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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063825
UUCD1 version UUC-MuM-00478
Ensembl Protein ID ENSMUSP00000138333.1
UniProt Accession O88738; E9PYU6; Q69ZM5; Q8BNX0; Q8BR72; Q8BRV7; Q8C737; BIRC6_MOUSE
Genbank Protein ID CAA76720.1; BAC30874.1; BAC32373.1; BAC35061.1; BAC37801.1; BAD32421.1
Protein Name Baculoviral IAP repeat-containing protein 6; BIR repeat-containing ubiquitin-conjugating enzyme; RING-type E3 ubiquitin transferase BIRC6; Ubiquitin-conjugating BIR domain enzyme apollon
Genbank Nucleotide ID Y17267; AC098726; AK045446; AK052612; AK079995; AK173143
Gene Name Birc6; Kiaa1289
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000024073.14 ENSMUST00000180037.7 ENSMUSP00000136329.1
ENSMUSG00000024073.14 ENSMUST00000182944.7 ENSMUSP00000138732.1
ENSMUSG00000024073.14 ENSMUST00000182597.7 ENSMUSP00000138333.1
ENSMUSG00000024073.14 ENSMUST00000182133.7 ENSMUSP00000138693.1
ENSMUSG00000024073.14 ENSMUST00000183224.7 ENSMUSP00000138270.1
ENSMUSG00000024073.14 ENSMUST00000177957.7 ENSMUSP00000137114.1
ENSMUSG00000024073.14 ENSMUST00000182323.1 ENSMUSP00000138672.1
ENSMUSG00000024073.14 ENSMUST00000182845.7 ENSMUSP00000138717.1
ENSMUSG00000024073.14 ENSMUST00000182278.2 ENSMUSP00000138343.1
ENSMUSG00000024073.14 ENSMUST00000182817.1 ENSMUSP00000138349.1
ENSMUSG00000024073.14 ENSMUST00000183249.1 ENSMUSP00000138521.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E2/UBC 6.70e-34 117.8 4602 4758
Active Site
Position(s) Description Evidence
4691 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00388}
Domain Profile

   E2/UBC
   S: 1    Rlkkelkelekdpp....egisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltk.....ifhPnvyen 78
           Rl++e+ +l+++ p    +++++++++e  l+ ++vli+Gp+dtpY++g+F+++++fp+dYP++PP v+++t+     +f+Pn+y++
   Q: 4602 RLAQEAVTLSTSLPlsssSSVFVRCDEE-RLDIMKVLITGPADTPYANGCFEFDVYFPQDYPSSPPLVNLETTgghsvRFNPNLYND 4687
           8999999999998877768899999999.6********************************************************* PP
   S: 79   GkvClsilk.....eeekWsp.alsvesvllsiqsll..aepnpesplneeaa...ellkknreeykkkvre 139
           GkvClsil+     +eekW+p ++s+ +vl+s+qsl+  aep++++p +e+++   + ++++re y+ ++r+
   Q: 4688 GKVCLSILNtwhgrPEEKWNPqTSSFLQVLVSVQSLIlvAEPYFNEPGYERSRgtpSGTQSSRE-YDGNIRQ 4758
           ********7788889******8899***********999***********99866555666655.9998875 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. Required for normal placenta development.
 Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. Required for normal placenta development.
Protein Sequence
(Fasta)
MVTGCGAAPP GTVTERLPSV IVLSAGRKMA AAAAEASGPS CSSAAAAAGA GAAGVSEWLV 60
LRDGCMRCDA DGLHSLSYHP ALNAILAVTS RGTIKVIDGT SGATLQASAL SAKPGGQVKC 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063825|E2,E2/UBC|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCATGCTCCA CCCCCTGGGC TCCGGCCCCT CCTTTGGTGC GGCCCTCTCT CCCCTCCCCC 60
GCCAGCCTGC GAGCTCGCTT GGCCTGGCCG GCCTGGCGGG CGACGTTCCC TGTGCGTGCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063825|E2,E2/UBC|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0967--Endosome
KW-0333--Golgi apparatus
KW-0472--Membrane
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-0646--Protease inhibitor
KW-1185--Reference proteome
KW-0789--Thiol protease inhibitor
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
Interpro

IPR001370--BIR_rpt
IPR022103--BIRC6
IPR008979--Galactose-bd-like
IPR000608--UBQ-conjugat_E2
IPR016135--UBQ-conjugating_enzyme/RWD
IPR015943--WD40/YVTN_repeat-like_dom
IPR017986--WD40_repeat_dom
PROSITE

PS50143--BIR_REPEAT_2
PS50127--UBIQUITIN_CONJUGAT_2
Pfam

PF00653--BIR
PF12356--BIRC6
PF00179--UQ_con
SMART

SM00238--BIR
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005768--C:endosome
GO:0005794--C:Golgi apparatus
GO:0043231--C:intracellular membrane-bounded organelle
GO:0016020--C:membrane
GO:0005815--C:microtubule organizing center
GO:0030496--C:midbody
GO:0000922--C:spindle pole
GO:0005802--C:trans-Golgi network
GO:0004869--F:cysteine-type endopeptidase inhibitor activity
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006915--P:apoptotic process
GO:0051301--P:cell division
GO:0060711--P:labyrinthine layer development
GO:0007067--P:mitotic nuclear division
GO:0043066--P:negative regulation of apoptotic process
GO:2001237--P:negative regulation of extrinsic apoptotic signaling pathway
GO:0001890--P:placenta development
GO:0008284--P:positive regulation of cell proliferation
GO:0016567--P:protein ubiquitination
GO:0042127--P:regulation of cell proliferation
GO:0032465--P:regulation of cytokinesis
GO:0009966--P:regulation of signal transduction
GO:0060712--P:spongiotrophoblast layer development
KEGG mmu:12211
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001583 Ailuropoda melanoleuca 94.68 0.00e+00 8523.00
IUUC-Atr-003108 Amborella trichopoda 42.31 9.00e-45 174.00
IUUC-Apl-004144 Anas platyrhynchos 90.24 0.00e+00 5513.00
IUUC-Aca-005257 Anolis carolinensis 88.27 0.00e+00 7924.00
IUUC-Ath-007217 Arabidopsis thaliana 37.40 1.00e-43 171.00
IUUC-Ame-011337 Astyanax mexicanus 77.17 0.00e+00 6618.00
IUUC-Bta-012501 Bos taurus 94.00 0.00e+00 8344.00
IUUC-Bdi-014931 Brachypodium distachyon 38.06 5.00e-46 179.00
IUUC-Bol-015976 Brassica oleracea 45.76 2.00e-45 176.00
IUUC-Bra-017967 Brassica rapa 45.76 9.00e-46 177.00
IUUC-Cel-018661 Caenorhabditis elegans 37.01 5.00e-81 295.00
IUUC-Cja-018746 Callithrix jacchus 94.96 0.00e+00 8446.00
IUUC-Cfa-020170 Canis familiaris 94.91 0.00e+00 8357.00
IUUC-Cpo-022138 Cavia porcellus 95.12 0.00e+00 5726.00
IUUC-Cre-022768 Chlamydomonas reinhardtii 45.25 7.00e-45 173.00
IUUC-Csa-023927 Chlorocebus sabaeus 95.12 0.00e+00 8456.00
IUUC-Cho-024890 Choloepus hoffmanni 92.69 0.00e+00 1915.00
IUUC-Cne-026995 Cryptococcus neoformans 42.21 6.00e-37 149.00
IUUC-Dre-027941 Danio rerio 78.92 0.00e+00 6944.00
IUUC-Dno-028913 Dasypus novemcinctus 93.16 0.00e+00 8314.00
IUUC-Dor-030715 Dipodomys ordii 93.57 0.00e+00 1919.00
IUUC-Dse-031232 Dothistroma septosporum 43.96 1.00e-37 152.00
IUUC-Dme-031592 Drosophila melanogaster 52.26 0.00e+00 666.00
IUUC-Ete-032587 Echinops telfairi 76.18 0.00e+00 2017.00
IUUC-Eca-033819 Equus caballus 95.05 0.00e+00 8453.00
IUUC-Eeu-034863 Erinaceus europaeus 85.83 0.00e+00 2517.00
IUUC-Fca-035505 Felis catus 92.19 0.00e+00 8158.00
IUUC-Fal-037318 Ficedula albicollis 90.46 0.00e+00 8096.00
IUUC-Gmo-039521 Gadus morhua 80.07 0.00e+00 1657.00
IUUC-Ggr-040040 Gaeumannomyces graminis 47.06 2.00e-33 138.00
IUUC-Gga-040728 Gallus gallus 90.14 0.00e+00 7997.00
IUUC-Gac-042251 Gasterosteus aculeatus 82.95 0.00e+00 1759.00
IUUC-Ggo-045562 Gorilla gorilla 93.76 0.00e+00 1565.00
IUUC-Hsa-046339 Homo sapiens 95.11 0.00e+00 8372.00
IUUC-Hvu-047441 Hordeum vulgare 46.70 8.00e-47 181.00
IUUC-Itr-048099 Ictidomys tridecemlineatus 96.23 0.00e+00 2679.00
IUUC-Lch-050164 Latimeria chalumnae 84.11 0.00e+00 7375.00
IUUC-Lpe-051294 Leersia perrieri 39.85 7.00e-47 181.00
IUUC-Loc-052800 Lepisosteus oculatus 83.86 0.00e+00 7401.00
IUUC-Laf-054034 Loxodonta africana 93.49 0.00e+00 8370.00
IUUC-Mcc-055267 Macaca mulatta 95.26 0.00e+00 8461.00
IUUC-Meu-056461 Macropus eugenii 89.73 0.00e+00 1192.00
IUUC-Mpo-057396 Magnaporthe poae 49.03 2.00e-34 141.00
IUUC-Mtr-057797 Medicago truncatula 39.11 9.00e-47 181.00
IUUC-Mga-059594 Meleagris gallopavo 89.85 0.00e+00 7575.00
IUUC-Mmr-061179 Microcebus murinus 95.46 0.00e+00 8461.00
IUUC-Mdo-062990 Monodelphis domestica 91.66 0.00e+00 8059.00
IUUC-Mac-064881 Musa acuminata 42.86 2.00e-41 163.00
IUUC-Mpu-065908 Mustela putorius furo 95.17 0.00e+00 5465.00
IUUC-Mlu-067106 Myotis lucifugus 93.85 0.00e+00 8366.00
IUUC-Nle-069347 Nomascus leucogenys 95.22 0.00e+00 8438.00
IUUC-Opr-070799 Ochotona princeps 85.68 0.00e+00 2500.00
IUUC-Ont-072046 Oreochromis niloticus 78.46 0.00e+00 6710.00
IUUC-Oan-073415 Ornithorhynchus anatinus 90.62 0.00e+00 3302.00
IUUC-Ocu-074556 Oryctolagus cuniculus 94.98 0.00e+00 8415.00
IUUC-Oba-075870 Oryza barthii 38.93 4.00e-47 182.00
IUUC-Obr-076463 Oryza brachyantha 38.43 2.00e-46 179.00
IUUC-Ogl-077040 Oryza glaberrima 39.10 2.00e-39 157.00
IUUC-Ogu-077966 Oryza glumaepatula 38.93 4.00e-47 182.00
IUUC-Oin-079561 Oryza indica 39.10 2.00e-39 156.00
IUUC-Olo-080416 Oryza longistaminata 39.47 5.00e-40 160.00
IUUC-Ome-081384 Oryza meridionalis 39.10 3.00e-39 156.00
IUUC-Oni-082326 Oryza nivara 39.08 6.00e-47 181.00
IUUC-Opu-083659 Oryza punctata 38.35 1.00e-45 177.00
IUUC-Oru-085077 Oryza rufipogon 38.93 4.00e-47 182.00
IUUC-Osa-086014 Oryza sativa 38.93 4.00e-47 182.00
IUUC-Ola-087459 Oryzias latipes 81.86 0.00e+00 2846.00
IUUC-Oga-088251 Otolemur garnettii 92.64 0.00e+00 8036.00
IUUC-Oar-090367 Ovis aries 94.44 0.00e+00 8395.00
IUUC-Ptr-091512 Pan troglodytes 95.13 0.00e+00 8418.00
IUUC-Pan-092222 Papio anubis 93.99 0.00e+00 8391.00
IUUC-Pma-094574 Petromyzon marinus 60.98 0.00e+00 2973.00
IUUC-Ppa-095592 Physcomitrella patens 40.15 3.00e-49 190.00
IUUC-Pfo-097086 Poecilia formosa 77.05 0.00e+00 6747.00
IUUC-Pab-098390 Pongo abelii 93.62 0.00e+00 8215.00
IUUC-Pop-099284 Populus trichocarpa 37.35 1.00e-41 164.00
IUUC-Pca-101036 Procavia capensis 86.72 0.00e+00 4028.00
IUUC-Pva-103053 Pteropus vampyrus 89.68 0.00e+00 3491.00
IUUC-Pte-104333 Pyrenophora teres 40.80 2.00e-43 171.00
IUUC-Pyt-104498 Pyrenophora triticirepentis 38.96 8.00e-44 172.00
IUUC-Rno-106049 Rattus norvegicus 97.47 0.00e+00 7026.00
IUUC-Sha-107483 Sarcophilus harrisii 88.58 0.00e+00 7583.00
IUUC-Smo-108915 Selaginella moellendorffii 42.59 6.00e-44 171.00
IUUC-Sly-110929 Solanum lycopersicum 38.15 6.00e-46 179.00
IUUC-Stu-112554 Solanum tuberosum 38.55 3.00e-46 180.00
IUUC-Sar-112965 Sorex araneus 83.87 0.00e+00 1754.00
IUUC-Sbi-113880 Sorghum bicolor 34.23 5.00e-44 172.00
IUUC-Ssc-115927 Sus scrofa 95.25 0.00e+00 5857.00
IUUC-Tgu-117132 Taeniopygia guttata 89.95 0.00e+00 7969.00
IUUC-Tru-118115 Takifugu rubripes 75.06 0.00e+00 6599.00
IUUC-Tsy-118899 Tarsius syrichta 91.74 0.00e+00 4914.00
IUUC-Tni-120891 Tetraodon nigroviridis 74.01 0.00e+00 6571.00
IUUC-Tae-125407 Triticum aestivum 47.25 5.00e-47 182.00
IUUC-Tur-126479 Triticum urartu 45.86 4.00e-43 169.00
IUUC-Tme-126930 Tuber melanosporum 43.05 5.00e-48 186.00
IUUC-Tbe-127630 Tupaia belangeri 91.17 0.00e+00 1501.00
IUUC-Ttr-128629 Tursiops truncatus 92.77 0.00e+00 8236.00
IUUC-Vpa-130310 Vicugna pacos 93.91 0.00e+00 8123.00
IUUC-Xtr-131861 Xenopus tropicalis 82.47 0.00e+00 7151.00
IUUC-Xma-133613 Xiphophorus maculatus 77.19 0.00e+00 6716.00
IUUC-Zma-135768 Zea mays 35.03 1.00e-44 176.00
Created Date 25-Jun-2017

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