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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063623
UUCD1 version UUC-MuM-00456
Ensembl Protein ID ENSMUSP00000046156.4
UniProt Accession Q5SUS0; Q5U4G1; FBW10_MOUSE
Genbank Protein ID CAI25650.1; AAH85108.1
Protein Name F-box/WD repeat-containing protein 10; F-box and WD-40 domain-containing protein 10
Genbank Nucleotide ID AL645847; BC085108
Gene Name Fbxw10
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000090173.8 ENSMUST00000036085.10 ENSMUSP00000046156.4
ENSMUSG00000090173.8 ENSMUST00000177336.7 ENSMUSP00000135294.1
ENSMUSG00000090173.8 ENSMUST00000176577.1 ENSMUSP00000135870.1
ENSMUSG00000090173.8 ENSMUST00000150989.7 ENSMUSP00000117872.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTM
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.00e-26 91.5 508 545
UBD/Beta-Prp 1.90e-63 215.5 434 701
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 1    gHtdsvtclaf.sdtllvsGsdDgtikvWDlrtgvllks 38
           gH++ +tcl+    ++lvsG+ Dg++k WD+ tg++lk+
   Q: 508  GHQGTITCLDVyK-NRLVSGAKDGQVKEWDIETGKCLKT 545
           8*********643.79********************986 PP
   

   UBD/Beta-Prp
   S: 17   kfspdksllatgsrdgtikvwdvttgkllrsl.sgheaevtavkfspdgkilvtgseDrtikvwdlstgkcvhtlkghedsvlslsfsp 104
           ++ ++++l+a +s +++i + d+ + k l     gh + v+a+ +s++++il++gs D  i+ wd++tg cv+++ gh+ ++++l++++
   Q: 434  HY-NGGDLMAISS-NRKIHLLDIMQTKELPIEfRGHAGSVRALFLSEEDNILLSGSYDLSIRYWDVKTGACVRIFYGHQGTITCLDVYK 520
           44.8899999998.9*******99988876555******************************************************** PP
   S: 105  sgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdgnllvsGslDrtvrlWdlktgkllrtltgghtdsvyslsfdsngk 193
             ++lvsG +d  ++ wd+etg+cl+    +h++ +  +++++   ++vs++  ++v++W + t++l +tltg h+++v++l f++   
   Q: 521  --NRLVSGAKDGQVKEWDIETGKCLK--TFKHKDPILAAKISE--TYIVSSCERGIVKVWHVVTAQLQKTLTG-HEGAVKCLFFNE--W 600
           ..***********************9..67788899*******..***************************9.**********99..8 PP
   S: 194  elvsgsldgtvklwdlq..tgecvrtlnghtdnvksvrfspnderlvsgssDgsiriWdlrsgdllktlqlhn..ssvisvavlsfgdn 278
           +lvsg+ dg v  w++    ++c+++++ h + v++v ++    r++s+  Dg iri++  +g++lk+++  +  + v     + +++n
   Q: 601  HLVSGGADGLVMAWSMVgkYERCLMAFK-HPKEVLQVSLL--YLRVISACGDGKIRIYNFLNGNCLKVIKVDArgDPVL---SFFYQGN 683
           ****************988888999987.56677788888..799999999********************98433333...3334777 PP
   S: 279  vlvlgsedskvniwklkkn 297
            +v+   ds++ ++++++ 
   Q: 684  RMVAH-TDSNILVFQFENV 701
           77766.4688999988775 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1 (By similarity).
 Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1 (By similarity).
Protein Sequence
(Fasta)
MENREPKLKQ APYFRCEKGP NWVPVCQKCE ACVLAWKIFA TKEWFRRVND ISQRRFLVSI 60
LGQLNSLYLL QYFQNILETT QGKDFIYNRS RIKLSRKGGK EEEVVKSSLN QMLDKTVERK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063623|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTTTCTAAGG AAGTCAGTAC AAAAAGCCAG ACTTCTACAG GCAGTTTCTG GGTCAGATCA 60
GTTTACCATC CATCGCAGTG CCTTACGGTT TCTCCAGATG TTCATCCCGA AGAGGCTCCA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063623|E3,WD_repeat;UBD,Beta-Prp|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR001810--F-box_dom
IPR020472--G-protein_beta_WD-40_rep
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF00400--WD40
PRINTS

PR00320--GPROTEINBRPT
SMART

SM00320--WD40
Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001837 Ailuropoda melanoleuca 70.72 0.00e+00 656.00
IUUC-Apl-003572 Anas platyrhynchos 49.07 2.00e-125 443.00
IUUC-Aca-004297 Anolis carolinensis 43.79 2.00e-160 560.00
IUUC-Ame-011058 Astyanax mexicanus 38.17 1.00e-130 461.00
IUUC-Bta-012667 Bos taurus 69.76 0.00e+00 676.00
IUUC-Cja-019163 Callithrix jacchus 67.28 0.00e+00 1406.00
IUUC-Cfa-020784 Canis familiaris 69.19 0.00e+00 1467.00
IUUC-Cpo-021429 Cavia porcellus 68.63 0.00e+00 680.00
IUUC-Csa-023597 Chlorocebus sabaeus 73.03 0.00e+00 1039.00
IUUC-Cho-024559 Choloepus hoffmanni 59.73 9.00e-176 610.00
IUUC-Dre-027496 Danio rerio 43.86 8.00e-108 384.00
IUUC-Dno-028995 Dasypus novemcinctus 67.85 0.00e+00 1399.00
IUUC-Ete-032823 Echinops telfairi 76.76 7.00e-88 318.00
IUUC-Eca-033666 Equus caballus 66.52 0.00e+00 1160.00
IUUC-Eeu-035054 Erinaceus europaeus 67.89 9.00e-90 325.00
IUUC-Fca-035589 Felis catus 65.23 0.00e+00 1361.00
IUUC-Fal-037403 Ficedula albicollis 38.08 1.00e-138 487.00
IUUC-Gmo-038669 Gadus morhua 39.85 5.00e-53 202.00
IUUC-Gga-041227 Gallus gallus 47.81 6.00e-124 438.00
IUUC-Hsa-046221 Homo sapiens 68.66 0.00e+00 1466.00
IUUC-Itr-049011 Ictidomys tridecemlineatus 68.04 0.00e+00 1442.00
IUUC-Lch-050046 Latimeria chalumnae 35.08 3.00e-178 619.00
IUUC-Loc-052366 Lepisosteus oculatus 37.22 0.00e+00 633.00
IUUC-Laf-053745 Loxodonta africana 67.53 0.00e+00 1446.00
IUUC-Mcc-054826 Macaca mulatta 69.63 0.00e+00 1467.00
IUUC-Meu-056636 Macropus eugenii 45.31 1.00e-53 205.00
IUUC-Mga-060185 Meleagris gallopavo 44.68 8.00e-123 434.00
IUUC-Mdo-062382 Monodelphis domestica 51.20 0.00e+00 676.00
IUUC-Mpu-066872 Mustela putorius furo 62.17 0.00e+00 1134.00
IUUC-Mlu-067552 Myotis lucifugus 68.63 6.00e-180 624.00
IUUC-Nle-069247 Nomascus leucogenys 70.76 0.00e+00 1100.00
IUUC-Opr-070455 Ochotona princeps 69.21 0.00e+00 676.00
IUUC-Ont-071926 Oreochromis niloticus 42.36 2.00e-95 343.00
IUUC-Oan-073411 Ornithorhynchus anatinus 39.78 0.00e+00 733.00
IUUC-Ocu-073893 Oryctolagus cuniculus 68.31 0.00e+00 1196.00
IUUC-Oga-087937 Otolemur garnettii 69.85 0.00e+00 682.00
IUUC-Oar-089680 Ovis aries 66.63 0.00e+00 1399.00
IUUC-Ptr-091549 Pan troglodytes 65.29 0.00e+00 1356.00
IUUC-Pan-091904 Papio anubis 70.41 0.00e+00 1466.00
IUUC-Psi-093181 Pelodiscus sinensis 41.82 0.00e+00 795.00
IUUC-Pma-094711 Petromyzon marinus 42.63 4.00e-71 261.00
IUUC-Pab-098067 Pongo abelii 68.66 0.00e+00 1466.00
IUUC-Pca-100867 Procavia capensis 67.21 0.00e+00 756.00
IUUC-Pva-102209 Pteropus vampyrus 71.35 0.00e+00 1033.00
IUUC-Rno-105374 Rattus norvegicus 81.74 0.00e+00 1669.00
IUUC-Sha-107459 Sarcophilus harrisii 45.76 5.00e-105 374.00
IUUC-Tgu-117261 Taeniopygia guttata 43.85 3.00e-104 372.00
IUUC-Tru-117705 Takifugu rubripes 46.54 1.00e-42 165.00
IUUC-Tni-120365 Tetraodon nigroviridis 46.49 2.00e-41 162.00
IUUC-Tbe-128015 Tupaia belangeri 62.26 0.00e+00 941.00
IUUC-Ttr-128654 Tursiops truncatus 67.18 0.00e+00 971.00
IUUC-Vpa-130176 Vicugna pacos 61.66 0.00e+00 849.00
Created Date 25-Jun-2017

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