iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Hsa-046688

Ensembl Protein ID

ENSP00000368215.1

UniProt Accession

Q8N5C8; A6NDD9; Q6VQR0; TAB3_HUMAN

Genbank Protein ID

AAR06179.1; AAQ88279.1; AAQ92938.1; AAQ92939.1; AAH32526.1

Protein Name

TGF-beta-activated kinase 1 and MAP3K7-binding protein 3; Mitogen-activated protein kinase kinase kinase 7-interacting protein 3; NF-kappa-B-activating protein 1; TAK1-binding protein 3; TGF-beta-activated kinase 1-binding protein 3

Genbank Nucleotide ID

AY437560; AY371491; AY331591; AY331592; AC108359

Gene Name

TAB3; MAP3K7IP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000157625.15	ENST00000378933.5	ENSP00000368215.1
ENSG00000157625.15	ENST00000378932.6	ENSP00000368214.2
ENSG00000157625.15	ENST00000467136.5	ENSP00000433193.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
miRWalk	TargetScan	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
ClinVar	GWAS Central	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	HPRD
Phospho.ELM	UniProt	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/ZnF/NZF	NZF	15327770

Classification

Family	E-value	Score	Start	End
UBD/ZnF/NZF	1.40e-13	51.8	684	711
UBD/Alpha-Helix/CUE	1.20e-05	26.9	12	50

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/NZF

   S: 2    eaqWaCsaCTflNePeavkCemCsrpRg 29
           +a+W+C++CTflN+P++++Ce+C++pR+
   Q: 684  GAPWNCDSCTFLNHPALNRCEQCEMPRY 711
           78*************************7 PP

UBD/Alpha-Helix/CUE

   S: 5    aleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
            l+ L++ FP+ ++ v+ +++++n+++lea++ +L ++s
   Q: 12   VLHDLRQRFPEIPEGVVSQCMLQNNNNLEACCRALSQES 50
           699*********************************987 PP

Organism

Homo sapiens

Functional Description
(View)

Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor.

Protein Sequence
(Fasta)

MAQSSPQLDI QVLHDLRQRF PEIPEGVVSQ CMLQNNNNLE ACCRALSQES SKYLYMEYHS 60
PDDNRMNRNR LLHINLGIHS PSSYHPGDGA QLNGGRTLVH SSSDGHIDPQ HAAGKQLICL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CACATGACCA TTGGCTGGAG CCCAGTTGAC CAAGAAGGAA GCCAGAGAAA GCCACACATT 60
CGGGCGAGCA AGGTAGTTCT CTGTGTGATC TGATGCTACG GTCAGAACCT CAGAGTCCAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003892--CUE
IPR001876--Znf_RanBP2

PROSITE

PS51140--CUE
PS01358--ZF_RANBP2_1
PS50199--ZF_RANBP2_2

Pfam

PF02845--CUE

SMART

SM00546--CUE
SM00547--ZnF_RBZ

Gene Ontology

GO:0005829--C:cytosol
GO:0010008--C:endosome membrane
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0008270--F:zinc ion binding
GO:0000187--P:activation of MAPK activity
GO:0038095--P:Fc-epsilon receptor signaling pathway
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0007254--P:JNK cascade
GO:0002755--P:MyD88-dependent toll-like receptor signaling pathway
GO:0010507--P:negative regulation of autophagy
GO:0070423--P:nucleotide-binding oligomerization domain containing signaling pathway
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway

KEGG

hsa:257397

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001479	Ailuropoda melanoleuca	96.09	0.00e+00	1104.00
IUUC-Atr-002761	Amborella trichopoda	54.17	4.00e-04	38.90
IUUC-Apl-003957	Anas platyrhynchos	83.03	0.00e+00	900.00
IUUC-Aca-005020	Anolis carolinensis	77.64	0.00e+00	819.00
IUUC-Ame-011322	Astyanax mexicanus	46.65	9.00e-74	271.00
IUUC-Bta-012378	Bos taurus	81.27	3.00e-152	531.00
IUUC-Cja-018917	Callithrix jacchus	99.02	0.00e+00	1142.00
IUUC-Cfa-020333	Canis familiaris	97.07	0.00e+00	1119.00
IUUC-Cpo-022384	Cavia porcellus	92.63	0.00e+00	1102.00
IUUC-Csa-023536	Chlorocebus sabaeus	99.44	0.00e+00	1093.00
IUUC-Csv-025843	Ciona savignyi	34.96	6.00e-14	70.50
IUUC-Dre-028192	Danio rerio	50.00	4.00e-71	262.00
IUUC-Dno-029493	Dasypus novemcinctus	95.52	0.00e+00	1060.00
IUUC-Dme-031784	Drosophila melanogaster	54.55	3.00e-04	40.80
IUUC-Ete-032743	Echinops telfairi	93.01	0.00e+00	1101.00
IUUC-Eca-033530	Equus caballus	96.37	0.00e+00	1113.00
IUUC-Eeu-035002	Erinaceus europaeus	96.08	0.00e+00	929.00
IUUC-Fca-035595	Felis catus	96.37	0.00e+00	1095.00
IUUC-Fal-036772	Ficedula albicollis	80.14	0.00e+00	892.00
IUUC-Gmo-038724	Gadus morhua	54.62	3.00e-51	196.00
IUUC-Gga-040397	Gallus gallus	83.82	3.00e-143	502.00
IUUC-Gac-042605	Gasterosteus aculeatus	63.89	4.00e-65	242.00
IUUC-Ggo-045454	Gorilla gorilla	99.58	0.00e+00	1118.00
IUUC-Itr-048163	Ictidomys tridecemlineatus	96.37	0.00e+00	1113.00
IUUC-Lch-049632	Latimeria chalumnae	58.66	1.00e-170	593.00
IUUC-Laf-054539	Loxodonta africana	97.35	0.00e+00	1117.00
IUUC-Mcc-055842	Macaca mulatta	99.44	0.00e+00	1099.00
IUUC-Mla-058933	Melampsora laricipopulina	43.59	1.20e-01	30.80
IUUC-Mga-059642	Meleagris gallopavo	79.67	0.00e+00	863.00
IUUC-Mmr-061140	Microcebus murinus	98.04	0.00e+00	1132.00
IUUC-Mdo-062726	Monodelphis domestica	88.98	0.00e+00	1064.00
IUUC-Mmu-063805	Mus musculus	94.83	0.00e+00	1090.00
IUUC-Mpu-066164	Mustela putorius furo	96.51	0.00e+00	1121.00
IUUC-Mlu-066947	Myotis lucifugus	93.02	0.00e+00	1024.00
IUUC-Nle-069044	Nomascus leucogenys	99.86	0.00e+00	1121.00
IUUC-Opr-071211	Ochotona princeps	88.12	0.00e+00	698.00
IUUC-Ont-071714	Oreochromis niloticus	51.24	1.00e-68	254.00
IUUC-Oan-072910	Ornithorhynchus anatinus	77.82	2.00e-99	356.00
IUUC-Ocu-074006	Oryctolagus cuniculus	96.51	0.00e+00	1105.00
IUUC-Obr-076087	Oryza brachyantha	33.96	6.00e-04	37.70
IUUC-Ola-087258	Oryzias latipes	63.14	4.00e-71	262.00
IUUC-Oga-088238	Otolemur garnettii	96.63	0.00e+00	1084.00
IUUC-Oar-090069	Ovis aries	95.68	0.00e+00	1085.00
IUUC-Ptr-091494	Pan troglodytes	100.00	0.00e+00	1123.00
IUUC-Pan-092668	Papio anubis	99.58	0.00e+00	1093.00
IUUC-Psi-093369	Pelodiscus sinensis	80.97	0.00e+00	917.00
IUUC-Pfo-096048	Poecilia formosa	47.88	2.00e-73	270.00
IUUC-Pab-097899	Pongo abelii	99.18	2.00e-158	552.00
IUUC-Pca-100126	Procavia capensis	92.24	0.00e+00	963.00
IUUC-Pva-103031	Pteropus vampyrus	91.64	0.00e+00	1002.00
IUUC-Rno-105308	Rattus norvegicus	93.58	0.00e+00	1081.00
IUUC-Sha-107639	Sarcophilus harrisii	88.84	0.00e+00	1041.00
IUUC-Sar-113032	Sorex araneus	93.38	2.00e-170	593.00
IUUC-Ssc-115940	Sus scrofa	96.23	0.00e+00	1103.00
IUUC-Tgu-116804	Taeniopygia guttata	86.08	0.00e+00	824.00
IUUC-Tru-118326	Takifugu rubripes	45.49	2.00e-55	210.00
IUUC-Tsy-119508	Tarsius syrichta	94.03	5.00e-159	555.00
IUUC-Tni-120668	Tetraodon nigroviridis	42.27	2.00e-73	270.00
IUUC-Tbe-127935	Tupaia belangeri	96.54	3.00e-167	582.00
IUUC-Ttr-128906	Tursiops truncatus	92.05	0.00e+00	1070.00
IUUC-Vpa-130231	Vicugna pacos	87.10	3.00e-140	491.00
IUUC-Xtr-131801	Xenopus tropicalis	67.92	0.00e+00	797.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence