iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089905

Ensembl Protein ID

ENSOARP00000013254.1

UniProt Accession

W5PS25; W5PS25_SHEEP

Genbank Protein ID

ENSOARP00000013254

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AMGL01022141

Gene Name

KLHL20

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000012372.1	ENSOART00000013448.1	ENSOARP00000013254.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	3.80e-22	78.6	81	148
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	1.60e-11	43.3	180	211

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgkldene 69
           +Dv+lvvg +++ ah+++L+a+S++F+a+f++el es+ + +v+i+d++  +++ l++F Yt++++ +e
   Q: 81   CDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESR-QTEVVIRDIDERAMELLIDFAYTSQITVEE 148
           9*************************************.*************************98765 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhFk 32
           ++Nclgi++fAd+++c++L   a++f++++F+
   Q: 180  PSNCLGIRAFADTHSCRELLRIADKFTQHNFQ 211
           89*****************************6 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

SALECGEGYF SWCMEGKPMR RCTNIRPGET GMDVTSRCTL GDPNKLPEGV PQPARMPYIS 60
DKHPRQTLEV INLLRKHREL CDVVLVVGAK KIYAHRVILS ACSPYFRAMF TGELAESRQT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAACAACTGC AAAAATCTGT GTAGATTCCA TTATGAAGAA CAGCTAAAGA AAATGTGGTT 60
AAGTTCATGC TTAGCCTATA ATAGTTATCA GGAAACCAGC AGCAGCCTTT CATTAATATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR011043--Gal_Oxase/kelch_b-propeller
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0016605--C:PML body
GO:0005802--C:trans-Golgi network
GO:0004842--F:ubiquitin-protein transferase activity
GO:0006895--P:Golgi to endosome transport
GO:0043066--P:negative regulation of apoptotic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1990390--P:protein K33-linked ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001974	Ailuropoda melanoleuca	98.85	0.00e+00	1251.00
IUUC-Apl-003481	Anas platyrhynchos	98.70	0.00e+00	1264.00
IUUC-Aca-004877	Anolis carolinensis	99.01	0.00e+00	1252.00
IUUC-Aly-005957	Arabidopsis lyrata	35.93	2.00e-39	157.00
IUUC-Aor-010180	Aspergillus oryzae	24.19	3.00e-09	55.80
IUUC-Ame-011440	Astyanax mexicanus	98.65	0.00e+00	1217.00
IUUC-Bta-012603	Bos taurus	99.84	0.00e+00	1263.00
IUUC-Bol-016130	Brassica oleracea	27.14	7.00e-16	79.30
IUUC-Bra-016881	Brassica rapa	27.27	5.00e-17	83.20
IUUC-Cel-018464	Caenorhabditis elegans	59.51	0.00e+00	715.00
IUUC-Cja-019119	Callithrix jacchus	99.84	0.00e+00	1263.00
IUUC-Cfa-020169	Canis familiaris	99.84	0.00e+00	1263.00
IUUC-Cpo-021519	Cavia porcellus	99.36	0.00e+00	1284.00
IUUC-Csa-024173	Chlorocebus sabaeus	99.84	0.00e+00	1263.00
IUUC-Cho-024820	Choloepus hoffmanni	91.42	0.00e+00	790.00
IUUC-Cin-025270	Ciona intestinalis	75.34	0.00e+00	888.00
IUUC-Csv-026308	Ciona savignyi	75.26	0.00e+00	895.00
IUUC-Dre-027423	Danio rerio	98.82	0.00e+00	1219.00
IUUC-Dno-029350	Dasypus novemcinctus	99.52	0.00e+00	1288.00
IUUC-Dor-031011	Dipodomys ordii	100.00	3.00e-168	585.00
IUUC-Dme-032170	Drosophila melanogaster	80.77	0.00e+00	956.00
IUUC-Ete-033187	Echinops telfairi	99.77	0.00e+00	886.00
IUUC-Eca-033751	Equus caballus	99.84	0.00e+00	1290.00
IUUC-Eeu-034901	Erinaceus europaeus	99.51	0.00e+00	1259.00
IUUC-Fca-035752	Felis catus	98.72	0.00e+00	1120.00
IUUC-Fal-037630	Ficedula albicollis	99.01	0.00e+00	1249.00
IUUC-Gmo-039481	Gadus morhua	96.89	0.00e+00	1238.00
IUUC-Gga-040971	Gallus gallus	99.18	0.00e+00	1256.00
IUUC-Gac-042602	Gasterosteus aculeatus	97.21	0.00e+00	1239.00
IUUC-Ggo-044588	Gorilla gorilla	99.84	0.00e+00	1291.00
IUUC-Hsa-046641	Homo sapiens	99.84	0.00e+00	1263.00
IUUC-Itr-048394	Ictidomys tridecemlineatus	99.83	0.00e+00	1252.00
IUUC-Lch-049968	Latimeria chalumnae	98.69	0.00e+00	1253.00
IUUC-Loc-052720	Lepisosteus oculatus	97.70	0.00e+00	1248.00
IUUC-Lma-053201	Leptosphaeria maculans	27.21	2.00e-09	56.20
IUUC-Laf-054156	Loxodonta africana	99.84	0.00e+00	1292.00
IUUC-Mcc-054629	Macaca mulatta	99.84	0.00e+00	1263.00
IUUC-Meu-056605	Macropus eugenii	99.36	0.00e+00	644.00
IUUC-Mga-060014	Meleagris gallopavo	98.35	0.00e+00	1228.00
IUUC-Mmr-060814	Microcebus murinus	99.17	0.00e+00	1249.00
IUUC-Mdo-062242	Monodelphis domestica	99.18	0.00e+00	1255.00
IUUC-Mmu-064309	Mus musculus	99.83	0.00e+00	1252.00
IUUC-Mpu-066587	Mustela putorius furo	99.84	0.00e+00	1263.00
IUUC-Mlu-066958	Myotis lucifugus	96.38	0.00e+00	1203.00
IUUC-Nle-069059	Nomascus leucogenys	98.36	0.00e+00	1238.00
IUUC-Ont-072129	Oreochromis niloticus	97.21	0.00e+00	1238.00
IUUC-Oan-073073	Ornithorhynchus anatinus	98.84	0.00e+00	1244.00
IUUC-Ocu-073909	Oryctolagus cuniculus	99.01	0.00e+00	1250.00
IUUC-Ola-086392	Oryzias latipes	96.56	0.00e+00	1228.00
IUUC-Olu-087696	Ostreococcus lucimarinus	36.44	8.00e-32	130.00
IUUC-Oga-088693	Otolemur garnettii	98.69	0.00e+00	1250.00
IUUC-Ptr-091059	Pan troglodytes	99.84	0.00e+00	1263.00
IUUC-Pan-091833	Papio anubis	94.62	0.00e+00	787.00
IUUC-Psi-093499	Pelodiscus sinensis	99.18	0.00e+00	1248.00
IUUC-Pma-094404	Petromyzon marinus	80.33	0.00e+00	944.00
IUUC-Pfo-096891	Poecilia formosa	97.54	0.00e+00	1239.00
IUUC-Pab-097715	Pongo abelii	95.40	0.00e+00	1194.00
IUUC-Pva-102944	Pteropus vampyrus	83.74	0.00e+00	1028.00
IUUC-Rno-104878	Rattus norvegicus	99.84	0.00e+00	1263.00
IUUC-Sha-107444	Sarcophilus harrisii	99.18	0.00e+00	1256.00
IUUC-Ssc-115565	Sus scrofa	99.83	0.00e+00	1249.00
IUUC-Tgu-116902	Taeniopygia guttata	98.54	0.00e+00	1261.00
IUUC-Tru-118692	Takifugu rubripes	97.54	0.00e+00	1243.00
IUUC-Tsy-119031	Tarsius syrichta	92.45	0.00e+00	1144.00
IUUC-Tbe-127517	Tupaia belangeri	93.68	0.00e+00	1155.00
IUUC-Ttr-128366	Tursiops truncatus	99.84	0.00e+00	1263.00
IUUC-Vpa-130465	Vicugna pacos	99.51	0.00e+00	1258.00
IUUC-Vvi-131673	Vitis vinifera	34.33	5.00e-42	166.00
IUUC-Xtr-132243	Xenopus tropicalis	98.20	0.00e+00	1244.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence