iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-012939

Ensembl Protein ID

ENSBTAP00000008072.3

UniProt Accession

Q2HJ23; MLP3A_BOVIN

Genbank Protein ID

AAI13349.1

Protein Name

Microtubule-associated proteins 1A/1B light chain 3A; Autophagy-related protein LC3 A; Autophagy-related ubiquitin-like modifier LC3 A; MAP1 light chain 3-like protein 1; MAP1A/MAP1B light chain 3 A; Microtubule-associated protein 1 light chain 3 alpha

Genbank Nucleotide ID

BC113348

Gene Name

MAP1LC3A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000006135.3	ENSBTAT00000008072.3	ENSBTAP00000008072.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UBL/ATG8	1.80e-50	169.6	15	120

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UBL/ATG8

   S: 1    krkeevekirdkfpdkiPvivekakkeki.peldkkkylvPsdltvgqlvkiirkrlqlraedalfllvnn.slvsvsatlaeiyeeek 87
           +r++ev++ir+++p+kiPvi+e++k+ek+ p+ldk+k+lvP+++++++lvkiir+rlql++++a+fllvn+ s+vsvs+++a+iye+ek
   Q: 15   DRCKEVQQIREQHPSKIPVIIERYKGEKQlPVLDKTKFLVPDHVNMSELVKIIRRRLQLNPTQAFFLLVNQhSMVSVSTPIADIYEQEK 103
           69**************************99*********************************************************** PP
   S: 88   dedgflyvayaseetfG 104
           dedgfly++yas+etfG
   Q: 104  DEDGFLYMVYASQETFG 120
           ****************9 PP

Organism

Bos taurus

Functional Description
(View)

Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

Protein Sequence
(Fasta)

MPSDRPFKQR RSFADRCKEV QQIREQHPSK IPVIIERYKG EKQLPVLDKT KFLVPDHVNM 60
SELVKIIRRR LQLNPTQAFF LLVNQHSMVS VSTPIADIYE QEKDEDGFLY MVYASQETFG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGACGCCGCC GGGCTCAGCG CGAGCCCCGG AGCCCTTGTG CGCGAGGCGC GGAGCCCCCG 60
GAGCCCCCGG ACCGCAGCCA CATCCCTGCG TCGCGCGCCC CGGAGGTCCG GCCTGCGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0072--Autophagy
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0206--Cytoskeleton
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0493--Microtubule
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0833--Ubl conjugation pathway

Interpro

IPR004241--Atg8-like
IPR029071--Ubiquitin-rel_dom

Pfam

PF02991--Atg8

Gene Ontology

GO:0044754--C:autolysosome
GO:0005776--C:autophagosome
GO:0000421--C:autophagosome membrane
GO:0031410--C:cytoplasmic vesicle
GO:0005829--C:cytosol
GO:0012505--C:endomembrane system
GO:0005874--C:microtubule
GO:0031090--C:organelle membrane
GO:0008429--F:phosphatidylethanolamine binding
GO:0005543--F:phospholipid binding
GO:0000045--P:autophagosome assembly
GO:0000422--P:mitophagy

KEGG

bta:514547

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001444	Ailuropoda melanoleuca	97.27	4.00e-60	222.00
IUUC-Apl-003457	Anas platyrhynchos	88.33	1.00e-59	220.00
IUUC-Aca-004647	Anolis carolinensis	95.87	2.00e-66	243.00
IUUC-Ame-010918	Astyanax mexicanus	96.67	4.00e-66	242.00
IUUC-Cel-018533	Caenorhabditis elegans	59.65	2.00e-35	140.00
IUUC-Cja-018774	Callithrix jacchus	98.15	1.00e-59	221.00
IUUC-Cfa-020676	Canis familiaris	97.50	1.00e-66	244.00
IUUC-Cpo-022407	Cavia porcellus	99.17	4.00e-68	248.00
IUUC-Csa-023226	Chlorocebus sabaeus	99.17	4.00e-68	248.00
IUUC-Cin-025249	Ciona intestinalis	76.67	3.00e-53	199.00
IUUC-Dre-027607	Danio rerio	96.67	4.00e-66	242.00
IUUC-Dno-029031	Dasypus novemcinctus	99.17	4.00e-68	248.00
IUUC-Ete-032915	Echinops telfairi	99.07	1.00e-59	220.00
IUUC-Eca-033844	Equus caballus	97.27	4.00e-60	222.00
IUUC-Eeu-034695	Erinaceus europaeus	98.13	4.00e-59	218.00
IUUC-Fca-035743	Felis catus	95.16	2.00e-65	240.00
IUUC-Fal-036789	Ficedula albicollis	97.22	5.00e-59	219.00
IUUC-Gmo-039473	Gadus morhua	95.83	5.00e-66	242.00
IUUC-Gga-040489	Gallus gallus	95.87	1.00e-66	244.00
IUUC-Gac-041849	Gasterosteus aculeatus	94.17	9.00e-65	238.00
IUUC-Ggo-044780	Gorilla gorilla	99.07	6.00e-60	222.00
IUUC-Hsa-046055	Homo sapiens	99.17	4.00e-68	248.00
IUUC-Itr-048837	Ictidomys tridecemlineatus	99.17	4.00e-68	249.00
IUUC-Lch-050578	Latimeria chalumnae	91.67	8.00e-63	231.00
IUUC-Loc-052008	Lepisosteus oculatus	97.50	9.00e-67	244.00
IUUC-Laf-054392	Loxodonta africana	91.67	2.00e-60	223.00
IUUC-Mcc-055894	Macaca mulatta	99.07	5.00e-60	222.00
IUUC-Mga-059593	Meleagris gallopavo	96.30	6.00e-59	218.00
IUUC-Mmr-061787	Microcebus murinus	99.17	4.00e-68	248.00
IUUC-Mdo-062276	Monodelphis domestica	98.35	1.00e-67	247.00
IUUC-Mmu-063357	Mus musculus	99.17	4.00e-68	248.00
IUUC-Mpu-065740	Mustela putorius furo	97.52	2.00e-67	247.00
IUUC-Mlu-067688	Myotis lucifugus	98.35	1.00e-67	247.00
IUUC-Nle-069441	Nomascus leucogenys	99.07	5.00e-60	222.00
IUUC-Opr-071159	Ochotona princeps	99.07	1.00e-59	220.00
IUUC-Ont-071272	Oreochromis niloticus	95.83	5.00e-66	242.00
IUUC-Oan-073060	Ornithorhynchus anatinus	89.42	2.00e-52	196.00
IUUC-Ola-087353	Oryzias latipes	94.17	6.00e-65	238.00
IUUC-Oga-088213	Otolemur garnettii	99.17	4.00e-68	248.00
IUUC-Oar-089438	Ovis aries	94.12	1.00e-61	228.00
IUUC-Ptr-090906	Pan troglodytes	99.07	6.00e-60	221.00
IUUC-Pan-091989	Papio anubis	99.07	4.00e-60	222.00
IUUC-Psi-093576	Pelodiscus sinensis	90.98	1.00e-59	221.00
IUUC-Pfo-097503	Poecilia formosa	95.83	7.00e-66	241.00
IUUC-Pab-098040	Pongo abelii	99.17	4.00e-68	248.00
IUUC-Rno-104943	Rattus norvegicus	99.17	4.00e-68	248.00
IUUC-Ssc-115937	Sus scrofa	98.35	1.00e-66	244.00
IUUC-Tgu-116715	Taeniopygia guttata	96.33	1.00e-58	217.00
IUUC-Tru-117554	Takifugu rubripes	96.26	8.00e-58	214.00
IUUC-Tni-120190	Tetraodon nigroviridis	92.50	1.00e-63	234.00
IUUC-Vpa-130194	Vicugna pacos	96.26	2.00e-57	213.00
IUUC-Xtr-132257	Xenopus tropicalis	93.33	7.00e-64	234.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence