iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mlu-067992

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAPE02035677

Gene Name

HECTD3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMLUG00000029921.1	ENSMLUT00000022216.1	ENSMLUP00000019163.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.80e-76	257.8	476	802

Active Site

Position(s)	Description	Evidence
772	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 8    rlevefvgEegldlgGvtreflallskelqnpd......lglflysendketlqpnpdsglknp..ehlklFeflGrllgkalqdgrll 88
            +e++f  E  +d+gG +r+ la +s+el+ ++      l++f++++n+ + +  ++d+++ np  + +  +e++G+l+g al+ +++l
   Q: 476  WWECKFIAEGIIDQGGGFRDSLADMSEELCPSSadtpvpLPFFVRTANQGNGTGEARDMYVPNPscRDFAKYEWIGQLMGAALRGKEFL 564
           355*****************************9999*99**********************9999999********************* PP
   S: 89   dlplsksfyklllgkklsl.edleevdpelykslkeikenaesdieelgldltfsvseei...lgetkeeeLkpgGenipVtneNkeeY 173
            l l+ +++k+l g+++s+ +d+++vd+ l+k l+ ++      +++++++++f ++ +    l++++++eL+pgG  i V +e+++++
   Q: 565  VLALPGFVWKQLSGEEVSWsKDFPAVDSVLVKLLEVMEG-----MDKETFEFKFGKELTFttvLSDQQVVELIPGGTGIVVGYEDRSRF 648
           **************************************5.....56666777777443334449************************* PP
   S: 174  vklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           ++lv ++rl+e  keqv+a++ G+ +v+p+ +l+l+t++ele  +cG++e++v++l+k t++++ +++++  +q+Fwe+l++f++e+r+
   Q: 649  IQLVQKARLEE-SKEQVAAMQTGLLKVVPQAVLDLLTWQELEKKVCGDPEVTVDALRKLTRFED-FEPSDTRVQYFWEALNNFTNEDRS 735
           **********9.9*************************************************76.************************ PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirk...dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +fL+FvTg+srlP+        r++++++    +++d lP+s+TC ++L LP+Y s ++++ekL+yA  ++ +++
   Q: 736  RFLRFVTGRSRLPA--------RIYIYPDklgCETTDALPESSTCSSTLFLPQYASAKVCEEKLRYAAYNCVAID 802
           *************6........55666666877889*********************************998776 PP

Organism

Myotis lucifugus

Protein Sequence
(Fasta)

LYQDPASPSR VLLPVWEAEG LGLRVGAAGP APGPGSGPLR AARNSIELRR ASCVRTGEEL 60
CNGHGLWVKL TKEQLAEHLG DCGLDEGWLL VCRPAEGGAR LVPIDTPDHL QRRQQLFGVD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTATCAGG ACCCCGCGAG CCCTTCGCGC GTGCTGCTGC CCGTGTGGGA GGCGGAGGGC 60
CTGGGGCTGC GCGTGGGAGC GGCGGGCCCG GCCCCAGGCC CCGGCTCCGG GCCCCTGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR004939--APC_su10/DOC_dom
IPR008979--Galactose-bd-like
IPR000569--HECT_dom

PROSITE

PS51284--DOC
PS50237--HECT

Pfam

PF03256--ANAPC10
PF00632--HECT

SMART

SM01337--APC10
SM00119--HECTc

Gene Ontology

GO:0048471--C:perinuclear region of cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001229	Ailuropoda melanoleuca	96.92	0.00e+00	1583.00
IUUC-Apl-003715	Anas platyrhynchos	85.39	0.00e+00	1315.00
IUUC-Aca-004377	Anolis carolinensis	83.03	0.00e+00	1327.00
IUUC-Ame-011918	Astyanax mexicanus	67.87	0.00e+00	1071.00
IUUC-Bta-012736	Bos taurus	97.53	0.00e+00	1603.00
IUUC-Cja-019926	Callithrix jacchus	96.67	0.00e+00	1586.00
IUUC-Cfa-020753	Canis familiaris	97.92	0.00e+00	1164.00
IUUC-Cpo-021415	Cavia porcellus	96.67	0.00e+00	1588.00
IUUC-Csa-023096	Chlorocebus sabaeus	96.92	0.00e+00	1588.00
IUUC-Dre-028746	Danio rerio	73.13	0.00e+00	1158.00
IUUC-Dno-029293	Dasypus novemcinctus	97.74	0.00e+00	1066.00
IUUC-Dor-031113	Dipodomys ordii	98.52	0.00e+00	1234.00
IUUC-Ete-032601	Echinops telfairi	89.04	0.00e+00	1407.00
IUUC-Eca-034198	Equus caballus	96.79	0.00e+00	1569.00
IUUC-Eeu-034708	Erinaceus europaeus	97.10	0.00e+00	897.00
IUUC-Fca-035478	Felis catus	97.16	0.00e+00	1598.00
IUUC-Fal-037366	Ficedula albicollis	84.17	0.00e+00	1303.00
IUUC-Gmo-039020	Gadus morhua	75.30	0.00e+00	1043.00
IUUC-Gga-040332	Gallus gallus	83.94	0.00e+00	1346.00
IUUC-Gac-042336	Gasterosteus aculeatus	73.32	0.00e+00	1195.00
IUUC-Ggo-045382	Gorilla gorilla	97.16	0.00e+00	1592.00
IUUC-Hsa-046562	Homo sapiens	97.16	0.00e+00	1592.00
IUUC-Itr-048208	Ictidomys tridecemlineatus	97.41	0.00e+00	1601.00
IUUC-Lch-049606	Latimeria chalumnae	65.37	0.00e+00	835.00
IUUC-Loc-052448	Lepisosteus oculatus	65.76	0.00e+00	1019.00
IUUC-Laf-054507	Loxodonta africana	96.18	0.00e+00	1581.00
IUUC-Mcc-055690	Macaca mulatta	97.04	0.00e+00	1591.00
IUUC-Meu-055970	Macropus eugenii	85.12	0.00e+00	1387.00
IUUC-Mga-059654	Meleagris gallopavo	85.60	0.00e+00	1301.00
IUUC-Mmr-061069	Microcebus murinus	97.16	0.00e+00	1593.00
IUUC-Mdo-062547	Monodelphis domestica	91.73	0.00e+00	787.00
IUUC-Mmu-063096	Mus musculus	97.04	0.00e+00	1576.00
IUUC-Mpu-065846	Mustela putorius furo	96.67	0.00e+00	1595.00
IUUC-Nle-069565	Nomascus leucogenys	97.24	0.00e+00	1492.00
IUUC-Opr-070853	Ochotona princeps	84.13	0.00e+00	1013.00
IUUC-Ont-071628	Oreochromis niloticus	73.39	0.00e+00	1167.00
IUUC-Ocu-074094	Oryctolagus cuniculus	97.29	0.00e+00	1597.00
IUUC-Ola-087384	Oryzias latipes	73.03	0.00e+00	1201.00
IUUC-Oga-088224	Otolemur garnettii	96.79	0.00e+00	1593.00
IUUC-Oar-090043	Ovis aries	91.48	0.00e+00	1496.00
IUUC-Ptr-090852	Pan troglodytes	96.92	0.00e+00	1583.00
IUUC-Pan-092787	Papio anubis	97.04	0.00e+00	1592.00
IUUC-Psi-092986	Pelodiscus sinensis	73.15	0.00e+00	981.00
IUUC-Pma-094416	Petromyzon marinus	40.31	4.00e-164	572.00
IUUC-Pfo-096720	Poecilia formosa	73.13	0.00e+00	1202.00
IUUC-Pab-098325	Pongo abelii	96.78	0.00e+00	1214.00
IUUC-Pca-100885	Procavia capensis	82.87	0.00e+00	1195.00
IUUC-Pva-102829	Pteropus vampyrus	84.54	0.00e+00	976.00
IUUC-Rno-104882	Rattus norvegicus	97.29	0.00e+00	1595.00
IUUC-Sha-106811	Sarcophilus harrisii	91.04	1.00e-115	409.00
IUUC-Sar-113020	Sorex araneus	82.42	0.00e+00	703.00
IUUC-Ssc-115436	Sus scrofa	97.78	7.00e-158	549.00
IUUC-Tgu-117042	Taeniopygia guttata	83.70	0.00e+00	1340.00
IUUC-Tru-118419	Takifugu rubripes	71.32	0.00e+00	1123.00
IUUC-Tsy-118829	Tarsius syrichta	96.49	0.00e+00	974.00
IUUC-Tni-120410	Tetraodon nigroviridis	59.30	0.00e+00	886.00
IUUC-Tbe-128113	Tupaia belangeri	97.65	0.00e+00	771.00
IUUC-Ttr-128167	Tursiops truncatus	92.60	0.00e+00	1499.00
IUUC-Xtr-132910	Xenopus tropicalis	65.92	0.00e+00	1035.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence