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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063883
UUCD1 version UUC-MuM-00425
Ensembl Protein ID ENSMUSP00000067521.4
UniProt Accession Q1H9T6; A2A8B1; Q99K15; TZAP_MOUSE
Genbank Protein ID CAJ44110.1; CAM24576.2; AAH05515.1
Protein Name Telomere zinc finger-associated protein; Krueppel-related zinc finger protein 3 homolog; Zinc finger and BTB domain-containing protein 48
Genbank Nucleotide ID AM161454; AL611927; BC005515
Gene Name Zbtb48; Hkr3; Tzap
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000028952.12 ENSMUST00000155389.7 ENSMUSP00000114726.1
ENSMUSG00000028952.12 ENSMUST00000066715.10 ENSMUSP00000067521.4
ENSMUSG00000028952.12 ENSMUST00000156748.1 ENSMUSP00000117079.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 3.20e-06 28.5 26 87
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +D +l vgg +f+ah +vLa +S++F++       +++ ++ v++    +e f  ll+F Ytg l +
   Q: 26   CDATLDVGGLVFKAHWSVLACCSHFFQRIY----GDGT-GGSVVLPAGFAEIFGLLLDFFYTGHLAL 87
           89**************************99....4666.899*********************9976 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Telomere-binding protein that acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to long telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression the J and/or S elements in MHC II promoter. Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A.
 Telomere-binding protein that acts as a regulator of telomere length. Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. Preferentially binds to long telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres. Also acts as a transcription regulator that binds to promoter regions. Regulates expression the J and/or S elements in MHC II promoter. Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A.
Protein Sequence
(Fasta)
MDGSFVQHSV RVLQELNKQR EKGQYCDATL DVGGLVFKAH WSVLACCSHF FQRIYGDGTG 60
GSVVLPAGFA EIFGLLLDFF YTGHLALTSG NRDQVLLAAK ELRVPEAVEL CQSFQPQTSV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063883|E3,BTB_Other|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTATGTCACA TCCGGCGCGG CGGCGGTGGC GTCTCCGCGC TGTGGGCCGG GCAGTAGTTA 60
GTCTTGTGGG CGGTGGAAGT GGTCTAGGCC GGAGCAGTGA AGCCGGTGTG AGCCGGGAGG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063883|E3,BTB_Other|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0010--Activator
KW-0025--Alternative splicing
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0779--Telomere
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR000210--BTB/POZ_dom
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2
Pfam

PF00651--BTB
SMART

SM00225--BTB
SM00355--ZnF_C2H2
Gene Ontology

GO:0000781--C:chromosome, telomeric region
GO:0005829--C:cytosol
GO:0005654--C:nucleoplasm
GO:0003691--F:double-stranded telomeric DNA binding
GO:0042802--F:identical protein binding
GO:0046872--F:metal ion binding
GO:0006355--P:regulation of transcription, DNA-templated
GO:0010833--P:telomere maintenance via telomere lengthening
GO:0006351--P:transcription, DNA-templated
KEGG mmu:100090
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001731 Ailuropoda melanoleuca 88.23 0.00e+00 1180.00
IUUC-Bta-012521 Bos taurus 87.16 0.00e+00 1156.00
IUUC-Cja-019221 Callithrix jacchus 82.85 0.00e+00 1079.00
IUUC-Cfa-020921 Canis familiaris 85.67 0.00e+00 1136.00
IUUC-Cpo-021758 Cavia porcellus 88.66 0.00e+00 1164.00
IUUC-Csa-023497 Chlorocebus sabaeus 90.55 0.00e+00 1215.00
IUUC-Dno-029919 Dasypus novemcinctus 86.57 0.00e+00 1158.00
IUUC-Dor-030586 Dipodomys ordii 88.76 0.00e+00 1194.00
IUUC-Ete-032430 Echinops telfairi 83.82 0.00e+00 1096.00
IUUC-Eca-033442 Equus caballus 89.53 0.00e+00 1169.00
IUUC-Eeu-034922 Erinaceus europaeus 85.59 0.00e+00 778.00
IUUC-Fca-035486 Felis catus 88.23 0.00e+00 1175.00
IUUC-Gmo-039194 Gadus morhua 55.30 0.00e+00 627.00
IUUC-Gga-040361 Gallus gallus 90.25 0.00e+00 734.00
IUUC-Ggo-045193 Gorilla gorilla 90.55 0.00e+00 1186.00
IUUC-Hsa-046618 Homo sapiens 90.84 0.00e+00 1223.00
IUUC-Itr-048576 Ictidomys tridecemlineatus 90.26 0.00e+00 1208.00
IUUC-Lch-049869 Latimeria chalumnae 59.57 0.00e+00 800.00
IUUC-Laf-053873 Loxodonta africana 85.05 0.00e+00 1124.00
IUUC-Mcc-055703 Macaca mulatta 90.70 0.00e+00 1217.00
IUUC-Meu-056339 Macropus eugenii 79.51 0.00e+00 1059.00
IUUC-Mmr-061354 Microcebus murinus 90.55 0.00e+00 1203.00
IUUC-Mdo-062372 Monodelphis domestica 68.95 4.00e-137 482.00
IUUC-Mpu-066260 Mustela putorius furo 87.79 0.00e+00 1184.00
IUUC-Mlu-067675 Myotis lucifugus 80.81 0.00e+00 996.00
IUUC-Nle-069672 Nomascus leucogenys 90.84 0.00e+00 1225.00
IUUC-Opr-070357 Ochotona princeps 84.92 0.00e+00 1135.00
IUUC-Oan-072874 Ornithorhynchus anatinus 78.86 0.00e+00 1021.00
IUUC-Ocu-073872 Oryctolagus cuniculus 87.79 0.00e+00 1169.00
IUUC-Oga-088469 Otolemur garnettii 89.39 0.00e+00 1234.00
IUUC-Oar-090081 Ovis aries 79.39 0.00e+00 1016.00
IUUC-Ptr-090537 Pan troglodytes 90.84 0.00e+00 1193.00
IUUC-Pan-092530 Papio anubis 90.70 0.00e+00 1217.00
IUUC-Psi-093837 Pelodiscus sinensis 74.07 0.00e+00 997.00
IUUC-Pab-097987 Pongo abelii 89.24 0.00e+00 1186.00
IUUC-Pca-100921 Procavia capensis 84.01 0.00e+00 1114.00
IUUC-Rno-105597 Rattus norvegicus 96.49 0.00e+00 1326.00
IUUC-Sha-107605 Sarcophilus harrisii 90.32 0.00e+00 663.00
IUUC-Sar-113191 Sorex araneus 61.29 2.00e-100 360.00
IUUC-Ssc-115656 Sus scrofa 88.42 0.00e+00 1188.00
IUUC-Tsy-119603 Tarsius syrichta 96.26 3.00e-98 352.00
IUUC-Tni-120741 Tetraodon nigroviridis 72.37 8.00e-146 510.00
IUUC-Ttr-129274 Tursiops truncatus 86.77 0.00e+00 1145.00
IUUC-Vpa-130774 Vicugna pacos 71.28 0.00e+00 863.00
Created Date 25-Jun-2017

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