iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-005238

UUCD1 version

UUC-AnC-00399

Ensembl Protein ID

ENSACAP00000011659.3

UniProt Accession

H9GI85; H9GI85_ANOCA

Protein Name

Uncharacterized protein

Gene Name

SMURF1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000011792.3	ENSACAT00000011899.3	ENSACAP00000011659.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	8.40e-128	426.4	397	729

Active Site

Position(s)	Description	Evidence
698	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 397  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 484
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+n++Vt+eNk+eYv+l+v+
   Q: 485  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNVSVTEENKKEYVRLYVN 569
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ +++ds+ ++wFw+++e+f++e r+++LqFv
   Q: 570  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CMADSNIVKWFWQAVEAFDEERRARLLQFV 657
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+    prlf+i+  da++d+lP+++TCfn++++P+Y+++e+l+ekLl+A+eet gF +
   Q: 658  TGSTRVPLQGFKALQgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYETYEKLYEKLLTAVEETCGFAV 729
           ***************************99999**************************************76 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MSNAGSRRSG SSIKIRLTVL CAKNLAKKDF FRLPDPFAKV VVDGSGQCHS TDTVKNTLDP 60
KWNQHYDLYV GKSDSITISV WNHKKIHKKQ GAGFLGCVRL LSNAISRLKD TGYQRLDLCK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGAGGGAG GGCGAGGGAG AAGGAAGGGG CGGCGCGAGG CGTTTTCCGC GCAGGCGCAG 60
TTCGCGTCCG GCGGGGCGGG CGTCGAGCTC GGTGAGGCGG CGCCGCCTCC GCCGCCGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

KEGG

acs:100556808

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001459	Ailuropoda melanoleuca	90.28	0.00e+00	1388.00
IUUC-Apl-004155	Anas platyrhynchos	93.28	0.00e+00	1435.00
IUUC-Ame-010901	Astyanax mexicanus	89.50	0.00e+00	1370.00
IUUC-Bta-013221	Bos taurus	88.80	0.00e+00	1323.00
IUUC-Cja-018985	Callithrix jacchus	92.37	0.00e+00	1445.00
IUUC-Cfa-020568	Canis familiaris	90.58	0.00e+00	1395.00
IUUC-Cpo-022531	Cavia porcellus	91.58	0.00e+00	1434.00
IUUC-Csa-024145	Chlorocebus sabaeus	96.03	0.00e+00	1464.00
IUUC-Cho-024963	Choloepus hoffmanni	79.54	0.00e+00	743.00
IUUC-Dre-028341	Danio rerio	89.65	0.00e+00	1375.00
IUUC-Dno-029705	Dasypus novemcinctus	89.74	0.00e+00	1380.00
IUUC-Eca-034125	Equus caballus	92.05	0.00e+00	1408.00
IUUC-Fca-035905	Felis catus	93.81	0.00e+00	1404.00
IUUC-Fal-037336	Ficedula albicollis	96.08	0.00e+00	1428.00
IUUC-Gmo-039486	Gadus morhua	79.81	0.00e+00	858.00
IUUC-Gga-040218	Gallus gallus	94.89	0.00e+00	1465.00
IUUC-Gac-041707	Gasterosteus aculeatus	84.08	0.00e+00	1267.00
IUUC-Ggo-045408	Gorilla gorilla	87.06	0.00e+00	1309.00
IUUC-Hsa-045878	Homo sapiens	92.50	0.00e+00	1447.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	92.04	0.00e+00	1408.00
IUUC-Loc-052628	Lepisosteus oculatus	83.90	0.00e+00	1351.00
IUUC-Laf-053644	Loxodonta africana	90.71	0.00e+00	1372.00
IUUC-Mcc-055479	Macaca mulatta	87.60	0.00e+00	1300.00
IUUC-Mga-059723	Meleagris gallopavo	92.82	0.00e+00	1409.00
IUUC-Mdo-063005	Monodelphis domestica	96.45	0.00e+00	1471.00
IUUC-Mmu-063634	Mus musculus	94.82	0.00e+00	1426.00
IUUC-Mpu-065898	Mustela putorius furo	94.45	0.00e+00	1408.00
IUUC-Mlu-067584	Myotis lucifugus	90.13	0.00e+00	1405.00
IUUC-Nle-069033	Nomascus leucogenys	92.72	0.00e+00	1416.00
IUUC-Ont-072265	Oreochromis niloticus	82.04	0.00e+00	1277.00
IUUC-Oan-073621	Ornithorhynchus anatinus	90.80	0.00e+00	1430.00
IUUC-Ocu-073960	Oryctolagus cuniculus	91.26	0.00e+00	1382.00
IUUC-Oga-088579	Otolemur garnettii	92.24	0.00e+00	1442.00
IUUC-Oar-090396	Ovis aries	89.01	0.00e+00	1310.00
IUUC-Ptr-091624	Pan troglodytes	92.50	0.00e+00	1447.00
IUUC-Pan-092479	Papio anubis	92.59	0.00e+00	1414.00
IUUC-Pfo-097203	Poecilia formosa	84.28	0.00e+00	1293.00
IUUC-Pab-097540	Pongo abelii	92.16	0.00e+00	1375.00
IUUC-Pca-100379	Procavia capensis	71.71	0.00e+00	631.00
IUUC-Rno-105396	Rattus norvegicus	94.82	0.00e+00	1427.00
IUUC-Sha-107216	Sarcophilus harrisii	92.57	0.00e+00	1437.00
IUUC-Ssc-116413	Sus scrofa	92.49	0.00e+00	1373.00
IUUC-Tgu-116723	Taeniopygia guttata	92.60	0.00e+00	1406.00
IUUC-Tru-117843	Takifugu rubripes	82.30	0.00e+00	1277.00
IUUC-Tsy-119455	Tarsius syrichta	90.25	0.00e+00	1321.00
IUUC-Tni-120037	Tetraodon nigroviridis	81.16	0.00e+00	1211.00
IUUC-Tbe-127879	Tupaia belangeri	78.71	0.00e+00	1148.00
IUUC-Ttr-128423	Tursiops truncatus	90.69	0.00e+00	1330.00
IUUC-Xtr-132237	Xenopus tropicalis	86.92	0.00e+00	1376.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence