iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus
DNA Methylation
MethyCancer	TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/APC_C/APC_C	APC_C	21107322; 16763193

Organism

Homo sapiens

Functional Description
(View)

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.

Protein Sequence
(Fasta)

MDSEVQRDGR ILDLIDDAWR EDKLPYEDVA IPLNELPEPE QDNGGTTESV KEQEMKWTDL 60
ALQYLHENVP PIGN 74

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Nucleotide Sequence
(Fasta)

ACACTAAATG AGCGGGTCCC CTTGTGCCGT GAATGAAGTA GTCCCAACAG CGCTAGCTAG 60
ACAGCAGCCC TGGCAGGGAG GCCGCACTGG GGTCTCTCCG CTGAAAAGGA AGGTGGGTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0498--Mitosis
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR008401--Apc13p

Pfam

PF05839--Apc13p

Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0070979--P:protein K11-linked ubiquitination

KEGG

hsa:25847

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002060	Ailuropoda melanoleuca	100.00	8.00e-39	150.00
IUUC-Apl-003793	Anas platyrhynchos	98.65	2.00e-38	149.00
IUUC-Ang-009807	Aspergillus niger	40.74	6.90e-02	31.60
IUUC-Ame-011473	Astyanax mexicanus	82.43	2.00e-32	129.00
IUUC-Bta-013245	Bos taurus	100.00	8.00e-39	150.00
IUUC-Bdi-014946	Brachypodium distachyon	28.33	4.50e-02	28.90
IUUC-Cja-019842	Callithrix jacchus	100.00	8.00e-39	150.00
IUUC-Cfa-020699	Canis familiaris	98.63	6.00e-38	148.00
IUUC-Cpo-021689	Cavia porcellus	100.00	8.00e-39	150.00
IUUC-Cre-022801	Chlamydomonas reinhardtii	36.84	1.00e-04	37.70
IUUC-Csa-024230	Chlorocebus sabaeus	100.00	8.00e-39	150.00
IUUC-Cho-024912	Choloepus hoffmanni	100.00	3.00e-19	86.30
IUUC-Dre-027502	Danio rerio	82.43	1.00e-32	130.00
IUUC-Dno-030028	Dasypus novemcinctus	98.65	3.00e-38	149.00
IUUC-Dme-032017	Drosophila melanogaster	47.69	2.00e-13	67.00
IUUC-Fca-036477	Felis catus	98.65	1.00e-38	150.00
IUUC-Gmo-038910	Gadus morhua	82.19	2.00e-31	126.00
IUUC-Gga-040341	Gallus gallus	97.30	5.00e-38	148.00
IUUC-Gac-041662	Gasterosteus aculeatus	82.43	7.00e-33	131.00
IUUC-Ggo-044981	Gorilla gorilla	100.00	8.00e-39	150.00
IUUC-Itr-048223	Ictidomys tridecemlineatus	98.65	1.00e-38	150.00
IUUC-Lch-049909	Latimeria chalumnae	85.14	7.00e-33	131.00
IUUC-Loc-052273	Lepisosteus oculatus	83.78	6.00e-33	131.00
IUUC-Laf-054010	Loxodonta africana	98.65	1.00e-38	150.00
IUUC-Mcc-055444	Macaca mulatta	100.00	8.00e-39	150.00
IUUC-Meu-056616	Macropus eugenii	97.30	4.00e-38	148.00
IUUC-Mor-056997	Magnaporthe oryzae	32.86	5.60e-02	29.60
IUUC-Mpo-057556	Magnaporthe poae	33.80	3.00e-02	30.40
IUUC-Mmr-061624	Microcebus murinus	100.00	8.00e-39	150.00
IUUC-Mdo-062411	Monodelphis domestica	97.30	4.00e-38	148.00
IUUC-Mmu-063347	Mus musculus	95.95	1.00e-36	144.00
IUUC-Mlu-067784	Myotis lucifugus	98.65	3.00e-38	149.00
IUUC-Nle-069142	Nomascus leucogenys	100.00	8.00e-39	150.00
IUUC-Opr-070423	Ochotona princeps	92.68	4.00e-18	82.00
IUUC-Ont-072545	Oreochromis niloticus	82.43	6.00e-33	131.00
IUUC-Ocu-073965	Oryctolagus cuniculus	98.65	5.00e-39	154.00
IUUC-Ola-087398	Oryzias latipes	82.43	6.00e-33	131.00
IUUC-Olu-087731	Ostreococcus lucimarinus	45.24	1.10e-02	31.20
IUUC-Oga-088169	Otolemur garnettii	98.65	1.00e-38	150.00
IUUC-Oar-089282	Ovis aries	100.00	8.00e-39	150.00
IUUC-Ptr-090825	Pan troglodytes	100.00	8.00e-39	150.00
IUUC-Pan-092483	Papio anubis	100.00	8.00e-39	150.00
IUUC-Pma-094442	Petromyzon marinus	72.86	2.00e-25	106.00
IUUC-Ppa-095318	Physcomitrella patens	33.33	3.00e-02	29.60
IUUC-Pfo-097112	Poecilia formosa	82.43	6.00e-33	131.00
IUUC-Pab-097629	Pongo abelii	100.00	8.00e-39	150.00
IUUC-Pca-100124	Procavia capensis	100.00	8.00e-39	150.00
IUUC-Pva-103072	Pteropus vampyrus	100.00	8.00e-39	150.00
IUUC-Rno-105841	Rattus norvegicus	95.95	1.00e-36	144.00
IUUC-Sha-107152	Sarcophilus harrisii	97.30	4.00e-38	148.00
IUUC-Ssc-115839	Sus scrofa	91.89	2.00e-34	136.00
IUUC-Tru-117841	Takifugu rubripes	85.14	9.00e-34	134.00
IUUC-Tsy-119486	Tarsius syrichta	97.56	4.00e-19	85.90
IUUC-Tur-126739	Triticum urartu	37.50	7.90e-02	28.10
IUUC-Ttr-128740	Tursiops truncatus	97.56	3.00e-16	76.30
IUUC-Vpa-130292	Vicugna pacos	98.65	2.00e-38	150.00
IUUC-Xtr-132252	Xenopus tropicalis	89.19	7.00e-27	111.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence