iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

   S: 4    lwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
           +++l ++ ++Lqh CRlaI++c+g+     i++LPLP +LkdYL+++++q
   Q: 153  TKPLYTSAPTLQHFCRLAINKCTGT-----IWGLPLPTRLKDYLEEYKFQ 197
           678999*******************.....8***************9886 PP

Organism

Mus musculus

Protein Sequence
(Fasta)

MTLRCLEPSG NGADRTRSQW GTAGLPEEQS PEAARLAKAL RELSQTGWYW GSMTVNEAKE 60
KLKEAPEGTF LIRDSSHSDY LLTIFVKTSA GPTNLRIEYQ DGKFRLDSII CVKSKLKQFD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGACCCTGC GGTGCCTGGA GCCCTCCGGG AATGGAGCGG ACAGGACGCG GAGCCAGTGG 60
GGGACCGCGG GGTTGCCGGA GGAACAGTCC CCCGAGGCGG CACGTCTGGC GAAAGCCCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028410--SOCS2
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

PRINTS

PR00401--SH2DOMAIN

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046627--P:negative regulation of insulin receptor signaling pathway
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0016567--P:protein ubiquitination
GO:0001558--P:regulation of cell growth

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002075	Ailuropoda melanoleuca	93.94	1.00e-103	368.00
IUUC-Apl-003484	Anas platyrhynchos	78.43	3.00e-71	260.00
IUUC-Aca-004253	Anolis carolinensis	70.12	2.00e-70	258.00
IUUC-Ame-011267	Astyanax mexicanus	61.68	2.00e-58	218.00
IUUC-Bta-013183	Bos taurus	92.42	4.00e-97	347.00
IUUC-Cja-018862	Callithrix jacchus	93.43	5.00e-99	353.00
IUUC-Cfa-020226	Canis familiaris	92.89	8.00e-95	338.00
IUUC-Cpo-022414	Cavia porcellus	92.93	2.00e-100	357.00
IUUC-Csa-023758	Chlorocebus sabaeus	92.93	6.00e-101	359.00
IUUC-Cho-024471	Choloepus hoffmanni	83.33	1.00e-70	258.00
IUUC-Dre-028288	Danio rerio	56.72	2.00e-62	231.00
IUUC-Dno-029036	Dasypus novemcinctus	92.93	7.00e-104	369.00
IUUC-Ete-033023	Echinops telfairi	90.91	3.00e-106	377.00
IUUC-Fca-036469	Felis catus	93.94	2.00e-98	351.00
IUUC-Fal-036642	Ficedula albicollis	73.46	3.00e-70	257.00
IUUC-Gmo-039331	Gadus morhua	53.17	1.00e-34	138.00
IUUC-Gga-040809	Gallus gallus	75.47	2.00e-71	261.00
IUUC-Gac-041398	Gasterosteus aculeatus	58.93	1.00e-57	215.00
IUUC-Ggo-045341	Gorilla gorilla	93.94	4.00e-99	353.00
IUUC-Hsa-046557	Homo sapiens	93.43	2.00e-109	387.00
IUUC-Itr-049013	Ictidomys tridecemlineatus	76.92	5.00e-90	323.00
IUUC-Lch-050160	Latimeria chalumnae	62.42	3.00e-50	191.00
IUUC-Loc-051825	Lepisosteus oculatus	61.54	8.00e-60	223.00
IUUC-Laf-053560	Loxodonta africana	92.93	5.00e-97	346.00
IUUC-Mcc-055890	Macaca mulatta	92.93	4.00e-98	350.00
IUUC-Meu-056218	Macropus eugenii	79.29	2.00e-94	337.00
IUUC-Mga-059755	Meleagris gallopavo	70.69	4.00e-70	257.00
IUUC-Mmr-061387	Microcebus murinus	93.94	1.00e-100	358.00
IUUC-Mdo-062383	Monodelphis domestica	81.31	5.00e-95	339.00
IUUC-Mpu-066459	Mustela putorius furo	93.43	7.00e-98	349.00
IUUC-Mlu-068040	Myotis lucifugus	93.94	1.00e-104	372.00
IUUC-Nle-069016	Nomascus leucogenys	88.89	2.00e-96	344.00
IUUC-Opr-071087	Ochotona princeps	88.38	7.00e-102	362.00
IUUC-Ont-072340	Oreochromis niloticus	59.20	2.00e-58	218.00
IUUC-Oan-073443	Ornithorhynchus anatinus	77.78	3.00e-89	320.00
IUUC-Ocu-074539	Oryctolagus cuniculus	95.43	6.00e-99	353.00
IUUC-Ola-087004	Oryzias latipes	58.86	5.00e-54	203.00
IUUC-Oga-088438	Otolemur garnettii	93.43	2.00e-101	360.00
IUUC-Oar-089932	Ovis aries	92.42	7.00e-97	346.00
IUUC-Ptr-091037	Pan troglodytes	93.94	4.00e-99	353.00
IUUC-Pan-092767	Papio anubis	92.93	3.00e-98	350.00
IUUC-Psi-093099	Pelodiscus sinensis	75.47	2.00e-72	264.00
IUUC-Pma-094671	Petromyzon marinus	44.83	5.00e-36	144.00
IUUC-Pfo-097073	Poecilia formosa	53.11	1.00e-53	202.00
IUUC-Pab-098319	Pongo abelii	93.43	2.00e-104	371.00
IUUC-Pca-101117	Procavia capensis	91.41	2.00e-96	344.00
IUUC-Pva-102117	Pteropus vampyrus	92.42	2.00e-95	341.00
IUUC-Rno-105913	Rattus norvegicus	96.97	9.00e-106	375.00
IUUC-Sha-106500	Sarcophilus harrisii	81.22	2.00e-93	334.00
IUUC-Ssc-115252	Sus scrofa	93.94	1.00e-101	361.00
IUUC-Tgu-117524	Taeniopygia guttata	75.47	9.00e-70	255.00
IUUC-Tni-120263	Tetraodon nigroviridis	57.23	5.00e-55	206.00
IUUC-Tbe-127915	Tupaia belangeri	91.92	5.00e-94	336.00
IUUC-Ttr-128372	Tursiops truncatus	93.43	5.00e-101	359.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence