iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cpo-021284

Ensembl Protein ID

ENSCPOP00000009505.2

UniProt Accession

H0VH81; H0VH81_CAVPO

Genbank Protein ID

ENSCPOP00000009505

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAKN02008492

Gene Name

ARHGEF7

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000010585.3	ENSCPOT00000010680.2	ENSCPOP00000009505.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	6.50e-15	54.8	149	204

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
            +v++ ++++ +n+deL++ kGdv++v     +++gW++g  + +g+ G fP+n+v++++
   Q: 149  LVVKAKFNFQQTNEDELSFSKGDVIHVT--RVEEGGWWEG--THNGRTGWFPSNYVREIK 204
           5799***********************7..999*******..8**************996 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

XPKKTIADPE RLCRAGVLKD GVVLCRLLER LLPGTIEKVY PEPRSESECL SNIREFLRAC 60
GASLRLETFD ANDLYQGQNF NKVLSSLVTL NKVTADIGLG SDSVCARPSS HRIKSFDSLG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

NNGCCCAAGA AAACCATCGC GGACCCCGAG CGCCTGTGTC GGGCAGGCGT CCTCAAGGAT 60
GGGGTGGTCC TCTGCAGGCT GCTGGAGCGC TTGCTGCCCG GGACCATCGA GAAAGTAAGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1185--Reference proteome

Interpro

IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR032409--GEF_CC
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR011511--SH3_2
IPR001452--SH3_domain

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF16523--betaPIX_CC
PF00307--CH
PF00169--PH
PF00621--RhoGEF
PF07653--SH3_2

PRINTS

PR00452--SH3DOMAIN

SMART

SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005829--C:cytosol
GO:0005925--C:focal adhesion
GO:0030027--C:lamellipodium
GO:0043005--C:neuron projection
GO:0043025--C:neuronal cell body
GO:0005886--C:plasma membrane
GO:0043234--C:protein complex
GO:0000322--C:storage vacuole
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0048041--P:focal adhesion assembly
GO:0007030--P:Golgi organization
GO:0002244--P:hematopoietic progenitor cell differentiation
GO:0035556--P:intracellular signal transduction
GO:0030032--P:lamellipodium assembly
GO:0043065--P:positive regulation of apoptotic process
GO:0010763--P:positive regulation of fibroblast migration
GO:0060124--P:positive regulation of growth hormone secretion
GO:2000394--P:positive regulation of lamellipodium morphogenesis
GO:0032092--P:positive regulation of protein binding
GO:1900026--P:positive regulation of substrate adhesion-dependent cell spreading
GO:1904424--P:regulation of GTP binding
GO:0035023--P:regulation of Rho protein signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001259	Ailuropoda melanoleuca	89.74	0.00e+00	1235.00
IUUC-Aca-004591	Anolis carolinensis	89.57	0.00e+00	1313.00
IUUC-Ame-010759	Astyanax mexicanus	75.06	0.00e+00	1212.00
IUUC-Bta-013328	Bos taurus	91.23	0.00e+00	1416.00
IUUC-Cja-018742	Callithrix jacchus	92.15	0.00e+00	1156.00
IUUC-Cfa-020756	Canis familiaris	93.51	0.00e+00	1112.00
IUUC-Csa-023162	Chlorocebus sabaeus	93.96	0.00e+00	1451.00
IUUC-Cho-024736	Choloepus hoffmanni	72.42	2.00e-165	575.00
IUUC-Cin-025535	Ciona intestinalis	40.51	7.00e-95	341.00
IUUC-Cgl-026676	Colletotrichum gloeosporioides	42.86	2.00e-11	65.50
IUUC-Cne-026866	Cryptococcus neoformans	52.94	2.00e-12	68.90
IUUC-Dre-028646	Danio rerio	74.47	0.00e+00	1193.00
IUUC-Dno-029461	Dasypus novemcinctus	93.84	0.00e+00	1444.00
IUUC-Dor-030623	Dipodomys ordii	82.04	0.00e+00	1069.00
IUUC-Dme-032219	Drosophila melanogaster	45.99	9.00e-97	348.00
IUUC-Ete-032236	Echinops telfairi	79.23	0.00e+00	774.00
IUUC-Eca-034137	Equus caballus	95.12	0.00e+00	1332.00
IUUC-Fca-035742	Felis catus	91.65	0.00e+00	1108.00
IUUC-Fal-037205	Ficedula albicollis	92.06	0.00e+00	1152.00
IUUC-Gmo-039475	Gadus morhua	68.64	0.00e+00	1025.00
IUUC-Gga-040539	Gallus gallus	76.60	0.00e+00	937.00
IUUC-Gac-042615	Gasterosteus aculeatus	64.54	0.00e+00	909.00
IUUC-Ggo-044470	Gorilla gorilla	88.47	0.00e+00	1256.00
IUUC-Hsa-046398	Homo sapiens	90.04	0.00e+00	1257.00
IUUC-Loc-052146	Lepisosteus oculatus	84.02	0.00e+00	1306.00
IUUC-Laf-053891	Loxodonta africana	90.17	0.00e+00	1390.00
IUUC-Mcc-055483	Macaca mulatta	90.17	0.00e+00	1260.00
IUUC-Mga-059410	Meleagris gallopavo	90.46	0.00e+00	1296.00
IUUC-Mmr-060758	Microcebus murinus	93.18	0.00e+00	1223.00
IUUC-Mdo-061900	Monodelphis domestica	79.03	0.00e+00	1199.00
IUUC-Mmu-063849	Mus musculus	93.83	0.00e+00	1273.00
IUUC-Mpu-065876	Mustela putorius furo	93.34	0.00e+00	1105.00
IUUC-Mlu-067970	Myotis lucifugus	94.87	0.00e+00	1332.00
IUUC-Nle-069685	Nomascus leucogenys	76.17	0.00e+00	1000.00
IUUC-Opr-071132	Ochotona princeps	61.93	0.00e+00	695.00
IUUC-Ont-071815	Oreochromis niloticus	74.59	0.00e+00	1189.00
IUUC-Oan-073057	Ornithorhynchus anatinus	92.06	0.00e+00	1169.00
IUUC-Ola-086663	Oryzias latipes	73.21	0.00e+00	1066.00
IUUC-Oga-088103	Otolemur garnettii	93.49	0.00e+00	1277.00
IUUC-Ptr-091162	Pan troglodytes	89.99	0.00e+00	1200.00
IUUC-Pan-092093	Papio anubis	85.18	0.00e+00	1316.00
IUUC-Pma-094701	Petromyzon marinus	60.72	1.00e-120	426.00
IUUC-Pfo-096736	Poecilia formosa	67.34	0.00e+00	1025.00
IUUC-Pab-097641	Pongo abelii	80.81	0.00e+00	1222.00
IUUC-Pva-102819	Pteropus vampyrus	89.90	0.00e+00	1205.00
IUUC-Pte-104123	Pyrenophora teres	45.00	1.00e-10	62.40
IUUC-Rno-106099	Rattus norvegicus	94.91	0.00e+00	1446.00
IUUC-Sha-106845	Sarcophilus harrisii	78.01	0.00e+00	1086.00
IUUC-Ssc-116036	Sus scrofa	78.85	0.00e+00	1089.00
IUUC-Tgu-117498	Taeniopygia guttata	90.75	0.00e+00	1355.00
IUUC-Tru-118278	Takifugu rubripes	72.87	0.00e+00	1074.00
IUUC-Tsy-118990	Tarsius syrichta	92.06	0.00e+00	931.00
IUUC-Tni-120852	Tetraodon nigroviridis	73.85	0.00e+00	944.00
IUUC-Tvi-122534	Trichoderma virens	42.65	2.00e-11	65.50
IUUC-Ttr-128922	Tursiops truncatus	86.85	0.00e+00	1105.00
IUUC-Xtr-132012	Xenopus tropicalis	83.31	0.00e+00	1179.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence