iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
HINT
Post-translational Modifications (PTMs)
CPLM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	4.50e-09	37.5	263	312

Active Site

Position(s)	Description	Evidence
679	Proton donor/acceptor	{ECO:0000256\|PIRSR:PIRSR602717-51}

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCrs 53
           k C  C+++g++ ++++ C+ C++ fH +C  ++  + +p+   wiC+ Cr 
   Q: 263  KTCSSCRDQGKNADNMLFCDSCDRGFHMECCDPP-LTRMPKGM-WICQICRP 312
           68999******99*********************.9*****97.******85 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MVKLANPLYT EWILEAIKKV KKQKQRPSEE RICNAVSSSH GLDRRTVLEQ LELSVKDGTI 60
LKVSNKGLNS YKDPDNPGRI ALPKPRNHGK LDTKQSVDWN KLLKRAFEGL AETGGSTLKS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTCGGAGCT CACTGTCTCC AAGATGGCGG CCGTGTCAGT TTGGGGCATC TCCGCGGTCC 60
GGCCCGGGCC CCCGGGATCC CGGCTGTCTT CCCCCCAGGT AAGGAGCCGA GGGGCCGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016181--Acyl_CoA_acyltransferase
IPR002717--HAT_MYST-type
IPR005818--Histone_H1/H5_H15
IPR031280--KAT6A
IPR011991--WHTH_DNA-bd_dom
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51504--H15
PS51726--MYST_HAT
PS50016--ZF_PHD_2

Pfam

PF01853--MOZ_SAS
PF00628--PHD

SMART

SM00526--H15
SM00249--PHD

Gene Ontology

GO:0005829--C:cytosol
GO:0070776--C:MOZ/MORF histone acetyltransferase complex
GO:0016607--C:nuclear speck
GO:0005730--C:nucleolus
GO:0000786--C:nucleosome
GO:0016605--C:PML body
GO:0003677--F:DNA binding
GO:0004402--F:histone acetyltransferase activity
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0090398--P:cellular senescence
GO:0043966--P:histone H3 acetylation
GO:0030099--P:myeloid cell differentiation
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0006334--P:nucleosome assembly
GO:0045893--P:positive regulation of transcription, DNA-templated

KEGG

mmu:244349

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001219	Ailuropoda melanoleuca	86.90	0.00e+00	2393.00
IUUC-Aca-004549	Anolis carolinensis	72.85	0.00e+00	1617.00
IUUC-Ame-010711	Astyanax mexicanus	69.29	8.00e-180	625.00
IUUC-Bta-013426	Bos taurus	86.87	0.00e+00	1907.00
IUUC-Cja-019124	Callithrix jacchus	89.28	0.00e+00	1974.00
IUUC-Cfa-021165	Canis familiaris	87.27	0.00e+00	2369.00
IUUC-Cpo-022332	Cavia porcellus	82.32	0.00e+00	1964.00
IUUC-Cne-026801	Cryptococcus neoformans	63.59	1.00e-73	271.00
IUUC-Dre-028624	Danio rerio	78.57	0.00e+00	676.00
IUUC-Dno-029878	Dasypus novemcinctus	82.02	0.00e+00	1864.00
IUUC-Ete-032342	Echinops telfairi	90.26	0.00e+00	1779.00
IUUC-Eca-033925	Equus caballus	87.02	0.00e+00	2343.00
IUUC-Fca-035985	Felis catus	88.48	0.00e+00	2384.00
IUUC-Gmo-039182	Gadus morhua	74.34	0.00e+00	1193.00
IUUC-Gga-041028	Gallus gallus	79.92	0.00e+00	1769.00
IUUC-Gac-042131	Gasterosteus aculeatus	72.27	0.00e+00	1182.00
IUUC-Ggo-044664	Gorilla gorilla	88.71	0.00e+00	1951.00
IUUC-Hsa-046832	Homo sapiens	88.46	0.00e+00	1942.00
IUUC-Loc-052537	Lepisosteus oculatus	75.91	0.00e+00	1241.00
IUUC-Laf-053686	Loxodonta africana	87.47	0.00e+00	2339.00
IUUC-Mcc-055429	Macaca mulatta	88.95	0.00e+00	1959.00
IUUC-Mvi-060531	Microbotryum violaceum	54.91	6.00e-72	266.00
IUUC-Mmr-061249	Microcebus murinus	85.81	0.00e+00	1927.00
IUUC-Mdo-062826	Monodelphis domestica	68.85	0.00e+00	1046.00
IUUC-Mpu-066585	Mustela putorius furo	87.00	0.00e+00	2374.00
IUUC-Mlu-066965	Myotis lucifugus	85.90	0.00e+00	2263.00
IUUC-Nle-069270	Nomascus leucogenys	88.22	0.00e+00	1934.00
IUUC-Opr-070963	Ochotona princeps	76.52	0.00e+00	1617.00
IUUC-Ont-071466	Oreochromis niloticus	70.00	2.00e-180	627.00
IUUC-Oan-073367	Ornithorhynchus anatinus	82.29	0.00e+00	2209.00
IUUC-Ocu-074100	Oryctolagus cuniculus	80.72	0.00e+00	1756.00
IUUC-Ola-087293	Oryzias latipes	67.84	0.00e+00	1191.00
IUUC-Oga-089052	Otolemur garnettii	91.40	0.00e+00	824.00
IUUC-Oar-089692	Ovis aries	84.25	0.00e+00	1830.00
IUUC-Ptr-091107	Pan troglodytes	88.63	0.00e+00	1924.00
IUUC-Pan-092524	Papio anubis	88.23	0.00e+00	1953.00
IUUC-Pfo-096641	Poecilia formosa	69.84	0.00e+00	1175.00
IUUC-Pab-098311	Pongo abelii	88.15	0.00e+00	1950.00
IUUC-Pca-100810	Procavia capensis	84.72	0.00e+00	1731.00
IUUC-Pgr-103522	Puccinia graminis	50.00	1.00e-68	254.00
IUUC-Pyt-104594	Pyrenophora triticirepentis	36.30	6.00e-46	179.00
IUUC-Rno-104990	Rattus norvegicus	94.52	0.00e+00	2558.00
IUUC-Sha-106816	Sarcophilus harrisii	83.50	0.00e+00	2246.00
IUUC-Sre-115066	Sporisorium reilianum	55.56	1.00e-77	285.00
IUUC-Tgu-116639	Taeniopygia guttata	79.64	0.00e+00	1768.00
IUUC-Tru-118571	Takifugu rubripes	72.75	0.00e+00	1207.00
IUUC-Tni-119936	Tetraodon nigroviridis	69.82	0.00e+00	1226.00
IUUC-Tbe-127928	Tupaia belangeri	95.44	0.00e+00	1578.00
IUUC-Uma-129445	Ustilago maydis	56.84	2.00e-79	291.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence