iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037029

Ensembl Protein ID

ENSFALP00000006598.1

UniProt Accession

U3JUZ4; U3JUZ4_FICAL

Genbank Protein ID

ENSFALP00000006598

Protein Name

Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme 16; Ubiquitin thioesterase 16; Ubiquitin-specific-processing protease 16

Genbank Nucleotide ID

AGTO01021195

Gene Name

USP16

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000006325.1	ENSFALT00000006627.1	ENSFALP00000006598.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.90e-82	276.2	194	822

Active Site

Position(s)	Description	Evidence
203	Nucleophile	ECO:0000256\|HAMAP-Rule:MF_03062}
759	Proton acceptor	ECO:0000256\|HAMAP-Rule:MF_03062}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..........kkkeklneenp...........kepkgellkslqklfeelwkskkkav 68
           +Gl+NlgNtC++N+v+Q Ls++p lrell+e          +         +            ++ g+l+ +++++++e++++kk++v
   Q: 194  KGLSNLGNTCFFNAVMQNLSQTPVLRELLKEakmpgttikiE---------SpelcvepqlikLDQPGPLTLAMHQFVTEMQETKKGVV 273
           5******************************75443333332.........14666666677788899********************* PP
   S: 69   sprellkalkkeaeefsgyeqqDaqEflaflldqleeelkk.....eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlks 152
           +p+el+++++k+a +f+gy+qqD++E+l++lld+++ e  +       +   ++ ++++++ +++++e++kkk  +s+++++F+g+l+s
   Q: 274  TPKELFAQVCKKAIRFKGYQQQDSHELLRYLLDGMRAEEIQqisvgILKALSDSNKQNEEELKKKIKEYEKKKGIQSFVDRIFGGELTS 362
           ***********************************98886646665333333333334444445569999******************* PP
   S: 153  qikclecdnvssreepfldlslpvpgkeetkke........................................................ 185
           +i+c+ec++vs  +e+fldlslpv + ++ k +                                                        
   Q: 363  TIMCEECRTVSLVHESFLDLSLPVLDVQKVKITkrenikknkekgsedeedkinnhylkqkyeppgmskhlqkkmkkqtkkqaksqrrq 451
           *************************99988877999***************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 452  qklqgkvlqltglsateqperdvqynqesetemssetldkkqeveslhdcedhcltqkdlnirgnsseissesrhenagkpeqeceeke 540
           ***************************************************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 541  svtdlsvegldspvkfvngfdnlslkeedddnedeeelatdfsklhlgasesdtstlddlqpvpnktcevstddpetafctlanreeln 629
           ***************************************************************************************** PP
   S: 186  ....slqdcLesftkeeelegenkyycekckkkqe................aekklklkklPevLilhLkRfsfseeqksrekinkkve 254
               s+++cL +ft++e+l++ nk+ c+ c+++                  a+k++ ++  P++L+lhLkRf  ++++ + +k+n++v+
   Q: 630  peedSVHHCLYQFTRNETLTETNKLLCDVCTQRHCgpknniksekkyvytnAKKQMLISLAPPILTLHLKRF--QHAGFNLQKVNRHVK 716
           *******************************77777888888888888888*********************..9999*********** PP
   S: 255  fpleLdlspfctspeekqke...kkkYeLiavvvHsGslssGHYvayvkn.......................ekgkWllfdDskVtev 317
           fp+ +dl+pfct ++++++e   k+ Y+L++vv HsG+++sGHY+ayvk                         kg+W++++D++V++v
   Q: 717  FPEVIDLAPFCTAKCKNVAEgntKVLYSLYGVVEHSGTMRSGHYTAYVKMramnnhlsdlvlrgqsqasetepVKGQWFHISDTHVQPV 805
           *************99999888889**************************999999999998888888877777999************ PP
   S: 318  keeevleetgstaYvlfYkr 337
           + ++vl+   s+aY+lfY+r
   Q: 806  SVSKVLS---SQAYLLFYER 822
           *******...********98 PP

Organism

Ficedula albicollis

Functional Description
(View)

Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.

Protein Sequence
(Fasta)

MGKKRIKGKT AQSDESPDTL KPVCTHIRKG LDQGHVRKAL QNVEWHVCQD CKADSKTQEK 60
AEEEETDEGT SIWLCLKCGH RGCDRNSPDQ HALKHFETPR SDSHCLVLNL DNWSVWCYLC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCACTGTTC CTTTTAGGAA CAATTACAGA CAGCAAAGAT GGGGAAGAAA CGCATCAAAG 60
GCAAAACTGC ACAGTCTGAT GAGTCTCCAG ATACACTGAG TATGTTTCCT TGGAGAAGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0010--Activator
KW-0131--Cell cycle
KW-0132--Cell division
KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0498--Mitosis
KW-0539--Nucleus
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR030849--UBP16
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004197--F:cysteine-type endopeptidase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0051301--P:cell division
GO:0006974--P:cellular response to DNA damage stimulus
GO:0070537--P:histone H2A K63-linked deubiquitination
GO:0007067--P:mitotic nuclear division
GO:0035522--P:monoubiquitinated histone H2A deubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0045901--P:positive regulation of translational elongation
GO:0051289--P:protein homotetramerization
GO:0051726--P:regulation of cell cycle
GO:0006351--P:transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

fab:101818029

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000997	Aegilops tauschii	29.06	4.00e-29	123.00
IUUC-Aml-001931	Ailuropoda melanoleuca	59.38	0.00e+00	854.00
IUUC-Atr-003015	Amborella trichopoda	28.97	6.00e-33	136.00
IUUC-Apl-004145	Anas platyrhynchos	78.26	0.00e+00	1120.00
IUUC-Aca-004314	Anolis carolinensis	61.97	0.00e+00	882.00
IUUC-Ame-011659	Astyanax mexicanus	45.95	1.00e-98	354.00
IUUC-Bta-013362	Bos taurus	58.97	0.00e+00	855.00
IUUC-Bdi-014624	Brachypodium distachyon	29.41	4.00e-29	123.00
IUUC-Bol-015941	Brassica oleracea	29.97	3.00e-32	134.00
IUUC-Bra-016751	Brassica rapa	28.38	2.00e-30	128.00
IUUC-Cja-019177	Callithrix jacchus	59.38	0.00e+00	858.00
IUUC-Cfa-020051	Canis familiaris	58.98	0.00e+00	847.00
IUUC-Cpo-021886	Cavia porcellus	58.19	0.00e+00	840.00
IUUC-Csa-024103	Chlorocebus sabaeus	59.64	0.00e+00	857.00
IUUC-Cho-024315	Choloepus hoffmanni	53.14	1.00e-72	267.00
IUUC-Cin-025775	Ciona intestinalis	48.23	6.00e-38	149.00
IUUC-Csv-026075	Ciona savignyi	50.25	2.00e-53	203.00
IUUC-Cme-027348	Cyanidioschyzon merolae	36.91	2.00e-18	87.00
IUUC-Dre-028388	Danio rerio	51.84	4.00e-103	369.00
IUUC-Dno-029409	Dasypus novemcinctus	59.07	0.00e+00	854.00
IUUC-Dor-030443	Dipodomys ordii	57.34	4.00e-105	375.00
IUUC-Dme-031870	Drosophila melanogaster	48.34	1.00e-30	129.00
IUUC-Ete-032807	Echinops telfairi	59.43	1.00e-119	423.00
IUUC-Eca-033479	Equus caballus	59.29	0.00e+00	863.00
IUUC-Eeu-034835	Erinaceus europaeus	51.44	1.00e-95	344.00
IUUC-Fca-036320	Felis catus	59.38	0.00e+00	860.00
IUUC-Gmo-039480	Gadus morhua	45.95	6.00e-99	354.00
IUUC-Gga-040527	Gallus gallus	77.51	0.00e+00	1103.00
IUUC-Gac-042343	Gasterosteus aculeatus	45.43	1.00e-101	364.00
IUUC-Gma-044402	Glycine max	28.39	5.00e-35	143.00
IUUC-Ggo-045598	Gorilla gorilla	58.97	0.00e+00	857.00
IUUC-Hsa-046598	Homo sapiens	59.76	0.00e+00	858.00
IUUC-Hvu-047146	Hordeum vulgare	29.87	7.00e-30	125.00
IUUC-Itr-047951	Ictidomys tridecemlineatus	58.36	0.00e+00	849.00
IUUC-Lpe-050703	Leersia perrieri	29.19	2.00e-29	124.00
IUUC-Loc-051814	Lepisosteus oculatus	53.07	1.00e-110	393.00
IUUC-Laf-053732	Loxodonta africana	57.88	0.00e+00	847.00
IUUC-Mcc-054661	Macaca mulatta	59.76	0.00e+00	859.00
IUUC-Meu-055967	Macropus eugenii	60.66	2.00e-114	406.00
IUUC-Mla-059026	Melampsora laricipopulina	36.00	1.00e-16	81.60
IUUC-Mga-059551	Meleagris gallopavo	76.84	0.00e+00	1123.00
IUUC-Mvi-060391	Microbotryum violaceum	31.61	1.00e-18	88.20
IUUC-Mmr-061747	Microcebus murinus	59.78	0.00e+00	837.00
IUUC-Mdo-062220	Monodelphis domestica	58.95	0.00e+00	805.00
IUUC-Mmu-063582	Mus musculus	56.00	0.00e+00	810.00
IUUC-Mac-064941	Musa acuminata	34.06	7.00e-37	149.00
IUUC-Mpu-066339	Mustela putorius furo	58.82	0.00e+00	843.00
IUUC-Mlu-067511	Myotis lucifugus	58.81	0.00e+00	826.00
IUUC-Nle-069252	Nomascus leucogenys	60.00	0.00e+00	859.00
IUUC-Opr-070969	Ochotona princeps	57.09	0.00e+00	790.00
IUUC-Ont-071786	Oreochromis niloticus	48.91	1.00e-102	367.00
IUUC-Ocu-074704	Oryctolagus cuniculus	58.79	0.00e+00	822.00
IUUC-Oba-075094	Oryza barthii	30.12	1.00e-29	125.00
IUUC-Obr-076743	Oryza brachyantha	29.19	3.00e-29	124.00
IUUC-Ogl-077739	Oryza glaberrima	30.12	8.00e-30	125.00
IUUC-Ogu-078851	Oryza glumaepatula	30.12	1.00e-29	125.00
IUUC-Oin-079402	Oryza indica	30.12	1.00e-29	125.00
IUUC-Olo-080431	Oryza longistaminata	30.12	1.00e-29	125.00
IUUC-Ome-081580	Oryza meridionalis	29.81	2.00e-29	124.00
IUUC-Oni-082644	Oryza nivara	30.12	1.00e-29	125.00
IUUC-Opu-083452	Oryza punctata	29.38	7.00e-30	126.00
IUUC-Oru-084546	Oryza rufipogon	30.12	1.00e-29	125.00
IUUC-Osa-085858	Oryza sativa	30.12	1.00e-29	125.00
IUUC-Ola-086795	Oryzias latipes	46.59	1.00e-101	363.00
IUUC-Oga-088713	Otolemur garnettii	58.72	0.00e+00	839.00
IUUC-Oar-089887	Ovis aries	59.02	0.00e+00	855.00
IUUC-Ptr-091670	Pan troglodytes	59.64	0.00e+00	858.00
IUUC-Pan-092293	Papio anubis	59.76	0.00e+00	859.00
IUUC-Psi-093101	Pelodiscus sinensis	64.39	0.00e+00	941.00
IUUC-Pfo-097202	Poecilia formosa	47.61	3.00e-107	382.00
IUUC-Pab-098773	Pongo abelii	60.67	0.00e+00	650.00
IUUC-Pop-099136	Populus trichocarpa	30.63	2.00e-41	164.00
IUUC-Pca-101069	Procavia capensis	51.85	6.00e-160	557.00
IUUC-Ppe-101794	Prunus persica	30.96	2.00e-36	147.00
IUUC-Pva-103092	Pteropus vampyrus	54.66	8.00e-105	374.00
IUUC-Rno-105237	Rattus norvegicus	57.14	0.00e+00	808.00
IUUC-Sha-106889	Sarcophilus harrisii	60.00	0.00e+00	840.00
IUUC-Sja-107712	Schizosaccharomyces japonicus	29.65	7.00e-19	89.00
IUUC-Spo-108149	Schizosaccharomyces pombe	32.52	2.00e-20	94.70
IUUC-Ssl-108648	Sclerotinia sclerotiorum	26.44	1.00e-11	65.10
IUUC-Sit-110283	Setaria italica	31.50	3.00e-30	127.00
IUUC-Sly-111491	Solanum lycopersicum	29.95	4.00e-36	146.00
IUUC-Stu-112820	Solanum tuberosum	30.39	5.00e-38	152.00
IUUC-Sar-113530	Sorex araneus	57.75	0.00e+00	826.00
IUUC-Sbi-113785	Sorghum bicolor	36.71	2.00e-24	108.00
IUUC-Ssc-116091	Sus scrofa	59.43	0.00e+00	837.00
IUUC-Tgu-117478	Taeniopygia guttata	89.24	0.00e+00	1286.00
IUUC-Tru-118640	Takifugu rubripes	48.71	6.00e-105	375.00
IUUC-Tsy-119042	Tarsius syrichta	50.07	2.00e-149	522.00
IUUC-Tca-121701	Theobroma cacao	28.98	1.00e-36	148.00
IUUC-Tae-125351	Triticum aestivum	28.75	2.00e-28	121.00
IUUC-Tur-126788	Triticum urartu	28.12	4.00e-28	120.00
IUUC-Tbe-127309	Tupaia belangeri	56.23	5.00e-93	335.00
IUUC-Ttr-128271	Tursiops truncatus	58.72	0.00e+00	840.00
IUUC-Vpa-130674	Vicugna pacos	58.10	0.00e+00	768.00
IUUC-Xtr-131869	Xenopus tropicalis	49.43	0.00e+00	697.00
IUUC-Xma-134195	Xiphophorus maculatus	47.53	1.00e-107	384.00
IUUC-Zma-135157	Zea mays	30.34	2.00e-25	110.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence