iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	Mentha
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.90e-102	342.5	788	1122

Active Site

Position(s)	Description	Evidence
1090	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvg.....EegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsk 94
           dl+ +++++fv      E+g+d gGv+refl++l+k  ++p+ g+f+ + ++k   +pn +  ++  +++k+++f+Gr+lgk+++++ l++lpl++
   Q: 788  DLRFKFRIQFVSslgldEAGIDGGGVFREFLSELIKTAFDPNRGFFMVTTDNKLYPNPNVADLFE--DYEKHYYFIGRILGKSIYENLLVELPLAE 881
           66667888888888899******************************************999974..9**************************** PP
   S: 95   sfyklllgk..klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegike 188
           +f+ +l gk  +++++ l+++dpely++l ++k++ + d++el+ld+t  v +++lg+t+ +eLkp+G++ipVtn+N+ eY +l+++y+l+ +i++
   Q: 882  FFLTKLAGKysDVDIHQLASLDPELYRNLLYLKDY-SGDVSELNLDFT--VASSSLGQTQIVELKPQGQSIPVTNSNRIEYLQLIADYKLNVQIRR 974
           *********667889********************.668888655555..56888***************************************** PP
   S: 189  qveafreGfneviplellslFteeelellicGe.eeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk 283
           +++afr+G+++v+p+e+l +F+++el++li+G    id+edlkk+++y g++++++p i +Fwevle+f++ +r+++L+FvT++sr Pl Gf++l 
   Q: 975  HCNAFRKGLSNVLPIEWLYMFSNKELQILISGAeIPIDLEDLKKHCEYGGEFSPEHPSIVTFWEVLEGFDDMQRRQLLKFVTSCSRPPLLGFKDLD 1070
           *********************************889************************************************************ PP
   S: 284  prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           p  f i++ ++ +rlP+++TC+n+LkLP++++ e+++ekLlyAi++++gFels
   Q: 1071 PP-FFIQNTGDMERLPTASTCTNLLKLPPFKTVEQMREKLLYAIQSGAGFELS 1122
           99.777777999**************************************985 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MFGFDGEYRR RPVQSLGGAS HTCDRDTVIR KAALERQKRN ELRQKENGAV VLQSYARSFI 60
HRQRRKRAER EVFDIYLMGH KDGIVEDESL TFLLRRLNFF YSIREAKDSE RLIEVCQQIL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATAACTTGCT ATCGAAATAC GCAAGAGAAA TATACAAATC ATTGGCAAAT TGGGATTTAC 60
GCATTTCAAA TTCGATCGTA TCGGCAGGAA ACGCGTGTAA AATAGTCAAT TTCCGATCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR000048--IQ_motif_EF-hand-BS

PROSITE

PS50237--HECT
PS50096--IQ

Pfam

PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0000209--P:protein polyubiquitination

KEGG

dme:Dmel_CG3356

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001355	Ailuropoda melanoleuca	37.79	0.00e+00	647.00
IUUC-Apl-003731	Anas platyrhynchos	37.87	0.00e+00	681.00
IUUC-Aca-005248	Anolis carolinensis	37.82	0.00e+00	699.00
IUUC-Ago-007748	Ashbya gossypii	37.35	2.00e-69	256.00
IUUC-Acl-008158	Aspergillus clavatus	36.97	3.00e-71	263.00
IUUC-Afl-008398	Aspergillus flavus	37.61	7.00e-74	271.00
IUUC-Afu-008937	Aspergillus fumigatus	37.61	2.00e-72	266.00
IUUC-Ani-009252	Aspergillus nidulans	36.97	2.00e-78	287.00
IUUC-Ang-009773	Aspergillus niger	37.61	5.00e-73	268.00
IUUC-Aor-009940	Aspergillus oryzae	37.61	6.00e-74	271.00
IUUC-Ate-010395	Aspergillus terreus	37.39	9.00e-74	271.00
IUUC-Ame-010769	Astyanax mexicanus	39.97	2.00e-117	416.00
IUUC-Bgr-012269	Blumeria graminis	38.70	3.00e-73	268.00
IUUC-Bta-012841	Bos taurus	48.50	1.00e-178	619.00
IUUC-Bci-013743	Botrytis cinerea	33.56	2.00e-82	300.00
IUUC-Bdi-014123	Brachypodium distachyon	43.12	6.00e-99	354.00
IUUC-Cja-019743	Callithrix jacchus	45.79	6.00e-175	607.00
IUUC-Cfa-021031	Canis familiaris	47.90	6.00e-176	610.00
IUUC-Cpo-022401	Cavia porcellus	48.50	2.00e-180	625.00
IUUC-Cre-022725	Chlamydomonas reinhardtii	44.76	1.00e-89	322.00
IUUC-Csa-024107	Chlorocebus sabaeus	48.07	4.00e-177	614.00
IUUC-Cho-024750	Choloepus hoffmanni	48.86	1.00e-133	469.00
IUUC-Cin-025432	Ciona intestinalis	41.40	7.00e-91	326.00
IUUC-Cgl-026559	Colletotrichum gloeosporioides	37.28	5.00e-79	288.00
IUUC-Cne-026841	Cryptococcus neoformans	44.67	3.00e-88	319.00
IUUC-Cme-027265	Cyanidioschyzon merolae	44.34	8.00e-93	334.00
IUUC-Dre-028196	Danio rerio	48.43	3.00e-176	611.00
IUUC-Dno-029024	Dasypus novemcinctus	48.29	1.00e-177	616.00
IUUC-Dse-031416	Dothistroma septosporum	36.94	2.00e-78	286.00
IUUC-Eca-033828	Equus caballus	37.74	0.00e+00	656.00
IUUC-Eeu-034604	Erinaceus europaeus	58.71	3.00e-65	243.00
IUUC-Fca-035907	Felis catus	37.78	0.00e+00	684.00
IUUC-Fal-037389	Ficedula albicollis	37.49	0.00e+00	694.00
IUUC-Fox-037788	Fusarium oxysporum	35.74	6.00e-86	311.00
IUUC-Fso-038088	Fusarium solani	35.21	2.00e-81	296.00
IUUC-Gmo-039254	Gadus morhua	37.73	1.00e-91	330.00
IUUC-Ggr-039941	Gaeumannomyces graminis	37.64	3.00e-79	289.00
IUUC-Gga-040310	Gallus gallus	37.98	0.00e+00	694.00
IUUC-Gac-042054	Gasterosteus aculeatus	38.57	9.00e-101	360.00
IUUC-Ggo-045031	Gorilla gorilla	48.07	3.00e-177	615.00
IUUC-Hsa-045880	Homo sapiens	48.21	1.00e-177	616.00
IUUC-Kpa-049307	Komagataella pastoris	32.88	1.00e-66	247.00
IUUC-Lch-050403	Latimeria chalumnae	37.72	0.00e+00	629.00
IUUC-Loc-052218	Lepisosteus oculatus	48.51	2.00e-178	618.00
IUUC-Lma-053096	Leptosphaeria maculans	37.88	4.00e-76	279.00
IUUC-Laf-054162	Loxodonta africana	35.69	6.00e-150	524.00
IUUC-Mcc-055127	Macaca mulatta	48.21	1.00e-177	616.00
IUUC-Mor-057021	Magnaporthe oryzae	33.28	4.00e-72	266.00
IUUC-Mpo-057570	Magnaporthe poae	36.76	6.00e-75	275.00
IUUC-Mla-059124	Melampsora laricipopulina	45.54	7.00e-100	356.00
IUUC-Mga-059581	Meleagris gallopavo	37.90	0.00e+00	683.00
IUUC-Mvi-060445	Microbotryum violaceum	37.60	3.00e-103	369.00
IUUC-Mmr-061360	Microcebus murinus	47.92	3.00e-173	601.00
IUUC-Mdo-062194	Monodelphis domestica	36.54	0.00e+00	679.00
IUUC-Mmu-064189	Mus musculus	37.94	0.00e+00	676.00
IUUC-Mpu-066439	Mustela putorius furo	47.99	1.00e-175	609.00
IUUC-Mlu-068228	Myotis lucifugus	37.69	0.00e+00	657.00
IUUC-Nfi-068280	Neosartorya fischeri	37.61	1.00e-72	267.00
IUUC-Ncr-068869	Neurospora crassa	33.97	3.00e-79	289.00
IUUC-Nle-069687	Nomascus leucogenys	47.92	1.00e-175	609.00
IUUC-Ont-071836	Oreochromis niloticus	47.32	3.00e-178	618.00
IUUC-Oan-072800	Ornithorhynchus anatinus	38.08	0.00e+00	702.00
IUUC-Ocu-074587	Oryctolagus cuniculus	48.20	5.00e-178	617.00
IUUC-Ola-087209	Oryzias latipes	47.77	2.00e-179	622.00
IUUC-Olu-087699	Ostreococcus lucimarinus	43.82	1.00e-86	311.00
IUUC-Oga-088776	Otolemur garnettii	47.77	5.00e-172	597.00
IUUC-Oar-089441	Ovis aries	48.50	4.00e-178	617.00
IUUC-Ptr-091273	Pan troglodytes	48.21	1.00e-177	616.00
IUUC-Pan-091981	Papio anubis	48.21	1.00e-177	616.00
IUUC-Psi-093203	Pelodiscus sinensis	35.80	9.00e-153	533.00
IUUC-Pma-094738	Petromyzon marinus	38.33	0.00e+00	700.00
IUUC-Pno-095132	Phaeosphaeria nodorum	33.75	3.00e-54	206.00
IUUC-Pfo-097511	Poecilia formosa	48.58	0.00e+00	627.00
IUUC-Pab-098634	Pongo abelii	44.58	6.00e-157	547.00
IUUC-Pop-099574	Populus trichocarpa	42.33	2.00e-88	319.00
IUUC-Pca-100987	Procavia capensis	60.88	2.00e-140	492.00
IUUC-Pva-103034	Pteropus vampyrus	35.01	5.00e-169	587.00
IUUC-Pgr-103513	Puccinia graminis	35.31	4.00e-100	358.00
IUUC-Ptt-103967	Puccinia triticina	32.62	2.00e-87	316.00
IUUC-Pte-104105	Pyrenophora teres	33.80	9.00e-75	275.00
IUUC-Pyt-104449	Pyrenophora triticirepentis	37.45	3.00e-74	273.00
IUUC-Rno-105380	Rattus norvegicus	44.40	4.00e-130	458.00
IUUC-Sce-106446	Saccharomyces cerevisiae	39.47	2.00e-66	246.00
IUUC-Sha-107108	Sarcophilus harrisii	35.71	1.00e-172	599.00
IUUC-Sja-107889	Schizosaccharomyces japonicus	41.75	1.00e-87	317.00
IUUC-Spo-108097	Schizosaccharomyces pombe	42.08	2.00e-88	320.00
IUUC-Ssl-108520	Sclerotinia sclerotiorum	33.85	6.00e-82	298.00
IUUC-Sar-113687	Sorex araneus	43.96	1.00e-100	360.00
IUUC-Sre-115038	Sporisorium reilianum	43.81	2.00e-93	336.00
IUUC-Ssc-115378	Sus scrofa	53.52	1.00e-118	419.00
IUUC-Tgu-116729	Taeniopygia guttata	37.37	0.00e+00	682.00
IUUC-Tru-118068	Takifugu rubripes	48.07	3.00e-179	622.00
IUUC-Tsy-118942	Tarsius syrichta	63.67	2.00e-95	343.00
IUUC-Tni-120732	Tetraodon nigroviridis	47.47	8.00e-175	607.00
IUUC-Tre-121892	Trichoderma reesei	41.31	1.00e-83	304.00
IUUC-Tvi-122354	Trichoderma virens	34.57	2.00e-84	306.00
IUUC-Tme-127102	Tuber melanosporum	35.57	2.00e-88	320.00
IUUC-Tbe-127351	Tupaia belangeri	46.61	4.00e-147	514.00
IUUC-Ttr-129061	Tursiops truncatus	45.96	6.00e-165	574.00
IUUC-Uma-129343	Ustilago maydis	44.55	4.00e-96	345.00
IUUC-Vda-129748	Verticillium dahliae	38.02	3.00e-73	269.00
IUUC-Xtr-132094	Xenopus tropicalis	37.47	0.00e+00	683.00
IUUC-Xma-133923	Xiphophorus maculatus	48.58	0.00e+00	627.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence