iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-063468

Ensembl Protein ID

ENSMUSP00000082270.3

UniProt Accession

Q69ZF8; Q497U7; Q8CBI7; MSL2_MOUSE

Genbank Protein ID

BAD32486.1; AAI00372.1; BAC29248.1

Protein Name

E3 ubiquitin-protein ligase MSL2; Male-specific lethal 2-like 1; Male-specific lethal-2 homolog; Male-specific lethal-2 homolog 1; RING finger protein 184

Genbank Nucleotide ID

AK173208; BC100371; AK035934

Gene Name

Msl2; Kiaa1585; Msl2l1; Rnf184

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000066415.4	ENSMUST00000189616.1	ENSMUSP00000139396.1
ENSMUSG00000066415.4	ENSMUST00000085177.4	ENSMUSP00000082270.3

Annotation

mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	98.96	0.00e+00	1048.00	IUUC-Hsa-046940

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

Component of histone acetyltransferase complex responsible for the majority of histone H4 acetylation at lysine 16 which is implicated in the formation of higher-order chromatin structure (By similarity). Acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A. This activity is greatly enhanced by heterodimerization with MSL1. H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-5' (H3K4me) and 'Lys-80' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (By similarity).

Protein Sequence
(Fasta)

MNPVNATALY ISASRLVLNY DPGDPKAFTE INRLLPYFRQ SLSCCVCGHL LQDPIAPTNS 60
TCQHYVCKTC KGKKMMMKPS CSWCKDYEQF EENKQLSILV NCYKKLCEYI TQTTLARDII 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACAGTGTCT TTGCCCGTTG GGGTAACGGT CGTCGTTACC GGCCGGGCCT GAGGCGCCGC 60
ACCATCTACT GCGGCCGGAG TAGCCCCGGC CCAACGGAGC TAGAGCGGCG CGAGAAGAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0436--Ligase
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR032049--Msl2-CXC
IPR032043--Msl2_Znf-RING
IPR033467--Tesmin/TSO1-like_CXC
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF16682--MSL2-CXC
PF16685--zf-RING_10

SMART

SM01114--CXC

Gene Ontology

GO:0072487--C:MSL complex
GO:0016874--F:ligase activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0043984--P:histone H4-K16 acetylation

KEGG

mmu:77853

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002110	Ailuropoda melanoleuca	98.79	0.00e+00	1020.00
IUUC-Apl-003940	Anas platyrhynchos	82.71	0.00e+00	761.00
IUUC-Acl-008267	Aspergillus clavatus	33.93	1.50e-01	31.60
IUUC-Ame-010946	Astyanax mexicanus	57.95	2.00e-159	555.00
IUUC-Bta-012906	Bos taurus	98.09	0.00e+00	1011.00
IUUC-Cja-019438	Callithrix jacchus	99.13	0.00e+00	1045.00
IUUC-Cfa-020717	Canis familiaris	98.61	0.00e+00	1018.00
IUUC-Cpo-021407	Cavia porcellus	98.79	0.00e+00	1044.00
IUUC-Csa-023801	Chlorocebus sabaeus	98.96	0.00e+00	1045.00
IUUC-Cho-024478	Choloepus hoffmanni	97.46	0.00e+00	949.00
IUUC-Cin-025751	Ciona intestinalis	44.63	2.00e-30	125.00
IUUC-Csv-026353	Ciona savignyi	42.74	2.00e-29	122.00
IUUC-Dre-027439	Danio rerio	57.73	2.00e-152	532.00
IUUC-Dno-029323	Dasypus novemcinctus	92.72	0.00e+00	1025.00
IUUC-Dme-032080	Drosophila melanogaster	38.81	3.00e-09	57.40
IUUC-Ete-032763	Echinops telfairi	97.49	0.00e+00	835.00
IUUC-Eca-033874	Equus caballus	98.61	0.00e+00	1048.00
IUUC-Fca-035538	Felis catus	98.79	0.00e+00	1020.00
IUUC-Fal-037168	Ficedula albicollis	81.13	0.00e+00	823.00
IUUC-Gmo-039463	Gadus morhua	66.18	2.00e-52	199.00
IUUC-Gga-040838	Gallus gallus	83.25	0.00e+00	877.00
IUUC-Gac-041568	Gasterosteus aculeatus	70.31	1.00e-46	179.00
IUUC-Ggo-045165	Gorilla gorilla	98.96	0.00e+00	1045.00
IUUC-Hsa-046940	Homo sapiens	98.96	0.00e+00	1045.00
IUUC-Itr-048075	Ictidomys tridecemlineatus	98.30	0.00e+00	941.00
IUUC-Lch-049993	Latimeria chalumnae	72.93	0.00e+00	748.00
IUUC-Loc-052104	Lepisosteus oculatus	63.99	3.00e-170	592.00
IUUC-Laf-054282	Loxodonta africana	98.27	0.00e+00	1039.00
IUUC-Mcc-054618	Macaca mulatta	98.81	0.00e+00	904.00
IUUC-Meu-056240	Macropus eugenii	89.95	0.00e+00	878.00
IUUC-Mga-059313	Meleagris gallopavo	81.10	0.00e+00	788.00
IUUC-Mmr-060641	Microcebus murinus	98.81	0.00e+00	910.00
IUUC-Mpu-066403	Mustela putorius furo	98.68	0.00e+00	922.00
IUUC-Mlu-067092	Myotis lucifugus	96.89	0.00e+00	1013.00
IUUC-Nle-069656	Nomascus leucogenys	98.79	0.00e+00	1043.00
IUUC-Opr-070922	Ochotona princeps	98.09	0.00e+00	1033.00
IUUC-Ont-071492	Oreochromis niloticus	48.48	4.00e-123	435.00
IUUC-Oan-072851	Ornithorhynchus anatinus	80.68	0.00e+00	786.00
IUUC-Ocu-073895	Oryctolagus cuniculus	99.31	0.00e+00	1047.00
IUUC-Ola-087132	Oryzias latipes	48.29	7.00e-116	410.00
IUUC-Oga-088381	Otolemur garnettii	98.96	0.00e+00	1046.00
IUUC-Oar-089727	Ovis aries	98.09	0.00e+00	1012.00
IUUC-Ptr-090506	Pan troglodytes	98.96	0.00e+00	1045.00
IUUC-Pan-091684	Papio anubis	98.96	0.00e+00	1045.00
IUUC-Psi-093464	Pelodiscus sinensis	82.38	0.00e+00	740.00
IUUC-Pno-094894	Phaeosphaeria nodorum	37.70	2.00e-02	33.90
IUUC-Pfo-096951	Poecilia formosa	50.38	2.00e-44	173.00
IUUC-Pab-097981	Pongo abelii	93.06	2.00e-150	524.00
IUUC-Pca-100212	Procavia capensis	98.20	0.00e+00	694.00
IUUC-Pva-102132	Pteropus vampyrus	98.27	0.00e+00	1035.00
IUUC-Pte-104312	Pyrenophora teres	35.14	1.50e-02	34.30
IUUC-Rno-105868	Rattus norvegicus	98.96	0.00e+00	1021.00
IUUC-Sha-107624	Sarcophilus harrisii	91.03	0.00e+00	969.00
IUUC-Ssl-108482	Sclerotinia sclerotiorum	26.83	5.00e-03	32.30
IUUC-Sar-113641	Sorex araneus	97.57	0.00e+00	1042.00
IUUC-Ssc-116207	Sus scrofa	98.44	0.00e+00	1014.00
IUUC-Tru-117652	Takifugu rubripes	49.11	1.00e-129	457.00
IUUC-Tsy-119274	Tarsius syrichta	96.60	0.00e+00	933.00
IUUC-Tni-120021	Tetraodon nigroviridis	47.05	1.00e-126	447.00
IUUC-Tvi-122401	Trichoderma virens	23.73	1.80e-01	31.60
IUUC-Ttr-128251	Tursiops truncatus	98.76	0.00e+00	706.00
IUUC-Vpa-130513	Vicugna pacos	98.61	0.00e+00	1018.00
IUUC-Vvi-131498	Vitis vinifera	24.69	7.00e-03	33.10
IUUC-Xtr-132490	Xenopus tropicalis	71.21	0.00e+00	729.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence