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Tag Content
UUCD2 ID IUUC-Dre-027472
UUCD1 version UUC-DaR-00231
Ensembl Protein ID ENSDARP00000123243.1
UniProt Accession B8JLD4; B8JLD4_DANRE
Genbank Protein ID ENSDARP00000123243
Protein Name HECT and RLD domain-containing E3 ubiquitin protein ligase 3
Genbank Nucleotide ID CU467858
Gene Name herc3; si:ch73-190m4.3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000075887.4 ENSDART00000141977.1 ENSDARP00000123243.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 1.60e-94 317.9 722 1045
Active Site
Position(s) Description Evidence
1014 Glycyl thioester intermediate {ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
            dlkk l+v f gEe++d+gGvt+ef+ ll+kel np +g+f++ ++++  ++ ++        + ++F+++G+++g+a++++ ++d
   Q: 722  VDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELMNPIYGMFTQYSESNLLWFSDKCFV-----EHNWFHLIGIICGLAIYNSTVVD 803
           589***************************************99999999999888665.....578******************** PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           l+++ ++yk+ll+ + +l+dl+e+ p+  +sl++++e  e d+ee+ ++l+f ++ e +g t+++eL++gG++i V ++N++e+v++
   Q: 804  LHFPLVLYKKLLEISPTLDDLKELSPTEGRSLQQLLEF-EGDVEET-FCLNFAITREYYGITEVKELVQGGKTIAVDKTNRKEFVQA 888
           ************************************99.7899997.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +++y + + ++eq+ af++Gf +v+  e+lslF+++el  ++ G++++++e+++k+++ykg++++++p++++Fwev++efs e++k+
   Q: 889  YLQYVFSDAVQEQYSAFSSGFLKVCGGEILSLFQPSELMAMVVGNNNYNWEEMEKNASYKGEFSATHPTVKMFWEVFHEFSLEKKKQ 975
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           fL F+Tgs+r+P+ G+a+l+   +vi+  +a+++ lP ++TC+n+L++P Y++ke+l+++L+ A+e+ +gF+l
   Q: 976  FLLFLTGSDRIPIHGMASLR---IVIQStAAEEHYLPVAHTCYNMLDMPCYQTKETLRQRLTQAVEQYEGFSL 1045
           ********************...8888867788**************************************97 PP
   
Organism Danio rerio
Protein Sequence
(Fasta)
MMLCWGSSGA GQLGIGASEA SVFEPRSCCV FDGRGLKEVA CGNQHSLFLL HDGSVYTCGS 60
NSCGQLGHDK GGSRPELVGA LDAQKISGVS CGQAHSLAVN EQGQVFAWGA GDGGQLGLGT 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dre-027472|E3,HECT|Danio rerio
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GAGTCGTAAC TTCCTTGTTT TTGTCGGAAC CATTAAACTG AAAGCATTCC AGCAATATAC 60
GGTCAAAATA AAGAGGAGGC GAGATGCATT TCACCAGGTA ACACTTTCCA AATTAACCCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dre-027472|E3,HECT|Danio rerio
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
Pfam

PF00632--HECT
PF00415--RCC1
PRINTS

PR00633--RCCNDNSATION
SMART

SM00119--HECTc
Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
KEGG dre:100003587
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001673 Ailuropoda melanoleuca 66.35 0.00e+00 1382.00
IUUC-Apl-003535 Anas platyrhynchos 67.40 0.00e+00 1404.00
IUUC-Aca-005223 Anolis carolinensis 66.25 0.00e+00 1390.00
IUUC-Ame-010816 Astyanax mexicanus 82.78 0.00e+00 1508.00
IUUC-Bta-013373 Bos taurus 66.44 0.00e+00 1388.00
IUUC-Cel-018150 Caenorhabditis elegans 33.92 3.00e-154 539.00
IUUC-Cja-019609 Callithrix jacchus 66.44 0.00e+00 1379.00
IUUC-Cfa-021071 Canis familiaris 66.25 0.00e+00 1377.00
IUUC-Cpo-021548 Cavia porcellus 66.16 0.00e+00 1373.00
IUUC-Csa-023987 Chlorocebus sabaeus 66.44 0.00e+00 1380.00
IUUC-Cho-024325 Choloepus hoffmanni 72.36 0.00e+00 883.00
IUUC-Dno-029241 Dasypus novemcinctus 65.94 0.00e+00 1368.00
IUUC-Dor-030672 Dipodomys ordii 55.76 0.00e+00 659.00
IUUC-Ete-032642 Echinops telfairi 64.82 0.00e+00 1310.00
IUUC-Eca-033646 Equus caballus 66.16 0.00e+00 1375.00
IUUC-Eeu-035098 Erinaceus europaeus 62.28 0.00e+00 846.00
IUUC-Fal-036952 Ficedula albicollis 67.49 0.00e+00 1404.00
IUUC-Gmo-039297 Gadus morhua 77.65 0.00e+00 1615.00
IUUC-Gga-040591 Gallus gallus 66.86 0.00e+00 1392.00
IUUC-Gac-041741 Gasterosteus aculeatus 79.14 0.00e+00 1696.00
IUUC-Gma-043616 Glycine max 37.25 9.00e-51 194.00
IUUC-Ggo-044769 Gorilla gorilla 66.48 0.00e+00 1377.00
IUUC-Hsa-046066 Homo sapiens 66.44 0.00e+00 1380.00
IUUC-Itr-048311 Ictidomys tridecemlineatus 66.38 0.00e+00 1376.00
IUUC-Lch-050301 Latimeria chalumnae 68.64 0.00e+00 1467.00
IUUC-Loc-052803 Lepisosteus oculatus 78.68 0.00e+00 1744.00
IUUC-Laf-053364 Loxodonta africana 66.54 0.00e+00 1383.00
IUUC-Mcc-054930 Macaca mulatta 66.44 0.00e+00 1381.00
IUUC-Meu-056274 Macropus eugenii 53.94 3.00e-158 552.00
IUUC-Mga-059563 Meleagris gallopavo 67.21 0.00e+00 1402.00
IUUC-Mmr-060792 Microcebus murinus 65.59 0.00e+00 1348.00
IUUC-Mdo-062195 Monodelphis domestica 66.57 0.00e+00 1382.00
IUUC-Mmu-063855 Mus musculus 65.40 0.00e+00 1370.00
IUUC-Mpu-066308 Mustela putorius furo 66.35 0.00e+00 1381.00
IUUC-Mlu-066927 Myotis lucifugus 66.25 0.00e+00 1382.00
IUUC-Nle-070090 Nomascus leucogenys 66.54 0.00e+00 1381.00
IUUC-Opr-070891 Ochotona princeps 59.29 0.00e+00 1177.00
IUUC-Ont-072201 Oreochromis niloticus 77.25 0.00e+00 1637.00
IUUC-Ocu-074770 Oryctolagus cuniculus 66.44 0.00e+00 1383.00
IUUC-Ola-086550 Oryzias latipes 78.27 0.00e+00 1686.00
IUUC-Oga-088831 Otolemur garnettii 66.06 0.00e+00 1370.00
IUUC-Oar-090449 Ovis aries 66.54 0.00e+00 1386.00
IUUC-Pan-092135 Papio anubis 66.48 0.00e+00 1382.00
IUUC-Psi-093832 Pelodiscus sinensis 66.00 0.00e+00 1394.00
IUUC-Pfo-097268 Poecilia formosa 78.80 0.00e+00 1689.00
IUUC-Pab-098249 Pongo abelii 66.35 0.00e+00 1380.00
IUUC-Pca-100855 Procavia capensis 60.25 0.00e+00 890.00
IUUC-Pva-102506 Pteropus vampyrus 63.89 0.00e+00 1189.00
IUUC-Rno-105242 Rattus norvegicus 65.78 0.00e+00 1410.00
IUUC-Sar-113612 Sorex araneus 73.59 4.00e-163 569.00
IUUC-Ssc-115473 Sus scrofa 66.54 0.00e+00 1384.00
IUUC-Tgu-116974 Taeniopygia guttata 67.43 0.00e+00 1386.00
IUUC-Tru-118077 Takifugu rubripes 76.37 0.00e+00 1604.00
IUUC-Tsy-119619 Tarsius syrichta 56.34 0.00e+00 1168.00
IUUC-Tni-120807 Tetraodon nigroviridis 77.53 0.00e+00 1630.00
IUUC-Tbe-127640 Tupaia belangeri 64.24 0.00e+00 1293.00
IUUC-Ttr-129172 Tursiops truncatus 66.16 0.00e+00 1368.00
IUUC-Xtr-132194 Xenopus tropicalis 59.16 0.00e+00 1145.00
Created Date 25-Jun-2017

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