iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-051961

Ensembl Protein ID

ENSLOCP00000015568.1

UniProt Accession

W5N4K9; W5N4K9_LEPOC

Genbank Protein ID

ENSLOCP00000015568

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AHAT01016579

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000012648.1	ENSLOCT00000015597.1	ENSLOCP00000015568.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.70e-100	336.7	269	680
UBD/ZnF/ZnF_UBP	7.30e-25	87.2	24	84

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenp........................................... 42
           tGl+NlgNtCYmNS+LQ+Ls+++++re++l+    +++e l+++n+                                           
   Q: 269  TGLRNLGNTCYMNSILQVLSHLQKFRECFLTldlcETEELLAKTNRprggaglsgkvvngtahsgtasgrndkpapgglsaagkqgplp 357
           7******************************999766666666666999**********************************999999 PP
   S: 43   ................kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkeknkpk 115
                           + ++ +l+++l++lf+ +w++++  vsp ++l++++++ + f+gy+qqDaqEfl+ lld++++el        
   Q: 358  slnaaelvqpkeprssSRQQMSLCHELHTLFRVMWSGRWALVSPFAMLHSVWNLIPAFRGYDQQDAQEFLCELLDKVQQEL-------- 438
           999999999999998888888************************************************************........ PP
   S: 116  eeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke...........slqdcLes 193
            e+e+++++    ++++k +k+  ++++++F+gql sq++cl+c+ +s++ epf+dlsl++p++ ++ ++           +l+++L++
   Q: 439  -ESEGTKRKIVIPISQRKLTKQVLKVVNTIFHGQLLSQVTCLTCNYKSNTVEPFWDLSLEFPERYHCVEKgagtlayhsdcTLTEMLAK 526
           .56777888889999**************************************************99888******************* PP
   S: 194  ftkeeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeek 271
           ft++e leg+  y c++c++k++           a k+l + +lP+vL lhLkRf++s + ++reki  +v+f + L+++p+c++++ +
   Q: 527  FTETEALEGRI-YACDQCNSKRRksspkplvlteACKQLLIYRLPQVLRLHLKRFRWSGR-NHREKIGVHVTFDQVLNMEPYCCKDSLS 613
           ********965.*******999999999999999***********************997.8889********************8888 PP
   S: 272  qke..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkr 337
           + +  + +Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Dsk ++++ eev++   ++aY+lfY++
   Q: 614  SLHreSFTYDLSAVVMHHGkGFGSGHYTAYCYNTEGGfWVHCNDSKMNVCSVEEVCN---TQAYILFYTQ 680
           7655699**************************9999********************...********98 PP

UBD/ZnF/ZnF_UBP

   S: 1    kkcsvcdktenlWlcLtcgsvgCGRyvegHalkHyeetqhplvlslstlsvycYacddyvh 61
           ++c  c++te++W cL+c++v CGRy+++Ha++H++e++hpl++++++l+v+cY+cddyv 
   Q: 24   WRCVACRTTESVWACLKCSHVACGRYMDEHARQHFRESRHPLAMEVRELDVFCYVCDDYVL 84
           89*********************************************************96 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

MDRCKHVGRL RLSQDHSILN PQKWRCVACR TTESVWACLK CSHVACGRYM DEHARQHFRE 60
SRHPLAMEVR ELDVFCYVCD DYVLNDNAEG DLKLLRGALS TVRDPSCPGR RSLRSLAAGD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCCCAGCCG CCAATGGAGA ACCGAGCCTA CCAGTCGATG GATCCACTTC TGTCCAATCA 60
GCGCGCCAGA GGGGGGCGGG ACTCTTCCTG TTCGGTTGTC TCGCGGTCGG TGACAGCTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002395	Ailuropoda melanoleuca	76.53	0.00e+00	639.00
IUUC-Apl-003658	Anas platyrhynchos	71.33	0.00e+00	917.00
IUUC-Aca-005278	Anolis carolinensis	71.37	0.00e+00	915.00
IUUC-Ame-011403	Astyanax mexicanus	69.42	0.00e+00	805.00
IUUC-Bta-012911	Bos taurus	68.16	0.00e+00	836.00
IUUC-Cja-019171	Callithrix jacchus	68.79	0.00e+00	870.00
IUUC-Cfa-020408	Canis familiaris	67.49	0.00e+00	841.00
IUUC-Cpo-022233	Cavia porcellus	67.77	0.00e+00	830.00
IUUC-Csa-024272	Chlorocebus sabaeus	67.38	0.00e+00	701.00
IUUC-Cho-025051	Choloepus hoffmanni	72.70	7.00e-145	507.00
IUUC-Dre-027577	Danio rerio	70.14	0.00e+00	847.00
IUUC-Dno-029856	Dasypus novemcinctus	69.08	0.00e+00	862.00
IUUC-Eca-033851	Equus caballus	65.36	0.00e+00	787.00
IUUC-Fca-035919	Felis catus	78.28	3.00e-171	594.00
IUUC-Fal-037290	Ficedula albicollis	72.13	0.00e+00	847.00
IUUC-Gmo-039249	Gadus morhua	84.64	8.00e-163	567.00
IUUC-Gga-040383	Gallus gallus	72.84	0.00e+00	715.00
IUUC-Gac-042595	Gasterosteus aculeatus	71.70	0.00e+00	905.00
IUUC-Ggo-044979	Gorilla gorilla	69.51	0.00e+00	867.00
IUUC-Hsa-046743	Homo sapiens	69.51	0.00e+00	869.00
IUUC-Itr-048251	Ictidomys tridecemlineatus	67.77	0.00e+00	859.00
IUUC-Lch-050294	Latimeria chalumnae	71.47	0.00e+00	893.00
IUUC-Laf-053819	Loxodonta africana	76.34	0.00e+00	640.00
IUUC-Mcc-055048	Macaca mulatta	69.51	0.00e+00	865.00
IUUC-Mga-059720	Meleagris gallopavo	74.70	0.00e+00	702.00
IUUC-Mdo-062073	Monodelphis domestica	70.98	0.00e+00	908.00
IUUC-Mmu-064095	Mus musculus	68.54	0.00e+00	862.00
IUUC-Mpu-066318	Mustela putorius furo	77.43	0.00e+00	666.00
IUUC-Mlu-067090	Myotis lucifugus	77.20	0.00e+00	660.00
IUUC-Nle-069486	Nomascus leucogenys	69.51	0.00e+00	867.00
IUUC-Opr-070563	Ochotona princeps	68.30	0.00e+00	863.00
IUUC-Ont-072103	Oreochromis niloticus	71.64	0.00e+00	914.00
IUUC-Oan-073245	Ornithorhynchus anatinus	84.15	3.00e-160	558.00
IUUC-Ocu-074851	Oryctolagus cuniculus	76.85	1.00e-143	503.00
IUUC-Ola-086413	Oryzias latipes	72.33	0.00e+00	742.00
IUUC-Oga-088862	Otolemur garnettii	68.78	0.00e+00	864.00
IUUC-Oar-089462	Ovis aries	74.46	0.00e+00	627.00
IUUC-Ptr-091525	Pan troglodytes	68.90	0.00e+00	800.00
IUUC-Pan-092363	Papio anubis	69.51	0.00e+00	861.00
IUUC-Psi-093353	Pelodiscus sinensis	71.59	0.00e+00	921.00
IUUC-Pma-094155	Petromyzon marinus	58.14	4.00e-84	304.00
IUUC-Pfo-096413	Poecilia formosa	73.04	0.00e+00	919.00
IUUC-Pab-098592	Pongo abelii	67.55	0.00e+00	701.00
IUUC-Pca-100449	Procavia capensis	67.77	0.00e+00	861.00
IUUC-Pva-102868	Pteropus vampyrus	77.20	0.00e+00	655.00
IUUC-Rno-105190	Rattus norvegicus	68.54	0.00e+00	865.00
IUUC-Sha-107337	Sarcophilus harrisii	70.33	0.00e+00	905.00
IUUC-Sar-113561	Sorex araneus	86.43	1.00e-73	270.00
IUUC-Ssc-115735	Sus scrofa	67.63	0.00e+00	833.00
IUUC-Tru-117585	Takifugu rubripes	72.09	0.00e+00	894.00
IUUC-Tsy-118814	Tarsius syrichta	69.02	0.00e+00	853.00
IUUC-Tni-120600	Tetraodon nigroviridis	71.80	0.00e+00	853.00
IUUC-Vpa-130263	Vicugna pacos	85.19	1.00e-169	588.00
IUUC-Xtr-132090	Xenopus tropicalis	70.85	0.00e+00	866.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence