iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Xtr-132881

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAMC01003094

Gene Name

ube3a

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXETG00000024326.3	ENSXETT00000052575.3	ENSXETP00000052575.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	3.50e-109	365.4	582	908

Active Site

Position(s)	Description	Evidence
877	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e+ k++++ np+s+    e +  F+++G++lg+a++++ +ld+
   Q: 582  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDESTKHSWF-NPSSF----ETEGQFTLIGIVLGLAIYNNCILDV 665
           689***********************************************9998.88887....789********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfs.vseeilgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl++ +p ly+slke++e+ e ++ee  + +tf+  +++++g+   ++Lk++G++ip+tneN++e+v+l++
   Q: 666  HFPMVVYRKLMGKKGTFRDLADSHPVLYQSLKELLEY-EGNVEED-MMMTFQiSQTDLFGNPLMHDLKENGDKIPITNENRKEFVSLYT 752
           *************************************.6677775.8999993445569****************************** PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           +y+l++++++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+++lk++t+y+ggyt+ds+ i+ Fwe++++f++e+++ fLq
   Q: 753  DYILNKSVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNLDFQALKDTTEYDGGYTRDSNIIKEFWEIVNSFTEEQKRLFLQ 841
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d drlP+s+TCfn+L LPeYs+ke+lke+Ll Ai+++kgF++
   Q: 842  FTTGTDRAPVGGLGKLK---MIIAKNGPDtDRLPTSHTCFNVLLLPEYSNKEKLKERLLKAITYAKGFGM 908
           *****************...8888866666**************************************97 PP

Organism

Xenopus tropicalis

Protein Sequence
(Fasta)

MSSPDKRWQQ EREGAPEPEE RRTNTPRSSP GHSPEGDSRS PGDPYSENLE NSRMKRAAAK 60
HLIERYYHQL TEGCGNETCT NEFCASCPTF LRMDNNAAAI KALELYKVNA KLCDPHPSKK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTCGCGAG ATGAGACTTT TGACGTCGGG ATTAGCTGTC CGGCAGGGGC CAGGAATCTG 60
GGTATTATCG GCGTTGCGGG ACGTTTAAGC AGCAATCTGG GACTGCGGGC TGTGTTTAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A

PROSITE

PS50237--HECT

Pfam

PF16558--AZUL
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0061630--F:ubiquitin protein ligase activity
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002214	Ailuropoda melanoleuca	92.28	0.00e+00	1537.00
IUUC-Atr-003144	Amborella trichopoda	45.23	2.00e-96	346.00
IUUC-Apl-003742	Anas platyrhynchos	90.62	0.00e+00	1593.00
IUUC-Aca-004873	Anolis carolinensis	91.91	0.00e+00	1593.00
IUUC-Ago-007908	Ashbya gossypii	34.86	4.00e-70	259.00
IUUC-Ani-009176	Aspergillus nidulans	33.17	1.00e-83	304.00
IUUC-Ame-011166	Astyanax mexicanus	86.13	0.00e+00	1448.00
IUUC-Bgr-011981	Blumeria graminis	37.97	6.00e-84	305.00
IUUC-Bta-013286	Bos taurus	91.04	0.00e+00	1504.00
IUUC-Cja-019707	Callithrix jacchus	91.50	0.00e+00	1553.00
IUUC-Cfa-020154	Canis familiaris	90.13	0.00e+00	1538.00
IUUC-Cpo-021292	Cavia porcellus	91.11	0.00e+00	1512.00
IUUC-Cre-022790	Chlamydomonas reinhardtii	47.80	1.00e-80	292.00
IUUC-Csa-023378	Chlorocebus sabaeus	91.16	0.00e+00	1545.00
IUUC-Cho-025059	Choloepus hoffmanni	89.25	0.00e+00	1470.00
IUUC-Cin-025643	Ciona intestinalis	44.42	0.00e+00	706.00
IUUC-Csv-026282	Ciona savignyi	44.18	0.00e+00	656.00
IUUC-Cme-027151	Cyanidioschyzon merolae	43.12	8.00e-99	355.00
IUUC-Dre-027901	Danio rerio	84.71	0.00e+00	1427.00
IUUC-Dno-029320	Dasypus novemcinctus	91.96	0.00e+00	1568.00
IUUC-Dor-030756	Dipodomys ordii	88.13	0.00e+00	697.00
IUUC-Dme-032035	Drosophila melanogaster	43.00	6.00e-167	581.00
IUUC-Eca-033843	Equus caballus	91.70	0.00e+00	1497.00
IUUC-Eeu-035109	Erinaceus europaeus	89.94	0.00e+00	1475.00
IUUC-Fca-036344	Felis catus	90.14	0.00e+00	1540.00
IUUC-Fal-036747	Ficedula albicollis	90.50	0.00e+00	1592.00
IUUC-Fox-037941	Fusarium oxysporum	32.33	7.00e-93	335.00
IUUC-Gmo-038840	Gadus morhua	63.75	0.00e+00	1101.00
IUUC-Gga-040399	Gallus gallus	90.50	0.00e+00	1592.00
IUUC-Gac-041933	Gasterosteus aculeatus	85.63	0.00e+00	1396.00
IUUC-Ggo-044804	Gorilla gorilla	91.59	0.00e+00	1546.00
IUUC-Hsa-045727	Homo sapiens	91.59	0.00e+00	1546.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	88.19	0.00e+00	1434.00
IUUC-Kpa-049152	Komagataella pastoris	34.72	1.00e-63	238.00
IUUC-Lch-050197	Latimeria chalumnae	90.36	0.00e+00	1558.00
IUUC-Loc-052743	Lepisosteus oculatus	88.83	0.00e+00	1539.00
IUUC-Lma-053245	Leptosphaeria maculans	35.11	2.00e-59	224.00
IUUC-Laf-053615	Loxodonta africana	91.24	0.00e+00	1546.00
IUUC-Mcc-054934	Macaca mulatta	91.47	0.00e+00	1544.00
IUUC-Meu-056061	Macropus eugenii	94.28	0.00e+00	1332.00
IUUC-Mor-057045	Magnaporthe oryzae	37.39	7.00e-84	305.00
IUUC-Mga-059271	Meleagris gallopavo	89.81	0.00e+00	1571.00
IUUC-Mmr-061288	Microcebus murinus	91.36	0.00e+00	1541.00
IUUC-Mdo-062975	Monodelphis domestica	93.58	0.00e+00	1597.00
IUUC-Mmu-063674	Mus musculus	89.55	0.00e+00	1496.00
IUUC-Mpu-066568	Mustela putorius furo	91.62	0.00e+00	1560.00
IUUC-Mlu-067522	Myotis lucifugus	84.83	0.00e+00	1436.00
IUUC-Nle-069505	Nomascus leucogenys	91.59	0.00e+00	1546.00
IUUC-Opr-070570	Ochotona princeps	84.20	0.00e+00	1385.00
IUUC-Ont-071527	Oreochromis niloticus	86.76	0.00e+00	1473.00
IUUC-Oan-073446	Ornithorhynchus anatinus	88.70	0.00e+00	1041.00
IUUC-Ocu-074922	Oryctolagus cuniculus	89.29	0.00e+00	1537.00
IUUC-Ola-086996	Oryzias latipes	84.54	0.00e+00	1461.00
IUUC-Oga-088261	Otolemur garnettii	91.93	0.00e+00	1526.00
IUUC-Oar-090024	Ovis aries	91.04	0.00e+00	1504.00
IUUC-Ptr-090455	Pan troglodytes	91.59	0.00e+00	1546.00
IUUC-Pan-092509	Papio anubis	89.76	0.00e+00	1383.00
IUUC-Psi-092974	Pelodiscus sinensis	90.84	0.00e+00	1561.00
IUUC-Pma-094643	Petromyzon marinus	71.02	0.00e+00	1242.00
IUUC-Pno-094886	Phaeosphaeria nodorum	35.84	2.00e-60	228.00
IUUC-Pfo-096905	Poecilia formosa	84.84	0.00e+00	1471.00
IUUC-Pab-097840	Pongo abelii	89.37	0.00e+00	1487.00
IUUC-Pca-100869	Procavia capensis	91.94	0.00e+00	1538.00
IUUC-Pva-103040	Pteropus vampyrus	92.56	0.00e+00	640.00
IUUC-Pgr-103315	Puccinia graminis	37.45	2.00e-76	280.00
IUUC-Ptt-103736	Puccinia triticina	38.43	1.00e-78	288.00
IUUC-Rno-105453	Rattus norvegicus	89.55	0.00e+00	1498.00
IUUC-Sce-106306	Saccharomyces cerevisiae	33.80	4.00e-67	249.00
IUUC-Sha-107651	Sarcophilus harrisii	93.58	0.00e+00	1599.00
IUUC-Ssl-108657	Sclerotinia sclerotiorum	35.32	1.00e-77	285.00
IUUC-Smo-108858	Selaginella moellendorffii	48.84	7.00e-114	404.00
IUUC-Sar-113293	Sorex araneus	91.94	0.00e+00	1531.00
IUUC-Ssc-115979	Sus scrofa	91.46	0.00e+00	1523.00
IUUC-Tgu-116901	Taeniopygia guttata	90.50	0.00e+00	1592.00
IUUC-Tru-118368	Takifugu rubripes	86.27	0.00e+00	1469.00
IUUC-Tsy-119516	Tarsius syrichta	88.07	0.00e+00	1421.00
IUUC-Tni-120143	Tetraodon nigroviridis	84.56	0.00e+00	1462.00
IUUC-Tre-122108	Trichoderma reesei	40.00	8.00e-81	295.00
IUUC-Tbe-127484	Tupaia belangeri	87.11	0.00e+00	1053.00
IUUC-Ttr-129078	Tursiops truncatus	91.47	0.00e+00	1499.00
IUUC-Vda-129969	Verticillium dahliae	37.75	5.00e-85	309.00
IUUC-Vpa-130312	Vicugna pacos	84.17	0.00e+00	1286.00
IUUC-Xma-133122	Xiphophorus maculatus	84.62	0.00e+00	1465.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence