iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-090758

UUCD1 version

UUC-PaT-00162

Ensembl Protein ID

ENSPTRP00000006096.5

UniProt Accession

H2Q3F3; H2Q3F3_PANTR

Genbank Protein ID

JAA06780.1; JAA21068.1; JAA25805.1; JAA41194.1

Protein Name

TNF receptor-associated factor 6

Genbank Nucleotide ID

AACZ03078427; GABF01001077; GABD01007295; GABE01003545

Gene Name

TRAF6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000003510.5	ENSPTRT00000006610.5	ENSPTRP00000006096.5

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	3.60e-07	30.1	66	127

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrli 65
           + + CpI l   r+ v +p+G+ + +++I k +++ g++cPv+++ l e++l P ++ +r i
   Q: 66   SKYECPICLMALREAVQTPCGHRFCKACIIKSIRDAGHKCPVDNEILLENQLFPDNFAKREI 127
           5689*****************************999999*****************999977 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MSLLNCENSC GSSQSESDCC VAMASSCSAA TKDDSVGGTA STGNLSSSFM EEIQGYDVEF 60
DPPLESKYEC PICLMALREA VQTPCGHRFC KACIIKSIRD AGHKCPVDNE ILLENQLFPD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCAGAGAAG GCGGAAGCAG TGGCGTCCGC AGCTGGGGCT TGGCCTGCGG GCGGCCAGCG 60
AAGGTGGCGA AGGCTCCCAC TGGATCCAGA GTTTGCCGTC CAAGCAGCCT CGTCTCGGCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0675--Receptor
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR002083--MATH/TRAF_dom
IPR012227--TNF_rcpt--assoc_TRAF
IPR008974--TRAF-like
IPR027139--TRAF6
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR001293--Znf_TRAF

PROSITE

PS50144--MATH
PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS50145--ZF_TRAF

Pfam

PF02176--zf-TRAF

SMART

SM00061--MATH
SM00184--RING

Gene Ontology

GO:0035631--C:CD40 receptor complex
GO:0009898--C:cytoplasmic side of plasma membrane
GO:0005829--C:cytosol
GO:0005811--C:lipid particle
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0043234--C:protein complex
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0007250--P:activation of NF-kappaB-inducing kinase activity
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045453--P:bone resorption
GO:0048468--P:cell development
GO:0071222--P:cellular response to lipopolysaccharide
GO:0007249--P:I-kappaB kinase/NF-kappaB signaling
GO:0070498--P:interleukin-1-mediated signaling pathway
GO:0043011--P:myeloid dendritic cell differentiation
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0001843--P:neural tube closure
GO:0042475--P:odontogenesis of dentin-containing tooth
GO:0001503--P:ossification
GO:0030316--P:osteoclast differentiation
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045084--P:positive regulation of interleukin-12 biosynthetic process
GO:0032743--P:positive regulation of interleukin-2 production
GO:0045410--P:positive regulation of interleukin-6 biosynthetic process
GO:0043507--P:positive regulation of JUN kinase activity
GO:0031666--P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:0045672--P:positive regulation of osteoclast differentiation
GO:0002726--P:positive regulation of T cell cytokine production
GO:0042102--P:positive regulation of T cell proliferation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:2000679--P:positive regulation of transcription regulatory region DNA binding
GO:0051865--P:protein autoubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0042981--P:regulation of apoptotic process
GO:0051023--P:regulation of immunoglobulin secretion
GO:0050852--P:T cell receptor signaling pathway
GO:0042088--P:T-helper 1 type immune response

KEGG

ptr:451702

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001262	Ailuropoda melanoleuca	90.94	0.00e+00	954.00
IUUC-Apl-004062	Anas platyrhynchos	72.41	0.00e+00	830.00
IUUC-Aca-004636	Anolis carolinensis	70.80	0.00e+00	771.00
IUUC-Ame-011682	Astyanax mexicanus	52.23	9.00e-162	563.00
IUUC-Bta-012692	Bos taurus	89.30	0.00e+00	977.00
IUUC-Bci-013998	Botrytis cinerea	24.60	4.00e-14	72.80
IUUC-Cja-019426	Callithrix jacchus	95.03	0.00e+00	1004.00
IUUC-Cfa-020948	Canis familiaris	89.78	0.00e+00	840.00
IUUC-Cpo-021378	Cavia porcellus	88.95	0.00e+00	946.00
IUUC-Csa-024045	Chlorocebus sabaeus	98.85	0.00e+00	1053.00
IUUC-Cho-024973	Choloepus hoffmanni	76.19	5.00e-107	381.00
IUUC-Csv-026300	Ciona savignyi	39.53	8.00e-47	179.00
IUUC-Dre-027557	Danio rerio	56.72	2.00e-176	612.00
IUUC-Dno-030032	Dasypus novemcinctus	84.71	2.00e-143	501.00
IUUC-Dor-030790	Dipodomys ordii	92.40	0.00e+00	981.00
IUUC-Dme-031921	Drosophila melanogaster	26.62	1.00e-38	154.00
IUUC-Ete-032952	Echinops telfairi	89.06	5.00e-171	593.00
IUUC-Eca-033924	Equus caballus	84.90	0.00e+00	867.00
IUUC-Eeu-034734	Erinaceus europaeus	86.42	0.00e+00	886.00
IUUC-Fca-036222	Felis catus	82.84	0.00e+00	838.00
IUUC-Fal-036834	Ficedula albicollis	73.46	0.00e+00	733.00
IUUC-Fox-037935	Fusarium oxysporum	29.44	4.00e-21	96.30
IUUC-Gmo-039061	Gadus morhua	57.65	2.00e-89	322.00
IUUC-Ggr-040084	Gaeumannomyces graminis	28.38	4.00e-13	69.30
IUUC-Gga-040599	Gallus gallus	72.84	0.00e+00	836.00
IUUC-Gac-041977	Gasterosteus aculeatus	55.66	9.00e-167	580.00
IUUC-Ggo-044508	Gorilla gorilla	91.41	0.00e+00	945.00
IUUC-Hsa-046349	Homo sapiens	99.62	0.00e+00	1090.00
IUUC-Itr-047966	Ictidomys tridecemlineatus	92.26	0.00e+00	991.00
IUUC-Lch-049821	Latimeria chalumnae	67.26	0.00e+00	754.00
IUUC-Lpe-051025	Leersia perrieri	25.29	3.00e-06	45.80
IUUC-Loc-051995	Lepisosteus oculatus	59.58	0.00e+00	626.00
IUUC-Laf-054115	Loxodonta africana	85.95	0.00e+00	937.00
IUUC-Mcc-055298	Macaca mulatta	98.47	0.00e+00	1047.00
IUUC-Mor-057263	Magnaporthe oryzae	30.09	2.00e-17	84.00
IUUC-Mpo-057517	Magnaporthe poae	28.51	1.00e-14	74.70
IUUC-Mga-059340	Meleagris gallopavo	72.66	0.00e+00	813.00
IUUC-Mvi-060553	Microbotryum violaceum	27.68	4.00e-15	75.90
IUUC-Mmr-061063	Microcebus murinus	91.93	0.00e+00	962.00
IUUC-Mdo-062075	Monodelphis domestica	80.41	0.00e+00	909.00
IUUC-Mmu-063780	Mus musculus	88.30	0.00e+00	907.00
IUUC-Mac-064529	Musa acuminata	25.00	2.00e-09	56.60
IUUC-Mpu-065748	Mustela putorius furo	89.28	0.00e+00	959.00
IUUC-Mlu-067888	Myotis lucifugus	89.03	0.00e+00	948.00
IUUC-Nle-069234	Nomascus leucogenys	99.62	0.00e+00	1059.00
IUUC-Opr-070393	Ochotona princeps	97.18	9.00e-124	436.00
IUUC-Ont-072459	Oreochromis niloticus	54.06	1.00e-174	605.00
IUUC-Oan-073578	Ornithorhynchus anatinus	81.43	0.00e+00	900.00
IUUC-Ocu-074201	Oryctolagus cuniculus	91.31	0.00e+00	969.00
IUUC-Oba-075457	Oryza barthii	27.59	1.00e-08	53.90
IUUC-Ogl-077406	Oryza glaberrima	27.59	1.00e-08	54.30
IUUC-Ogu-078803	Oryza glumaepatula	27.03	6.00e-09	55.10
IUUC-Oin-079307	Oryza indica	27.59	1.00e-08	54.30
IUUC-Olo-080508	Oryza longistaminata	28.16	4.00e-09	55.50
IUUC-Ome-081315	Oryza meridionalis	26.44	5.00e-08	52.00
IUUC-Oni-082966	Oryza nivara	27.03	6.00e-09	55.10
IUUC-Opu-084160	Oryza punctata	25.86	3.00e-08	52.40
IUUC-Oru-085055	Oryza rufipogon	27.03	6.00e-09	55.10
IUUC-Osa-085780	Oryza sativa	27.59	9.00e-09	54.30
IUUC-Ola-087319	Oryzias latipes	58.94	7.00e-91	327.00
IUUC-Olu-087748	Ostreococcus lucimarinus	23.14	6.00e-11	61.60
IUUC-Oga-087936	Otolemur garnettii	90.28	0.00e+00	960.00
IUUC-Oar-089379	Ovis aries	88.75	0.00e+00	977.00
IUUC-Pan-092590	Papio anubis	98.66	0.00e+00	1048.00
IUUC-Psi-093948	Pelodiscus sinensis	71.48	0.00e+00	805.00
IUUC-Pma-094434	Petromyzon marinus	50.72	3.00e-76	279.00
IUUC-Pfo-096912	Poecilia formosa	52.56	2.00e-168	585.00
IUUC-Pab-097651	Pongo abelii	100.00	0.00e+00	1062.00
IUUC-Pca-100958	Procavia capensis	90.08	0.00e+00	718.00
IUUC-Pva-103247	Pteropus vampyrus	93.25	2.00e-131	462.00
IUUC-Rno-104994	Rattus norvegicus	86.79	0.00e+00	919.00
IUUC-Sha-106494	Sarcophilus harrisii	83.05	0.00e+00	923.00
IUUC-Sar-113375	Sorex araneus	88.43	0.00e+00	935.00
IUUC-Sre-115218	Sporisorium reilianum	27.63	1.00e-15	78.60
IUUC-Ssc-115417	Sus scrofa	89.09	0.00e+00	968.00
IUUC-Tgu-117232	Taeniopygia guttata	72.48	0.00e+00	789.00
IUUC-Tru-118321	Takifugu rubripes	53.42	7.00e-167	580.00
IUUC-Tni-120475	Tetraodon nigroviridis	56.47	7.00e-165	573.00
IUUC-Tbe-127719	Tupaia belangeri	81.25	0.00e+00	829.00
IUUC-Ttr-129264	Tursiops truncatus	89.72	3.00e-126	445.00
IUUC-Uma-129620	Ustilago maydis	27.67	6.00e-17	82.80
IUUC-Vpa-130244	Vicugna pacos	89.33	2.00e-128	452.00
IUUC-Xtr-131948	Xenopus tropicalis	64.87	0.00e+00	748.00
IUUC-Xma-133132	Xiphophorus maculatus	53.09	1.00e-169	589.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence