iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-002302

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACTA01048060

Gene Name

ITCH

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000009134.1	ENSAMET00000010054.1	ENSAMEP00000009638.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.70e-136	454.5	540	872

Active Site

Position(s)	Description	Evidence
841	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f gEegld+gGv+re+++lls+e+ np+++lf+y  +d+++lq+np+s++ np+hlk+F+f+Gr++++al++g+++d+
   Q: 540  PQDLRRRLWVIFPGEEGLDYGGVAREWFFLLSHEVLNPMYCLFEYAGKDNYCLQINPASYI-NPDHLKYFRFIGRFIAMALFHGKFIDT 627
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+k++ l+dle++dpe+y+sl ++ken   +iee+gl++ fsv++eilge+k+++Lkp+G ni Vt+eNkeeY++ v+e
   Q: 628  GFSLPFYKRILNKPVGLKDLESIDPEFYNSLIWVKEN---NIEECGLEMYFSVDKEILGEIKSHDLKPNGGNILVTEENKEEYIRMVAE 713
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +rl +g++eq++af eGfne++p++ l++F+++ele+l+cG++eid++d+++++ y++ yt++s++i wFw++++e+++e+r ++LqFv
   Q: 714  WRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEVLLCGMQEIDLNDWQRHAIYRH-YTRTSKQIMWFWQFVKEIDNEKRMRLLQFV 801
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGfa+l+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 802  TGTCRLPVGGFADLMgsngPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 872
           *********************************************************************96 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

FNAQICRPVG GMSGSGSQLG SMGSLTMKSQ LQITVISAKL KENKKNWFGP SPYVEVTVDG 60
QSKKTEKCNN TNSPKWKQPL TVIVTPVSKL HFRVWSHQTL KSDVLLGTAA LDIFETLKSN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCAATGCTC AGATTTGCCG TCCTGTTGGT GGTATGTCTG GCAGTGGATC ACAGCTTGGT 60
TCAATGGGTA GCCTGACCAT GAAATCACAA CTTCAGATCA CTGGTAAGTC TTAAAAAGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0031410--C:cytoplasmic vesicle
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0016874--F:ligase activity
GO:0043021--F:ribonucleoprotein complex binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0046642--P:negative regulation of alpha-beta T cell proliferation
GO:0043066--P:negative regulation of apoptotic process
GO:0050687--P:negative regulation of defense response to virus
GO:0046329--P:negative regulation of JNK cascade
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0045732--P:positive regulation of protein catabolic process
GO:0002669--P:positive regulation of T cell anergy
GO:0035519--P:protein K29-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0090085--P:regulation of protein deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003752	Anas platyrhynchos	83.97	0.00e+00	1456.00
IUUC-Aca-005338	Anolis carolinensis	81.37	0.00e+00	1446.00
IUUC-Ago-007742	Ashbya gossypii	48.71	6.00e-162	564.00
IUUC-Ame-010601	Astyanax mexicanus	88.25	0.00e+00	1122.00
IUUC-Bta-012782	Bos taurus	97.22	0.00e+00	1590.00
IUUC-Cja-018899	Callithrix jacchus	92.45	0.00e+00	1565.00
IUUC-Cfa-020648	Canis familiaris	97.60	0.00e+00	1615.00
IUUC-Cpo-022073	Cavia porcellus	96.75	0.00e+00	1636.00
IUUC-Csa-023252	Chlorocebus sabaeus	96.52	0.00e+00	1637.00
IUUC-Cho-024695	Choloepus hoffmanni	89.59	0.00e+00	1616.00
IUUC-Cne-026849	Cryptococcus neoformans	47.47	1.00e-158	553.00
IUUC-Dre-028451	Danio rerio	75.74	0.00e+00	1307.00
IUUC-Dno-029884	Dasypus novemcinctus	96.40	0.00e+00	1662.00
IUUC-Eca-033793	Equus caballus	97.36	0.00e+00	1665.00
IUUC-Eeu-034716	Erinaceus europaeus	93.23	0.00e+00	890.00
IUUC-Fca-035605	Felis catus	98.82	0.00e+00	1674.00
IUUC-Fal-037126	Ficedula albicollis	84.47	0.00e+00	1457.00
IUUC-Gmo-038596	Gadus morhua	80.55	0.00e+00	1011.00
IUUC-Gga-040832	Gallus gallus	84.45	0.00e+00	1475.00
IUUC-Gac-041658	Gasterosteus aculeatus	87.16	0.00e+00	1125.00
IUUC-Ggo-044535	Gorilla gorilla	93.12	0.00e+00	1615.00
IUUC-Hsa-046564	Homo sapiens	92.80	0.00e+00	1625.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	95.79	0.00e+00	1567.00
IUUC-Kpa-049273	Komagataella pastoris	49.05	4.00e-163	568.00
IUUC-Lch-050454	Latimeria chalumnae	92.29	0.00e+00	1167.00
IUUC-Loc-052647	Lepisosteus oculatus	74.86	0.00e+00	1361.00
IUUC-Laf-054383	Loxodonta africana	97.46	0.00e+00	1657.00
IUUC-Mcc-055532	Macaca mulatta	96.52	0.00e+00	1638.00
IUUC-Mga-059661	Meleagris gallopavo	84.03	0.00e+00	1468.00
IUUC-Mmr-061135	Microcebus murinus	96.98	0.00e+00	1666.00
IUUC-Mdo-062505	Monodelphis domestica	87.66	0.00e+00	1514.00
IUUC-Mmu-063375	Mus musculus	95.02	0.00e+00	1588.00
IUUC-Mpu-066203	Mustela putorius furo	99.08	0.00e+00	1650.00
IUUC-Mlu-067837	Myotis lucifugus	96.79	0.00e+00	1659.00
IUUC-Nle-069244	Nomascus leucogenys	95.60	0.00e+00	1617.00
IUUC-Opr-070585	Ochotona princeps	90.25	0.00e+00	1575.00
IUUC-Ont-071798	Oreochromis niloticus	88.10	0.00e+00	1144.00
IUUC-Ocu-074298	Oryctolagus cuniculus	96.88	0.00e+00	1628.00
IUUC-Ola-086526	Oryzias latipes	85.57	0.00e+00	1122.00
IUUC-Oga-088167	Otolemur garnettii	89.94	0.00e+00	1514.00
IUUC-Oar-090316	Ovis aries	80.78	0.00e+00	1206.00
IUUC-Ptr-090819	Pan troglodytes	92.02	0.00e+00	1586.00
IUUC-Pan-092454	Papio anubis	96.09	0.00e+00	1647.00
IUUC-Psi-093319	Pelodiscus sinensis	82.55	0.00e+00	1435.00
IUUC-Pfo-097346	Poecilia formosa	85.01	0.00e+00	1108.00
IUUC-Pab-097580	Pongo abelii	86.05	0.00e+00	1466.00
IUUC-Pca-100923	Procavia capensis	79.12	0.00e+00	1363.00
IUUC-Pva-103209	Pteropus vampyrus	95.82	0.00e+00	1587.00
IUUC-Rno-104924	Rattus norvegicus	94.04	0.00e+00	1604.00
IUUC-Sha-107175	Sarcophilus harrisii	89.43	0.00e+00	1509.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	44.66	3.00e-159	555.00
IUUC-Spo-108171	Schizosaccharomyces pombe	50.80	3.00e-162	565.00
IUUC-Sar-113761	Sorex araneus	86.46	0.00e+00	1486.00
IUUC-Tgu-116632	Taeniopygia guttata	80.00	0.00e+00	1333.00
IUUC-Tru-118442	Takifugu rubripes	89.10	0.00e+00	1124.00
IUUC-Tsy-119198	Tarsius syrichta	90.02	0.00e+00	1522.00
IUUC-Tni-120168	Tetraodon nigroviridis	87.06	0.00e+00	1061.00
IUUC-Tbe-127756	Tupaia belangeri	77.41	0.00e+00	1305.00
IUUC-Ttr-128504	Tursiops truncatus	91.54	0.00e+00	1197.00
IUUC-Vpa-130103	Vicugna pacos	82.74	0.00e+00	1404.00
IUUC-Xtr-132885	Xenopus tropicalis	76.69	0.00e+00	1382.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence