iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tgu-116595

Ensembl Protein ID

ENSTGUP00000004903.1

UniProt Accession

H0Z2W1; H0Z2W1_TAEGU

Genbank Protein ID

ENSTGUP00000004903

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABQF01033729

Gene Name

VAV3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000004635.1	ENSTGUT00000004952.1	ENSTGUP00000004903.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	9.60e-15	54.1	779	830

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
           ++ yd+ a +  eL+l kGdvv++   +   +gW++g  e +g+ G fP+ +ve+
   Q: 779  IARYDFCARDMRELSLLKGDVVKIY-TKMSANGWWRG--EVNGRVGWFPSTYVEE 830
           578*********************9.999999*****..9************985 PP

Organism

Taeniopygia guttata

Protein Sequence
(Fasta)

CGQWLISCKV LPPNHRVTWD TAQVFDLAQT LRDGVLLCQL LNNLRSHSIN LKEINLRPQM 60
SQFLCLKNIR TFLSACCEIF GMKKSELFEA FDLFDVRDFG KVIETLSKLS RTPIALGTGI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGCGGGCAGT GGCTGATCAG CTGCAAGGTG CTGCCGCCCA ACCACCGGGT GACCTGGGAC 60
ACGGCCCAGG TCTTCGACCT GGCGCAGACG CTGCGCGACG GCGTCCTGCT CTGCCAGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0862--Zinc

Interpro

IPR022613--CAMSAP_CH
IPR001715--CH-domain
IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR002219--PE/DAG-bd
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR000980--SH2
IPR011511--SH3_2
IPR001452--SH3_domain
IPR003096--SM22_calponin

PROSITE

PS50021--CH
PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50001--SH2
PS50002--SH3
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF11971--CAMSAP_CH
PF00169--PH
PF00621--RhoGEF
PF00017--SH2
PF07653--SH3_2

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00888--SM22CALPONIN

SMART

SM00109--C1
SM00033--CH
SM00233--PH
SM00325--RhoGEF
SM00252--SH2
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005886--C:plasma membrane
GO:0030676--F:Rac guanyl-nucleotide exchange factor activity
GO:0050853--P:B cell receptor signaling pathway
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007229--P:integrin-mediated signaling pathway
GO:0030032--P:lamellipodium assembly
GO:0030593--P:neutrophil chemotaxis
GO:0030890--P:positive regulation of B cell proliferation
GO:0045785--P:positive regulation of cell adhesion
GO:0043552--P:positive regulation of phosphatidylinositol 3-kinase activity
GO:0008361--P:regulation of cell size
GO:0035023--P:regulation of Rho protein signal transduction
GO:0042493--P:response to drug
GO:0007264--P:small GTPase mediated signal transduction
GO:0006906--P:vesicle fusion

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001362	Ailuropoda melanoleuca	83.29	0.00e+00	1387.00
IUUC-Apl-003734	Anas platyrhynchos	91.81	0.00e+00	1391.00
IUUC-Aca-004477	Anolis carolinensis	81.31	0.00e+00	1381.00
IUUC-Ath-007340	Arabidopsis thaliana	50.00	1.10e-02	34.30
IUUC-Ame-011279	Astyanax mexicanus	65.36	0.00e+00	1068.00
IUUC-Bta-012722	Bos taurus	83.00	0.00e+00	1384.00
IUUC-Cel-018578	Caenorhabditis elegans	29.21	4.00e-72	266.00
IUUC-Cja-018941	Callithrix jacchus	82.90	0.00e+00	1380.00
IUUC-Cfa-020266	Canis familiaris	82.44	0.00e+00	1229.00
IUUC-Cpo-021966	Cavia porcellus	81.65	0.00e+00	1168.00
IUUC-Csa-023892	Chlorocebus sabaeus	82.04	0.00e+00	1268.00
IUUC-Cin-025115	Ciona intestinalis	36.41	7.00e-134	471.00
IUUC-Csv-025995	Ciona savignyi	35.12	4.00e-140	491.00
IUUC-Dre-028199	Danio rerio	65.39	0.00e+00	1083.00
IUUC-Dno-029474	Dasypus novemcinctus	83.12	0.00e+00	1385.00
IUUC-Eca-033961	Equus caballus	83.49	0.00e+00	1244.00
IUUC-Eeu-034719	Erinaceus europaeus	64.94	0.00e+00	687.00
IUUC-Fca-036572	Felis catus	82.92	0.00e+00	1364.00
IUUC-Fal-036802	Ficedula albicollis	91.04	0.00e+00	1537.00
IUUC-Gmo-039409	Gadus morhua	67.38	0.00e+00	1132.00
IUUC-Gga-040884	Gallus gallus	91.22	0.00e+00	1508.00
IUUC-Gac-041395	Gasterosteus aculeatus	70.70	0.00e+00	1185.00
IUUC-Ggo-044460	Gorilla gorilla	80.00	0.00e+00	1189.00
IUUC-Hsa-046099	Homo sapiens	80.16	0.00e+00	1371.00
IUUC-Itr-048144	Ictidomys tridecemlineatus	79.07	0.00e+00	1186.00
IUUC-Lch-049650	Latimeria chalumnae	77.36	3.00e-95	340.00
IUUC-Loc-052487	Lepisosteus oculatus	70.21	0.00e+00	1201.00
IUUC-Laf-054564	Loxodonta africana	82.58	0.00e+00	1380.00
IUUC-Mcc-054622	Macaca mulatta	80.05	0.00e+00	1371.00
IUUC-Meu-056680	Macropus eugenii	77.28	0.00e+00	1266.00
IUUC-Mga-060013	Meleagris gallopavo	90.10	0.00e+00	1486.00
IUUC-Mmr-061251	Microcebus murinus	79.42	0.00e+00	1379.00
IUUC-Mdo-061875	Monodelphis domestica	82.84	0.00e+00	1393.00
IUUC-Mmu-063735	Mus musculus	82.94	0.00e+00	1385.00
IUUC-Mpu-065856	Mustela putorius furo	83.41	0.00e+00	1395.00
IUUC-Mlu-068108	Myotis lucifugus	79.70	0.00e+00	1333.00
IUUC-Nle-069863	Nomascus leucogenys	78.78	0.00e+00	1346.00
IUUC-Opr-070372	Ochotona princeps	73.27	0.00e+00	898.00
IUUC-Ont-072286	Oreochromis niloticus	70.84	0.00e+00	1213.00
IUUC-Ocu-074194	Oryctolagus cuniculus	83.53	0.00e+00	1373.00
IUUC-Ola-086336	Oryzias latipes	70.02	0.00e+00	1182.00
IUUC-Oga-089104	Otolemur garnettii	58.37	0.00e+00	957.00
IUUC-Oar-089272	Ovis aries	82.58	0.00e+00	1420.00
IUUC-Ptr-090652	Pan troglodytes	80.69	0.00e+00	1367.00
IUUC-Pan-092550	Papio anubis	78.89	0.00e+00	1210.00
IUUC-Psi-093784	Pelodiscus sinensis	82.16	0.00e+00	1289.00
IUUC-Ppa-095161	Physcomitrella patens	46.15	2.00e-09	56.20
IUUC-Pfo-097308	Poecilia formosa	68.66	0.00e+00	1177.00
IUUC-Pab-098698	Pongo abelii	80.45	0.00e+00	1365.00
IUUC-Pva-102262	Pteropus vampyrus	82.33	0.00e+00	1320.00
IUUC-Rno-105421	Rattus norvegicus	82.23	0.00e+00	1380.00
IUUC-Sha-107325	Sarcophilus harrisii	82.96	0.00e+00	1411.00
IUUC-Sar-113456	Sorex araneus	77.41	0.00e+00	1306.00
IUUC-Ssc-115338	Sus scrofa	57.29	0.00e+00	889.00
IUUC-Tru-117884	Takifugu rubripes	64.91	0.00e+00	1119.00
IUUC-Tsy-119429	Tarsius syrichta	82.57	0.00e+00	795.00
IUUC-Tni-119951	Tetraodon nigroviridis	67.18	0.00e+00	1108.00
IUUC-Tbe-127995	Tupaia belangeri	76.75	3.00e-164	572.00
IUUC-Ttr-128281	Tursiops truncatus	83.06	0.00e+00	1385.00
IUUC-Vpa-130066	Vicugna pacos	46.58	1.00e-34	141.00
IUUC-Xtr-132427	Xenopus tropicalis	70.55	0.00e+00	1217.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence