iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gac-042519

UUCD1 version

UUC-GaA-00629

Ensembl Protein ID

ENSGACP00000016366.1

UniProt Accession

G3PFJ2; G3PFJ2_GASAC

Protein Name

E3 ubiquitin-protein ligase parkin

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGACG00000012371.1	ENSGACT00000016390.1	ENSGACP00000016358.1
ENSGACG00000012371.1	ENSGACT00000016398.1	ENSGACP00000016366.1
ENSGACG00000012371.1	ENSGACT00000016406.1	ENSGACP00000016374.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UBQ/UBQ_Other	6.30e-08	32.8	14	71

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_Other

   S: 14   tlkvnpsdtVaeLKekiekklgippeqqrLiykGkiLeddktLadyglkdgstihlle 71
           ++++ + ++Va+L++ + +++g+++e  r +++G++L+   tL+ ++l++ st+h+++
   Q: 14   PVELQEEASVADLQQLVGSQQGVHAELLRVLFAGRELKSSFTLQGCDLPEQSTVHVVL 71
           66778889************************************************96 PP

Organism

Gasterosteus aculeatus

Functional Description
(View)

Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

Protein Sequence
(Fasta)

MIIYVRYNLG PCVPVELQEE ASVADLQQLV GSQQGVHAEL LRVLFAGREL KSSFTLQGCD 60
LPEQSTVHVV LPKSAPTPGH LLLLRERLAG GGQEEGNSLA RLDISSSRFP CTPPGLDGSN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTGAACGACA AATCGGCTGA TGATAAGTGA GCCCTGCCTC GAATCTGCCA CAAGTATACT 60
TATACCTCAC ATACACTACA AGTATAGTGT ATGTGAGGTA TACGTAGGAT TCGTTTTTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR003977--Parkin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF01485--IBR
PF00240--ubiquitin

PRINTS

PR01475--PARKIN

SMART

SM00647--IBR
SM00213--UBQ

Gene Ontology

GO:0005829--C:cytosol
GO:0005739--C:mitochondrion
GO:0005634--C:nucleus
GO:0000151--C:ubiquitin ligase complex
GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001814	Ailuropoda melanoleuca	46.51	9.00e-69	253.00
IUUC-Apl-003304	Anas platyrhynchos	57.94	2.00e-114	405.00
IUUC-Aca-004908	Anolis carolinensis	53.27	6.00e-32	128.00
IUUC-Ame-011856	Astyanax mexicanus	57.66	2.00e-154	538.00
IUUC-Bta-013014	Bos taurus	50.00	3.00e-107	382.00
IUUC-Cel-018687	Caenorhabditis elegans	29.47	4.00e-40	158.00
IUUC-Cja-019274	Callithrix jacchus	45.82	5.00e-69	254.00
IUUC-Cfa-020461	Canis familiaris	45.70	6.00e-68	250.00
IUUC-Cpo-022251	Cavia porcellus	44.78	4.00e-69	254.00
IUUC-Csa-023112	Chlorocebus sabaeus	45.27	5.00e-64	237.00
IUUC-Cho-024504	Choloepus hoffmanni	34.37	8.00e-73	267.00
IUUC-Dre-028202	Danio rerio	57.02	2.00e-142	498.00
IUUC-Dno-028946	Dasypus novemcinctus	50.00	1.00e-23	100.00
IUUC-Dor-030508	Dipodomys ordii	42.09	7.00e-73	267.00
IUUC-Dme-031980	Drosophila melanogaster	40.88	4.00e-102	365.00
IUUC-Ete-032281	Echinops telfairi	42.01	2.00e-49	189.00
IUUC-Eca-033228	Equus caballus	45.64	1.00e-68	253.00
IUUC-Fal-037507	Ficedula albicollis	51.06	7.00e-136	477.00
IUUC-Gmo-038744	Gadus morhua	61.48	4.00e-95	341.00
IUUC-Gga-040353	Gallus gallus	50.84	4.00e-134	471.00
IUUC-Hsa-046016	Homo sapiens	50.64	3.00e-129	455.00
IUUC-Itr-048744	Ictidomys tridecemlineatus	50.11	9.00e-122	430.00
IUUC-Loc-052389	Lepisosteus oculatus	53.33	7.00e-137	480.00
IUUC-Mcc-054933	Macaca mulatta	50.63	7.00e-129	453.00
IUUC-Meu-055963	Macropus eugenii	41.27	6.00e-79	287.00
IUUC-Mpo-057509	Magnaporthe poae	32.93	2.00e-10	59.70
IUUC-Mga-059626	Meleagris gallopavo	61.33	2.00e-23	100.00
IUUC-Mmr-061566	Microcebus murinus	58.53	2.00e-60	224.00
IUUC-Mdo-062933	Monodelphis domestica	68.06	3.00e-25	105.00
IUUC-Mmu-063561	Mus musculus	50.00	2.00e-133	469.00
IUUC-Mpu-065799	Mustela putorius furo	45.48	1.00e-68	253.00
IUUC-Mlu-068134	Myotis lucifugus	48.77	7.00e-90	323.00
IUUC-Nle-070078	Nomascus leucogenys	44.95	5.00e-70	257.00
IUUC-Opr-070541	Ochotona princeps	49.90	4.00e-117	414.00
IUUC-Ont-071743	Oreochromis niloticus	66.88	5.00e-178	617.00
IUUC-Ola-086426	Oryzias latipes	72.51	2.00e-74	270.00
IUUC-Oga-088867	Otolemur garnettii	49.16	3.00e-125	441.00
IUUC-Oar-089365	Ovis aries	49.32	5.00e-97	347.00
IUUC-Ptr-091371	Pan troglodytes	50.63	4.00e-128	451.00
IUUC-Pan-092443	Papio anubis	46.28	3.00e-68	251.00
IUUC-Psi-093851	Pelodiscus sinensis	46.34	4.00e-57	214.00
IUUC-Pfo-097194	Poecilia formosa	62.80	2.00e-161	562.00
IUUC-Pab-097999	Pongo abelii	56.00	6.00e-53	201.00
IUUC-Pca-100410	Procavia capensis	48.50	3.00e-103	368.00
IUUC-Pva-102300	Pteropus vampyrus	45.74	3.00e-104	372.00
IUUC-Rno-105556	Rattus norvegicus	45.79	9.00e-69	253.00
IUUC-Sar-113121	Sorex araneus	68.42	1.00e-42	167.00
IUUC-Ssc-116435	Sus scrofa	46.26	2.00e-68	251.00
IUUC-Tgu-117489	Taeniopygia guttata	51.06	1.00e-135	476.00
IUUC-Tru-117927	Takifugu rubripes	65.62	0.00e+00	641.00
IUUC-Tsy-119372	Tarsius syrichta	59.13	1.00e-108	386.00
IUUC-Tni-120043	Tetraodon nigroviridis	65.06	8.00e-164	570.00
IUUC-Tbe-127539	Tupaia belangeri	43.34	4.00e-96	345.00
IUUC-Ttr-129149	Tursiops truncatus	49.79	1.00e-132	466.00
IUUC-Vpa-130439	Vicugna pacos	38.82	4.00e-83	301.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence