032089	Drosophila melanogaster	44.50	8.00e-89	322.00
IUUC-Ete-033040	Echinops telfairi	77.32	0.00e+00	1477.00
IUUC-Eca-033449	Equus caballus	89.91	0.00e+00	1878.00
IUUC-Eeu-034693	Erinaceus europaeus	97.41	2.00e-133	470.00
IUUC-Fca-035794	Felis catus	98.11	0.00e+00	930.00
IUUC-Fal-037322	Ficedula albicollis	78.61	0.00e+00	879.00
IUUC-Gmo-038584	Gadus morhua	66.87	0.00e+00	682.00
IUUC-Gga-041188	Gallus gallus	82.38	0.00e+00	907.00
IUUC-Gac-041850	Gasterosteus aculeatus	74.75	0.00e+00	754.00
IUUC-Ggo-045565	Gorilla gorilla	87.78	0.00e+00	1832.00
IUUC-Hsa-046438	Homo sapiens	87.69	0.00e+00	1831.00
IUUC-Itr-048883	Ictidomys tridecemlineatus	90.75	0.00e+00	1831.00
IUUC-Kpa-049321	Komagataella pastoris	33.51	5.00e-51	196.00
IUUC-Lch-050485	Latimeria chalumnae	83.33	0.00e+00	875.00
IUUC-Loc-052769	Lepisosteus oculatus	77.50	0.00e+00	771.00
IUUC-Lma-053021	Leptosphaeria maculans	32.53	1.00e-56	215.00
IUUC-Laf-053432	Loxodonta africana	82.59	0.00e+00	1009.00
IUUC-Mcc-055823	Macaca mulatta	87.51	0.00e+00	1825.00
IUUC-Meu-056099	Macropus eugenii	97.40	5.00e-165	575.00
IUUC-Mla-059089	Melampsora laricipopulina	40.18	3.00e-72	266.00
IUUC-Mga-059739	Meleagris gallopavo	81.67	0.00e+00	897.00
IUUC-Mvi-060559	Microbotryum violaceum	39.83	9.00e-79	288.00
IUUC-Mmr-061158	Microcebus murinus	87.21	0.00e+00	1785.00
IUUC-Mdo-061801	Monodelphis domestica	86.61	0.00e+00	963.00
IUUC-Mmu-063665	Mus musculus	83.06	0.00e+00	1665.00
IUUC-Mpu-066738	Mustela putorius furo	89.19	0.00e+00	1818.00
IUUC-Mlu-067307	Myotis lucifugus	86.63	0.00e+00	1784.00
IUUC-Nfi-068410	Neosartorya fischeri	31.94	6.00e-53	202.00
IUUC-Nle-069314	Nomascus leucogenys	87.43	0.00e+00	1821.00
IUUC-Opr-070378	Ochotona princeps	79.75	0.00e+00	1205.00
IUUC-Ont-071545	Oreochromis niloticus	74.18	0.00e+00	771.00
IUUC-Oan-073537	Ornithorhynchus anatinus	74.42	0.00e+00	1477.00
IUUC-Ocu-074193	Oryctolagus cuniculus	89.93	0.00e+00	1837.00
IUUC-Ola-086622	Oryzias latipes	57.35	0.00e+00	1077.00
IUUC-Oga-088271	Otolemur garnettii	85.56	0.00e+00	1770.00
IUUC-Ptr-091339	Pan troglodytes	88.76	0.00e+00	1878.00
IUUC-Pan-091783	Papio anubis	81.17	0.00e+00	896.00
IUUC-Psi-093187	Pelodiscus sinensis	63.22	2.00e-151	530.00
IUUC-Pma-094626	Petromyzon marinus	58.47	3.00e-145	508.00
IUUC-Pfo-096463	Poecilia formosa	76.02	0.00e+00	765.00
IUUC-Pab-097645	Pongo abelii	87.24	0.00e+00	1825.00
IUUC-Pva-103222	Pteropus vampyrus	84.27	0.00e+00	895.00
IUUC-Pgr-103408	Puccinia graminis	35.92	5.00e-57	216.00
IUUC-Ptt-103699	Puccinia triticina	46.15	1.00e-68	255.00
IUUC-Pte-104348	Pyrenophora teres	28.83	8.00e-42	166.00
IUUC-Pyt-104711	Pyrenophora triticirepentis	30.23	2.00e-52	201.00
IUUC-Rno-105510	Rattus norvegicus	82.78	0.00e+00	1693.00
IUUC-Sce-106166	Saccharomyces cerevisiae	35.81	7.00e-53	202.00
IUUC-Sha-106879	Sarcophilus harrisii	85.34	0.00e+00	949.00
IUUC-Sja-107836	Schizosaccharomyces japonicus	36.29	1.00e-49	191.00
IUUC-Sar-113019	Sorex araneus	82.03	0.00e+00	1704.00
IUUC-Sre-115031	Sporisorium reilianum	37.33	3.00e-70	260.00
IUUC-Ssc-116334	Sus scrofa	92.95	0.00e+00	1909.00
IUUC-Tgu-117062	Taeniopygia guttata	78.86	0.00e+00	880.00
IUUC-Tru-117908	Takifugu rubripes	57.62	0.00e+00	1154.00
IUUC-Tsy-118867	Tarsius syrichta	81.60	0.00e+00	1022.00
IUUC-Tni-120206	Tetraodon nigroviridis	74.65	0.00e+00	738.00
IUUC-Tme-127144	Tuber melanosporum	40.28	6.00e-80	292.00
IUUC-Tbe-127877	Tupaia belangeri	98.04	1.00e-84	308.00
IUUC-Ttr-128580	Tursiops truncatus	90.15	0.00e+00	1176.00
IUUC-Uma-129340	Ustilago maydis	36.52	7.00e-73	269.00
IUUC-Vpa-130541	Vicugna pacos	89.54	0.00e+00	1852.00
IUUC-Xtr-132161	Xenopus tropicalis	58.55	0.00e+00	1195.00
IUUC-Xma-134271	Xiphophorus maculatus	73.41	0.00e+00	764.00
IUUC-Yli-134561	Yarrowia lipolytica	36.19	1.00e-60	228.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence