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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063524
UUCD1 version UUC-MuM-00638
Ensembl Protein ID ENSMUSP00000047012.7
UniProt Accession Q8BIA4; Q8BI62; Q8BI75; Q8BI76; Q8CID8; Q921Z1; FBXW8_MOUSE
Genbank Protein ID BAC28712.1; BAC33128.1; BAC33147.1; BAC35527.1; AAH09095.2; AAH24091.1
Protein Name F-box/WD repeat-containing protein 8; F-box and WD-40 domain-containing protein 8
Genbank Nucleotide ID AK034447; AK047695; AK047756; AK053794; BC009095; BC024091
Gene Name Fbxw8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000032867.8 ENSMUST00000049474.8 ENSMUSP00000047012.7
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
circBasemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMPhospho.ELM
UniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 7.70e-13 49.2 435 467
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 6    vtclaf..sd.tllvsGsdDgtikvWDlrtgvl 35
            tc++   s  +l+vsG+ D  +++ Dlr+++ 
   Q: 435  FTCVNIrdSPpNLMVSGNMDRRVRIHDLRSDKI 467
           589999973359*****************9875 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation. Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (By similarity).
 Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradatation, thereby affecting cell proliferation and differentiation. Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (By similarity).
Protein Sequence
(Fasta)
MDDHNLEEFR RHWQEELAQS QALRRRRRLE AGERRSPRRP EAGARGEPAS GYLGLAQGLL 60
EGAGRPPAPR PGRGGDRKDT SSRSRSPPDR DATEPEPLVD QLIRDLNELD DVPFFDVRLP 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063524|E3,WD_repeat|Mus musculus
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Nucleotide Sequence
(Fasta)
GACTACGGAC ACTTCCGGCG GATGGACAGT CCGTCCCCAT TCTGGCAGCC CCTGGGTGCC 60
GCGTCGGCCT GGGCGCGTCA AGCATGGACG ACCACAACCT GGAGGAGTTC CGCCGGCACT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063524|E3,WD_repeat|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0333--Golgi apparatus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
KW-0853--WD repeat
Interpro

IPR001810--F-box_dom
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom
PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF12937--F-box-like
SMART

SM00256--FBOX
SM00320--WD40
Gene Ontology

GO:1990393--C:3M complex
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008283--P:cell proliferation
GO:0007030--P:Golgi organization
GO:0060716--P:labyrinthine layer blood vessel development
GO:0050775--P:positive regulation of dendrite morphogenesis
GO:0016567--P:protein ubiquitination
GO:0060712--P:spongiotrophoblast layer development
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:231672
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001274 Ailuropoda melanoleuca 86.49 0.00e+00 942.00
IUUC-Apl-003239 Anas platyrhynchos 60.33 0.00e+00 689.00
IUUC-Aca-004756 Anolis carolinensis 59.11 8.00e-135 473.00
IUUC-Ame-011198 Astyanax mexicanus 47.33 3.00e-57 215.00
IUUC-Bta-012430 Bos taurus 54.16 1.00e-141 496.00
IUUC-Cja-019131 Callithrix jacchus 74.58 0.00e+00 843.00
IUUC-Cfa-021022 Canis familiaris 78.20 0.00e+00 915.00
IUUC-Cpo-021898 Cavia porcellus 78.44 0.00e+00 933.00
IUUC-Csa-023452 Chlorocebus sabaeus 77.59 0.00e+00 910.00
IUUC-Cho-024759 Choloepus hoffmanni 72.12 0.00e+00 796.00
IUUC-Dre-028123 Danio rerio 46.11 3.00e-147 515.00
IUUC-Dno-029045 Dasypus novemcinctus 87.75 0.00e+00 853.00
IUUC-Dor-030433 Dipodomys ordii 77.68 0.00e+00 774.00
IUUC-Ete-032465 Echinops telfairi 81.25 0.00e+00 766.00
IUUC-Eca-034134 Equus caballus 86.99 0.00e+00 909.00
IUUC-Eeu-035047 Erinaceus europaeus 75.76 0.00e+00 777.00
IUUC-Fca-036574 Felis catus 87.14 0.00e+00 895.00
IUUC-Fal-037665 Ficedula albicollis 59.48 1.00e-174 606.00
IUUC-Gmo-039137 Gadus morhua 39.53 5.00e-68 251.00
IUUC-Gga-040711 Gallus gallus 62.20 0.00e+00 664.00
IUUC-Gac-041675 Gasterosteus aculeatus 52.63 2.00e-55 208.00
IUUC-Ggo-045331 Gorilla gorilla 81.10 0.00e+00 832.00
IUUC-Hsa-046240 Homo sapiens 77.96 0.00e+00 899.00
IUUC-Itr-048412 Ictidomys tridecemlineatus 88.21 0.00e+00 890.00
IUUC-Loc-052631 Lepisosteus oculatus 50.26 2.00e-167 582.00
IUUC-Laf-054127 Loxodonta africana 78.32 7.00e-63 232.00
IUUC-Mcc-055083 Macaca mulatta 78.13 0.00e+00 893.00
IUUC-Mga-060113 Meleagris gallopavo 61.02 0.00e+00 652.00
IUUC-Mmr-061780 Microcebus murinus 83.83 0.00e+00 938.00
IUUC-Mdo-063066 Monodelphis domestica 59.51 0.00e+00 711.00
IUUC-Mpu-066913 Mustela putorius furo 86.77 0.00e+00 914.00
IUUC-Mlu-067924 Myotis lucifugus 82.64 0.00e+00 932.00
IUUC-Nle-069558 Nomascus leucogenys 77.87 0.00e+00 850.00
IUUC-Opr-070506 Ochotona princeps 86.13 0.00e+00 909.00
IUUC-Ont-071514 Oreochromis niloticus 45.91 3.00e-148 518.00
IUUC-Ocu-074477 Oryctolagus cuniculus 85.98 0.00e+00 879.00
IUUC-Ola-087416 Oryzias latipes 45.06 3.00e-147 515.00
IUUC-Oga-088643 Otolemur garnettii 81.94 0.00e+00 939.00
IUUC-Oar-090172 Ovis aries 85.57 0.00e+00 892.00
IUUC-Ptr-090870 Pan troglodytes 78.09 0.00e+00 903.00
IUUC-Pan-092017 Papio anubis 77.13 0.00e+00 899.00
IUUC-Psi-093794 Pelodiscus sinensis 62.63 0.00e+00 654.00
IUUC-Pfo-096192 Poecilia formosa 50.29 4.00e-149 521.00
IUUC-Pab-097882 Pongo abelii 77.09 0.00e+00 890.00
IUUC-Pca-100902 Procavia capensis 73.62 9.00e-141 493.00
IUUC-Pva-103139 Pteropus vampyrus 82.80 0.00e+00 951.00
IUUC-Rno-105798 Rattus norvegicus 95.46 0.00e+00 1011.00
IUUC-Sha-106576 Sarcophilus harrisii 62.02 0.00e+00 676.00
IUUC-Ssc-115923 Sus scrofa 73.03 0.00e+00 879.00
IUUC-Tgu-116667 Taeniopygia guttata 55.73 3.00e-117 415.00
IUUC-Tru-118323 Takifugu rubripes 43.85 6.00e-144 504.00
IUUC-Tsy-118818 Tarsius syrichta 75.59 6.00e-109 387.00
IUUC-Tni-120438 Tetraodon nigroviridis 42.65 2.00e-139 489.00
IUUC-Tbe-127784 Tupaia belangeri 91.26 5.00e-111 394.00
IUUC-Ttr-128288 Tursiops truncatus 73.41 0.00e+00 799.00
IUUC-Vpa-130307 Vicugna pacos 81.10 0.00e+00 772.00
Created Date 25-Jun-2017

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