iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Fal-037110

Ensembl Protein ID

ENSFALP00000004498.1

UniProt Accession

U3JNZ4; U3JNZ4_FICAL

Genbank Protein ID

ENSFALP00000004498

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AGTO01000454

Gene Name

HECW2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFALG00000004319.1	ENSFALT00000004522.1	ENSFALP00000004498.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	7.50e-122	406.6	1149	1481

Active Site

Position(s)	Description	Evidence
1449	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld
   Q: 1149 DLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALIHQYLLD 1234
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+  ++l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLkpgG+nipVt++Nk+eY+++
   Q: 1235 AFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDN---DIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIER 1317
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1318 MVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1404
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ + lP+++TCfn+L+LP+Y+s + l+ekLl+A+eet+ F+l+
   Q: 1405 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1481
           **************************************************************************985 PP

Organism

Ficedula albicollis

Protein Sequence
(Fasta)

MQFRIHRHLL EWPDENSPAN FWDSKNRGVT GTQKGQIVWR IEPGPYFMES EIKICFKYYH 60
GVSGALRATT PCITVKNPAV MMGVEGTDEG ASGAQHSRKL VSFTLSDIRA AGLKKGMFFN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TAGGATTTAA GGATCCTCCT GTTTACACCA GCCCGCCCGT GCTGCGGGGC TGTGGCCATG 60
CTGAGGAATC CTCCCATGGA CAAGGCAAGG AAGGAAGTGG AGGGAGGATG GGGCTTCGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0072686--C:mitotic spindle
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030071--P:regulation of mitotic metaphase/anaphase transition

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	82.94	0.00e+00	2417.00
IUUC-Apl-003935	Anas platyrhynchos	92.67	0.00e+00	2660.00
IUUC-Aca-004558	Anolis carolinensis	85.60	0.00e+00	2451.00
IUUC-Ame-010893	Astyanax mexicanus	88.61	0.00e+00	1305.00
IUUC-Bta-013093	Bos taurus	95.08	0.00e+00	1560.00
IUUC-Cja-019651	Callithrix jacchus	83.10	0.00e+00	2408.00
IUUC-Cfa-021232	Canis familiaris	98.11	0.00e+00	1609.00
IUUC-Cpo-021770	Cavia porcellus	81.80	0.00e+00	2373.00
IUUC-Csa-023970	Chlorocebus sabaeus	84.73	0.00e+00	2403.00
IUUC-Cho-024512	Choloepus hoffmanni	77.06	0.00e+00	2107.00
IUUC-Csv-026127	Ciona savignyi	66.67	7.00e-155	540.00
IUUC-Dre-028275	Danio rerio	86.08	0.00e+00	1480.00
IUUC-Dno-029963	Dasypus novemcinctus	83.59	0.00e+00	2373.00
IUUC-Dor-030282	Dipodomys ordii	74.12	0.00e+00	1414.00
IUUC-Dme-032217	Drosophila melanogaster	71.91	0.00e+00	657.00
IUUC-Ete-033132	Echinops telfairi	81.72	0.00e+00	1240.00
IUUC-Eca-033978	Equus caballus	83.32	0.00e+00	2395.00
IUUC-Fca-036157	Felis catus	84.81	0.00e+00	2394.00
IUUC-Gmo-039291	Gadus morhua	70.79	0.00e+00	1155.00
IUUC-Gga-040821	Gallus gallus	92.99	0.00e+00	2672.00
IUUC-Gac-042181	Gasterosteus aculeatus	84.91	0.00e+00	1428.00
IUUC-Ggo-044862	Gorilla gorilla	83.91	0.00e+00	2412.00
IUUC-Hsa-046219	Homo sapiens	83.96	0.00e+00	2447.00
IUUC-Lch-050526	Latimeria chalumnae	78.22	0.00e+00	2246.00
IUUC-Loc-052648	Lepisosteus oculatus	85.70	0.00e+00	1519.00
IUUC-Laf-054005	Loxodonta africana	84.79	0.00e+00	2430.00
IUUC-Mcc-055314	Macaca mulatta	84.46	0.00e+00	2401.00
IUUC-Meu-056356	Macropus eugenii	81.10	0.00e+00	795.00
IUUC-Mga-060074	Meleagris gallopavo	92.63	0.00e+00	2556.00
IUUC-Mmr-061526	Microcebus murinus	91.31	0.00e+00	1730.00
IUUC-Mdo-063017	Monodelphis domestica	85.24	0.00e+00	2390.00
IUUC-Mmu-064165	Mus musculus	83.11	0.00e+00	2363.00
IUUC-Mpu-065835	Mustela putorius furo	93.89	0.00e+00	1538.00
IUUC-Mlu-067709	Myotis lucifugus	80.76	0.00e+00	2334.00
IUUC-Nle-069308	Nomascus leucogenys	83.89	0.00e+00	2409.00
IUUC-Opr-070330	Ochotona princeps	69.75	0.00e+00	1911.00
IUUC-Ont-071345	Oreochromis niloticus	87.02	0.00e+00	1446.00
IUUC-Ocu-074775	Oryctolagus cuniculus	81.71	0.00e+00	2307.00
IUUC-Ola-087225	Oryzias latipes	82.27	0.00e+00	1344.00
IUUC-Oga-088177	Otolemur garnettii	82.14	0.00e+00	2352.00
IUUC-Oar-089452	Ovis aries	84.89	0.00e+00	2417.00
IUUC-Ptr-090806	Pan troglodytes	84.10	0.00e+00	2422.00
IUUC-Pan-091838	Papio anubis	84.68	0.00e+00	2395.00
IUUC-Psi-094090	Pelodiscus sinensis	88.57	0.00e+00	2510.00
IUUC-Pfo-096520	Poecilia formosa	67.68	0.00e+00	1486.00
IUUC-Pab-098405	Pongo abelii	83.96	0.00e+00	2415.00
IUUC-Pca-100441	Procavia capensis	77.06	0.00e+00	1757.00
IUUC-Pva-102324	Pteropus vampyrus	97.61	0.00e+00	1602.00
IUUC-Rno-105943	Rattus norvegicus	81.80	0.00e+00	2418.00
IUUC-Sha-106985	Sarcophilus harrisii	88.69	0.00e+00	1674.00
IUUC-Sar-113505	Sorex araneus	94.32	0.00e+00	1519.00
IUUC-Ssc-115439	Sus scrofa	76.98	0.00e+00	1415.00
IUUC-Tgu-117078	Taeniopygia guttata	96.20	0.00e+00	2659.00
IUUC-Tru-118671	Takifugu rubripes	84.46	0.00e+00	1448.00
IUUC-Tni-120619	Tetraodon nigroviridis	86.30	0.00e+00	1427.00
IUUC-Tbe-127975	Tupaia belangeri	79.66	0.00e+00	1889.00
IUUC-Ttr-128469	Tursiops truncatus	77.38	0.00e+00	2144.00
IUUC-Vpa-130498	Vicugna pacos	73.47	0.00e+00	1951.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence