iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cne-026849

Ensembl Protein ID

AAW44909

UniProt Accession

Q5KC94; Q55JG6; Q5KC94_CRYNJ

Genbank Protein ID

AAW44909.1

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AE017348

Gene Name

CNH00220

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
CNH00220	AAW44909	AAW44909

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.20e-124	413.1	501	832

Active Site

Position(s)	Description	Evidence
801	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllg 102
           ++dlkkrl+++f+gE+gld+gG++ref++lls+e++np ++lf+ys+ d++tlq+np+sg+ npehl++F+f+Gr++g+ ++++r+ld+ +  sfyk++lg
   Q: 501  PNDLKKRLMIKFEGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPNSGV-NPEHLNYFKFIGRVVGLGIFHRRFLDAYFIVSFYKMILG 600
           579*********************************************************9.89************************************* PP
   S: 103  kklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfnevipl 203
           kk+ l+dle+vd+ l++ l++++en   di+   ++ tfs++ee++ge+ +++LkpgG++++Vt++Nk++Yv+lv+eyr+ +++ eq++af +Gfne+ip+
   Q: 601  KKIALQDLESVDAGLFRGLTWMLEN---DITGV-IEDTFSITEEHFGEVVTVDLKPGGRDVEVTEDNKKDYVDLVTEYRISKRVSEQFQAFMSGFNELIPQ 697
           ***********************99...99998.999**************************************************************** PP
   S: 204  ellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPs 300
           el+++F+e+elelli G++eidv+d++k+t y+g y++++++++wFw++++++ +e+++++LqF+Tg+sr+P++Gf++l+    pr+f+i+k+++ ++lP+
   Q: 698  ELINVFDERELELLIGGMSEIDVDDWQKHTDYRG-YNPSDEVVEWFWKIVKNWPAEKKSRLLQFTTGTSRIPVNGFKDLQgsdgPRRFTIEKAGEVTQLPK 797
           ********************************76.****************************************************************** PP
   S: 301  snTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           s+TCfn+++LP Y+s+e l++kL++A+eet gF++
   Q: 798  SHTCFNRIDLPAYKSYEALEQKLTIAVEETVGFGQ 832
           *********************************96 PP

Organism

Cryptococcus neoformans

Protein Sequence
(Fasta)

MVAFTATGNR NLTRKIRVTI VAADSLIKRD ILRLPDPFAI VSVDSEQIHT TSVIKRTLNP 60
YWNENFDIDV KDSSIVAVQI FDQRKFKRKQ DQGFLGVINI KVSDVIDLEL GGQEMLTKEL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATCTCGCCT TTCTTTTCGT CCAACGCCCA CTCTAGACCC GTCTGTACTA ATACTGCCCA 60
TAAAATTTCC TCAATCTTCA CACCATGGTC GCCTTCACGG CCACTGGAAA CAGAAACTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005934--C:cellular bud tip
GO:0010008--C:endosome membrane
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005794--C:Golgi apparatus
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0016874--F:ligase activity
GO:0035091--F:phosphatidylinositol binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0034644--P:cellular response to UV
GO:0006333--P:chromatin assembly or disassembly
GO:0032511--P:late endosome to vacuole transport via multivesicular body sorting pathway
GO:0007005--P:mitochondrion organization
GO:0016973--P:poly(A)+ mRNA export from nucleus
GO:0045723--P:positive regulation of fatty acid biosynthetic process
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0048260--P:positive regulation of receptor-mediated endocytosis
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032956--P:regulation of actin cytoskeleton organization
GO:0010794--P:regulation of dolichol biosynthetic process
GO:0032443--P:regulation of ergosterol biosynthetic process
GO:0031384--P:regulation of initiation of mating projection growth
GO:0010793--P:regulation of mRNA export from nucleus
GO:0010796--P:regulation of multivesicular body size
GO:0006808--P:regulation of nitrogen utilization
GO:0019220--P:regulation of phosphate metabolic process
GO:2000203--P:regulation of ribosomal large subunit export from nucleus
GO:2000232--P:regulation of rRNA processing
GO:2000238--P:regulation of tRNA export from nucleus
GO:2000235--P:regulation of tRNA processing
GO:0010795--P:regulation of ubiquinone biosynthetic process
GO:0042493--P:response to drug
GO:0034517--P:ribophagy
GO:0070086--P:ubiquitin-dependent endocytosis
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

KEGG

cne:CNH00220

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002302	Ailuropoda melanoleuca	47.97	2.00e-161	561.00
IUUC-Apl-003893	Anas platyrhynchos	46.25	2.00e-155	541.00
IUUC-Aca-005338	Anolis carolinensis	48.31	6.00e-162	562.00
IUUC-Ago-007742	Ashbya gossypii	69.19	0.00e+00	878.00
IUUC-Acl-008273	Aspergillus clavatus	71.99	0.00e+00	888.00
IUUC-Afl-008713	Aspergillus flavus	62.51	0.00e+00	999.00
IUUC-Afu-009103	Aspergillus fumigatus	62.43	0.00e+00	971.00
IUUC-Ani-009259	Aspergillus nidulans	62.86	0.00e+00	1001.00
IUUC-Ang-009738	Aspergillus niger	64.02	0.00e+00	1015.00
IUUC-Aor-010053	Aspergillus oryzae	76.25	2.00e-141	493.00
IUUC-Ate-010529	Aspergillus terreus	64.29	0.00e+00	1014.00
IUUC-Ame-010601	Astyanax mexicanus	49.40	9.00e-162	561.00
IUUC-Bgr-012148	Blumeria graminis	60.61	0.00e+00	956.00
IUUC-Bta-012782	Bos taurus	47.97	1.00e-161	561.00
IUUC-Bci-013785	Botrytis cinerea	61.49	0.00e+00	983.00
IUUC-Bol-016533	Brassica oleracea	47.62	7.00e-76	275.00
IUUC-Cel-018299	Caenorhabditis elegans	45.14	2.00e-148	518.00
IUUC-Cja-018732	Callithrix jacchus	48.58	8.00e-155	539.00
IUUC-Cfa-021226	Canis familiaris	46.17	1.00e-154	538.00
IUUC-Cpo-022073	Cavia porcellus	47.97	7.00e-162	562.00
IUUC-Csa-023252	Chlorocebus sabaeus	46.51	2.00e-162	564.00
IUUC-Cho-024695	Choloepus hoffmanni	47.14	1.00e-162	565.00
IUUC-Cin-025212	Ciona intestinalis	44.35	2.00e-148	518.00
IUUC-Csv-026256	Ciona savignyi	45.95	2.00e-150	524.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	60.50	0.00e+00	976.00
IUUC-Dre-028809	Danio rerio	48.63	3.00e-161	560.00
IUUC-Dno-029466	Dasypus novemcinctus	48.24	2.00e-154	538.00
IUUC-Dor-030138	Dipodomys ordii	47.41	2.00e-150	524.00
IUUC-Dse-031241	Dothistroma septosporum	62.09	0.00e+00	1023.00
IUUC-Dme-032041	Drosophila melanogaster	45.92	1.00e-146	512.00
IUUC-Ete-032779	Echinops telfairi	45.67	4.00e-140	490.00
IUUC-Eca-033445	Equus caballus	48.58	2.00e-154	538.00
IUUC-Eeu-035247	Erinaceus europaeus	48.41	3.00e-153	533.00
IUUC-Fca-035605	Felis catus	47.97	3.00e-161	560.00
IUUC-Fal-037126	Ficedula albicollis	46.92	4.00e-164	570.00
IUUC-Fox-037774	Fusarium oxysporum	61.80	0.00e+00	976.00
IUUC-Fso-038393	Fusarium solani	60.43	0.00e+00	969.00
IUUC-Gmo-039674	Gadus morhua	43.45	6.00e-152	529.00
IUUC-Ggr-040107	Gaeumannomyces graminis	59.58	0.00e+00	971.00
IUUC-Gga-041276	Gallus gallus	45.08	2.00e-154	537.00
IUUC-Gac-042020	Gasterosteus aculeatus	48.24	2.00e-152	531.00
IUUC-Ggo-045332	Gorilla gorilla	48.58	4.00e-154	536.00
IUUC-Hsa-045968	Homo sapiens	48.58	2.00e-154	538.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	46.51	4.00e-162	563.00
IUUC-Kpa-049273	Komagataella pastoris	61.24	0.00e+00	983.00
IUUC-Lch-050454	Latimeria chalumnae	48.14	4.00e-162	563.00
IUUC-Loc-052647	Lepisosteus oculatus	45.93	4.00e-162	563.00
IUUC-Lma-052980	Leptosphaeria maculans	56.36	2.00e-162	563.00
IUUC-Laf-054383	Loxodonta africana	47.97	1.00e-161	561.00
IUUC-Mcc-055532	Macaca mulatta	46.51	2.00e-162	564.00
IUUC-Meu-056436	Macropus eugenii	46.07	2.00e-121	428.00
IUUC-Mor-057097	Magnaporthe oryzae	61.50	0.00e+00	996.00
IUUC-Mpo-057442	Magnaporthe poae	58.50	0.00e+00	898.00
IUUC-Mla-058996	Melampsora laricipopulina	64.92	0.00e+00	1088.00
IUUC-Mga-059661	Meleagris gallopavo	46.60	5.00e-163	566.00
IUUC-Mvi-060395	Microbotryum violaceum	65.30	0.00e+00	1058.00
IUUC-Mmr-061135	Microcebus murinus	46.67	4.00e-162	563.00
IUUC-Mdo-062505	Monodelphis domestica	47.28	5.00e-161	559.00
IUUC-Mmu-064136	Mus musculus	48.58	9.00e-155	539.00
IUUC-Mpu-066203	Mustela putorius furo	47.97	1.00e-161	561.00
IUUC-Mlu-067837	Myotis lucifugus	48.31	2.00e-162	564.00
IUUC-Nfi-068427	Neosartorya fischeri	64.58	0.00e+00	1007.00
IUUC-Ncr-068918	Neurospora crassa	61.71	0.00e+00	967.00
IUUC-Nle-069244	Nomascus leucogenys	46.67	3.00e-162	563.00
IUUC-Opr-071044	Ochotona princeps	48.24	3.00e-153	533.00
IUUC-Ont-071798	Oreochromis niloticus	47.01	2.00e-162	564.00
IUUC-Oan-073497	Ornithorhynchus anatinus	44.62	7.00e-157	545.00
IUUC-Ocu-074160	Oryctolagus cuniculus	48.34	2.00e-152	531.00
IUUC-Ola-087467	Oryzias latipes	48.16	1.00e-153	535.00
IUUC-Oga-088460	Otolemur garnettii	48.58	2.00e-154	538.00
IUUC-Oar-090198	Ovis aries	48.18	1.00e-154	538.00
IUUC-Ptr-090939	Pan troglodytes	48.58	2.00e-154	538.00
IUUC-Pan-092454	Papio anubis	46.51	3.00e-162	563.00
IUUC-Psi-093645	Pelodiscus sinensis	45.93	3.00e-156	544.00
IUUC-Pma-094364	Petromyzon marinus	49.51	2.00e-137	480.00
IUUC-Pno-095118	Phaeosphaeria nodorum	61.81	0.00e+00	992.00
IUUC-Pfo-096937	Poecilia formosa	48.76	1.00e-162	565.00
IUUC-Pab-098088	Pongo abelii	48.58	2.00e-154	537.00
IUUC-Pca-100596	Procavia capensis	44.16	3.00e-142	497.00
IUUC-Pva-102354	Pteropus vampyrus	48.75	2.00e-154	538.00
IUUC-Pgr-103620	Puccinia graminis	71.34	0.00e+00	925.00
IUUC-Ptt-103806	Puccinia triticina	69.71	0.00e+00	787.00
IUUC-Pte-104016	Pyrenophora teres	63.38	0.00e+00	1010.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	63.38	0.00e+00	1010.00
IUUC-Rno-105318	Rattus norvegicus	48.58	1.00e-154	538.00
IUUC-Sce-106289	Saccharomyces cerevisiae	71.16	0.00e+00	888.00
IUUC-Sha-107175	Sarcophilus harrisii	45.29	8.00e-162	562.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	59.57	0.00e+00	999.00
IUUC-Spo-108171	Schizosaccharomyces pombe	61.21	0.00e+00	1001.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	60.38	0.00e+00	976.00
IUUC-Stu-112908	Solanum tuberosum	33.61	1.00e-55	209.00
IUUC-Sar-113761	Sorex araneus	47.80	2.00e-160	557.00
IUUC-Sre-114929	Sporisorium reilianum	76.22	0.00e+00	932.00
IUUC-Ssc-115368	Sus scrofa	40.59	7.00e-150	522.00
IUUC-Tgu-116632	Taeniopygia guttata	45.32	3.00e-155	540.00
IUUC-Tru-118442	Takifugu rubripes	48.54	9.00e-163	565.00
IUUC-Tsy-119492	Tarsius syrichta	48.58	2.00e-153	534.00
IUUC-Tni-120151	Tetraodon nigroviridis	46.69	6.00e-154	536.00
IUUC-Tre-122203	Trichoderma reesei	60.14	0.00e+00	959.00
IUUC-Tvi-122595	Trichoderma virens	59.18	0.00e+00	963.00
IUUC-Tme-126897	Tuber melanosporum	61.44	0.00e+00	932.00
IUUC-Tbe-127793	Tupaia belangeri	47.75	6.00e-133	466.00
IUUC-Ttr-128275	Tursiops truncatus	47.44	7.00e-153	532.00
IUUC-Uma-129332	Ustilago maydis	76.39	0.00e+00	890.00
IUUC-Vda-129753	Verticillium dahliae	60.46	0.00e+00	945.00
IUUC-Vpa-130503	Vicugna pacos	49.59	3.00e-133	468.00
IUUC-Xtr-132859	Xenopus tropicalis	46.34	3.00e-158	550.00
IUUC-Xma-133797	Xiphophorus maculatus	47.85	4.00e-155	540.00
IUUC-Yli-134668	Yarrowia lipolytica	68.23	0.00e+00	887.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence