iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-045969

UUCD1 version

UUC-HoS-00425

Ensembl Protein ID

ENSP00000262843.6

UniProt Accession

Q9UJV3; A6NEL8; A6PVI5; Q5JYF5; Q8WWK1; Q9UJR9; TRIM1_HUMAN

Genbank Protein ID

AAF07341.1; CAB56154.1; CAI42073.1; CAI42073.1; CAO72053.1; CAO72053.1; AAH17707.1; AAP35309.1

Protein Name

Probable E3 ubiquitin-protein ligase MID2; Midin-2; Midline defect 2; Midline-2; RING finger protein 60; RING-type E3 ubiquitin transferase MID2; Tripartite motif-containing protein 1

Genbank Nucleotide ID

AF196481; Y18880; AL034399; AL109946; AL109946; AL034399; BC017707; BT006663

Gene Name

MID2; FXY2; RNF60; TRIM1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000080561.13	ENST00000262843.10	ENSP00000262843.6
ENSG00000080561.13	ENST00000443968.2	ENSP00000413976.2

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	RepTar	miRNAMap	SomamiR
miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
ClinVar	GWAS Central	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18248090

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	6.80e-07	31.4	30	80

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkw......pglknssskefrCPlCr 46
           C+iCle f+d pl+lpC H  +++C +++       g + +  ++f+CP+Cr
   Q: 30   CPICLELFED-PLLLPCAHSLCFSCAHRIlvsscsSGESIEPITAFQCPTCR 80
           **********.999***************999999888888999999****8 PP

Organism

Homo sapiens

Functional Description
(View)

May play a role in microtubule stabilization.

Protein Sequence
(Fasta)

MGESPASVVL NASGGLFSLK METLESELTC PICLELFEDP LLLPCAHSLC FSCAHRILVS 60
SCSSGESIEP ITAFQCPTCR YVISLNHRGL DGLKRNVTLQ NIIDRFQKAS VSGPNSPSES 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTCAAGATG ACAGGGCGCT GGAGAAAAGG CTGCTGGAAT CAGCTGGTAG GTACAGTAGT 60
AACCCGAGCC CCACCCACCG GCTGCCTTTG CTTGCTCAGG TTTCTCCGGT CACTCCTGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0225--Disease mutation
KW-0991--Mental retardation
KW-0479--Metal-binding
KW-0493--Microtubule
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003649--Bbox_C
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR017903--COS_domain
IPR003961--FN3_dom
IPR013783--Ig-like_fold
IPR033491--MID2
IPR003877--SPRY_dom
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS51262--COS
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00622--SPRY
PF00643--zf-B_box
PF13445--zf-RING_UBOX

PRINTS

PR01407--BUTYPHLNCDUF

SMART

SM00502--BBC
SM00336--BBOX
SM00060--FN3
SM00184--RING
SM00449--SPRY

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005874--C:microtubule
GO:0042802--F:identical protein binding
GO:0008017--F:microtubule binding
GO:0051219--F:phosphoprotein binding
GO:0046982--F:protein heterodimerization activity
GO:0042803--F:protein homodimerization activity
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0045087--P:innate immune response
GO:0046597--P:negative regulation of viral entry into host cell
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0010508--P:positive regulation of autophagy
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0035372--P:protein localization to microtubule
GO:0016567--P:protein ubiquitination

KEGG

hsa:11043

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001342	Ailuropoda melanoleuca	99.18	0.00e+00	1524.00
IUUC-Apl-004167	Anas platyrhynchos	89.36	0.00e+00	1326.00
IUUC-Cja-019379	Callithrix jacchus	99.44	0.00e+00	1493.00
IUUC-Cfa-021219	Canis familiaris	94.97	0.00e+00	1405.00
IUUC-Cpo-021954	Cavia porcellus	94.13	0.00e+00	1397.00
IUUC-Csa-023047	Chlorocebus sabaeus	95.65	0.00e+00	1454.00
IUUC-Cho-025087	Choloepus hoffmanni	90.43	0.00e+00	800.00
IUUC-Dre-028003	Danio rerio	76.60	0.00e+00	1167.00
IUUC-Dno-029344	Dasypus novemcinctus	94.55	0.00e+00	1401.00
IUUC-Dor-030160	Dipodomys ordii	91.74	0.00e+00	1069.00
IUUC-Ete-032883	Echinops telfairi	91.36	0.00e+00	1357.00
IUUC-Eca-033688	Equus caballus	95.24	0.00e+00	1411.00
IUUC-Eeu-034882	Erinaceus europaeus	88.84	0.00e+00	1311.00
IUUC-Fca-036427	Felis catus	99.18	0.00e+00	1526.00
IUUC-Fal-036967	Ficedula albicollis	76.70	0.00e+00	1075.00
IUUC-Gmo-038518	Gadus morhua	68.91	0.00e+00	991.00
IUUC-Gga-040408	Gallus gallus	87.99	0.00e+00	1355.00
IUUC-Gac-041617	Gasterosteus aculeatus	79.06	0.00e+00	1195.00
IUUC-Ggo-045217	Gorilla gorilla	99.73	0.00e+00	1534.00
IUUC-Itr-049079	Ictidomys tridecemlineatus	99.44	0.00e+00	1493.00
IUUC-Lch-050468	Latimeria chalumnae	82.73	0.00e+00	1209.00
IUUC-Laf-054029	Loxodonta africana	98.60	0.00e+00	1483.00
IUUC-Mcc-055424	Macaca mulatta	99.73	0.00e+00	1526.00
IUUC-Meu-056432	Macropus eugenii	93.57	0.00e+00	1299.00
IUUC-Mga-059599	Meleagris gallopavo	82.50	0.00e+00	1185.00
IUUC-Mmr-061432	Microcebus murinus	98.08	0.00e+00	1508.00
IUUC-Mdo-061989	Monodelphis domestica	89.84	0.00e+00	1372.00
IUUC-Mmu-063963	Mus musculus	99.16	0.00e+00	1487.00
IUUC-Mpu-065964	Mustela putorius furo	95.10	0.00e+00	1446.00
IUUC-Mlu-067148	Myotis lucifugus	94.96	0.00e+00	1444.00
IUUC-Nle-069552	Nomascus leucogenys	95.77	0.00e+00	1452.00
IUUC-Opr-070968	Ochotona princeps	98.83	2.00e-156	546.00
IUUC-Ont-072260	Oreochromis niloticus	75.87	0.00e+00	1003.00
IUUC-Ocu-074109	Oryctolagus cuniculus	94.69	0.00e+00	1443.00
IUUC-Oga-089063	Otolemur garnettii	99.30	0.00e+00	1491.00
IUUC-Oar-089845	Ovis aries	94.82	0.00e+00	1444.00
IUUC-Ptr-091360	Pan troglodytes	100.00	0.00e+00	1539.00
IUUC-Pan-092900	Papio anubis	98.92	0.00e+00	1526.00
IUUC-Pfo-096044	Poecilia formosa	76.51	0.00e+00	1003.00
IUUC-Pab-098637	Pongo abelii	95.51	0.00e+00	1452.00
IUUC-Pva-102319	Pteropus vampyrus	97.06	0.00e+00	1450.00
IUUC-Rno-105496	Rattus norvegicus	94.83	0.00e+00	1442.00
IUUC-Sha-107246	Sarcophilus harrisii	89.60	0.00e+00	1374.00
IUUC-Ssc-115858	Sus scrofa	94.95	0.00e+00	1440.00
IUUC-Tru-118237	Takifugu rubripes	79.64	0.00e+00	1208.00
IUUC-Tsy-119383	Tarsius syrichta	99.42	0.00e+00	1440.00
IUUC-Tni-119919	Tetraodon nigroviridis	80.11	0.00e+00	1225.00
IUUC-Ttr-128902	Tursiops truncatus	99.30	0.00e+00	1492.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence