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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046430
UUCD1 version UUC-HoS-01119
Ensembl Protein ID ENSP00000424372.1
UniProt Accession Q70EL2; B2RXG0; Q5T062; Q86T44; Q86TC0; Q9BRU1; UBP45_HUMAN
Genbank Protein ID CAE47746.2; CAD89915.1; CAD91148.1; CAI17192.1; CAI17192.1; CAI19761.1; CAI19761.1; AAH05991.1; AAI50649.1; AAI57839.1
Protein Name Ubiquitin carboxyl-terminal hydrolase 45; Deubiquitinating enzyme 45; Ubiquitin thioesterase 45; Ubiquitin-specific-processing protease 45
Genbank Nucleotide ID AJ583819; AL713747; AL832030; AL513550; AL137784; AL137784; AL513550; BC005991; BC150648; BC157838
Gene Name USP45
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000123552.17 ENST00000500704.6 ENSP00000424372.1
ENSG00000123552.17 ENST00000496518.6 ENSP00000421248.1
ENSG00000123552.17 ENST00000369233.6 ENSP00000358236.2
ENSG00000123552.17 ENST00000506871.5 ENSP00000422460.1
ENSG00000123552.17 ENST00000511403.5 ENSP00000423374.1
ENSG00000123552.17 ENST00000496090.6 ENSP00000421706.1
ENSG00000123552.17 ENST00000507717.5 ENSP00000425876.1
ENSG00000123552.17 ENST00000329966.10 ENSP00000330540.5
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
DUB/USP USP 14715245
Classification
Family E-value Score Start End
DUB/USP 6.30e-85 287.0 191 812
Active Site
Position(s) Description Evidence
199 Nucleophile ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
746 Proton acceptor ECO:0000255|PROSITE-ProRule:PRU10092,
ECO:0000255|PROSITE-ProRule:PRU10093}
Domain Profile

   DUB/USP
   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle..kkkeklneenp..............kepkgellkslqklfeelwkskkkavsprellkal 77
           G++NlgNtC++N+v+Q L+++  l++l++e  +  ++++ +                 ++ g+l+++l  +++++ +++k+  sp+ l+++l
   Q: 191  GITNLGNTCFFNAVMQNLAQTYTLTDLMNEikE--SSTKLK-IfpssdsqldplvveLSRPGPLTSALFLFLHSMKETEKGPLSPKVLFNQL 279
           9*****************************542..333222.23445566666777777777****************************** PP
   S: 78   kkeaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsde......aeekkkkknkslisdlFqgqlksqikclecdnvs 163
           +++a++f+ ++qqD+qE+l++lld++++e +k+ + ++ +++++ ++++ d+      + + k+  + ++i+++F g+l+s+++c+ec+n+s
   Q: 280  CQKAPRFKDFQQQDSQELLHYLLDAVRTEETKRIQASILKAFNNPTTKTADDetrkkvKAYGKEGVKMNFIDRIFIGELTSTVMCEECANIS 371
           ******************************99888888888888877777773443335555555555************************ PP
   S: 164  sreepfldlslpvpgkeetkke...................................................................... 185
           + ++pf+d+slp+ +++ +k++                                                                      
   Q: 372  TVKDPFIDISLPIIEERVSKPLlwgrmnkyrslretdhdrysgnvtienihqpraakkhssskdksqlihdrkcirklssgetvtyqknenl 463
           *****************99888********************************************************************** PP
   S: 186  ............................................................................................ 185
                                                                                                       
   Q: 464  emngdslmfaslmnsesrlnesptddsekeashsesnvdadsepsesesaskqtglfrsssgsgvqpdgplyplsagkllytketdsgdkem 555
           ******************************************************************************************** PP
   S: 186  ...............................................................slqdcLesftkeeelegenkyycekckkk 214
                                                                          s+q+cL +ft+ e l g+nk+ ce+c+k+
   Q: 556  aeaiselrlsstvtgdqdfdrenqplnisnnlcflegkhlrsyspqnafqtlsqsyittskecSIQSCLYQFTSMELLMGNNKLLCENCTKN 647
           ******************************************************************************************88 PP
   S: 215  qe...................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqke..kkkYeLiavvv 285
           ++                   a+k+l ++ +P vLilhLkRf  ++++ s +k+n++v+fpl+Ldl+pfc+ ++++ ++  k+ Y L+++v 
   Q: 648  KQkyqeetsfaekkvegvytnARKQLLISAVPAVLILHLKRF--HQAGLSLRKVNRHVDFPLMLDLAPFCSATCKNASVgdKVLYGLYGIVE 737
           888999999999999999999*********************..9999************************88887667799********* PP
   S: 286  HsGslssGHYvayvkn..........................ekgkWllfdDskVtevkeeevleetgstaYvlfYkr 337
           HsGs+++GHY+ayvk                           + g+W++++D++ ++v+e++ l+   ++aY+lfY+r
   Q: 738  HSGSMREGHYTAYVKVrtpsrklsehntkkknvpglkaadneSAGQWVHVSDTYLQVVPESRALS---AQAYLLFYER 812
           ****************999999999999999999999888777888*******************...********98 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MRVKDPTKAL PEKAKRSKRP TVPHDEDSSD DIAVGLTCQH VSHAISVNHV KRAIAENLWS 60
VCSECLKERR FYDGQLVLTS DIWLCLKCGF QGCGKNSESQ HSLKHFKSSR TEPHCIIINL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046430|DUB,USP|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GATAAAAGTT GGTGCTGGAG AGGCAGCATG CAAAGCGAAA AGAAGGGACT GCTTTGAGTT 60
CTAGACCCAA CGCCTCCGGT AACCACCTTC ATTTCTCTGG CTTCTGCTGG CTCATCGGTA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046430|DUB,USP|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00443--UCH
PF02148--zf-UBP
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0070911--P:global genome nucleotide-excision repair
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG hsa:85015
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002331 Ailuropoda melanoleuca 73.51 0.00e+00 1088.00
IUUC-Apl-003512 Anas platyrhynchos 66.95 0.00e+00 1041.00
IUUC-Aca-004284 Anolis carolinensis 59.25 0.00e+00 938.00
IUUC-Ame-010735 Astyanax mexicanus 62.98 4.00e-85 308.00
IUUC-Bta-012880 Bos taurus 81.56 0.00e+00 1261.00
IUUC-Cja-019144 Callithrix jacchus 92.64 0.00e+00 1501.00
IUUC-Cfa-020971 Canis familiaris 82.86 0.00e+00 724.00
IUUC-Cpo-022497 Cavia porcellus 69.47 0.00e+00 1082.00
IUUC-Csa-023910 Chlorocebus sabaeus 94.16 0.00e+00 1443.00
IUUC-Cho-024358 Choloepus hoffmanni 61.90 1.00e-109 390.00
IUUC-Dre-028106 Danio rerio 61.17 6.00e-150 525.00
IUUC-Dno-029456 Dasypus novemcinctus 76.33 0.00e+00 702.00
IUUC-Dor-030438 Dipodomys ordii 63.53 0.00e+00 931.00
IUUC-Dme-031870 Drosophila melanogaster 46.71 2.00e-35 145.00
IUUC-Ete-032736 Echinops telfairi 64.34 0.00e+00 928.00
IUUC-Eca-034211 Equus caballus 82.66 0.00e+00 1330.00
IUUC-Eeu-034797 Erinaceus europaeus 81.01 3.00e-85 309.00
IUUC-Fca-035947 Felis catus 77.82 0.00e+00 1142.00
IUUC-Fal-037199 Ficedula albicollis 66.89 0.00e+00 918.00
IUUC-Gmo-039228 Gadus morhua 61.01 6.00e-140 491.00
IUUC-Gga-040823 Gallus gallus 63.06 2.00e-162 565.00
IUUC-Gac-042406 Gasterosteus aculeatus 59.52 6.00e-136 478.00
IUUC-Ggo-045402 Gorilla gorilla 98.90 0.00e+00 1623.00
IUUC-Itr-048855 Ictidomys tridecemlineatus 81.07 0.00e+00 744.00
IUUC-Lch-049547 Latimeria chalumnae 57.89 0.00e+00 896.00
IUUC-Loc-052842 Lepisosteus oculatus 58.14 0.00e+00 880.00
IUUC-Laf-053988 Loxodonta africana 83.05 0.00e+00 1338.00
IUUC-Mcc-055491 Macaca mulatta 88.96 0.00e+00 1437.00
IUUC-Meu-056256 Macropus eugenii 63.49 3.00e-172 598.00
IUUC-Mtr-057945 Medicago truncatula 31.27 2.00e-33 137.00
IUUC-Mla-059026 Melampsora laricipopulina 30.73 3.00e-16 80.50
IUUC-Mga-059833 Meleagris gallopavo 59.60 6.00e-165 574.00
IUUC-Mmr-060952 Microcebus murinus 84.96 0.00e+00 1335.00
IUUC-Mdo-062642 Monodelphis domestica 69.77 0.00e+00 1068.00
IUUC-Mmu-063945 Mus musculus 77.53 0.00e+00 1209.00
IUUC-Mpu-065944 Mustela putorius furo 75.55 0.00e+00 1158.00
IUUC-Mlu-067049 Myotis lucifugus 80.98 0.00e+00 1258.00
IUUC-Nle-069828 Nomascus leucogenys 96.32 0.00e+00 1572.00
IUUC-Opr-070672 Ochotona princeps 70.73 4.00e-143 502.00
IUUC-Ont-072121 Oreochromis niloticus 58.78 1.00e-133 470.00
IUUC-Oan-073656 Ornithorhynchus anatinus 64.69 0.00e+00 1026.00
IUUC-Ocu-074323 Oryctolagus cuniculus 80.68 0.00e+00 1248.00
IUUC-Ola-087238 Oryzias latipes 59.66 4.00e-146 511.00
IUUC-Oga-088379 Otolemur garnettii 77.24 0.00e+00 1214.00
IUUC-Oar-089718 Ovis aries 81.85 0.00e+00 1261.00
IUUC-Ptr-091358 Pan troglodytes 99.02 0.00e+00 1629.00
IUUC-Pan-092023 Papio anubis 94.60 0.00e+00 1539.00
IUUC-Psi-093256 Pelodiscus sinensis 65.70 0.00e+00 969.00
IUUC-Pfo-097285 Poecilia formosa 51.95 1.00e-119 424.00
IUUC-Pab-098539 Pongo abelii 98.16 0.00e+00 1602.00
IUUC-Pca-100610 Procavia capensis 67.35 0.00e+00 916.00
IUUC-Pva-102985 Pteropus vampyrus 90.27 0.00e+00 695.00
IUUC-Rno-105538 Rattus norvegicus 77.08 0.00e+00 1215.00
IUUC-Sha-107022 Sarcophilus harrisii 72.62 1.00e-178 620.00
IUUC-Sja-107712 Schizosaccharomyces japonicus 26.78 2.00e-19 91.70
IUUC-Spo-108149 Schizosaccharomyces pombe 30.19 5.00e-20 93.60
IUUC-Sar-113637 Sorex araneus 70.05 0.00e+00 1053.00
IUUC-Ssc-115870 Sus scrofa 81.54 0.00e+00 1305.00
IUUC-Tgu-116907 Taeniopygia guttata 67.52 0.00e+00 1048.00
IUUC-Tru-117835 Takifugu rubripes 51.96 2.00e-109 390.00
IUUC-Tsy-118869 Tarsius syrichta 78.06 0.00e+00 1211.00
IUUC-Tbe-128041 Tupaia belangeri 65.53 0.00e+00 945.00
IUUC-Ttr-128901 Tursiops truncatus 81.05 0.00e+00 1269.00
IUUC-Vpa-130331 Vicugna pacos 82.68 0.00e+00 1184.00
IUUC-Xtr-131794 Xenopus tropicalis 64.88 2.00e-145 509.00
Created Date 25-Jun-2017

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