iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000184787.18	ENST00000345496.6	ENSP00000338348.3
ENSG00000184787.18	ENST00000491513.5	ENSP00000418423.1
ENSG00000184787.18	ENST00000478200.1	ENSP00000420671.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	CircNet
miRTarBase	microRNA	TRANSFAC	miRWalk
TargetScan	RepTar	SomamiR	miRcode
RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	PhosphositePlus	dbPTM	HPRD
UniProt	BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E2/UBC	E2_UBC	20682791; 17310145; 21143188

Classification

Family	E-value	Score	Start	End
E2/UBC	1.00e-49	169.6	8	157

Active Site

Position(s)	Description	Evidence
89	Glycyl thioester intermediate	N/A

Domain Profile

E2/UBC

   S: 1    RlkkelkelekdppegisakpvdesdltewevlilGpedtpYeggvFkleiefpedYPfkPPkvkfltkifhPnvyenGkvClsilk..... 87
           Rl+ e+k+l+ +ppegi+a+p++e++++ewe+li+Gpedt++e gvF + ++fp dYP++PPk++f+ ++fhPn+y++G+vC+sil+     
   Q: 8    RLMAEYKQLTLNPPEGIVAGPMNEENFFEWEALIMGPEDTCFEFGVFPAILSFPLDYPLSPPKMRFTCEMFHPNIYPDGRVCISILHapgdd 99
           99************************************************************************************889999 PP
   S: 88   ......eeekWspalsvesvllsiqsllaepnpesplneeaaellkknreeykkkvre 139
                 ++e+Wsp++sve++lls++s+laepn es++n++a+++++++re++ k++++
   Q: 100  pmgyesSAERWSPVQSVEKILLSVVSMLAEPNDESGANVDASKMWRDDREQFYKIAKQ 157
           9999999**********************************************99875 PP

Organism

Homo sapiens

Functional Description
(View)

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD).

Protein Sequence
(Fasta)

MAGTALKRLM AEYKQLTLNP PEGIVAGPMN EENFFEWEAL IMGPEDTCFE FGVFPAILSF 60
PLDYPLSPPK MRFTCEMFHP NIYPDGRVCI SILHAPGDDP MGYESSAERW SPVQSVEKIL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACAAGACCAG GACCCTGAGG CCTCTGGAAG TGCCGGGACC GAACCAACCC CGCAGAGCGA 60
CTAAGGCGAG GGCAGGAGCC AAGAGAATCG TAGCCGCGGT CGCGGGTTGA GCTCCCACCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000608--UBQ-conjugat_E2
IPR023313--UBQ-conjugating_AS
IPR016135--UBQ-conjugating_enzyme/RWD

PROSITE

PS00183--UBIQUITIN_CONJUGAT_1
PS50127--UBIQUITIN_CONJUGAT_2

Pfam

PF00179--UQ_con

Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005524--F:ATP binding
GO:0061631--F:ubiquitin conjugating enzyme activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0031625--F:ubiquitin protein ligase binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0044257--P:cellular protein catabolic process
GO:0035458--P:cellular response to interferon-beta
GO:1904153--P:negative regulation of retrograde protein transport, ER to cytosol
GO:0070936--P:protein K48-linked ubiquitination
GO:0018279--P:protein N-linked glycosylation via asparagine
GO:0016567--P:protein ubiquitination
GO:0030433--P:ubiquitin-dependent ERAD pathway
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

hsa:7327

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002172	Ailuropoda melanoleuca	92.36	2.00e-85	307.00
IUUC-Apl-003761	Anas platyrhynchos	93.21	4.00e-88	316.00
IUUC-Aca-005062	Anolis carolinensis	97.58	2.00e-92	331.00
IUUC-Ago-007853	Ashbya gossypii	62.42	2.00e-58	218.00
IUUC-Acl-008080	Aspergillus clavatus	62.65	8.00e-59	219.00
IUUC-Afl-008478	Aspergillus flavus	62.05	8.00e-58	216.00
IUUC-Afu-009051	Aspergillus fumigatus	62.65	6.00e-59	219.00
IUUC-Ani-009271	Aspergillus nidulans	60.84	2.00e-52	197.00
IUUC-Ang-009748	Aspergillus niger	63.25	6.00e-59	219.00
IUUC-Aor-010228	Aspergillus oryzae	62.05	7.00e-58	216.00
IUUC-Ate-010293	Aspergillus terreus	62.65	5.00e-59	219.00
IUUC-Ame-011698	Astyanax mexicanus	93.33	1.00e-90	324.00
IUUC-Bgr-012226	Blumeria graminis	60.98	4.00e-57	213.00
IUUC-Bta-013277	Bos taurus	99.19	1.00e-70	258.00
IUUC-Bci-013676	Botrytis cinerea	60.98	1.00e-56	211.00
IUUC-Cel-018676	Caenorhabditis elegans	76.97	2.00e-74	271.00
IUUC-Cja-019767	Callithrix jacchus	98.79	2.00e-95	341.00
IUUC-Cfa-020047	Canis familiaris	95.76	1.00e-93	334.00
IUUC-Cpo-021507	Cavia porcellus	99.39	7.00e-96	342.00
IUUC-Csa-023745	Chlorocebus sabaeus	93.29	1.00e-88	318.00
IUUC-Cho-024667	Choloepus hoffmanni	64.97	3.00e-53	200.00
IUUC-Cin-025310	Ciona intestinalis	81.82	1.00e-79	288.00
IUUC-Csv-025961	Ciona savignyi	81.21	3.00e-79	287.00
IUUC-Cgl-026553	Colletotrichum gloeosporioides	64.81	5.00e-61	226.00
IUUC-Cne-026903	Cryptococcus neoformans	56.97	3.00e-47	181.00
IUUC-Dre-027900	Danio rerio	93.94	9.00e-91	325.00
IUUC-Dno-029688	Dasypus novemcinctus	93.33	3.00e-89	320.00
IUUC-Dor-030374	Dipodomys ordii	65.36	3.00e-52	197.00
IUUC-Dse-031253	Dothistroma septosporum	63.64	5.00e-62	229.00
IUUC-Dme-031849	Drosophila melanogaster	81.82	1.00e-79	288.00
IUUC-Ete-033010	Echinops telfairi	99.39	2.00e-94	337.00
IUUC-Eca-033294	Equus caballus	95.54	4.00e-88	316.00
IUUC-Eeu-034947	Erinaceus europaeus	73.23	3.00e-48	183.00
IUUC-Fca-036442	Felis catus	95.62	5.00e-77	279.00
IUUC-Fal-037188	Ficedula albicollis	96.08	6.00e-86	309.00
IUUC-Fox-037762	Fusarium oxysporum	62.42	5.00e-60	223.00
IUUC-Fso-038181	Fusarium solani	61.82	3.00e-59	220.00
IUUC-Gmo-038663	Gadus morhua	90.91	2.00e-88	317.00
IUUC-Ggr-039808	Gaeumannomyces graminis	64.81	1.00e-61	228.00
IUUC-Gga-040355	Gallus gallus	98.18	1.00e-94	338.00
IUUC-Gac-041847	Gasterosteus aculeatus	93.33	2.00e-91	327.00
IUUC-Ggo-045202	Gorilla gorilla	100.00	2.00e-96	343.00
IUUC-Itr-048349	Ictidomys tridecemlineatus	98.79	9.00e-96	342.00
IUUC-Kpa-049317	Komagataella pastoris	63.80	3.00e-59	220.00
IUUC-Lch-049596	Latimeria chalumnae	86.06	5.00e-82	296.00
IUUC-Loc-052346	Lepisosteus oculatus	93.50	5.00e-66	242.00
IUUC-Lma-053126	Leptosphaeria maculans	68.94	5.00e-52	196.00
IUUC-Laf-054560	Loxodonta africana	93.29	6.00e-88	315.00
IUUC-Mcc-055172	Macaca mulatta	100.00	2.00e-96	343.00
IUUC-Meu-056891	Macropus eugenii	95.54	6.00e-88	315.00
IUUC-Mor-057260	Magnaporthe oryzae	63.58	2.00e-60	224.00
IUUC-Mpo-057468	Magnaporthe poae	65.43	4.00e-62	230.00
IUUC-Mla-059084	Melampsora laricipopulina	58.72	1.00e-55	209.00
IUUC-Mga-059939	Meleagris gallopavo	90.24	2.00e-86	311.00
IUUC-Mvi-060514	Microbotryum violaceum	66.06	2.00e-59	221.00
IUUC-Mmr-061029	Microcebus murinus	94.05	2.00e-88	317.00
IUUC-Mdo-061820	Monodelphis domestica	98.79	1.00e-95	341.00
IUUC-Mmu-063123	Mus musculus	100.00	2.00e-96	343.00
IUUC-Mpu-065866	Mustela putorius furo	88.48	6.00e-86	309.00
IUUC-Mlu-067220	Myotis lucifugus	94.38	5.00e-88	316.00
IUUC-Nfi-068395	Neosartorya fischeri	62.65	6.00e-59	219.00
IUUC-Ncr-068623	Neurospora crassa	63.19	9.00e-59	219.00
IUUC-Nle-070007	Nomascus leucogenys	100.00	2.00e-96	343.00
IUUC-Opr-071095	Ochotona princeps	100.00	2.00e-64	236.00
IUUC-Ont-071736	Oreochromis niloticus	93.33	3.00e-90	323.00
IUUC-Oan-073475	Ornithorhynchus anatinus	95.54	2.00e-87	314.00
IUUC-Ocu-074820	Oryctolagus cuniculus	96.13	1.00e-87	315.00
IUUC-Ola-087571	Oryzias latipes	92.73	5.00e-90	322.00
IUUC-Oga-087956	Otolemur garnettii	98.81	9.00e-46	174.00
IUUC-Oar-089706	Ovis aries	99.39	3.00e-96	343.00
IUUC-Ptr-090798	Pan troglodytes	100.00	2.00e-96	343.00
IUUC-Pan-091967	Papio anubis	100.00	2.00e-96	343.00
IUUC-Psi-093524	Pelodiscus sinensis	94.70	4.00e-84	303.00
IUUC-Pma-094602	Petromyzon marinus	91.37	3.00e-74	270.00
IUUC-Pno-094979	Phaeosphaeria nodorum	65.45	3.00e-63	234.00
IUUC-Pfo-097330	Poecilia formosa	93.94	3.00e-91	327.00
IUUC-Pab-098225	Pongo abelii	99.39	1.00e-95	341.00
IUUC-Pca-101040	Procavia capensis	98.04	1.00e-87	314.00
IUUC-Pva-102507	Pteropus vampyrus	82.80	1.00e-72	265.00
IUUC-Pgr-103674	Puccinia graminis	60.82	1.00e-56	212.00
IUUC-Ptt-103840	Puccinia triticina	59.65	8.00e-56	209.00
IUUC-Pte-104389	Pyrenophora teres	67.27	1.00e-65	241.00
IUUC-Pyt-104703	Pyrenophora triticirepentis	66.67	9.00e-65	239.00
IUUC-Rno-105228	Rattus norvegicus	100.00	2.00e-96	343.00
IUUC-Sce-106233	Saccharomyces cerevisiae	62.42	4.00e-56	210.00
IUUC-Sha-107274	Sarcophilus harrisii	91.57	2.00e-88	317.00
IUUC-Sja-107937	Schizosaccharomyces japonicus	68.94	3.00e-66	243.00
IUUC-Spo-108269	Schizosaccharomyces pombe	68.32	2.00e-66	244.00
IUUC-Ssl-108636	Sclerotinia sclerotiorum	61.59	6.00e-58	216.00
IUUC-Sre-114952	Sporisorium reilianum	64.85	6.00e-58	216.00
IUUC-Ssc-115365	Sus scrofa	92.73	6.00e-88	315.00
IUUC-Tgu-116816	Taeniopygia guttata	98.18	1.00e-94	338.00
IUUC-Tru-118547	Takifugu rubripes	80.70	7.00e-51	191.00
IUUC-Tni-120278	Tetraodon nigroviridis	89.76	2.00e-86	311.00
IUUC-Tre-122131	Trichoderma reesei	63.58	5.00e-60	223.00
IUUC-Tvi-122669	Trichoderma virens	63.58	2.00e-60	224.00
IUUC-Tme-127052	Tuber melanosporum	68.71	9.00e-67	245.00
IUUC-Tbe-127792	Tupaia belangeri	100.00	2.00e-96	343.00
IUUC-Ttr-128619	Tursiops truncatus	95.00	8.00e-65	238.00
IUUC-Uma-129587	Ustilago maydis	64.24	1.00e-57	215.00
IUUC-Vda-129914	Verticillium dahliae	62.96	2.00e-59	221.00
IUUC-Xtr-132450	Xenopus tropicalis	96.36	1.00e-92	331.00
IUUC-Xma-133016	Xiphophorus maculatus	94.55	2.00e-91	327.00
IUUC-Yli-134379	Yarrowia lipolytica	72.22	7.00e-69	252.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence