iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045936

UUCD1 version

UUC-HoS-00145

Ensembl Protein ID

ENSP00000379116.2

UniProt Accession

Q5T0T0; B2R8E7; H0Y7C6; Q5T0S8; Q8TC72; MARH8_HUMAN

Genbank Protein ID

BAG36144.1; EAW86647.1; EAW86648.1; AAH25394.1; AAH66988.1

Protein Name

E3 ubiquitin-protein ligase MARCH8; Cellular modulator of immune recognition; Membrane-associated RING finger protein 8; Membrane-associated RING-CH protein VIII; RING finger protein 178; RING-type E3 ubiquitin transferase MARCH8

Genbank Nucleotide ID

AK313340; AL445201; CH471160; BC025394; BC066988

Gene Name

MARCH8; MIR; RNF178

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000165406.15	ENST00000453424.6	ENSP00000411848.2
ENSG00000165406.15	ENST00000395769.6	ENSP00000379116.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA
DNA & RNA Element
UTRdb	AREsite	circRNADb	miRTarBase
microRNA	TRANSFAC	RepTar	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	UniProt	BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	12582153; 19703975; 16619033

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.17	14.1	80	127

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdg.plvlpC.....gHvfhadClqkwpglknssskefrCPlCr 46
           C iC+++ +d+ pl++pC      H+ h+ Clq+w     +ss +  C lC+
   Q: 80   CRICHCEGDDEsPLITPChctgsLHFVHQACLQQW----IKSSDTRCCELCK 127
           ****88885555*****9445444888********....8899999*****6 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase that mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. May also promote ubiquitination and endocytosis of TFRC and FAS.

Protein Sequence
(Fasta)

MSMPLHQISA IPSQDAISAR VYRSKTKEKE REEQNEKTLG HFMSHSSNIS KAGSPPSASA 60
PAPVSSFSRT SITPSSQDIC RICHCEGDDE SPLITPCHCT GSLHFVHQAC LQQWIKSSDT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCGGTGTCC TCCCGCGGAG GGGCGTAGGG TGTAAACAGG CGACGCGCTG GGGGAGGTGC 60
GGCCTTGCTG CGTCCACGTC TCGGGCATGC TCGAGGCGGG CCAGGGCGGT AGCGCCGCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-1064--Adaptive immunity
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0968--Cytoplasmic vesicle
KW-0967--Endosome
KW-0391--Immunity
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033275--MARCH-like
IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51292--ZF_RING_CH

Pfam

PF12906--RINGv

SMART

SM00744--RINGv

Gene Ontology

GO:0030659--C:cytoplasmic vesicle membrane
GO:0031901--C:early endosome membrane
GO:0005768--C:endosome
GO:0016021--C:integral component of membrane
GO:0005765--C:lysosomal membrane
GO:0005764--C:lysosome
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0002250--P:adaptive immune response
GO:0000209--P:protein polyubiquitination

KEGG

hsa:220972

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-013415	Bos taurus	90.72	1.00e-151	528.00
IUUC-Cfa-020901	Canis familiaris	89.00	5.00e-146	509.00
IUUC-Cpo-021679	Cavia porcellus	89.53	1.00e-132	465.00
IUUC-Csa-023704	Chlorocebus sabaeus	97.59	5.00e-152	530.00
IUUC-Dre-027670	Danio rerio	77.66	6.00e-123	433.00
IUUC-Dno-028902	Dasypus novemcinctus	88.32	1.00e-145	508.00
IUUC-Dme-031717	Drosophila melanogaster	56.02	2.00e-59	223.00
IUUC-Eca-033918	Equus caballus	91.56	1.00e-122	431.00
IUUC-Gmo-039585	Gadus morhua	76.03	2.00e-121	428.00
IUUC-Gga-040516	Gallus gallus	86.25	4.00e-142	497.00
IUUC-Gac-041554	Gasterosteus aculeatus	76.71	1.00e-122	432.00
IUUC-Lch-049853	Latimeria chalumnae	81.10	3.00e-133	467.00
IUUC-Loc-052142	Lepisosteus oculatus	76.35	3.00e-121	427.00
IUUC-Laf-054075	Loxodonta africana	91.56	3.00e-123	434.00
IUUC-Mcc-054834	Macaca mulatta	97.94	1.00e-152	531.00
IUUC-Mmr-061603	Microcebus murinus	94.16	5.00e-154	536.00
IUUC-Mdo-062578	Monodelphis domestica	87.67	7.00e-144	503.00
IUUC-Mmu-063373	Mus musculus	89.00	7.00e-146	509.00
IUUC-Nle-069774	Nomascus leucogenys	98.28	1.00e-152	531.00
IUUC-Ocu-074342	Oryctolagus cuniculus	79.38	9.00e-123	432.00
IUUC-Ola-086344	Oryzias latipes	77.48	8.00e-112	396.00
IUUC-Oga-088670	Otolemur garnettii	90.76	1.00e-127	449.00
IUUC-Ptr-090574	Pan troglodytes	97.94	3.00e-153	533.00
IUUC-Pan-092925	Papio anubis	96.91	1.00e-151	528.00
IUUC-Psi-093085	Pelodiscus sinensis	86.25	5.00e-133	466.00
IUUC-Pma-094229	Petromyzon marinus	57.78	2.00e-71	261.00
IUUC-Pfo-097524	Poecilia formosa	65.01	2.00e-115	408.00
IUUC-Pab-098165	Pongo abelii	98.63	2.00e-153	534.00
IUUC-Rno-105837	Rattus norvegicus	89.00	7.00e-146	509.00
IUUC-Sha-107014	Sarcophilus harrisii	88.94	4.00e-119	421.00
IUUC-Tru-117951	Takifugu rubripes	75.86	1.00e-102	365.00
IUUC-Tni-120496	Tetraodon nigroviridis	75.88	3.00e-106	377.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence