iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ocu-074841

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAGW02025076

Gene Name

HERC1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000014796.3	ENSOCUT00000014828.3	ENSOCUP00000012750.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.00e-92	311.1	4491	4825
E3 adaptor/Cullin RING/DCX/DWD	6.20e-17	61.1	3411	3441

Active Site

Position(s)	Description	Evidence
4794	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 6    kkrle.vefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknp.....ehlklFeflGrllgkalqdgr 86
            +r++ v++vgE + d+gGv+ ++++++++el++  + l+  s+n ++++ +n+d++l np     ehl  F+flG+l+g+a+++++
   Q: 4491 PSRAWkVKLVGEGADDAGGVFDDTITEMCQELETGIVDLLIPSPNATAEVGYNRDRFLFNPsacldEHLMQFKFLGILMGVAIRTKK 4577
           466666********************************************************************************* PP
   S: 87   lldlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeee..LkpgGenipVtneNke 171
           +ldl+l+++++k+l+  +l+ledleevd  ++++l++i++ ++s i+e++++ ++  ++ + ++++ ++  ++pgG++ip t +N++
   Q: 4578 PLDLHLAPVVWKQLCCIPLTLEDLEEVDLLYVQTLNSILHIEDSGITEESFHEMIPLDSFVGQSADGKMvpIIPGGNSIPLTFSNRK 4664
           *******************************************************9999887777766666**************** PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
           eYv++ +eyrl+e +++qv+a+reG+++++p  llsl+t+++le+++cG+++i+v+ lkk  +y++ + e+++ +qwFw++leefs+
   Q: 4665 EYVERAIEYRLHE-MDRQVAAVREGMSWIVPVPLLSLLTAKQLEQMVCGMPDISVDVLKKVVRYRE-VDEQHQLVQWFWHTLEEFSN 4749
           *************.**************************************************88.******************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           eer  f++Fv+g+srlP+ + a+++ ++f+i k d+  d+lP+s+TCf++L+LP+Yss+ ++ e+L+yAi++++++++
   Q: 4750 EERVLFMRFVSGRSRLPA-NTADIS-QRFQIMKvDRPYDSLPTSQTCFFQLRLPPYSSQLVMAERLRYAINNCRSIDM 4825
           *****************6.899999.679999956666***********************************99987 PP

E3 adaptor/Cullin RING/DCX/DWD

   S: 3    tds.vtclaf.sd.tllvsGsdDgtikvWDlr 31
           +++ +tc+ + +  +ll+++++Dgti+vW+++
   Q: 3411 QNRvMTCV-WcNKkGLLATSGNDGTIRVWNVT 3441
           55416677.*9778****************97 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

MATMVPPVKL KWLEHLNSSW ITEDSESIAT REGVAVLYSK LVSNKEVVPL PQQVLCLKGP 60
QLPDFERESL SSDEQDHYLD ALLSSQLALA KMVCSDSPFA GALRKRLLVL QRVFYALSNK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACTCATGGC TGAAGACTAA ACCAACATGG CAACTATGGT TCCACCAGTG AAACTGAAAT 60
GGCTTGAACA CTTGAACAGC TCCTGGATTA CAGAAGACAG TGAATCCATT GCTACAAGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat

Interpro

IPR001870--B30.2/SPRY
IPR013320--ConA-like_dom
IPR000569--HECT_dom
IPR016106--Pyr-dep_his-deCO2ase_subdom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens
IPR003877--SPRY_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50188--B302_SPRY
PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF00632--HECT
PF00415--RCC1
PF00622--SPRY
PF00400--WD40

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc
SM00449--SPRY
SM00320--WD40

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0021702--P:cerebellar Purkinje cell differentiation
GO:0010507--P:negative regulation of autophagy
GO:0050885--P:neuromuscular process controlling balance
GO:0031175--P:neuron projection development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001830	Ailuropoda melanoleuca	97.59	0.00e+00	8774.00
IUUC-Apl-003461	Anas platyrhynchos	92.73	0.00e+00	8382.00
IUUC-Aca-004452	Anolis carolinensis	85.17	0.00e+00	7406.00
IUUC-Aly-006545	Arabidopsis lyrata	36.66	8.00e-49	189.00
IUUC-Ame-011268	Astyanax mexicanus	60.94	0.00e+00	2242.00
IUUC-Bta-013213	Bos taurus	97.57	0.00e+00	8789.00
IUUC-Bdi-014791	Brachypodium distachyon	35.28	9.00e-53	201.00
IUUC-Bra-017584	Brassica rapa	34.36	7.00e-50	192.00
IUUC-Cja-019298	Callithrix jacchus	97.70	0.00e+00	8829.00
IUUC-Cfa-021213	Canis familiaris	97.64	0.00e+00	8882.00
IUUC-Cpo-021674	Cavia porcellus	95.84	0.00e+00	5906.00
IUUC-Cre-023014	Chlamydomonas reinhardtii	39.09	2.00e-50	192.00
IUUC-Csa-023341	Chlorocebus sabaeus	97.83	0.00e+00	8856.00
IUUC-Cho-024567	Choloepus hoffmanni	95.20	0.00e+00	1764.00
IUUC-Dre-028289	Danio rerio	79.67	0.00e+00	7164.00
IUUC-Dno-029988	Dasypus novemcinctus	96.83	0.00e+00	8733.00
IUUC-Dor-030636	Dipodomys ordii	94.80	0.00e+00	2152.00
IUUC-Ete-032598	Echinops telfairi	84.67	0.00e+00	1371.00
IUUC-Eca-033754	Equus caballus	97.58	0.00e+00	8814.00
IUUC-Eeu-034702	Erinaceus europaeus	90.35	0.00e+00	1486.00
IUUC-Fca-035900	Felis catus	97.92	0.00e+00	8871.00
IUUC-Fal-037034	Ficedula albicollis	91.42	0.00e+00	7270.00
IUUC-Gmo-039260	Gadus morhua	74.72	0.00e+00	1250.00
IUUC-Gga-040321	Gallus gallus	92.79	0.00e+00	8445.00
IUUC-Gac-042444	Gasterosteus aculeatus	58.39	0.00e+00	2232.00
IUUC-Gma-043808	Glycine max	33.94	1.00e-46	182.00
IUUC-Ggo-045134	Gorilla gorilla	93.04	0.00e+00	4776.00
IUUC-Hsa-046516	Homo sapiens	97.39	0.00e+00	8777.00
IUUC-Itr-048914	Ictidomys tridecemlineatus	98.07	0.00e+00	2582.00
IUUC-Lch-049903	Latimeria chalumnae	87.11	0.00e+00	7934.00
IUUC-Lpe-051165	Leersia perrieri	34.08	8.00e-51	194.00
IUUC-Loc-052149	Lepisosteus oculatus	85.09	0.00e+00	7608.00
IUUC-Laf-053426	Loxodonta africana	97.41	0.00e+00	8824.00
IUUC-Mcc-055826	Macaca mulatta	97.55	0.00e+00	8846.00
IUUC-Meu-056521	Macropus eugenii	84.47	0.00e+00	2233.00
IUUC-Mga-059567	Meleagris gallopavo	96.35	0.00e+00	2134.00
IUUC-Mmr-061512	Microcebus murinus	97.28	0.00e+00	8729.00
IUUC-Mdo-062177	Monodelphis domestica	91.94	0.00e+00	8308.00
IUUC-Mmu-064373	Mus musculus	97.10	0.00e+00	8773.00
IUUC-Mpu-066148	Mustela putorius furo	97.98	0.00e+00	8841.00
IUUC-Mlu-067680	Myotis lucifugus	97.28	0.00e+00	8748.00
IUUC-Nle-069633	Nomascus leucogenys	97.22	0.00e+00	8733.00
IUUC-Opr-070609	Ochotona princeps	97.32	0.00e+00	1479.00
IUUC-Ont-071249	Oreochromis niloticus	81.50	0.00e+00	7475.00
IUUC-Oan-073157	Ornithorhynchus anatinus	93.47	0.00e+00	8418.00
IUUC-Oba-075262	Oryza barthii	34.16	5.00e-49	188.00
IUUC-Obr-076115	Oryza brachyantha	34.61	7.00e-49	187.00
IUUC-Ogl-077586	Oryza glaberrima	34.16	5.00e-49	188.00
IUUC-Ogu-078796	Oryza glumaepatula	33.92	2.00e-48	186.00
IUUC-Oin-079298	Oryza indica	33.92	2.00e-48	186.00
IUUC-Olo-080768	Oryza longistaminata	35.36	1.00e-53	203.00
IUUC-Ome-081908	Oryza meridionalis	34.15	1.00e-47	183.00
IUUC-Oni-082049	Oryza nivara	33.92	2.00e-48	186.00
IUUC-Opu-083608	Oryza punctata	33.67	1.00e-49	190.00
IUUC-Oru-084712	Oryza rufipogon	33.92	2.00e-48	186.00
IUUC-Osa-086078	Oryza sativa	33.92	2.00e-48	186.00
IUUC-Ola-086889	Oryzias latipes	79.96	0.00e+00	7275.00
IUUC-Oga-088459	Otolemur garnettii	96.63	0.00e+00	8739.00
IUUC-Oar-089888	Ovis aries	97.53	0.00e+00	8758.00
IUUC-Ptr-091114	Pan troglodytes	97.41	0.00e+00	8802.00
IUUC-Pan-092442	Papio anubis	97.71	0.00e+00	8857.00
IUUC-Psi-093833	Pelodiscus sinensis	92.00	0.00e+00	5467.00
IUUC-Pma-094275	Petromyzon marinus	77.56	0.00e+00	1740.00
IUUC-Ppa-095790	Physcomitrella patens	36.08	4.00e-55	208.00
IUUC-Pfo-097262	Poecilia formosa	80.27	0.00e+00	7160.00
IUUC-Pab-097760	Pongo abelii	97.74	0.00e+00	5001.00
IUUC-Pop-099121	Populus trichocarpa	36.63	5.00e-52	199.00
IUUC-Pca-100465	Procavia capensis	96.13	0.00e+00	4585.00
IUUC-Ppe-101345	Prunus persica	34.02	4.00e-52	200.00
IUUC-Pva-102950	Pteropus vampyrus	96.52	0.00e+00	4158.00
IUUC-Rno-104892	Rattus norvegicus	97.05	0.00e+00	8699.00
IUUC-Sha-106633	Sarcophilus harrisii	93.54	0.00e+00	8329.00
IUUC-Smo-108827	Selaginella moellendorffii	35.40	5.00e-52	199.00
IUUC-Sit-110415	Setaria italica	36.44	3.00e-53	202.00
IUUC-Sly-111155	Solanum lycopersicum	37.10	3.00e-53	203.00
IUUC-Stu-112166	Solanum tuberosum	31.97	3.00e-49	190.00
IUUC-Sar-113251	Sorex araneus	86.98	0.00e+00	2489.00
IUUC-Ssc-116391	Sus scrofa	97.57	0.00e+00	8819.00
IUUC-Tgu-116554	Taeniopygia guttata	92.17	0.00e+00	8367.00
IUUC-Tru-118695	Takifugu rubripes	80.93	0.00e+00	7444.00
IUUC-Tsy-119647	Tarsius syrichta	91.64	0.00e+00	5663.00
IUUC-Tni-120707	Tetraodon nigroviridis	81.10	0.00e+00	7402.00
IUUC-Tbe-127346	Tupaia belangeri	90.15	0.00e+00	2610.00
IUUC-Ttr-128542	Tursiops truncatus	93.33	0.00e+00	5939.00
IUUC-Vpa-130611	Vicugna pacos	96.95	0.00e+00	4016.00
IUUC-Xtr-131933	Xenopus tropicalis	84.91	0.00e+00	7646.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence